MX2022001519A - Sistemas y metodos para preparacion de muestras, generacion de datos y analisis de proteina corona. - Google Patents

Sistemas y metodos para preparacion de muestras, generacion de datos y analisis de proteina corona.

Info

Publication number
MX2022001519A
MX2022001519A MX2022001519A MX2022001519A MX2022001519A MX 2022001519 A MX2022001519 A MX 2022001519A MX 2022001519 A MX2022001519 A MX 2022001519A MX 2022001519 A MX2022001519 A MX 2022001519A MX 2022001519 A MX2022001519 A MX 2022001519A
Authority
MX
Mexico
Prior art keywords
systems
methods
sample preparation
analysis
data generation
Prior art date
Application number
MX2022001519A
Other languages
English (en)
Spanish (es)
Inventor
Xiaoyan Zhao
William Manning
Young Kim
Brandon Kwan-Leong
Hope Liou
Original Assignee
Seer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=74504065&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022001519(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seer Inc filed Critical Seer Inc
Publication of MX2022001519A publication Critical patent/MX2022001519A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MX2022001519A 2019-08-05 2020-08-04 Sistemas y metodos para preparacion de muestras, generacion de datos y analisis de proteina corona. MX2022001519A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962883107P 2019-08-05 2019-08-05
PCT/US2020/044908 WO2021026172A1 (en) 2019-08-05 2020-08-04 Systems and methods for sample preparation, data generation, and protein corona analysis

Publications (1)

Publication Number Publication Date
MX2022001519A true MX2022001519A (es) 2022-04-06

Family

ID=74504065

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001519A MX2022001519A (es) 2019-08-05 2020-08-04 Sistemas y metodos para preparacion de muestras, generacion de datos y analisis de proteina corona.

Country Status (11)

Country Link
US (6) US11630112B2 (enExample)
EP (1) EP4010456A4 (enExample)
JP (3) JP7441303B2 (enExample)
KR (2) KR102704078B1 (enExample)
CN (4) CN114651058B (enExample)
AU (1) AU2020326698B2 (enExample)
CA (1) CA3146525A1 (enExample)
GB (1) GB2606810A (enExample)
IL (2) IL303893B1 (enExample)
MX (1) MX2022001519A (enExample)
WO (1) WO2021026172A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
AU2019374692B2 (en) * 2018-11-07 2025-08-28 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof
JP7518852B2 (ja) 2019-03-26 2024-07-18 シアー， インコーポレイテッド 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用
GB2606810A (en) 2019-08-05 2022-11-23 Seer Inc Systems and methods for sample preparation, data generation, and protein corona analysis
GB2603051B (en) 2020-01-30 2023-04-26 Prognomiq Inc Lung biomarkers and methods of use thereof
US20230324401A1 (en) * 2020-07-20 2023-10-12 Seer, Inc. Particles and methods of assaying
DE112021004478T5 (de) 2020-08-25 2023-09-14 Seer, Inc. Zusammensetzungen und verfahren zur bestimmung von proteinen und nukleinsäuren
AU2022249074A1 (en) 2021-03-31 2023-09-21 PrognomIQ, Inc. Multi-omic assessment
WO2023039479A1 (en) 2021-09-10 2023-03-16 PrognomIQ, Inc. Direct classification of raw biomolecule measurement data
JP2024534992A (ja) 2021-09-13 2024-09-26 プログノミック インコーポレイテッド 生体分子の増強された検出および定量
JP2025503712A (ja) * 2022-01-14 2025-02-04 シアー， インコーポレイテッド セクレトームをアッセイするためのシステムおよび方法
EP4466538A4 (en) * 2022-01-20 2026-01-14 Seer Inc PARTICLES AND ASSAY METHODS
IL317700A (en) * 2022-06-15 2025-02-01 Seer Inc Systems and methods for testing biomolecules
WO2024145237A2 (en) * 2022-12-29 2024-07-04 Seer, Inc. Methods and apparatuses for detecting biomolecule and analyte interactions
TWM647074U (zh) * 2023-02-02 2023-10-11 新原生細胞製備股份有限公司 三維培養裝置及生物培養器具
US20250207155A1 (en) * 2023-12-22 2025-06-26 Seer, Inc. Particle-based bioseparation assays
TWI921285B (zh) * 2025-09-18 2026-04-01 國立中興大學 牛乳的單一產地與非單一產地的混乳辨識方法
CN121545572A (zh) * 2026-01-20 2026-02-17 北京诺禾致源科技股份有限公司 蛋白质翻译后修饰数据分析处理系统、方法及服务器

Family Cites Families (281)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863873A (en) 1980-01-14 1989-09-05 Esa, Inc. Method for biological testing and/or developing pharmaceuticals for treatment of disorders
US4444879A (en) 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US4443319A (en) 1982-09-30 1984-04-17 E. I. Du Pont De Nemours And Company Device for electrophoresis
US4483885A (en) 1982-09-30 1984-11-20 E. I. Du Pont De Nemours & Company Method and device for electrophoresis
US6270961B1 (en) 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
CA1340966C (en) 1989-05-19 2000-04-18 Thomas R. Covey Method of protein analysis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5228989A (en) 1989-07-06 1993-07-20 Perseptive Biosystems, Inc. Perfusive chromatography
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US4977320A (en) 1990-01-22 1990-12-11 The Rockefeller University Electrospray ionization mass spectrometer with new features
US5170053A (en) 1990-08-30 1992-12-08 Finnigan Corporation Electrospray ion source and interface apparatus and method
US5245186A (en) 1991-11-18 1993-09-14 The Rockefeller University Electrospray ion source for mass spectrometry
EP0544969B1 (de) 1991-12-06 1997-03-05 Ciba-Geigy Ag Elektrophoretische Trennvorrichtung und elektrophoretisches Trennverfahren
US5227471A (en) 1992-01-30 1993-07-13 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma
US5958202A (en) 1992-09-14 1999-09-28 Perseptive Biosystems, Inc. Capillary electrophoresis enzyme immunoassay
US5358618A (en) 1993-01-22 1994-10-25 The Penn State Research Foundation Capillary electrophoresis apparatus with improved electroosmotic flow control
DE69333601T2 (de) 1993-04-15 2005-09-15 Zeptosens Ag Verfahren zur Steuerung der Probeneinführung bei Mikrosäulentrennungstechniken und Probenentnahmevorrichtungen
US5366140A (en) 1993-09-30 1994-11-22 Minnesota Mining And Manufacturing Company Patterned array of uniform metal microbeads
EP0653631B1 (de) 1993-11-11 2003-05-14 Aclara BioSciences, Inc. Vorrichtung und Verfahren zur elektrophoretischen Trennung von fluiden Substanzgemischen
ES2331494T3 (es) 1994-02-28 2010-01-05 Perkinelmer Health Sciences, Inc. Guia de iones multipolar para espectrometria de masas.
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
US5639656A (en) 1994-03-31 1997-06-17 Medical College Of Hampton Road Antibodies reactive with biological markers of benign prostate hyperplasia
US5498545A (en) 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
WO1996012187A1 (en) 1994-10-13 1996-04-25 Horus Therapeutics, Inc. Computer assisted methods for diagnosing diseases
US5545304A (en) 1995-05-15 1996-08-13 Battelle Memorial Institute Ion current detector for high pressure ion sources for monitoring separations
US5587582A (en) 1995-05-19 1996-12-24 Cornell Research Foundation, Inc. Self-aligning liquid junction
US5624539A (en) 1995-06-19 1997-04-29 The Penn State Research Foundation Real time monitoring of electroosmotic flow in capillary electrophoresis
WO1997001755A2 (en) 1995-06-26 1997-01-16 Perseptive Biosystems, Inc. High speed, automated, continuous flow, multi-dimensional molecular selection and analysis
FI953257A7 (fi) 1995-06-30 1996-12-31 Boehringer Mannheim Gmbh Rekombinanttinen ihmisen prostaspesifinen antigeeni ja sen käytöt
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6068749A (en) 1996-01-19 2000-05-30 Northeastern University Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications
WO1997029508A2 (en) 1996-02-08 1997-08-14 Perseptive Biosystems, Inc. Interface between liquid flow and mass spectrometer
SE9602638D0 (sv) 1996-07-03 1996-07-03 Pharmacia Biotech Ab An improved method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5788166A (en) 1996-08-27 1998-08-04 Cornell Research Foundation, Inc. Electrospray ionization source and method of using the same
US6110343A (en) 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US6863790B1 (en) 1997-02-06 2005-03-08 Board Of Regents University Of Texas System Sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry using an in-capillary electrode
US6157921A (en) 1998-05-01 2000-12-05 Barnhill Technologies, Llc Enhancing knowledge discovery using support vector machines in a distributed network environment
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6159739A (en) 1997-03-26 2000-12-12 University Of Washington Device and method for 3-dimensional alignment of particles in microfabricated flow channels
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6309816B1 (en) 1997-04-16 2001-10-30 Horus Therapeutics, Inc. Methods for diagnosing cancer by measuring creatine kinase
EP0881494A1 (de) 1997-04-29 1998-12-02 Roche Diagnostics GmbH Verfahren zur simultanen Bestimmung von Proteinen bzw. entsprechenden Derivaten
US6187190B1 (en) 1997-05-09 2001-02-13 Battelle Memorial Institute Apparatus for molecular weight separation
US6175112B1 (en) 1998-05-22 2001-01-16 Northeastern University On-line liquid sample deposition interface for matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectroscopy
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US5993633A (en) 1997-07-31 1999-11-30 Battelle Memorial Institute Capillary electrophoresis electrospray ionization mass spectrometry interface
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
JP2001516140A (ja) 1997-09-12 2001-09-25 アナリティカ オブ ブランフォード インコーポレーテッド 多重試料導入質量分光測定法
US6284113B1 (en) 1997-09-19 2001-09-04 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
US6007775A (en) 1997-09-26 1999-12-28 University Of Washington Multiple analyte diffusion based chemical sensor
US6139734A (en) 1997-10-20 2000-10-31 University Of Virginia Patent Foundation Apparatus for structural characterization of biological moieties through HPLC separation
US5928952A (en) 1997-11-05 1999-07-27 Zymark Corporation Scheduled system and method for processing chemical products
JP3219386B2 (ja) 1997-12-26 2001-10-15 松下電器産業株式会社 情報フィルタ装置及び情報フィルタ方法
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6318970B1 (en) 1998-03-12 2001-11-20 Micralyne Inc. Fluidic devices
AU3367799A (en) 1998-03-30 1999-10-18 Esa Inc. Methodology for predicting and/or diagnosing disease
US6658395B1 (en) 1998-05-01 2003-12-02 Biowulf Technologies, L.L.C. Enhancing knowledge discovery from multiple data sets using multiple support vector machines
US6107628A (en) 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
EP1876442A3 (en) 1998-09-17 2008-03-05 Advion BioSciences, Inc. Integrated monolithic microfabricated liquid chromatography system and method
US6086243A (en) 1998-10-01 2000-07-11 Sandia Corporation Electrokinetic micro-fluid mixer
US6413780B1 (en) 1998-10-14 2002-07-02 Abbott Laboratories Structure and method for performing a determination of an item of interest in a sample
JP2002527758A (ja) 1998-10-19 2002-08-27 ダイアデクスアス・インコーポレーテッド 前立腺癌を診断、監視、病期分類、イメージング及び治療する方法
US6240790B1 (en) 1998-11-09 2001-06-05 Agilent Technologies, Inc. Device for high throughout sample processing, analysis and collection, and methods of use thereof
ATE444481T1 (de) 1998-11-16 2009-10-15 California Inst Of Techn Gleichzeitige bestimmung von gleichgewichts- und kinetischen eigenschaften
DE19852928C1 (de) 1998-11-17 2000-08-03 Steffen Panzner Strukturen in Form von Hohlkugeln
US6091502A (en) 1998-12-23 2000-07-18 Micronics, Inc. Device and method for performing spectral measurements in flow cells with spatial resolution
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6375817B1 (en) 1999-04-16 2002-04-23 Perseptive Biosystems, Inc. Apparatus and methods for sample analysis
US6368562B1 (en) 1999-04-16 2002-04-09 Orchid Biosciences, Inc. Liquid transportation system for microfluidic device
JP4723725B2 (ja) 1999-04-20 2011-07-13 ターゲット ディスカバリー， インコーポレイテッド 代謝経路を分析するための方法
KR20020003384A (ko) 1999-04-26 2002-01-12 써로메드, 인크. 표현형 및 생물학적 마커 동정 시스템
US6714925B1 (en) 1999-05-01 2004-03-30 Barnhill Technologies, Llc System for identifying patterns in biological data using a distributed network
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6969615B2 (en) 1999-07-26 2005-11-29 20/20 Genesystems, Inc. Methods, devices, arrays and kits for detecting and analyzing biomolecules
US6977145B2 (en) 1999-07-28 2005-12-20 Serono Genetics Institute S.A. Method for carrying out a biochemical protocol in continuous flow in a microreactor
US6650413B2 (en) 1999-08-08 2003-11-18 Institut National D'optique Linear spectrometer
CA2382436C (en) 1999-08-30 2011-05-17 Illumina, Inc. Methods for improving signal detection from an array
US6284115B1 (en) 1999-09-21 2001-09-04 Agilent Technologies, Inc. In-line flow through micro-dialysis apparatus and method for high performance liquid phase separations
CA2386669A1 (en) 1999-10-07 2001-04-12 Ciphergen Biosystems, Inc. Prostate cancer marker proteins
US6936424B1 (en) 1999-11-16 2005-08-30 Matritech, Inc. Materials and methods for detection and treatment of breast cancer
US20020048777A1 (en) 1999-12-06 2002-04-25 Shujath Ali Method of diagnosing monitoring, staging, imaging and treating prostate cancer
US20020009727A1 (en) 2000-02-02 2002-01-24 Schultz Gary A. Detection of single nucleotide polymorphisms
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
MXPA02007665A (es) 2000-02-08 2004-08-23 Univ Michigan Trazado de despliegue diferencial de proteinas.
US6379791B1 (en) 2000-02-08 2002-04-30 3M Innovative Properties Company Compatibilized pressure-sensitive adhesives
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
ATE356357T1 (de) 2000-03-20 2007-03-15 Eastern Virginia Med School Prostatakrebs-marker
US6884578B2 (en) 2000-03-31 2005-04-26 Affymetrix, Inc. Genes differentially expressed in secretory versus proliferative endometrium
DE10021737C2 (de) 2000-05-04 2002-10-17 Hermann Haller Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird
US20020010552A1 (en) 2000-05-26 2002-01-24 Hugh Rienhoff System for genetically characterizing an individual for evaluation using genetic and phenotypic variation over a wide area network
AU7299301A (en) 2000-06-21 2002-01-02 Bioarray Solutions Ltd Multianalyte molecular analysis using application-specific random particle arrays
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
WO2002006829A2 (en) 2000-07-18 2002-01-24 Correlogic Systems, Inc. A process for discriminating between biological states based on hidden patterns from biological data
AUPQ886100A0 (en) 2000-07-19 2000-08-10 Biotron Limited Diagnostic test
CA2320549A1 (en) 2000-09-25 2002-03-25 Eastern Virginia Medical College Biomarkers of transitional cell carcinoma of the bladder
JP4361271B2 (ja) 2000-10-10 2009-11-11 バイオトローブ・インコーポレイテツド アッセイ、合成、および保存用の器具、ならびに、その作製、使用、および操作の方法
WO2002042776A2 (en) 2000-11-01 2002-05-30 Diadexus, Inc. Compositions and methods relating to prostate specific genes and proteins
US20030064377A1 (en) 2000-11-06 2003-04-03 Yongming Sun Compositions and methods relating to prostate specific genes and proteins
WO2002039431A2 (en) 2000-11-06 2002-05-16 Diadexus, Inc. Compositions and methods relating to prostate specific genes and proteins
WO2003031031A1 (en) 2000-11-16 2003-04-17 Ciphergen Biosystems, Inc. Method for analyzing mass spectra
AU4322102A (en) 2000-11-20 2002-06-18 Eastern Virginia Med School Methods and devices for the quantitative detection of prostate specific membraneantigen and other prostatic markers
AU2002217991A1 (en) 2000-11-21 2002-06-03 Diadexus, Inc. Compositions and methods relating to prostate specific genes and proteins
WO2002042499A2 (en) 2000-11-21 2002-05-30 Diadexus, Inc. Compositions and methods relating to prostate specific genes and proteins
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
US20020095260A1 (en) 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
US20020119490A1 (en) 2000-12-26 2002-08-29 Aebersold Ruedi H. Methods for rapid and quantitative proteome analysis
GB0103516D0 (en) 2001-02-13 2001-03-28 Cole Polytechnique Federale De Apparatus for dispensing a sample
WO2002070742A1 (en) 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
US20030228639A1 (en) 2001-03-19 2003-12-11 Wright George L Prostate cancer markers
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US20030148295A1 (en) 2001-03-20 2003-08-07 Wan Jackson Shek-Lam Expression profiles and methods of use
US6602855B2 (en) 2001-04-30 2003-08-05 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1449 daltons
US6627606B2 (en) 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1465 daltons
US6617308B2 (en) 2001-04-30 2003-09-09 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons
US6620787B2 (en) 2001-04-30 2003-09-16 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 2267 daltons
US6703366B2 (en) 2001-04-30 2004-03-09 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1,896 daltons
US6593298B2 (en) 2001-04-30 2003-07-15 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1690 daltons
US6677303B2 (en) 2001-04-30 2004-01-13 Syn X Pharma Biopolymer marker indicative of disease state having a molecular weight of 1097 daltons
US6756476B2 (en) 2001-04-30 2004-06-29 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 2021 daltons
US6627607B2 (en) 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1845 daltons
US6599877B2 (en) 2001-04-30 2003-07-29 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1020 daltons
US6620786B2 (en) 2001-04-30 2003-09-16 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having molecular weight of 2937 daltons
US6627608B2 (en) 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1206 daltons
CA2349265A1 (en) 2001-05-30 2002-11-30 Andrew Emili Protein expression profile database
US20030092029A1 (en) 2001-06-06 2003-05-15 Lee Josephson Magneitc-nanoparticle conjugates and methods of use
US20030013120A1 (en) 2001-07-12 2003-01-16 Patz Edward F. System and method for differential protein expression and a diagnostic biomarker discovery system and method using same
US7541003B2 (en) 2001-07-17 2009-06-02 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
US20030119062A1 (en) 2001-08-03 2003-06-26 Brame Cynthia J. Detection of differential expression of protein using gel-free proteomics
JP2005500543A (ja) 2001-08-13 2005-01-06 ビヨンド ジェノミクス， インコーポレイテッド 生物学的系をプロファイリングするための方法およびシステム
US6803568B2 (en) 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US20040043436A1 (en) 2001-09-21 2004-03-04 Antonia Vlahou Biomarkers of transitional cell carcinoma of the bladder
US20030078739A1 (en) 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US6835927B2 (en) 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
US20030089605A1 (en) 2001-10-19 2003-05-15 West Virginia University Research Corporation Microfluidic system for proteome analysis
US20030077611A1 (en) 2001-10-24 2003-04-24 Sention Methods and systems for dynamic gene expression profiling
WO2003038055A2 (en) 2001-10-31 2003-05-08 Mds Proteomics, Inc. Proteins involved in regulation of adipocytes and uses related thereto
US6780602B2 (en) 2001-11-01 2004-08-24 Microbiosystems, Limited Partnership Taxonomic identification of pathogenic microorganisms and their toxic proteins
CA2466837A1 (en) 2001-11-13 2003-05-22 Caprion Pharmaceuticals Inc. Mass intensity profiling system and uses thereof
US20040018519A1 (en) 2001-11-16 2004-01-29 Wright ,Jr. George L Methods and devices for quantitative detection of prostate specific membrane antigen and other prostatic markers
AU2002360815A1 (en) 2001-12-27 2003-07-24 Ciphergen Biosystems, Inc. Human breast cancer biomarkers
US20030153007A1 (en) 2001-12-28 2003-08-14 Jian Chen Automated systems and methods for analysis of protein post-translational modification
AU2003235749A1 (en) 2002-01-07 2003-07-24 John Hopkins University Biomarkers for detecting ovarian cancer
US20060088830A1 (en) 2002-02-21 2006-04-27 Eastern Virginia Medical School Protein biomarkers that distinguish prostate cancer from non-malignant cells
US20020193950A1 (en) 2002-02-25 2002-12-19 Gavin Edward J. Method for analyzing mass spectra
US7135286B2 (en) 2002-03-26 2006-11-14 Perlegen Sciences, Inc. Pharmaceutical and diagnostic business systems and methods
WO2003102589A1 (en) 2002-04-08 2003-12-11 Bioinfra Inc. Method and system for analysis of cancer biomarkers using proteome image mining
EP1496928A4 (en) 2002-04-08 2005-08-10 Ciphergen Biosystems Inc SERUM BIOMARKERS IN HEPATOCELLULAR CARCINOMA
CN100489534C (zh) 2002-04-15 2009-05-20 萨莫芬尼根有限责任公司 生物学分子的定量
US20030199001A1 (en) 2002-04-23 2003-10-23 Pitt Aldo M. Sample preparation of biological fluids for proteomic applications
US7718072B2 (en) 2002-04-26 2010-05-18 Abbott Laboratories Structure and method for handling magnetic particles in biological assays
WO2003091695A2 (en) 2002-04-26 2003-11-06 The Johns Hopkins University Identification of biomarkers for detecting prostate cancer
US7460960B2 (en) 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
JP2006509186A (ja) 2002-05-10 2006-03-16 イースタン バージニア メディカル スクール 前立腺癌バイオマーカー
CA2486327A1 (en) 2002-05-17 2003-11-27 Eastern Virginia Medical School Htlv-i tax induced killing of p53 null cancer cells
US20030224531A1 (en) 2002-05-29 2003-12-04 Brennen Reid A. Microplate with an integrated microfluidic system for parallel processing minute volumes of fluids
US7375234B2 (en) 2002-05-30 2008-05-20 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
WO2003102539A2 (en) 2002-05-31 2003-12-11 The Regents Of The University Of Michigan Automated protein analysis system comprising capillary electrophoresis-tandem mass spectrometry
AR040712A1 (es) 2002-07-29 2005-04-20 Correlogic Systems Inc Un metodo para inicialar un modelo de control para proceso de bioensayo
US20040153249A1 (en) 2002-08-06 2004-08-05 The Johns Hopkins University System, software and methods for biomarker identification
DE60332639D1 (de) 2002-08-06 2010-07-01 Univ Johns Hopkins Verwendung von biomarkern zum nachweis von eierstockkrebs
DE10247896B4 (de) 2002-10-14 2007-01-18 Bruker Daltonik Gmbh Mehrdimensionale Trennung von Biosubstanzgemischen für massenspektrometrische Analysen
WO2004055519A2 (en) 2002-12-17 2004-07-01 Sinogenomax Co. Ltd. Specific markers for pancreatic cancer
EP1739185A1 (en) 2002-12-18 2007-01-03 Ciphergen Biosystems, Inc. Serum biomarkers in lung cancer
EP1588144A3 (en) 2003-01-03 2005-12-21 Caprion Pharmaceuticals, Inc. Glycopeptide identification and analysis
DE10304106A1 (de) 2003-01-31 2004-08-26 Mosaiques Diagnostics And Therapeutics Ag Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird
US7695738B2 (en) 2003-02-19 2010-04-13 Academia Sinica Carbohydrate encapsulated nanoparticles
US7007710B2 (en) 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
EP1639365A1 (en) 2003-05-15 2006-03-29 Europroteome AG Differential diagnosis of colorectal cancer and other diseases of the colon
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
CA2534336A1 (en) 2003-08-01 2005-02-10 Correlogic Systems, Inc. Multiple high-resolution serum proteomic features for ovarian cancer detection
US20040106131A1 (en) 2003-08-18 2004-06-03 Swapan Roy Compositions and methods for proteomic investigations
AU2004267806A1 (en) 2003-08-20 2005-03-03 Bg Medicine, Inc. Methods and systems for profiling biological systems
EP1512970A1 (en) 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
DE10341193A1 (de) 2003-09-06 2005-03-31 Mosaiques Diagnostics And Therapeutics Ag Vorrichtung und Verfahren zur quantitativen Auswertung der in einer Körperflüssigkeitsprobe enthaltenden Polypeptide sowie Marker zur Erkennung von pathologischen Zuständen
US20050072915A1 (en) 2003-10-07 2005-04-07 Biospect Inc. Methods and apparatus for self-optimization of electrospray ionization devices
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CATCHES
US20050148100A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Methods and devices for using Raman-active probe constructs to assay biological samples
US20050181513A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by MAILDI mass spectrometry
EP1580559B1 (en) * 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methods for reducing the variance between analyte concentrations taken from complex sample mixtures
US20050244973A1 (en) 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
US9488655B2 (en) 2004-07-14 2016-11-08 The Regents Of The University Of California Biomarkers for detection of early- and late-stage endometrial cancer
WO2006032044A2 (en) 2004-09-15 2006-03-23 Microchip Biotechnologies, Inc. Microfluidic devices
US7449116B2 (en) 2004-10-01 2008-11-11 Agilent Technologies, Inc. Methods and systems for protein separation
DE102004051785B4 (de) 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
WO2006076612A2 (en) 2005-01-14 2006-07-20 Cabot Corporation A process for manufacturing application specific printable circuits (aspc’s) and other custom electronic devices
US8288169B2 (en) 2005-01-21 2012-10-16 Argylla Technologies Surface mediated self-assembly of nanoparticles
US9002652B1 (en) 2005-01-27 2015-04-07 Institute For Systems Biology Methods for identifying and using organ-specific proteins in blood
US20060172429A1 (en) * 2005-01-31 2006-08-03 Nilsson Erik J Methods of identification of biomarkers with mass spectrometry techniques
US7454988B2 (en) 2005-02-10 2008-11-25 Applera Corporation Method for fluid sampling using electrically controlled droplets
BRPI0611474A2 (pt) * 2005-05-26 2010-09-14 Ensemble Discovery Corp biodetecção por quìmica modelada com ácido nucléico
US20070009970A1 (en) 2005-07-08 2007-01-11 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
WO2007120248A2 (en) 2005-12-20 2007-10-25 The Ohio State University Research Foundation Nanoporous substrates for analytical methods
EP3147665A1 (en) 2005-12-22 2017-03-29 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
US9347945B2 (en) 2005-12-22 2016-05-24 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
US20070224644A1 (en) 2006-01-27 2007-09-27 Liotta Lance A Ocular fluid markers
JP5063616B2 (ja) 2006-02-03 2012-10-31 インテジェニックス インコーポレイテッド マイクロ流体デバイス
EP1987159B2 (en) 2006-02-08 2020-08-12 Illumina Cambridge Limited Method for sequencing a polynucleotide template
EP1882948A2 (de) 2006-07-28 2008-01-30 Qiagen GmbH Vorrichtung zur Probenverarbeitung
US7787681B2 (en) 2006-08-25 2010-08-31 The Trustees Of Columbia University In The City Of New York Systems and methods for robotic transport
US8053247B2 (en) * 2006-10-11 2011-11-08 Phynexus, Inc. Method and device for preparing an analyte for analysis by mass spectrometry
CN101169416A (zh) * 2006-10-23 2008-04-30 许洋 用磁珠支持基质及质谱判断质谱多肽谱和蛋白指纹的用途
WO2008083323A1 (en) * 2006-12-29 2008-07-10 Invitrogen Corporation Detection apparatus
US7815803B2 (en) 2007-06-14 2010-10-19 Roche Diagnostics Operations, Inc. Preparation of samples for LC-MS/MS using magnetic particles
WO2009006439A1 (en) 2007-06-29 2009-01-08 Correlogic Systems, Inc. Predictive markers for ovarian cancer
US9216080B2 (en) 2007-08-27 2015-12-22 Amo Groningen B.V. Toric lens with decreased sensitivity to cylinder power and rotation and method of using the same
EP2207030A4 (en) 2007-10-05 2010-12-08 Univ Hokkaido DEVICE FOR AUTOMATIC PRE-TREATMENT OF A SUGAR CHAIN
ES2448426T3 (es) 2007-10-12 2014-03-13 Pronota Nv Uso de aptámeros en proteómica
CA2703478C (en) 2007-10-29 2015-07-07 Csir Emulsion-derived particles
US8021891B2 (en) 2007-11-28 2011-09-20 University Of Massachusetts Methods and compositions for protein detection using nanoparticle-fluorescent polymer complexes
EP2234916A4 (en) 2008-01-22 2016-08-10 Integenx Inc UNIVERSAL SPECIMEN PREPARATION SYSTEM AND ITS USE IN AN INTEGRATED ANALYSIS SYSTEM
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
KR101039629B1 (ko) 2008-05-22 2011-06-08 성균관대학교산학협력단 생체물질의 검출방법, 생체물질 검출용 칩의 제조방법 및생물질 검출용 칩
CN101685080B (zh) * 2008-06-12 2012-10-31 高尚先 一种生物样品中蛋白质组的分析方法
WO2010042555A2 (en) 2008-10-06 2010-04-15 The Brigham And Women's Hospital, Inc. Particles with multiple functionalized surface domains
WO2010078601A1 (en) 2009-01-05 2010-07-08 The Regents Of The University Of California High throughput biomolecule separation and analysis
US20110306514A1 (en) 2009-01-14 2011-12-15 United States Department of Health and Human Services Ratio based biomarkers and methods of use thereof
EP2401619A1 (en) * 2009-02-26 2012-01-04 University College Dublin National University Of Ireland, Dublin A method for the selective concentration of a specific low abundance biomolecule
RU2559541C2 (ru) * 2009-06-05 2015-08-10 Интедженкс Инк. Универсальная система подготовки образцов и применение в интегрированной системе анализа
US20120190574A1 (en) 2009-06-19 2012-07-26 The Arizona Board of Regents, A body Corporate of the State of Arizona for and on behalf of Arizona Compound Arrays for Sample Profiling
EP2494364A1 (en) 2009-10-29 2012-09-05 Tethys Bioscience, Inc. Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes
US9910040B2 (en) 2012-07-09 2018-03-06 Sevident, Inc. Molecular nets comprising capture agents and linking agents
US9005994B2 (en) 2010-01-14 2015-04-14 University Of Central Florida Research Foundation, Inc. Methods for biomolecule and biomolecule complex (BMC) detection and analysis and the use of such for research and medical diagnosis
JP6114035B2 (ja) 2010-02-10 2017-04-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 肺癌検出用唾液バイオマーカー
US9149432B2 (en) 2010-03-19 2015-10-06 Massachusetts Institute Of Technology Lipid vesicle compositions and methods of use
US20120171694A1 (en) 2010-07-30 2012-07-05 Vermillion, Inc. Predictive markers and biomarker panels for ovarian cancer
WO2012031205A2 (en) 2010-09-03 2012-03-08 The Brigham And Women's Hospital, Inc. Lipid-polymer hybrid particles
US20170233798A1 (en) * 2010-10-22 2017-08-17 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US9329176B2 (en) 2010-11-18 2016-05-03 Academia Sinica Glycopeptide-functionalized nanoparticles arrays for capturing and detecting biomolecules
CN103703143B (zh) 2011-01-31 2016-12-14 爱普瑞斯生物公司 鉴定细胞中的多个表位的方法
JP2012172981A (ja) * 2011-02-17 2012-09-10 Jikei Univ 特異的反応検出キット、特異的反応検出装置、及び特異的反応検出方法
GB201103726D0 (en) 2011-03-04 2011-04-20 Immunovia Ab Method, array and use thereof
JP2014526032A (ja) 2011-06-07 2014-10-02 カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． 癌に対する循環バイオマーカー
US20130058923A1 (en) 2011-08-03 2013-03-07 Qun Huo Biomolecular interactions and interaction products as biomarkers for detection, diagnosis, prognosis and predicting therapeutic responses of human diseases
CN103874770A (zh) 2011-08-08 2014-06-18 卡里斯生命科学卢森堡控股有限责任公司 生物标志物组合物和方法
US20150168421A1 (en) 2012-04-05 2015-06-18 Integrated Diagnostics, Inc. Srm methods in alzheimer's disease and neurological disease assays
CN105229164B (zh) 2013-03-15 2019-02-12 爱科谱迅病理研究公司 指示癌症疗法的srm测定
US20140296096A1 (en) 2013-03-27 2014-10-02 Oslo Universitetssykehus Hf Prostate cancer markers and uses thereof
WO2014176435A2 (en) 2013-04-25 2014-10-30 Bergo Vladislav B Microarray compositions and methods of their use
WO2015099985A2 (en) 2013-12-23 2015-07-02 The Brigham And Women's Hospital, Inc. Cationic materials and formulations for drug delivery
DK3102612T3 (da) 2014-02-07 2024-10-28 European Molecular Biology Laboratory Proteomisk prøveforberedelse ved anvendelse af paramagnetiske kugler
CN103869080B (zh) 2014-03-06 2016-01-27 中国农业大学 慢性神经退行性疾病早期诊断标志物及应用
ES2939018T3 (es) * 2014-03-26 2023-04-18 Hoffmann La Roche IGFBP7 para diagnosticar una disfunción diastólica
US10272050B2 (en) 2014-10-14 2019-04-30 The Brigham And Women's Hospital, Inc. Nanoparticles and methods of use
TWI547693B (zh) * 2015-05-07 2016-09-01 希華晶體科技股份有限公司 感測方法及感測晶片
US10900975B2 (en) 2015-05-12 2021-01-26 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods of epitope binning and antibody profiling
WO2017091631A1 (en) 2015-11-23 2017-06-01 Massachusetts Institute Of Technology Protein corona phase molecular recognition
US20180361000A1 (en) 2015-12-11 2018-12-20 The General Hospital Corporation Dextran nanoparticles for macrophage specific imaging and therapy
WO2017173453A1 (en) 2016-04-01 2017-10-05 The Brigham And Women's Hospital, Inc. Stimuli-responsive nanoparticles for biomedical applications
WO2017168014A1 (de) * 2016-04-02 2017-10-05 Protagen Ag Markersequenzen für rheumatoide arthritis
GB201615128D0 (en) 2016-09-06 2016-10-19 Univ Manchester Methods
CA3029276C (en) * 2016-10-05 2023-03-07 Abbott Laboratories Devices and methods for sample analysis
WO2018067827A1 (en) 2016-10-05 2018-04-12 Avery Dennison Corporation Buddy clip
WO2018112470A1 (en) 2016-12-16 2018-06-21 The Brigham And Women's Hospital, Inc. Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
ES2993503T3 (en) 2016-12-16 2025-01-02 Brigham & Womens Hospital Inc System and method for protein corona sensor array for early detection of diseases
EP3649474A1 (en) * 2017-07-03 2020-05-13 Abbott Laboratories Improved methods for measuring ubiquitin carboxy-terminal hydrolase l1 levels in blood
US11009411B2 (en) 2017-08-14 2021-05-18 Sentons Inc. Increasing sensitivity of a sensor using an encoded signal
EP3729077B1 (en) * 2017-12-19 2024-03-27 Beckman Coulter, Inc. Integrated sample processing system with variable workflows
EP3502708B1 (en) * 2017-12-21 2023-09-27 Tecan Trading AG Monitoring a laboratory automation device via a simulation model
US12270741B2 (en) 2018-04-03 2025-04-08 Tymora Analytical Operations, Llc Methods for affinity-based non-antibody capture and purification of extracellular vesicles
GB2590185B (en) 2018-04-23 2022-09-28 Seer Inc Systems and methods for complex biomolecule sampling and biomarker discovery
AU2019374692B2 (en) 2018-11-07 2025-08-28 Seer, Inc. Compositions, methods and systems for protein corona analysis and uses thereof
JP7518852B2 (ja) 2019-03-26 2024-07-18 シアー， インコーポレイテッド 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用
GB2606810A (en) 2019-08-05 2022-11-23 Seer Inc Systems and methods for sample preparation, data generation, and protein corona analysis
WO2021087407A1 (en) 2019-11-02 2021-05-06 Seer, Inc. Systems for protein corona analysis
US20230212647A1 (en) 2020-05-29 2023-07-06 Seer, Inc. Systems and methods for rapid identification of proteins
US20230324401A1 (en) 2020-07-20 2023-10-12 Seer, Inc. Particles and methods of assaying
DE112021004478T5 (de) 2020-08-25 2023-09-14 Seer, Inc. Zusammensetzungen und verfahren zur bestimmung von proteinen und nukleinsäuren
US20220260559A1 (en) 2020-11-04 2022-08-18 Seer, Inc. Biomarkers for diagnosing alzheimer's disease
WO2022182989A1 (en) 2021-02-26 2022-09-01 Seer, Inc. Apparatus for biomolecule assay
WO2022232610A2 (en) 2021-04-29 2022-11-03 Seer, Inc. Peptide decorated nanoparticles for enrichment of specific protein subsets
US20240280558A1 (en) 2021-07-13 2024-08-22 Seer, Inc. Systems and methods for processing mass spectrometry datasets
US20230160882A1 (en) 2021-08-24 2023-05-25 Seer, Inc. Compositions and methods for low-volume biomolecule assays
US20230253113A1 (en) 2022-02-04 2023-08-10 Seer, Inc. Systems and methods for creating biomolecule embeddings
US20240385156A1 (en) 2023-05-16 2024-11-21 Seer, Inc. Methods and systems for analysis of mass spectrometry data

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