MX2020008559A - Compuestos heterocíclicos como inhibidores de la quinasa. - Google Patents
Compuestos heterocíclicos como inhibidores de la quinasa.Info
- Publication number
- MX2020008559A MX2020008559A MX2020008559A MX2020008559A MX2020008559A MX 2020008559 A MX2020008559 A MX 2020008559A MX 2020008559 A MX2020008559 A MX 2020008559A MX 2020008559 A MX2020008559 A MX 2020008559A MX 2020008559 A MX2020008559 A MX 2020008559A
- Authority
- MX
- Mexico
- Prior art keywords
- heterocyclic compounds
- kinase inhibitors
- compounds
- find
- cdk6
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 abstract 1
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 abstract 1
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 abstract 1
- 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862631437P | 2018-02-15 | 2018-02-15 | |
| PCT/US2019/018244 WO2019161224A1 (en) | 2018-02-15 | 2019-02-15 | Heterocyclic compounds as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020008559A true MX2020008559A (es) | 2021-01-08 |
Family
ID=67542098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020008559A MX2020008559A (es) | 2018-02-15 | 2019-02-15 | Compuestos heterocíclicos como inhibidores de la quinasa. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11174252B2 (https=) |
| EP (1) | EP3752491A4 (https=) |
| JP (1) | JP2021514359A (https=) |
| KR (1) | KR20200131246A (https=) |
| CN (1) | CN112334451A (https=) |
| AU (1) | AU2019220746A1 (https=) |
| BR (1) | BR112020015431A2 (https=) |
| CA (1) | CA3089592A1 (https=) |
| IL (1) | IL276509A (https=) |
| MA (1) | MA51846A (https=) |
| MX (1) | MX2020008559A (https=) |
| SG (1) | SG11202007754UA (https=) |
| WO (1) | WO2019161224A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3728228A1 (en) | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| KR102797697B1 (ko) | 2018-05-25 | 2025-04-22 | 에이2에이 파마수티칼스, 잉크. | 신종 항암제 후보로서, 매우 강력한 tacc3 억제제 |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| EP4013743A1 (en) * | 2019-08-14 | 2022-06-22 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| US20220281859A1 (en) * | 2019-08-14 | 2022-09-08 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| CN113244386A (zh) * | 2020-02-13 | 2021-08-13 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
| JP7807381B2 (ja) * | 2020-03-02 | 2026-01-27 | シロナックス リミテッド． | フェロトーシス阻害剤ジアリールアミンパラアセトアミド類 |
| CN116249701B (zh) * | 2020-10-12 | 2025-05-30 | 上海海雁医药科技有限公司 | 取代的二（吡啶-2-基）胺衍生物、其组合物及医药上的用途 |
| WO2022113003A1 (en) | 2020-11-27 | 2022-06-02 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| WO2022149057A1 (en) | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| WO2022169897A1 (en) * | 2021-02-03 | 2022-08-11 | Nuvation Bio Inc. | Crystalline forms of a cyclin-dependent kinase inhibitor |
| KR20240005751A (ko) * | 2021-04-12 | 2024-01-12 | 에이2에이 파마수티칼스, 잉크. | 암 치료를 위한 조성물 및 방법 |
| WO2022236253A1 (en) * | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| WO2022236256A1 (en) * | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| WO2022236255A2 (en) * | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| WO2022236257A1 (en) * | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| CN113264920B (zh) * | 2021-05-10 | 2022-09-02 | 中国药科大学 | 一种嘧啶苯并六元环母核的cdk6抑制剂及其制备方法和应用 |
| US20230000876A1 (en) * | 2021-06-09 | 2023-01-05 | Nuvation Bio Inc. | Treating cancers with a cyclin-dependent kinase inhibitor |
| JP7805983B2 (ja) | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
| EP4499625A4 (en) | 2022-03-24 | 2026-03-18 | A2A Pharmaceuticals Inc | CANCER COMPOSITIONS AND TREATMENT METHODS |
| WO2023205892A1 (en) * | 2022-04-27 | 2023-11-02 | Risen (Suzhou) Pharma Tech Co., Ltd. | Cdk inhibitors and pharmaceutical uses thereof |
| KR20250004015A (ko) * | 2022-04-29 | 2025-01-07 | 베이진 엘티디 | 사이클린 의존성 키나제 저해제로서의 치환된 7-(피리미딘-4-일)퀴놀린-4(1h)-온 화합물 |
| WO2024022487A1 (en) * | 2022-07-29 | 2024-02-01 | Allorion Therapeutics Inc | Aminoheteroaryl kinase inhibitors |
| CN117645604A (zh) * | 2022-09-05 | 2024-03-05 | 浙江同源康医药股份有限公司 | 用作cdk4激酶抑制剂的化合物及其应用 |
| EP4618755A1 (en) * | 2022-11-15 | 2025-09-24 | Larkspur Biosciences, Inc. | Inhibitors and degraders of pip4k protein |
| WO2025007859A1 (en) * | 2023-07-03 | 2025-01-09 | Insilico Medicine Ip Limited | Substituted thiazole compounds as cdk2/4/6 inhibitors and methods of use thereof |
| WO2025247364A1 (zh) * | 2024-05-30 | 2025-12-04 | 山东先声生物制药有限公司 | 杂环化合物作为cdk抑制剂及其用途 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL358271A1 (pl) | 2000-03-06 | 2004-08-09 | Warner-Lambert Company | 5-alkilopirydo[2,3-D]pirymidyny jako inhibitory kinazy tyrozyny |
| EP1373257B9 (en) * | 2001-03-29 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| EP1562938B1 (en) * | 2002-11-04 | 2007-08-29 | Vertex Pharmaceuticals Incorporated | Heteroaryl-pyrimidine derivatives as jak inhibitors |
| MX2007001126A (es) | 2004-07-27 | 2007-09-25 | Sgx Pharmaceuticals Inc | Moduladores de heterociclo cinasa de anillo fusionado. |
| US20060142312A1 (en) | 2004-12-23 | 2006-06-29 | Pfizer Inc | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones |
| RU2008110902A (ru) | 2005-08-25 | 2009-09-27 | Шеринг Корпорейшн (US) | Агонисты адренорецепторов альфа а2с |
| MX2010013876A (es) | 2008-06-20 | 2011-03-04 | Metabolex Inc | Agonistas de arilo grpr119 y sus usos . |
| ES2522346T3 (es) | 2008-08-22 | 2014-11-14 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de CDK |
| WO2010071846A2 (en) | 2008-12-19 | 2010-06-24 | Afraxis, Inc. | Compounds for treating neuropsychiatric conditions |
| JO2885B1 (en) | 2008-12-22 | 2015-03-15 | ايلي ليلي اند كومباني | Protein kinase inhibitors |
| KR101705158B1 (ko) | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Ｅｇｆｒ 억제제 및 질환 치료방법 |
| UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
| UY33226A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina deuterada como inhibidores de la cdk4/6 |
| EP2580213A4 (en) | 2010-06-09 | 2013-12-25 | Afraxis Holdings Inc | 8- (HETEROARYLMETHYL) PYRIDO [2,3-D] PYRIMIDIN-7 (8H) -ONES FOR THE TREATMENT OF CNS DISORDERS |
| US20130252967A1 (en) | 2010-06-10 | 2013-09-26 | Afraxis, Inc. | 8-(sulfonylbenzyl)pyrido[2,3-d]pyrimidin-7(8h)-ones for the treatment of cns disorders |
| EP2580215A4 (en) | 2010-06-10 | 2014-01-15 | Afraxis Holdings Inc | 8- (HETEROCYCYL) PYRIDO [2,3-D] PYRIMIDIN-7 (8H) -ONES FOR THE TREATMENT OF CNS DISORDERS |
| BR112013002112B1 (pt) | 2010-07-29 | 2021-04-06 | Rigel Pharmaceuticals, Inc. | Composto, composição farmacêutica, e, uso de um composto, ou de um respectivo sal farmaceuticamente aceitável, ou de uma composição |
| CA2807498C (en) | 2010-08-05 | 2017-02-07 | Temple University-Of The Commonwealth System Of Higher Education | 2-substituted-8-alkyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitriles and uses thereof |
| US8691830B2 (en) | 2010-10-25 | 2014-04-08 | G1 Therapeutics, Inc. | CDK inhibitors |
| WO2013175415A1 (en) | 2012-05-23 | 2013-11-28 | Piramal Enterprises Limited | Substituted pyrimidine compounds and uses thereof |
| AR091876A1 (es) | 2012-07-26 | 2015-03-04 | Novartis Ag | Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas |
| DK2968290T3 (da) | 2013-03-15 | 2019-11-25 | G1 Therapeutics Inc | Transient beskyttelse af normale celler under kemoterapi |
| WO2014144596A2 (en) | 2013-03-15 | 2014-09-18 | G1 Therapeutics, Inc. | Transient protection of hematopoietic stem and progenitor cells against ionizing radiation |
| WO2015048547A2 (en) | 2013-09-26 | 2015-04-02 | Rigel Pharmaceuticals, Inc. | Methods for using and biomarkers for ampk-activating compounds |
| US10016439B2 (en) | 2014-01-31 | 2018-07-10 | Ono Pharmaceutical Co., Ltd. | Fused imidazole compounds |
| RU2671494C2 (ru) | 2014-05-28 | 2018-11-01 | Шанхай Фокон Фармасьютикал Ко., Лтд | Некоторые ингибиторы протеинкиназы |
| CN105294655B (zh) | 2014-07-26 | 2019-03-15 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
| KR20170032244A (ko) | 2014-07-26 | 2017-03-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | Cdk 저해제로서 2-아미노-피리도[2,3-d]피리미딘-7(8h)-온 유도체 및 그 용도 |
| WO2016040858A1 (en) * | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| US9969719B2 (en) | 2015-03-11 | 2018-05-15 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Substituted 2-hydrogen-pyrazole derivative serving as anticancer drug |
| CN106608879A (zh) | 2015-10-27 | 2017-05-03 | 甘李药业股份有限公司 | 一种蛋白激酶抑制剂及其制备方法和医药用途 |
| CN106810536A (zh) | 2015-11-30 | 2017-06-09 | 甘李药业股份有限公司 | 一种蛋白激酶抑制剂及其制备方法和医药用途 |
| US11225492B2 (en) | 2015-12-13 | 2022-01-18 | Hangzhou Innogate Pharma Co., Ltd. | Heterocycles useful as anti-cancer agents |
| CN108779117B (zh) | 2015-12-27 | 2021-08-31 | 重庆复创医药研究有限公司 | 一类激酶抑制剂 |
| WO2017133701A1 (en) | 2016-02-06 | 2017-08-10 | Shanghai Fochon Pharmaceutical Co., Ltd. | Certain protein kinase inhibitors |
| CN107286180B (zh) | 2016-04-11 | 2019-07-02 | 上海勋和医药科技有限公司 | 杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用 |
| CN107286134B (zh) | 2016-04-11 | 2019-04-12 | 上海勋和医药科技有限公司 | 2，4-二取代嘧啶衍生物作为cdk抑制剂及其应用 |
| HUE064145T2 (hu) | 2016-04-15 | 2024-03-28 | Epizyme Inc | Amin-szubsztituált aril- vagy heteroaril vegyületek, mint EHMT1 és EHMT2 inhibitorok |
| WO2017185031A1 (en) | 2016-04-22 | 2017-10-26 | Dana-Farber Cancer Institute, Inc. | Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use |
| US10835535B2 (en) | 2016-05-07 | 2020-11-17 | Shanghai Fochon Pharmaceutical Co., Ltd. | Certain protein kinase inhibitors |
| WO2018005533A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Antiproliferative pyrimidine-based compounds |
| EP3858835A1 (en) | 2016-07-01 | 2021-08-04 | G1 Therapeutics, Inc. | Pyrimidine-based antiproliferative agents |
| JP7106462B2 (ja) | 2016-07-01 | 2022-07-26 | ジー１ セラピューティクス， インコーポレイテッド | Ｎ－（ヘテロアリール）－ピロロ［３，２－ｄ］ピリミジン－２－アミンの合成 |
| WO2018005863A1 (en) | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| EP3505519B1 (en) | 2016-11-11 | 2022-01-05 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Pyridinamine-substituted heterotricyclo compounds, preparation thereof, and use in medicines |
| ES2917377T3 (es) | 2016-12-22 | 2022-07-08 | Betta Pharmaceuticals Co Ltd | Derivados de benzimidazol, procedimientos de preparación y utilizaciones de los mismos |
| CN107382974B (zh) | 2017-06-08 | 2020-06-05 | 扬州市三药制药有限公司 | 一种嘧啶胺类化合物作为周期蛋白依赖性激酶4/6抑制剂的应用 |
| CA3088381A1 (en) | 2018-01-29 | 2019-08-01 | Beta Pharma, Inc. | 2h-indazole derivatives as cdk4 and cdk6 inhibitors and therapeutic uses thereof |
| US11479555B2 (en) | 2018-02-23 | 2022-10-25 | Newave Pharmaceutical Inc. | Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase |
| WO2020006210A1 (en) | 2018-06-27 | 2020-01-02 | Tufts Medical Center, Inc. | Pyridopyrimidine compounds and methods of their use |
| WO2020023480A1 (en) | 2018-07-23 | 2020-01-30 | Dana-Farber Cancer Institute, Inc. | Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use |
| BR112021001499A2 (pt) | 2018-07-27 | 2021-04-27 | California Institute Of Technology | inibidores de cdk e usos dos mesmos |
| CN110835334B (zh) | 2018-08-16 | 2022-10-18 | 中国药科大学 | 吲哚取代唑类化合物及其用途 |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020108661A1 (zh) | 2018-11-30 | 2020-06-04 | 杭州英创医药科技有限公司 | 作为cdk-hdac双通路抑制剂的杂环化合物 |
| CN113166110B (zh) | 2018-12-12 | 2023-08-11 | 暨南大学 | 2-氨基嘧啶类化合物及其应用 |
-
2019
- 2019-02-15 WO PCT/US2019/018244 patent/WO2019161224A1/en not_active Ceased
- 2019-02-15 CA CA3089592A patent/CA3089592A1/en active Pending
- 2019-02-15 SG SG11202007754UA patent/SG11202007754UA/en unknown
- 2019-02-15 US US16/277,355 patent/US11174252B2/en not_active Expired - Fee Related
- 2019-02-15 MA MA051846A patent/MA51846A/fr unknown
- 2019-02-15 BR BR112020015431-8A patent/BR112020015431A2/pt not_active Application Discontinuation
- 2019-02-15 KR KR1020207026424A patent/KR20200131246A/ko not_active Withdrawn
- 2019-02-15 EP EP19754726.8A patent/EP3752491A4/en not_active Withdrawn
- 2019-02-15 MX MX2020008559A patent/MX2020008559A/es unknown
- 2019-02-15 JP JP2020543494A patent/JP2021514359A/ja active Pending
- 2019-02-15 CN CN201980025159.XA patent/CN112334451A/zh active Pending
- 2019-02-15 AU AU2019220746A patent/AU2019220746A1/en not_active Abandoned
-
2020
- 2020-08-05 IL IL276509A patent/IL276509A/en unknown
-
2021
- 2021-10-01 US US17/449,779 patent/US20230062022A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20190248774A1 (en) | 2019-08-15 |
| JP2021514359A (ja) | 2021-06-10 |
| AU2019220746A1 (en) | 2020-08-27 |
| EP3752491A4 (en) | 2021-12-01 |
| US11174252B2 (en) | 2021-11-16 |
| IL276509A (en) | 2020-09-30 |
| US20230062022A1 (en) | 2023-03-02 |
| EP3752491A1 (en) | 2020-12-23 |
| SG11202007754UA (en) | 2020-09-29 |
| KR20200131246A (ko) | 2020-11-23 |
| WO2019161224A1 (en) | 2019-08-22 |
| CA3089592A1 (en) | 2019-08-22 |
| CN112334451A (zh) | 2021-02-05 |
| MA51846A (fr) | 2021-04-21 |
| BR112020015431A2 (pt) | 2020-12-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2020008559A (es) | Compuestos heterocíclicos como inhibidores de la quinasa. | |
| BR112022002532A2 (pt) | Compostos heterocíclicos como inibidores de quinase | |
| MX2020014245A (es) | Inhibidores de quinasas dependientes de ciclinas. | |
| AU2018347307A1 (en) | Heterocyclic compounds and uses thereof | |
| PH12018500792A1 (en) | Benzolactam compounds as protein kinase inhibitors | |
| SA522432225B1 (ar) | Cdk2 أمينات ثنائية الحلقة كمثبطات | |
| MX2025011774A (es) | Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2 | |
| IL275948A (en) | History of H2-indazole as CDK4 and CDK6 inhibitors and their medical uses | |
| PH12020552214A1 (en) | Ectonucleotidase inhibitors and methods of use thereof | |
| JOP20190076A1 (ar) | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret | |
| MX2021012418A (es) | Compuestos heterociclicos y sus usos. | |
| EA201890001A1 (ru) | Замещенные гетероциклические производные как ингибиторы циклинзависимой киназы (cdk) | |
| EA200970738A1 (ru) | Ингибиторы активности akt | |
| MX2017009571A (es) | Inhibidores heterociclicos de itk para el tratamiento de la inflamacion y cancer. | |
| EP2576549A4 (en) | Bicyclic Heteroarylkinase Inhibitors and Methods of Use | |
| MX2017004128A (es) | Derivados de diarilurea como inhibidores de quinasa p38. | |
| EA201790995A1 (ru) | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ | |
| NO20092657L (no) | Bicyclic heterocyclic compounds as FGFR inhibitors | |
| ZA201800787B (en) | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy | |
| SMT202500123T1 (it) | Composti eterociclici per uso nel trattamento del cancro | |
| MX2024013266A (es) | Compuestos de 6-(pirimidin-4-il)quinolina sustituidos como inhibidores de la cinasa dependiente de ciclina | |
| NZ779815A (en) | Indazolyl-isoxazole derivatives for the treatment of diseases such as cancer | |
| WO2022236255A3 (en) | Heterocyclic compounds as kinase inhibitors | |
| WO2020106751A8 (en) | Inhibitors of gli1 as therapeutic agents | |
| EA201990940A1 (ru) | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ |