MX2020005324A - Microorganismo modificado geneticamente para producir acido 3-hidroxidadipico, acido alfa-hidromuconico y/o acido adipico, y metodo de produccion para tales productos quimicos. - Google Patents

Microorganismo modificado geneticamente para producir acido 3-hidroxidadipico, acido alfa-hidromuconico y/o acido adipico, y metodo de produccion para tales productos quimicos.

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Publication number
MX2020005324A
MX2020005324A MX2020005324A MX2020005324A MX2020005324A MX 2020005324 A MX2020005324 A MX 2020005324A MX 2020005324 A MX2020005324 A MX 2020005324A MX 2020005324 A MX2020005324 A MX 2020005324A MX 2020005324 A MX2020005324 A MX 2020005324A
Authority
MX
Mexico
Prior art keywords
acid
gene
coa
modified microorganism
polypeptide
Prior art date
Application number
MX2020005324A
Other languages
English (en)
Inventor
Kenji Kawamura
Kyohei Isobe
Katsushige Yamada
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of MX2020005324A publication Critical patent/MX2020005324A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Se describe un microorganismo modificado genéticamente en donde se introduce un ácido nucleico que codifica una enzima que cataliza una reacción que reduce el 3-oxoadipil-CoA a 3-hidroxidipil-CoA. En el microorganismo modificado genéticamente, se lleva a cabo una de las siguientes acciones: se introduce un ácido nucleico que codifica cualquiera de los polipéptidos descritos en (a) a (c) a continuación; o, se mejora la expresión del polipéptido: (a) un polipéptido compuesto por una secuencia de aminoácidos representada por cualquiera de las SEC. ID NO.: 1-6 y 213, (b) un polipéptido que comprende cualquiera de las secuencias de aminoácidos de las SEC. ID NO.: 1-6 y 213 en el cual al menos un aminoácido ha sido sustituido, eliminado, insertado y/o añadido, el polipéptido tiene actividad enzimática que cataliza una reacción que reduce el 3-oxoadipil-CoA a 3-hidroxiadipil-CoA, y (c) un polipéptido que tiene una identidad de la secuencia con cualquiera de las secuencias de aminoácidos de las SEC. ID NO.: 1-6 y 213, el polipéptido que tienen actividad que reduce el 3-oxoadipil- CoA a 3-hidroxiadipil-CoA.
MX2020005324A 2017-11-30 2018-11-29 Microorganismo modificado geneticamente para producir acido 3-hidroxidadipico, acido alfa-hidromuconico y/o acido adipico, y metodo de produccion para tales productos quimicos. MX2020005324A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017230407 2017-11-30
PCT/JP2018/044080 WO2019107516A1 (ja) 2017-11-30 2018-11-29 ３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法

Publications (1)

Publication Number Publication Date
MX2020005324A true MX2020005324A (es) 2020-08-13

Family

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Family Applications (1)

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MX2020005324A MX2020005324A (es) 2017-11-30 2018-11-29 Microorganismo modificado geneticamente para producir acido 3-hidroxidadipico, acido alfa-hidromuconico y/o acido adipico, y metodo de produccion para tales productos quimicos.

Country Status (8)

Country Link
US (1) US20200291435A1 (es)
EP (1) EP3719121A4 (es)
JP (1) JP7331691B2 (es)
CN (1) CN111386339B (es)
BR (1) BR112020010328A2 (es)
CA (1) CA3083563A1 (es)
MX (1) MX2020005324A (es)
WO (1) WO2019107516A1 (es)

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Publication number Publication date
WO2019107516A1 (ja) 2019-06-06
CN111386339B (zh) 2024-05-10
US20200291435A1 (en) 2020-09-17
BR112020010328A2 (pt) 2020-11-17
EP3719121A1 (en) 2020-10-07
CN111386339A (zh) 2020-07-07
JPWO2019107516A1 (ja) 2020-10-08
CA3083563A1 (en) 2019-06-06
EP3719121A4 (en) 2021-12-15
JP7331691B2 (ja) 2023-08-23

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