CN112334451A - 作为激酶抑制剂的杂环化合物 - Google Patents

作为激酶抑制剂的杂环化合物 Download PDF

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Publication number
CN112334451A
CN112334451A CN201980025159.XA CN201980025159A CN112334451A CN 112334451 A CN112334451 A CN 112334451A CN 201980025159 A CN201980025159 A CN 201980025159A CN 112334451 A CN112334451 A CN 112334451A
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China
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formula
compound
alkylene
salt
fluoro
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Chinese (zh)
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S·M·范
S·查克拉瓦提
J·堪卡纳拉
B·普贾拉
A·谢特
B·巴哈特
A·K·阿加瓦尔
S·索尼
J·陈
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Novelson Biological Co ltd
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Novelson Biological Co ltd
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Publication of CN112334451A publication Critical patent/CN112334451A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980025159.XA 2018-02-15 2019-02-15 作为激酶抑制剂的杂环化合物 Pending CN112334451A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862631437P 2018-02-15 2018-02-15
US62/631,437 2018-02-15
PCT/US2019/018244 WO2019161224A1 (en) 2018-02-15 2019-02-15 Heterocyclic compounds as kinase inhibitors

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CN112334451A true CN112334451A (zh) 2021-02-05

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US (2) US11174252B2 (https=)
EP (1) EP3752491A4 (https=)
JP (1) JP2021514359A (https=)
KR (1) KR20200131246A (https=)
CN (1) CN112334451A (https=)
AU (1) AU2019220746A1 (https=)
BR (1) BR112020015431A2 (https=)
CA (1) CA3089592A1 (https=)
IL (1) IL276509A (https=)
MA (1) MA51846A (https=)
MX (1) MX2020008559A (https=)
SG (1) SG11202007754UA (https=)
WO (1) WO2019161224A1 (https=)

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CN113264920A (zh) * 2021-05-10 2021-08-17 中国药科大学 一种嘧啶苯并六元环母核的cdk6抑制剂及其制备方法和应用
CN114502536A (zh) * 2019-08-14 2022-05-13 诺维逊生物股份有限公司 作为激酶抑制剂的杂环化合物
CN116947840A (zh) * 2022-04-27 2023-10-27 润佳（苏州）医药科技有限公司 一种cdk降解剂及其用途
WO2024051702A1 (zh) * 2022-09-05 2024-03-14 浙江同源康医药股份有限公司 用作cdk4激酶抑制剂的化合物及其应用

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TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
US20220281859A1 (en) * 2019-08-14 2022-09-08 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
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JP7807381B2 (ja) * 2020-03-02 2026-01-27 シロナックス リミテッド． フェロトーシス阻害剤ジアリールアミンパラアセトアミド類
CN116249701B (zh) * 2020-10-12 2025-05-30 上海海雁医药科技有限公司 取代的二（吡啶-2-基）胺衍生物、其组合物及医药上的用途
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WO2022236253A1 (en) * 2021-05-03 2022-11-10 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
WO2022236256A1 (en) * 2021-05-03 2022-11-10 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
WO2022236255A2 (en) * 2021-05-03 2022-11-10 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
WO2022236257A1 (en) * 2021-05-03 2022-11-10 Nuvation Bio Inc. Heterocyclic compounds as kinase inhibitors
US20230000876A1 (en) * 2021-06-09 2023-01-05 Nuvation Bio Inc. Treating cancers with a cyclin-dependent kinase inhibitor
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WO2024022487A1 (en) * 2022-07-29 2024-02-01 Allorion Therapeutics Inc Aminoheteroaryl kinase inhibitors
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WO2025247364A1 (zh) * 2024-05-30 2025-12-04 山东先声生物制药有限公司 杂环化合物作为cdk抑制剂及其用途

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Publication number Priority date Publication date Assignee Title
CN114502536A (zh) * 2019-08-14 2022-05-13 诺维逊生物股份有限公司 作为激酶抑制剂的杂环化合物
CN113264920A (zh) * 2021-05-10 2021-08-17 中国药科大学 一种嘧啶苯并六元环母核的cdk6抑制剂及其制备方法和应用
CN116947840A (zh) * 2022-04-27 2023-10-27 润佳（苏州）医药科技有限公司 一种cdk降解剂及其用途
WO2024051702A1 (zh) * 2022-09-05 2024-03-14 浙江同源康医药股份有限公司 用作cdk4激酶抑制剂的化合物及其应用

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US20190248774A1 (en) 2019-08-15
JP2021514359A (ja) 2021-06-10
AU2019220746A1 (en) 2020-08-27
EP3752491A4 (en) 2021-12-01
US11174252B2 (en) 2021-11-16
IL276509A (en) 2020-09-30
US20230062022A1 (en) 2023-03-02
EP3752491A1 (en) 2020-12-23
SG11202007754UA (en) 2020-09-29
KR20200131246A (ko) 2020-11-23
WO2019161224A1 (en) 2019-08-22
CA3089592A1 (en) 2019-08-22
MA51846A (fr) 2021-04-21
BR112020015431A2 (pt) 2020-12-08
MX2020008559A (es) 2021-01-08

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