MX2022008083A - Contenedor de cultivo celular de un solo uso con uno o mas sensores en linea in situ. - Google Patents

Contenedor de cultivo celular de un solo uso con uno o mas sensores en linea in situ.

Info

Publication number
MX2022008083A
MX2022008083A MX2022008083A MX2022008083A MX2022008083A MX 2022008083 A MX2022008083 A MX 2022008083A MX 2022008083 A MX2022008083 A MX 2022008083A MX 2022008083 A MX2022008083 A MX 2022008083A MX 2022008083 A MX2022008083 A MX 2022008083A
Authority
MX
Mexico
Prior art keywords
situ
cell culture
culture container
use cell
online sensors
Prior art date
Application number
MX2022008083A
Other languages
English (en)
Inventor
Christian Schwald
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=69105717&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022008083(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2022008083A publication Critical patent/MX2022008083A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20—Degassing; Venting; Bubble traps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/38—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of metabolites or enzymes in the cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

En el presente documento se informa de un biorreactor de pequeño volumen que comprende un recipiente de cultivo y una placa de la cabeza del reactor, en donde el recipiente de cultivo tiene un volumen de trabajo de aproximadamente 20 ml a 350 ml y comprende dos o más sensores in situ, en donde la placa de la cabeza del reactor comprende un puerto de sensor in situ, en donde se conectan al puerto de sensor in situ al menos un sensor de glucosa in situ y un sensor de pH in situ.
MX2022008083A 2020-01-02 2020-12-30 Contenedor de cultivo celular de un solo uso con uno o mas sensores en linea in situ. MX2022008083A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20150132 2020-01-02
PCT/EP2020/088013 WO2021136798A1 (en) 2020-01-02 2020-12-30 Single-use cell culture container with one or more in-situ online sensors

Publications (1)

Publication Number Publication Date
MX2022008083A true MX2022008083A (es) 2022-07-11

Family

ID=69105717

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022008083A MX2022008083A (es) 2020-01-02 2020-12-30 Contenedor de cultivo celular de un solo uso con uno o mas sensores en linea in situ.

Country Status (12)

Country Link
US (1) US20220411736A1 (es)
EP (1) EP4085126B1 (es)
JP (1) JP7778076B2 (es)
KR (1) KR20220120582A (es)
CN (1) CN114945659A (es)
AU (1) AU2020419442A1 (es)
BR (1) BR112022013019A2 (es)
CA (1) CA3164000A1 (es)
ES (1) ES2987046T3 (es)
IL (1) IL294268A (es)
MX (1) MX2022008083A (es)
WO (1) WO2021136798A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025507790A (ja) * 2022-03-02 2025-03-21 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 高力価抗体のための製造プロセス
CN115353962A (zh) * 2022-09-13 2022-11-18 深圳市同信生物科技有限公司 一种一次性生物反应器及其制造方法
WO2025159985A1 (en) * 2024-01-23 2025-07-31 Global Life Sciences Solutions Usa Llc Small-scale bioreactor

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01102352A (ja) * 1987-10-16 1989-04-20 Toshiba Corp バイオセンサー
US8026096B1 (en) 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
KR20070015178A (ko) * 2004-04-27 2007-02-01 백스터 인터내셔널 인코포레이티드 교반-탱크 반응기 시스템
SG10201503987WA (en) * 2006-05-13 2015-06-29 Pall Life Sciences Belgium Disposable Bioreactor
US8057092B2 (en) * 2006-11-30 2011-11-15 Corning Incorporated Disposable spinner flask
DE102012010155B4 (de) 2012-05-24 2015-06-11 Pan-Biotech Gmbh Zellkulturbehälter für den Einmalgebrauch
KR20150056548A (ko) * 2012-09-18 2015-05-26 바이엘 테크놀로지 서비시즈 게엠베하 1회용 병 반응기 탱크
JP6463275B2 (ja) 2013-01-08 2019-01-30 イエール ユニバーシティ ヒトおよび大型哺乳動物の肺のバイオリアクター
US10059914B2 (en) 2013-11-21 2018-08-28 Distek, Inc. Disposable bioreactors and methods for construction and use thereof
KR102621101B1 (ko) * 2015-08-08 2024-01-05 스토베 게엠베하 생물학적 활동을 지원하는 일회용 생물 공정 시스템
JP6929882B2 (ja) 2016-02-23 2021-09-01 コーニング インコーポレイテッド 灌流バイオリアクタおよび連続細胞培養を実施するためのその使用方法
SG11202002339XA (en) 2017-10-16 2020-04-29 Regeneron Pharma Perfusion bioreactor and related methods of use
CN111801411B (zh) 2018-04-10 2023-07-18 Emd密理博公司 包括具有通道的可伸缩孔板的一次性容器
AU2019309101A1 (en) * 2018-07-27 2021-03-04 Univercells Technologies S.A. System and method for the production of biomolecules
NL2021470B1 (en) * 2018-08-15 2020-02-24 Applikon Biotechnology B V Lid configuration for a bioreactor
US20220041973A1 (en) * 2018-10-18 2022-02-10 University Of Maryland, College Park Integrated capsule system for real-time bioprocess monitoring and method of using the same
EP3924097A4 (en) * 2019-02-11 2022-11-16 Culture Biosciences, Inc. BIOREACTOR CONTAINER FOR AUTOMATED FERMENTATION SYSTEM

Also Published As

Publication number Publication date
US20220411736A1 (en) 2022-12-29
WO2021136798A1 (en) 2021-07-08
JP7778076B2 (ja) 2025-12-01
BR112022013019A2 (pt) 2022-09-06
EP4085126B1 (en) 2024-07-03
EP4085126C0 (en) 2024-07-03
AU2020419442A1 (en) 2022-06-09
EP4085126A1 (en) 2022-11-09
CN114945659A (zh) 2022-08-26
KR20220120582A (ko) 2022-08-30
IL294268A (en) 2022-08-01
ES2987046T3 (es) 2024-11-13
JP2023509434A (ja) 2023-03-08
CA3164000A1 (en) 2021-07-08

Similar Documents

Publication Publication Date Title
Bajracharya et al. Effects of controlled gas environments in solid‐substrate fermentations of rice
CA2403253A1 (en) Measuring metabolic rate changes
Le Mense et al. Production of mold amylases in submerged culture
CN107177512A (zh) 一种促进羊肚菌菌丝生长的培养基
CN101855973B (zh) 一种漆酶产生真菌菌株白耙齿菌及其培养方法和应用
Lu et al. High efficiency cell-recycle continuous sodium gluconate production by Aspergillus niger using on-line physiological parameters association analysis to regulate feed rate rationally
CN107488600A (zh) 一株高产耐氧化低温葡萄糖氧化酶的黑曲霉
RU2001949C1 (ru) Штамм гриба TRICHODERMA REESEI - продуцент целлюлолитических ферментов
Roche et al. Use of chitin measurement to estimate fungal biomass in solid state fermentation
CN106987573A (zh) 一种生产麦芽寡糖基海藻糖合成酶、麦芽寡糖基海藻糖水解酶的方法以及生产海藻糖的方法
BR112022013019A2 (pt) Biorreator de pequeno volume e métodos para cultivar uma célula de mamífero e para determinar as condições de cultivo
CN103695315B (zh) 一种用微生物发酵生产甲壳低聚糖的方法
Silveira et al. Optimization of glucoamylase production by Aspergillus niger in solid-state fermentation
Rowley et al. Isolation of a yeast‐lyzing Arthrobacter species and the production of the lytic enzyme complex in batch and continuous‐flow fermentors
CN105462868B (zh) 一种提高丙酮酸产量和生产强度的方法
CN104789635A (zh) 一种黑曲霉麸曲孢子活力的评价方法
CN107937479B (zh) 一种测定生防细菌代谢产物拮抗活性的方法
CN205774589U (zh) 培养细胞复层生长用放置式培养皿
CN210900683U (zh) 可监测调节酸碱度的食用菌种植架
CN102898207A (zh) 北虫草菌种液体培养基及其制备和使用方法
CN104798598A (zh) 一种可用于袋栽罐栽机械化接种的液体银耳菌种的生产技术
CN216821021U (zh) 一种新型食用菌培养装置
CN111944854A (zh) 一种利用海蟹共生烟曲霉制备抗癌活性化合物cha的方法
CN110129293A (zh) 一种葡萄糖氧化酶的工业发酵提取方法
CN103290096B (zh) 鉴定霉菌分解淀粉能力的方法