MX2020013000A - Composicion de hidrogel que comprende polimero reticulado. - Google Patents
Composicion de hidrogel que comprende polimero reticulado.Info
- Publication number
- MX2020013000A MX2020013000A MX2020013000A MX2020013000A MX2020013000A MX 2020013000 A MX2020013000 A MX 2020013000A MX 2020013000 A MX2020013000 A MX 2020013000A MX 2020013000 A MX2020013000 A MX 2020013000A MX 2020013000 A MX2020013000 A MX 2020013000A
- Authority
- MX
- Mexico
- Prior art keywords
- thiol
- crosslinked polymer
- hyaluronan
- hydrogel composition
- modification
- Prior art date
Links
- 229920006037 cross link polymer Polymers 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000000017 hydrogel Substances 0.000 title abstract 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 abstract 6
- 230000004048 modification Effects 0.000 abstract 3
- 238000012986 modification Methods 0.000 abstract 3
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 3
- 229940099552 hyaluronan Drugs 0.000 abstract 2
- 229920002674 hyaluronan Polymers 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/145—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Abstract
Una composición de hidrogel estéril que comprende un polímero reticulado, en donde el polímero reticulado es un producto de oxidación de un hialuronano modificado con tiol y en donde el hialuronano modificado con tiol tiene un grado de modificación de hialuronano con restos de tiol de más de aproximadamente 80 µmol por gramo de polímero, en donde el hialuronano modificado con tiol tiene un grado de modificación de hialuronano con restos de tiol de menos de aproximadamente 280 µmol por gramo de polímero, en donde la composición tiene un contenido de tiol residual de menos de 20% con respecto al grado de modificación del hialuronano modificado con tiol.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18178099 | 2018-06-15 | ||
EP18178098 | 2018-06-15 | ||
EP18178097 | 2018-06-15 | ||
PCT/EP2019/065755 WO2019238954A1 (en) | 2018-06-15 | 2019-06-14 | Hydrogel composition comprising a crosslinked polymer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020013000A true MX2020013000A (es) | 2021-03-29 |
Family
ID=66821271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020013000A MX2020013000A (es) | 2018-06-15 | 2019-06-14 | Composicion de hidrogel que comprende polimero reticulado. |
Country Status (11)
Country | Link |
---|---|
US (2) | US20210259943A1 (es) |
EP (2) | EP3806918A1 (es) |
JP (2) | JP7374133B2 (es) |
KR (2) | KR20210021363A (es) |
CN (3) | CN112334167A (es) |
BR (2) | BR112020024637B1 (es) |
CA (2) | CA3101412A1 (es) |
IL (2) | IL279446A (es) |
MA (2) | MA52880A (es) |
MX (1) | MX2020013000A (es) |
WO (2) | WO2019238954A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220403054A1 (en) * | 2019-12-19 | 2022-12-22 | Croma-Pharma Gmbh | Thiol-modified hyaluronan and hydrogel comprising the crosslinked hyaluronan |
CN115702937A (zh) * | 2021-08-04 | 2023-02-17 | 四川大学 | 改性多酚载体材料、靶向纳米递送系统及制备方法和用途 |
KR20230145624A (ko) * | 2022-04-08 | 2023-10-18 | (주)아크로스 | 안전성이 우수한 조직수복용 생체재료의 제조 방법 |
CN115414276A (zh) * | 2022-06-24 | 2022-12-02 | 辽宁德玛生物科技有限公司 | 一种注射用琼脂糖凝胶剂及其制备方法 |
EP4335876A1 (en) * | 2022-09-06 | 2024-03-13 | Scivision Biotech Inc. | Method of manufacturing auto-crosslinked hyaluronic acid gel and products thereof |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US6174999B1 (en) | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
US6630457B1 (en) | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
DE60207831D1 (de) | 2001-02-22 | 2006-01-12 | Anika Therapeutics Inc | Thiol-modifizierte hyaluronan-derivate |
CA2489712C (en) | 2002-06-21 | 2016-07-12 | University Of Utah Research Foundation | Crosslinked compounds and methods of making and using thereof |
JP4993465B2 (ja) | 2003-12-04 | 2012-08-08 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | 変性された高分子ならびにその製造方法および使用方法 |
US8143391B2 (en) | 2004-09-07 | 2012-03-27 | Chugai Seiyaku Kabushiki Kaisha | Process for producing water-soluble hyaluronic acid modification |
EP2038308A2 (en) | 2006-07-11 | 2009-03-25 | University of Utah Research Foundation | Thiolated macromolecules and methods of making and using thereof |
FR2909560B1 (fr) * | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
CN101200504B (zh) | 2006-12-11 | 2010-05-12 | 上海百瑞吉生物医药有限公司 | 高分子巯基化改性衍生物及其交联材料 |
DK2107913T3 (da) | 2006-12-22 | 2012-05-21 | Croma Pharma Ges M B H | Anvendelse af thiolerede polysaccharider til vævsopbygning |
WO2009005790A2 (en) * | 2007-06-29 | 2009-01-08 | Carbylan Biosurgery, Inc. | Sterile thiol-derivatized hyaluronic acid polymer compositions and uses thereof |
CA2694089A1 (en) * | 2007-07-16 | 2009-01-22 | Northeastern University | Therapeutic stable nanoparticles |
US9161970B2 (en) * | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
CN101367884A (zh) | 2008-09-25 | 2009-02-18 | 复旦大学 | 一种半胱胺修饰的巯基化透明质酸偶合物及其制备方法和应用 |
CN101721349B (zh) * | 2008-10-16 | 2011-07-20 | 常州百瑞吉生物医药有限公司 | 可注射原位交联水凝胶及其制备方法和用途 |
US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
CN102399295B (zh) * | 2010-09-09 | 2013-11-06 | 常州百瑞吉生物医药有限公司 | 低巯基化改性度生物相容高分子巯基化衍生物及其交联材料和用途 |
US9149422B2 (en) * | 2011-06-03 | 2015-10-06 | Allergan, Inc. | Dermal filler compositions including antioxidants |
US9393263B2 (en) * | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
KR20200116168A (ko) * | 2011-09-14 | 2020-10-08 | 알러간, 인코포레이티드 | 잔주름 치료를 위한 진피 필러 조성물 |
HUE050947T2 (hu) | 2011-12-08 | 2021-01-28 | Allergan Ind Sas | Dermális töltõkészítmények |
FR2997014B1 (fr) | 2012-10-24 | 2015-03-20 | Teoxane | Composition sterile dermo-injectable |
US20160082150A1 (en) | 2013-05-08 | 2016-03-24 | Allergan Industrie S.A.S. | Hyaluronic acid gels crosslinked by sodium trimetaphosphate |
ITMI20131193A1 (it) * | 2013-07-16 | 2015-01-17 | Ira Srl | Acido ialuronico reticolato, processo per la sua preparazione ed applicazioni in ambito estetico |
WO2016005785A1 (en) | 2014-07-11 | 2016-01-14 | Allergan Industrie, Sas | Hyaluronic acid gels crosslinked by sodium trimetaphosphate |
CN104892962B (zh) * | 2015-06-05 | 2017-12-08 | 四川大学 | 一种巯基/二硫键可控自交联透明质酸水凝胶的制备方法及其应用 |
IT201600096125A1 (it) * | 2016-09-26 | 2018-03-26 | Ntc Srl | Complesso e composizioni per il trattamento di affezioni oculari e cutanee |
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2019
- 2019-06-14 MA MA052880A patent/MA52880A/fr unknown
- 2019-06-14 CN CN201980040062.6A patent/CN112334167A/zh active Pending
- 2019-06-14 JP JP2020569875A patent/JP7374133B2/ja active Active
- 2019-06-14 JP JP2020569872A patent/JP2021526933A/ja active Pending
- 2019-06-14 MA MA052877A patent/MA52877A/fr unknown
- 2019-06-14 MX MX2020013000A patent/MX2020013000A/es unknown
- 2019-06-14 BR BR112020024637-9A patent/BR112020024637B1/pt active IP Right Grant
- 2019-06-14 CA CA3101412A patent/CA3101412A1/en active Pending
- 2019-06-14 US US17/252,549 patent/US20210259943A1/en active Pending
- 2019-06-14 KR KR1020217000861A patent/KR20210021363A/ko unknown
- 2019-06-14 KR KR1020217000860A patent/KR20210021362A/ko active Search and Examination
- 2019-06-14 BR BR112020024735-9A patent/BR112020024735B1/pt active IP Right Grant
- 2019-06-14 WO PCT/EP2019/065755 patent/WO2019238954A1/en active Application Filing
- 2019-06-14 CN CN201980038268.5A patent/CN112334165A/zh active Pending
- 2019-06-14 CA CA3101410A patent/CA3101410A1/en active Pending
- 2019-06-14 CN CN202310704045.6A patent/CN116650519A/zh active Pending
- 2019-06-14 EP EP19729775.7A patent/EP3806918A1/en active Pending
- 2019-06-14 US US17/252,532 patent/US20210260243A1/en active Pending
- 2019-06-14 WO PCT/EP2019/065756 patent/WO2019238955A1/en active Application Filing
- 2019-06-14 EP EP19731275.4A patent/EP3806919A1/en active Pending
-
2020
- 2020-12-14 IL IL279446A patent/IL279446A/en unknown
- 2020-12-14 IL IL279445A patent/IL279445A/en unknown
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WO2019238955A1 (en) | 2019-12-19 |
BR112020024637B1 (pt) | 2024-01-30 |
JP7374133B2 (ja) | 2023-11-06 |
JP2021526934A (ja) | 2021-10-11 |
IL279445A (en) | 2021-01-31 |
US20210260243A1 (en) | 2021-08-26 |
CA3101410A1 (en) | 2019-12-19 |
CN112334167A (zh) | 2021-02-05 |
CN112334165A (zh) | 2021-02-05 |
CA3101412A1 (en) | 2019-12-19 |
KR20210021363A (ko) | 2021-02-25 |
BR112020024637A2 (pt) | 2021-03-02 |
MA52880A (fr) | 2021-09-22 |
WO2019238954A1 (en) | 2019-12-19 |
BR112020024735A2 (pt) | 2021-03-23 |
EP3806919A1 (en) | 2021-04-21 |
US20210259943A1 (en) | 2021-08-26 |
MA52877A (fr) | 2021-04-21 |
CN116650519A (zh) | 2023-08-29 |
EP3806918A1 (en) | 2021-04-21 |
JP2021526933A (ja) | 2021-10-11 |
IL279446A (en) | 2021-01-31 |
BR112020024735B1 (pt) | 2024-02-27 |
KR20210021362A (ko) | 2021-02-25 |
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