BR0108883A - Sequência de ácido nucleico isolado, construção de ácido nucleico, vetor, microorganismo recombinante, e, processo para a preparação de ácidos carboxìlicos quirais ou aquirais - Google Patents

Sequência de ácido nucleico isolado, construção de ácido nucleico, vetor, microorganismo recombinante, e, processo para a preparação de ácidos carboxìlicos quirais ou aquirais

Info

Publication number
BR0108883A
BR0108883A BR0108883-1A BR0108883A BR0108883A BR 0108883 A BR0108883 A BR 0108883A BR 0108883 A BR0108883 A BR 0108883A BR 0108883 A BR0108883 A BR 0108883A
Authority
BR
Brazil
Prior art keywords
nucleic acid
chiral
vector
preparation
carboxylic acids
Prior art date
Application number
BR0108883-1A
Other languages
English (en)
Inventor
Marion Ress-Ldschke
Bernhard Hauer
Ralf Mattes
Dirk Engels
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR0108883A publication Critical patent/BR0108883A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"SEQuêNCIA DE áCIDO NUCLEICO ISOLADO, CONSTRUçãO DE áCIDO NUCLEICO, VETOR, MICROORGANISMO RECOMBINANTE, E, PROCESSO PARA A PREPARAçãO DE áCIDOS CARBOXìLICOS QUIRAIS OU AQUIRAIS". A invenção refere-se às seq³ências de ácido nucleico que codificam um polipeptídeo com atividade de nitrilase, as construções de ácido nucleico contendo os citados ácidos nucleicos e aos vetores contendo os citados ácidos nucleicos ou os citadas construções de ácido nucleico. A invenção também se refere às seq³ências de aminoácido que são codificadas pelas seq³ências de ácido nucleico e aos microorganismos contendo as citadas seq³ências de ácido nucleico, os citadas construções de ácido nucleico ou os vetores contendo as citadas seq³ências de ácido nucleico ou os citadas construções de ácido nucleico. A invenção também se refere a um método enzimático para a produção de ácidos carboxílicos a partir das correspondentes nitrilas.
BR0108883-1A 2000-03-03 2001-02-27 Sequência de ácido nucleico isolado, construção de ácido nucleico, vetor, microorganismo recombinante, e, processo para a preparação de ácidos carboxìlicos quirais ou aquirais BR0108883A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10010149A DE10010149A1 (de) 2000-03-03 2000-03-03 Nitrilase aus Rhodococcus rhodochrous NCIMB 11216
PCT/EP2001/002191 WO2001064857A1 (de) 2000-03-03 2001-02-27 Nitrilase aus rhodococcus rhodochrous ncimb 11216

Publications (1)

Publication Number Publication Date
BR0108883A true BR0108883A (pt) 2003-04-29

Family

ID=7633225

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108883-1A BR0108883A (pt) 2000-03-03 2001-02-27 Sequência de ácido nucleico isolado, construção de ácido nucleico, vetor, microorganismo recombinante, e, processo para a preparação de ácidos carboxìlicos quirais ou aquirais

Country Status (17)

Country Link
US (1) US20030157672A1 (pt)
EP (1) EP1268757A1 (pt)
JP (1) JP2003530832A (pt)
KR (1) KR20020077520A (pt)
CN (1) CN1411506A (pt)
AU (2) AU3380201A (pt)
BR (1) BR0108883A (pt)
CA (1) CA2400446A1 (pt)
DE (1) DE10010149A1 (pt)
HU (1) HUP0300155A2 (pt)
IL (1) IL151096A0 (pt)
MX (1) MXPA02008123A (pt)
NO (1) NO20024169L (pt)
PL (1) PL359496A1 (pt)
RU (1) RU2283864C2 (pt)
WO (1) WO2001064857A1 (pt)
ZA (1) ZA200207902B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1340101A (zh) * 1999-10-26 2002-03-13 昭和电工株式会社 新型红球菌属细菌、源自于红球菌属细菌的腈水解酶基因、腈水合酶基因和酰胺酶基因,以及利用它们生产羧酸的方法
US6562603B2 (en) * 2000-08-04 2003-05-13 E. I. Du Pont De Nemours And Company 3-hydroxycarboxylic acid production and use in branched polymers
CN100445375C (zh) * 2003-02-27 2008-12-24 巴斯福股份公司 经修饰的腈水解酶及它们在产生羧酸的方法中的用途
US7148051B2 (en) * 2004-08-16 2006-12-12 E. I. Du Pont De Nemours And Company Production of 3-hydroxycarboxylic acid using nitrilase
CN102796770B (zh) * 2004-12-22 2014-06-04 纳幕尔杜邦公司 乙醇酸的酶促生产
US20090130726A1 (en) * 2005-09-22 2009-05-21 Andrew Wells Process for converting aromatic halo-substituted dinitriles into halo-substituted cyanocarboxylic acids
JP4977362B2 (ja) * 2005-12-09 2012-07-18 矢崎総業株式会社 ローラ
CN102690766A (zh) * 2012-05-15 2012-09-26 中国科学院青岛生物能源与过程研究所 筛选生产底物广泛性的腈水解酶的菌株的方法
FR3002542B1 (fr) * 2013-02-28 2016-01-22 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique et application a la synthese de l'ivabradine et de ses sels
CN103757068B (zh) * 2014-01-10 2016-06-29 江苏清泉化学股份有限公司 一种苯甲酸衍生物的制备方法
CN103898083B (zh) * 2014-04-21 2016-06-29 武汉大学 一种新型水解酶超家族酰胺酶Azl13及其制备与应用
CN113025601A (zh) * 2019-12-25 2021-06-25 上海奥博生物医药技术有限公司 腈水解酶启动子优化表达及应用
CN114539458B (zh) * 2020-11-26 2023-07-25 西安蓝晓科技新材料股份有限公司 一种应用于固相合成的多孔树脂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK314989A (da) * 1988-06-27 1989-12-28 Asahi Chemical Ind Fremgangsmaade til fremstilling af optisk aktive alfa-substituerede organiske syrer, samt mikroorganismer og enzymer anvendelige ved fremgangsmaaden
JP3009421B2 (ja) * 1990-02-28 2000-02-14 秀明 山田 有機酸の生物学的製造法
JPH0799980A (ja) * 1993-10-05 1995-04-18 Japan Energy Corp ニトリラーゼ活性を有するポリペプチドをコードする遺伝子ｄｎａ、およびこれを含有する形質転換体によるニトリル類からカルボン酸の製造法
US5628190A (en) * 1994-10-03 1997-05-13 Ormat Industries Ltd. Geothermal power plant and condenser therefor
GB9525372D0 (en) * 1995-12-12 1996-02-14 Allied Colloids Ltd Enzymes, their preparation and their use in the production of ammonium acrylate
DE19848129A1 (de) * 1998-10-19 2000-04-20 Basf Ag Verfahren zur Herstellung chiraler Carbonsäuren aus Nitrilen mit Hilfe einer Nitrilase oder Mikroorganismen, die ein Gen für die Nitrilase enthalten

Also Published As

Publication number Publication date
PL359496A1 (en) 2004-08-23
HUP0300155A2 (en) 2003-05-28
AU2001233802B2 (en) 2006-01-12
CN1411506A (zh) 2003-04-16
KR20020077520A (ko) 2002-10-11
JP2003530832A (ja) 2003-10-21
NO20024169L (no) 2002-11-01
CA2400446A1 (en) 2001-09-07
RU2283864C2 (ru) 2006-09-20
EP1268757A1 (de) 2003-01-02
RU2002126270A (ru) 2004-03-10
US20030157672A1 (en) 2003-08-21
WO2001064857A1 (de) 2001-09-07
AU3380201A (en) 2001-09-12
IL151096A0 (en) 2003-04-10
ZA200207902B (en) 2004-03-29
NO20024169D0 (no) 2002-09-02
DE10010149A1 (de) 2001-09-06
MXPA02008123A (es) 2002-11-29

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TH37378A (th) " ยีนเพลนิซิลลินเอซิเสและโปรตีนที่ประมวลรหัสไว้ในยีนดังกล่าวและสายพันธ์ B.megaterium ที่มีดีเอ็นเอสายผสมที่มียีนเพลนิซิลินเอซิเลส "
TH37378EX (th) " ยีนเพลนิซิลลินเอซิเสและโปรตีนที่ประมวลรหัสไว้ในยีนดังกล่าวและสายพันธ์ B.megaterium ที่มีดีเอ็นเอสายผสมที่มียีนเพลนิซิลินเอซิเลส "

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A, 9A,10A E 11A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.