MX2020008317A - Sistemas y metodos para bioprocesamiento. - Google Patents

Sistemas y metodos para bioprocesamiento.

Info

Publication number
MX2020008317A
MX2020008317A MX2020008317A MX2020008317A MX2020008317A MX 2020008317 A MX2020008317 A MX 2020008317A MX 2020008317 A MX2020008317 A MX 2020008317A MX 2020008317 A MX2020008317 A MX 2020008317A MX 2020008317 A MX2020008317 A MX 2020008317A
Authority
MX
Mexico
Prior art keywords
bioprocessing
systems
methods
cells
module configured
Prior art date
Application number
MX2020008317A
Other languages
English (en)
Inventor
Zhen Liu
Weston Blaine Griffin
Alex D Corwin
Xiaohua Zhang
Reginald Donovan Smith
Chengkun Zhang
Vandana Keskar
Brian Michael Davis
Kashan Shaikh
Original Assignee
Global Life Sciences Solutions Usa Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/893,336 external-priority patent/US10889792B2/en
Application filed by Global Life Sciences Solutions Usa Llc filed Critical Global Life Sciences Solutions Usa Llc
Publication of MX2020008317A publication Critical patent/MX2020008317A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)

Abstract

Un sistema de bioprocesamiento incluye un primer módulo configurado para enriquecer y aislar una población de células, un segundo módulo configurado para activar, modificar genéticamente y expandir la población de células, y un tercer módulo configurado para cosechar la población expandida de células.
MX2020008317A 2018-02-09 2019-02-08 Sistemas y metodos para bioprocesamiento. MX2020008317A (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US15/893,336 US10889792B2 (en) 2018-02-09 2018-02-09 Cell expansion vessel systems and methods
US201862736144P 2018-09-25 2018-09-25
US201862736130P 2018-09-25 2018-09-25
US201862736143P 2018-09-25 2018-09-25
US201862736125P 2018-09-25 2018-09-25
US201862736115P 2018-09-25 2018-09-25
US201862736120P 2018-09-25 2018-09-25
US201862736154P 2018-09-25 2018-09-25
PCT/EP2019/053205 WO2019155026A1 (en) 2018-02-09 2019-02-08 Systems and methods for bioprocessing

Publications (1)

Publication Number Publication Date
MX2020008317A true MX2020008317A (es) 2020-11-24

Family

ID=65433651

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008317A MX2020008317A (es) 2018-02-09 2019-02-08 Sistemas y metodos para bioprocesamiento.

Country Status (10)

Country Link
EP (8) EP3749749A1 (es)
JP (10) JP2021512633A (es)
KR (6) KR20200120667A (es)
CN (9) CN112004921A (es)
AU (6) AU2019219292A1 (es)
BR (1) BR112020015746A2 (es)
CA (7) CA3089788A1 (es)
MX (1) MX2020008317A (es)
SG (6) SG11202007140XA (es)
WO (8) WO2019155033A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2019155033A1 (en) * 2018-02-09 2019-08-15 General Electric Company Bioprocessing vessel
KR20220130743A (ko) * 2020-01-20 2022-09-27 아드바 바이오테크놀로지 리미티드 생물반응기를 제어하는 장치 및 방법
CN115698255A (zh) * 2020-02-18 2023-02-03 米托斯生物有限公司 用于自动化细胞培养的系统和方法
EP3868861A1 (en) * 2020-02-18 2021-08-25 Sartorius Stedim Biotech GmbH Bioprocessing installation
US20230299259A1 (en) 2020-09-16 2023-09-21 Lg Energy Solution, Ltd. Method for manufacturing lithium metal electrode, lithium metal electrode manufactured thereby, and lithium secondary battery comprising same
CN114561265A (zh) 2020-11-27 2022-05-31 财团法人工业技术研究院 细胞活化反应器及细胞活化方法
CA3202851A1 (en) * 2020-12-15 2022-06-23 Global Life Sciences Solutions Usa Llc Culture vessel for a bioprocessing system
US20230272863A1 (en) * 2022-02-28 2023-08-31 Terumo Kabushiki Kaisha Multiple-Tube Pinch Valve Assembly
WO2023219846A1 (en) * 2022-05-09 2023-11-16 Waters Technologies Corporation Fluidic network for positive displacement aseptic sampling
KR102545720B1 (ko) * 2022-07-28 2023-06-20 이준범 3차원 동작 기계식 배양 시스템

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4143764A (en) * 1976-09-20 1979-03-13 Moss Iii L Howard Shipper container for flasks
JPS6019589Y2 (ja) * 1980-12-12 1985-06-12 日本テクトロン株式会社 微生物培養測定装置における恒温装置
US4601730A (en) * 1982-08-16 1986-07-22 Georgia Tech Research Corporation Air supply grate and ash removal system for wood gasifier
US5506117A (en) * 1989-10-18 1996-04-09 Cytokinetics, Inc. Biochemical process for growing living cells by measuring the amount of nutrient added to the reaction medium
GB2268187A (en) * 1992-07-01 1994-01-05 Univ Hull Cell culture vessels
US5693537A (en) * 1994-06-28 1997-12-02 Wilson; John R. Compartmentalized tissue culture flask
DE69534132T2 (de) * 1994-06-28 2005-09-29 Wilson Wolf Corp., New Brighton Zellkulturflasche mit mehreren kammern
AU4743596A (en) * 1995-12-29 1997-07-28 Alg Company Methods of preparing bone marrow stromal cells for use in gene therapy
US5726450A (en) * 1996-10-26 1998-03-10 Envirotest Systems Corp. Unmanned integrated optical remote emissions sensor (RES) for motor vehicles
US6068775A (en) * 1998-04-13 2000-05-30 Circe Biomedical, Inc. Removal of agent from cell suspension
JP4195287B2 (ja) * 2000-10-02 2008-12-10 エフ．キャノン トーマス 自動化されたバイオカルチャー及びバイオカルチャー実験システム
US7198940B2 (en) * 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
RU2284217C2 (ru) * 2001-03-01 2006-09-27 Шелл Интернэшнл Рисерч Маатсхаппий Б.В. Реактор
US7018588B2 (en) * 2001-06-14 2006-03-28 Millipore Corporation Multiwell test apparatus
EP1495108A2 (en) * 2002-04-08 2005-01-12 Millenium Biologix Inc. Automated tissue engineering system
GB2423151B (en) * 2003-07-23 2007-05-09 Essen Instr Inc Examination systems for biological samples
GB0410130D0 (en) * 2004-05-06 2004-06-09 Molmed Spa Cell preparation
JP4473711B2 (ja) * 2004-11-25 2010-06-02 株式会社アステック 培養装置
DE102005036763B4 (de) * 2005-08-04 2007-07-26 Inheco Industrial Heating And Cooling Gmbh System aus mehreren Inkubatoren
CN101277758A (zh) 2005-09-14 2008-10-01 Illumina公司 连续聚合物合成器
AU2006309684A1 (en) 2005-11-01 2007-05-10 Medinet Co., Ltd. Shaker for cell culture and shaken culture system in cell culture method
EP2115117A1 (en) * 2007-03-01 2009-11-11 CaridianBCT, Inc. Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling
US20110183407A1 (en) * 2008-03-12 2011-07-28 Cellectricon Ab Apparatus and method for tip alignment in multiwell plates
FR2931164B1 (fr) 2008-05-16 2010-08-20 Maco Pharma Sa Procede de conservation de cellules secretrices d'insuline destinees a etre transplantees
US9284523B2 (en) 2008-10-27 2016-03-15 Terumo Bct, Inc. Premounted fluid conveyance assembly for cell expansion system and method of use associated therewith
WO2010080032A2 (en) * 2009-01-09 2010-07-15 Stichting Het Nederlands Kanker Instituut Bead-assisted viral transduction
US20100291534A1 (en) * 2009-05-12 2010-11-18 National Central University Methods and Systems for Isolating, Ex Vivo Expanding and Harvesting Hematopoietic Stem Cells
WO2012002497A1 (ja) * 2010-07-01 2012-01-05 株式会社カネカ 細胞培養用ディスポセット、細胞培養装置及び細胞調製方法
EP2690167B1 (en) 2011-03-22 2017-07-26 Tokai Hit Co. Ltd. Culture apparatus for microscopic viewing and method of use thereof
EP2811011B1 (en) 2012-02-01 2020-05-06 Toyo Seikan Group Holdings, Ltd. Cell culture kit, and method of using cell culture kit
WO2013184800A2 (en) 2012-06-06 2013-12-12 Novozymes Bioag A/S Solid state bioreactor adapted for automation
WO2014033889A1 (ja) 2012-08-31 2014-03-06 株式会社日立製作所 自動培養装置及び自動培養方法
CN110066730A (zh) * 2012-09-27 2019-07-30 通用电气健康护理生物科学股份公司 切向流动灌注系统
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
GB2515751A (en) * 2013-07-01 2015-01-07 Tap Biosystems Phc Ltd Bioreactor consumable units
HUE055888T2 (hu) 2013-09-16 2022-01-28 Genzyme Corp Eljárások és összeállítások sejttenyészet feldolgozására
US9958432B2 (en) * 2013-09-20 2018-05-01 Lynx Biosciences, Inc. Cellular cis-co-culture systems for analysis
WO2015056302A1 (ja) 2013-10-15 2015-04-23 株式会社日立製作所 細胞培養装置
WO2015087369A1 (ja) * 2013-12-12 2015-06-18 ヤマハ発動機株式会社 ウェルプレート、該ウェルプレートを備えた対象物選別装置
WO2015111347A1 (ja) * 2014-01-27 2015-07-30 株式会社 日立ハイテクノロジーズ 流路制御方法および細胞培養装置
EP4215603A1 (en) * 2014-02-04 2023-07-26 Kite Pharma, Inc. Methods for producing autologous t cells useful to treat b cell malignancies and other cancers and compositions thereof
JP2015188391A (ja) 2014-03-28 2015-11-02 東洋製罐グループホールディングス株式会社 細胞培養方法、及び細胞培養システム
US10131876B2 (en) * 2014-04-24 2018-11-20 Miltenyi Biotec Gmbh Method for automated generation of genetically modified T cells
JP6444619B2 (ja) 2014-05-30 2018-12-26 オリンパス株式会社 培地交換システム
US9617566B2 (en) * 2014-07-11 2017-04-11 Lanzatech New Zealand Limited Control of bioreactor processes
GB201415329D0 (en) 2014-07-21 2014-10-15 Ge Healthcare Bio Sciences Parallel cell processing method and facility
JP5892216B1 (ja) 2014-09-17 2016-03-23 東洋製罐グループホールディングス株式会社 細胞培養システムにおける送液方法、及び細胞培養システム
EP3233284A4 (en) * 2014-12-15 2018-07-25 The Regents of The University of California Multi-organ cell culture system and methods of use thereof
US10519409B2 (en) * 2014-12-31 2019-12-31 Ge Healthcare Bio-Sciences Corp. Shaft-mounted fluid transfer assembly for a disposable bioreactor
US9944894B2 (en) 2015-01-16 2018-04-17 General Electric Company Pluripotent stem cell expansion and passage using a rocking platform bioreactor
WO2016118780A1 (en) * 2015-01-21 2016-07-28 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
CN107922904A (zh) * 2015-03-31 2018-04-17 兴盛生物科技股份有限公司 用于产生自体细胞疗法的细胞保持器
GB2555728A (en) * 2015-04-17 2018-05-09 Xcell Biosciences Inc Cancer cell enrichment system
WO2016170623A1 (ja) 2015-04-22 2016-10-27 株式会社安川電機 細胞培養システム及び細胞培養方法
GB201508752D0 (en) * 2015-05-21 2015-07-01 Mason Christopher And Veraitch Farlan S Cell culture device, system and methods of use thereof
US10458920B2 (en) * 2015-08-17 2019-10-29 Fenwal, Inc. Systems and methods for ensuring proper tubing installation for fluid processing systems
WO2017032829A1 (en) * 2015-08-25 2017-03-02 General Electric Company Improvements in and relating to biomanufacturing apparatus
US11286454B2 (en) 2015-08-31 2022-03-29 I Peace, Inc. Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells
JP2017085899A (ja) 2015-11-02 2017-05-25 シンフォニアテクノロジー株式会社 培養容器搬送装置
WO2017109083A1 (en) * 2015-12-22 2017-06-29 Ge Healthcare Bio-Sciences Corp. Improvements in and relating to instruments for processing cells
CN108697985B (zh) * 2016-02-26 2022-07-15 思拓凡瑞典有限公司 使用高精度夹管阀进行交叉流动过滤中的压力控制的方法
US11156627B2 (en) 2016-06-20 2021-10-26 Genesis Technologies Limited Automated cell processing systems and methods
JP7076876B2 (ja) 2016-12-29 2022-05-30 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー 混合システム
WO2019155033A1 (en) 2018-02-09 2019-08-15 General Electric Company Bioprocessing vessel

Also Published As

Publication number Publication date
CN111971382A (zh) 2020-11-20
SG11202007439TA (en) 2020-09-29
WO2019155028A1 (en) 2019-08-15
JP2024019666A (ja) 2024-02-09
JP7462949B2 (ja) 2024-04-08
RU2020126463A (ru) 2022-03-09
AU2019219295A1 (en) 2020-08-13
SG11202007425YA (en) 2020-09-29
KR20200120664A (ko) 2020-10-21
KR20200120665A (ko) 2020-10-21
JP2021513343A (ja) 2021-05-27
SG11202007435RA (en) 2020-09-29
CN111954710A (zh) 2020-11-17
CN112041423A (zh) 2020-12-04
AU2019219294A1 (en) 2020-08-13
JP2021513350A (ja) 2021-05-27
JP7403906B2 (ja) 2023-12-25
EP3749748A1 (en) 2020-12-16
AU2019219292A1 (en) 2020-08-27
EP3749744A1 (en) 2020-12-16
KR20200120667A (ko) 2020-10-21
EP3749749A1 (en) 2020-12-16
JP2021513344A (ja) 2021-05-27
KR20200120666A (ko) 2020-10-21
CN112020552A (zh) 2020-12-01
EP3749741A1 (en) 2020-12-16
AU2019219241A1 (en) 2020-08-13
CA3090046A1 (en) 2019-08-15
EP3749742A1 (en) 2020-12-16
CN111936613A (zh) 2020-11-13
WO2019155027A1 (en) 2019-08-15
CN112004921A (zh) 2020-11-27
CA3089925A1 (en) 2019-08-15
BR112020015746A2 (pt) 2020-12-08
JP2023133326A (ja) 2023-09-22
KR20200119277A (ko) 2020-10-19
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