MX2020012636A - Formas de monohidrato y cristalinas de 6-[(3s,4s)-4-metil-1-(pirim idin-2- ilmetil)pirrolidin-3-il]-3-tetrahidropiran-4-il-7h-imidazo [1,5-a]pirazin-8- ona. - Google Patents

Formas de monohidrato y cristalinas de 6-[(3s,4s)-4-metil-1-(pirim idin-2- ilmetil)pirrolidin-3-il]-3-tetrahidropiran-4-il-7h-imidazo [1,5-a]pirazin-8- ona.

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Publication number
MX2020012636A
MX2020012636A MX2020012636A MX2020012636A MX2020012636A MX 2020012636 A MX2020012636 A MX 2020012636A MX 2020012636 A MX2020012636 A MX 2020012636A MX 2020012636 A MX2020012636 A MX 2020012636A MX 2020012636 A MX2020012636 A MX 2020012636A
Authority
MX
Mexico
Prior art keywords
pyrazin
tetrahydropyran
pyrrolidin
pyrimidin
ylmethyl
Prior art date
Application number
MX2020012636A
Other languages
English (en)
Inventor
Suzanne Buttar
Jun Xu
Mateusz Pitak
Adam Ross Patterson
Samuel Alexander Stratford
Ioana Sovago
Peng Zhou
Haojuan Wei
Kuangchu Dai
Original Assignee
Imara Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imara Inc filed Critical Imara Inc
Publication of MX2020012636A publication Critical patent/MX2020012636A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente divulgación se refiere a formas polimórficas cristalinas de 6-[(3S,4S)-4-metil-1-(pirimidin-2-ilmetil) pirrolidin-3-il]-3-tetrahidropiran-4-il-7H-imidazo[1,5-a] pirazin-8-ona.
MX2020012636A 2018-05-25 2019-05-23 Formas de monohidrato y cristalinas de 6-[(3s,4s)-4-metil-1-(pirim idin-2- ilmetil)pirrolidin-3-il]-3-tetrahidropiran-4-il-7h-imidazo [1,5-a]pirazin-8- ona. MX2020012636A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862676381P 2018-05-25 2018-05-25
US201962788323P 2019-01-04 2019-01-04
PCT/US2019/033835 WO2019226944A1 (en) 2018-05-25 2019-05-23 Monohydrate and crystalline forms of 6-[(3s,4s)-4-methyl-1- (pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl- 7h-imid azo [1,5- a] pyrazin-8-one

Publications (1)

Publication Number Publication Date
MX2020012636A true MX2020012636A (es) 2021-01-29

Family

ID=68617192

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020012636A MX2020012636A (es) 2018-05-25 2019-05-23 Formas de monohidrato y cristalinas de 6-[(3s,4s)-4-metil-1-(pirim idin-2- ilmetil)pirrolidin-3-il]-3-tetrahidropiran-4-il-7h-imidazo [1,5-a]pirazin-8- ona.
MX2023009562A MX2023009562A (es) 2018-05-25 2020-11-24 Formas de monohidrato y cristalinas de 6-[(3s,4s)-4-metil-1-(pirim idin-2-ilmetil)pirrolidin-3-il]-3-tetrahidropiran-4-il-7h-imidazo [1,5-a]pirazin-8-ona.

Family Applications After (1)

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MX2023009562A MX2023009562A (es) 2018-05-25 2020-11-24 Formas de monohidrato y cristalinas de 6-[(3s,4s)-4-metil-1-(pirim idin-2-ilmetil)pirrolidin-3-il]-3-tetrahidropiran-4-il-7h-imidazo [1,5-a]pirazin-8-ona.

Country Status (18)

Country Link
US (1) US12006319B2 (es)
EP (2) EP4349403A3 (es)
JP (1) JP2021526134A (es)
KR (1) KR20210014662A (es)
CN (2) CN117843645A (es)
AU (1) AU2019275075A1 (es)
BR (2) BR122023022641A2 (es)
CA (1) CA3100988A1 (es)
DK (1) DK3801526T3 (es)
FI (1) FI3801526T3 (es)
HR (1) HRP20240363T1 (es)
IL (1) IL278875A (es)
LT (1) LT3801526T (es)
MA (1) MA52792A (es)
MX (2) MX2020012636A (es)
PT (1) PT3801526T (es)
SI (1) SI3801526T1 (es)
WO (1) WO2019226944A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2971969T3 (es) 2015-07-07 2024-06-10 H Lundbeck As Inhibidores de PDE9 con cadena principal de imidazopirazinona para el tratamiento de enfermedades periféricas
CN117843645A (zh) 2018-05-25 2024-04-09 伊马拉公司 一种pde9抑制剂的一水合物和结晶形态
EP3965768A1 (en) * 2019-05-07 2022-03-16 Imara Inc. Pde9 inhibitors for treating thalassemia

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