MX2020004559A - Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico. - Google Patents
Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.Info
- Publication number
- MX2020004559A MX2020004559A MX2020004559A MX2020004559A MX2020004559A MX 2020004559 A MX2020004559 A MX 2020004559A MX 2020004559 A MX2020004559 A MX 2020004559A MX 2020004559 A MX2020004559 A MX 2020004559A MX 2020004559 A MX2020004559 A MX 2020004559A
- Authority
- MX
- Mexico
- Prior art keywords
- kits
- nucleic acid
- acid encoding
- analysis
- barcoding
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 238000004458 analytical method Methods 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 229920002521 macromolecule Polymers 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108010026552 Proteome Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 238000003149 assay kit Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004001 molecular interaction Effects 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/6416—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/619—Detection means characterised by use of a special device being a video camera
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762579844P | 2017-10-31 | 2017-10-31 | |
| US201762582312P | 2017-11-06 | 2017-11-06 | |
| US201762583448P | 2017-11-08 | 2017-11-08 | |
| PCT/US2018/058565 WO2019089836A1 (en) | 2017-10-31 | 2018-10-31 | Kits for analysis using nucleic acid encoding and/or label |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020004559A true MX2020004559A (es) | 2020-10-05 |
Family
ID=66333623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020004559A MX2020004559A (es) | 2017-10-31 | 2018-10-31 | Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico. |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US11513126B2 (enExample) |
| EP (1) | EP3704249B1 (enExample) |
| JP (1) | JP7390027B2 (enExample) |
| KR (1) | KR102556494B1 (enExample) |
| CN (2) | CN119716077A (enExample) |
| AU (1) | AU2018358057B2 (enExample) |
| CA (1) | CA3081441C (enExample) |
| MX (1) | MX2020004559A (enExample) |
| SG (1) | SG11202003924YA (enExample) |
| WO (1) | WO2019089836A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE112012002570B4 (de) | 2011-06-23 | 2023-11-23 | Board Of Regents, The University Of Texas System | Identifizieren von Peptiden auf der Einzelmolekülebene |
| US11435358B2 (en) | 2011-06-23 | 2022-09-06 | Board Of Regents, The University Of Texas System | Single molecule peptide sequencing |
| WO2016069124A1 (en) | 2014-09-15 | 2016-05-06 | Board Of Regents, The University Of Texas System | Improved single molecule peptide sequencing |
| EP4299803A3 (en) | 2016-05-02 | 2024-03-27 | Encodia, Inc. | Macromolecule analysis employing nucleic acid encoding |
| DK3548652T3 (da) | 2016-12-01 | 2024-07-08 | Nautilus Subsidiary Inc | Fremgangsmåder til proteinanalyse |
| AU2018358057B2 (en) | 2017-10-31 | 2023-03-02 | Encodia, Inc. | Kits for analysis using nucleic acid encoding and/or label |
| SG11202003923PA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Methods and kits using nucleic acid encoding and/or label |
| IL326759A (en) | 2017-12-29 | 2026-04-01 | Nautilus Subsidiary Inc | Decoding approaches for protein identification |
| CN112236528A (zh) * | 2018-04-04 | 2021-01-15 | 诺迪勒思生物科技公司 | 产生纳米阵列和微阵列的方法 |
| US11302421B2 (en) * | 2018-04-13 | 2022-04-12 | The Hong Kong Polytechnic University | Data storage using peptides |
| CA3110800A1 (en) | 2018-07-12 | 2020-01-16 | Board Of Regents, The University Of Texas System | Molecular neighborhood detection by oligonucleotides |
| CN108866046A (zh) * | 2018-07-25 | 2018-11-23 | 辽宁润基生物科技有限公司 | 一种分离、纯化样品中外泌体和/或游离核酸的方法 |
| CA3117476A1 (en) | 2018-10-05 | 2020-04-09 | Board Of Regents, The University Of Texas System | Solid-phase n-terminal peptide capture and release |
| US10836798B2 (en) * | 2018-11-08 | 2020-11-17 | Government Of The United States Of America, As Represented By The Secretary Of Commerce | Amino acid-specific binder and selectively identifying an amino acid |
| TWI863941B (zh) | 2018-11-15 | 2024-12-01 | 美商寬騰矽公司 | 用於蛋白質定序之方法及組合物 |
| US11427814B2 (en) | 2019-03-26 | 2022-08-30 | Encodia, Inc. | Modified cleavases, uses thereof and related kits |
| CA3137716A1 (en) | 2019-04-23 | 2020-10-29 | Encodia, Inc. | Methods for spatial analysis of proteins and related kits |
| CN114072499B (zh) | 2019-04-30 | 2024-08-06 | Encodia公司 | 用于制备分析物的方法和相关试剂盒 |
| US20220227889A1 (en) * | 2019-04-30 | 2022-07-21 | Encodia, Inc. | Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide |
| EP3973299A4 (en) * | 2019-05-20 | 2023-04-19 | Encodia, Inc. | METHODS AND RELATED KITS FOR SPATIAL ANALYSIS |
| US20240042446A1 (en) * | 2019-10-18 | 2024-02-08 | Encodia, Inc. | Automated treatment of macromolecules for analysis and related apparatus |
| US20210148921A1 (en) * | 2019-10-28 | 2021-05-20 | Quantum-Si Incorporated | Methods of preparing an enriched sample for polypeptide sequencing |
| AU2020376809A1 (en) * | 2019-10-28 | 2022-06-02 | Quantum-Si Incorporated | Methods, kits and devices of preparing samples for multiplex polypeptide sequencing |
| JP2023501932A (ja) * | 2019-10-28 | 2023-01-20 | クアンタム－エスアイ インコーポレイテッド | 単一ペプチドの配列決定及び再構築の方法 |
| WO2021141924A1 (en) | 2020-01-07 | 2021-07-15 | Encodia, Inc. | Methods for stable complex formation and related kits |
| WO2021141922A1 (en) * | 2020-01-07 | 2021-07-15 | Encodia, Inc. | Methods for information transfer and related kits |
| EP4073263A4 (en) | 2020-01-07 | 2023-11-08 | Encodia, Inc. | METHOD FOR STABLE COMPLEX FORMATION AND CORRESPONDING KITS |
| EP3969611B1 (en) * | 2020-02-03 | 2025-12-10 | Illumina, Inc. | Biotin-streptavidin cleavage composition and library fragment cleavage |
| JP7445966B2 (ja) * | 2020-03-24 | 2024-03-08 | 国立研究開発法人産業技術総合研究所 | 糖鎖を解析する方法 |
| WO2021236983A2 (en) | 2020-05-20 | 2021-11-25 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
| AU2021288692A1 (en) | 2020-06-11 | 2023-02-02 | Nautilus Subsidiary, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
| CN116685725A (zh) * | 2020-08-19 | 2023-09-01 | Encodia 公司 | 顺序编码方法和相关试剂盒 |
| WO2022072560A1 (en) * | 2020-09-30 | 2022-04-07 | Encodia, Inc. | Polypeptide terminal binders and uses thereof |
| WO2022094148A1 (en) | 2020-10-30 | 2022-05-05 | Encodia, Inc. | Conjugation reagents and methods using 1,2-cyclohexanediones |
| KR20230118570A (ko) | 2020-11-11 | 2023-08-11 | 노틸러스 서브시디어리, 인크. | 강화된 결합 및 검출 특성을 갖는 친화성 시약 |
| EP4271997A4 (en) * | 2020-12-31 | 2024-12-04 | Encodia, Inc. | METALLOENZYMES FOR THE BIOMOLECULAR RECOGNITION OF N-TERMINAL MODIFIED PEPTIDES |
| US12092642B2 (en) | 2021-01-20 | 2024-09-17 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule quantitation |
| EP4281775B1 (en) | 2021-01-21 | 2026-04-29 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule preparation |
| CN112899152B (zh) * | 2021-02-02 | 2023-11-17 | 中国科学院苏州纳米技术与纳米仿生研究所 | 核酸快速扩增和检测的微流控芯片、检测方法及系统 |
| WO2022173690A1 (en) * | 2021-02-09 | 2022-08-18 | University Of Washington | Methods for protein identification through combinatorial barcoding |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| CN113129996B (zh) * | 2021-03-22 | 2022-04-12 | 复旦大学 | 一种基于分子动力学模拟的核酸适配体优化设计方法 |
| WO2022200793A1 (en) * | 2021-03-25 | 2022-09-29 | The University Of Birmingham | Analyte capture |
| WO2022217112A1 (en) * | 2021-04-09 | 2022-10-13 | Ultima Genomics, Inc. | Systems and methods for spatial screening of analytes |
| CN113281507B (zh) * | 2021-05-23 | 2022-08-16 | 吉林大学 | 一种金黄色葡萄球菌快速检测方法及试剂盒 |
| WO2022271983A1 (en) | 2021-06-24 | 2022-12-29 | Nautilus Biotechnology, Inc. | Methods and systems for assay refinement |
| CA3227872A1 (en) | 2021-09-09 | 2023-03-16 | James Henry JOLY | Characterization and localization of protein modifications |
| JP2024537689A (ja) * | 2021-09-22 | 2024-10-16 | ノーティラス・サブシディアリー・インコーポレイテッド | ポリペプチド相互作用を決定するための方法及びシステム |
| WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| US12474346B2 (en) | 2021-11-05 | 2025-11-18 | Encodia, Inc. | Methods and kits for multicycle encoding assay |
| EP4430206A1 (en) | 2021-11-10 | 2024-09-18 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
| US12612656B2 (en) | 2021-11-30 | 2026-04-28 | Nautilus Subsidiary, Inc. | Particle-based isolation of proteins and other analytes |
| CN113881753B (zh) * | 2021-12-08 | 2022-02-18 | 南京邮电大学 | 一种非诊断目的的基因定位方法 |
| US20250093339A1 (en) * | 2021-12-15 | 2025-03-20 | BioLegend, Inc. | Compositions and methods for enhanced sample multiplexing |
| EP4206674B1 (en) | 2021-12-28 | 2025-10-22 | Encodia, Inc. | High-throughput serotyping and antibody profiling assays |
| US12092578B2 (en) | 2022-03-29 | 2024-09-17 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
| EP4508435A4 (en) * | 2022-04-15 | 2026-04-15 | Encodia Inc | HIGH-SPEED PEPTIDE IDENTIFICATION USING CONJUGATED BINDERS AND KINETIC CODING |
| WO2023212490A1 (en) | 2022-04-25 | 2023-11-02 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| WO2023241720A1 (zh) * | 2022-06-17 | 2023-12-21 | 上海高探生物科技有限公司 | 样本处理系统及其制备方法 |
| EP4544077A1 (en) | 2022-06-21 | 2025-04-30 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| CA3261351A1 (en) * | 2022-07-12 | 2024-01-18 | Abrus Bio, Inc. | DETERMINATION OF PROTEIN INFORMATION BY RECODED AMINO ACID POLYMERS INTO DNA POLYMERS |
| WO2024030919A1 (en) | 2022-08-02 | 2024-02-08 | Glyphic Biotechnologies, Inc. | Protein sequencing via coupling of polymerizable molecules |
| WO2024040236A2 (en) | 2022-08-19 | 2024-02-22 | Abrus Bio, Inc. | Determination of protein information by recoding amino acid polymers into dna polymers |
| WO2024058967A1 (en) | 2022-09-13 | 2024-03-21 | Nautilus Subsidiary, Inc. | Systems and methods of validating new affinity reagents |
| WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| US20240192202A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | Fluidic media for single-analtye arrays |
| WO2024130000A1 (en) | 2022-12-15 | 2024-06-20 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| US20240301469A1 (en) | 2023-02-24 | 2024-09-12 | Nautilus Subsidiary, Inc. | Modifying, separating and detecting proteoforms |
| CN115976655A (zh) * | 2023-03-20 | 2023-04-18 | 深圳市小分子新药创新中心有限公司 | On-DNA酰肼化合物的合成方法、DNA编码化合物库 |
| EP4689173A1 (en) | 2023-03-24 | 2026-02-11 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| EP4720641A1 (en) | 2023-05-24 | 2026-04-08 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| EP4732011A1 (en) | 2023-06-21 | 2026-04-29 | Nautilus Subsidiary, Inc. | Compositions and methods for improving affinity reagent avidity |
| CN117019248B (zh) * | 2023-08-17 | 2025-05-02 | 杭州跃真生物科技有限公司 | 一种微孔芯片与单细胞分析方法 |
| US20250066841A1 (en) | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| WO2025080862A1 (en) * | 2023-10-10 | 2025-04-17 | Fluid Discovery | Quantitative partitioned amplification |
| GB202317028D0 (en) * | 2023-11-06 | 2023-12-20 | Oxford Nanopore Tech Ltd | Method |
| WO2025128588A1 (en) | 2023-12-11 | 2025-06-19 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| US20250205706A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| WO2025199236A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
| GB2642439A (en) * | 2024-07-05 | 2026-01-14 | Gitlife Biotech Ltd | Methods and compositions |
| US20260092914A1 (en) | 2024-09-27 | 2026-04-02 | Nautilus Subsidiary, Inc. | Single analyte characterization under equilibrium binding conditions |
| CN119851760B (zh) * | 2025-01-14 | 2025-09-30 | 大连理工大学 | 一种基于三进制dna编码库的核酸检测方法 |
| CN120078882A (zh) * | 2025-05-07 | 2025-06-03 | 中国人民解放军军事科学院军事医学研究院 | 一种多糖-蛋白缀合物、其纳米颗粒以及疫苗组合物 |
Family Cites Families (161)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863870A (en) | 1988-03-10 | 1989-09-05 | Bio-Affinity Systems, Inc. | Method of thioacylation peptide sequencing with alcoholysis of thiazolinones |
| US5484735A (en) | 1989-08-23 | 1996-01-16 | Northwestern University | Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids |
| US5049507A (en) | 1989-12-21 | 1991-09-17 | Applied Biosystems, Inc. | Method of C-terminal peptide sequencing |
| DK0604552T3 (da) | 1991-09-18 | 1997-08-04 | Affymax Tech Nv | Fremgangsmåde til syntese af forskellige samlinger af oligomerer |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
| GB9421819D0 (en) | 1994-10-29 | 1994-12-14 | Cancer Res Campaign Tech | Sequence analysis of saccharide material |
| CA2176414A1 (en) | 1995-05-18 | 1996-11-19 | S. David Kimball | Acyl guanidine and amidine prodrugs |
| CA2225553A1 (en) | 1995-08-03 | 1997-02-20 | Rijksuniversiteit Te Leiden | Cell derived antigen presenting vesicles |
| JP3124507B2 (ja) | 1996-05-24 | 2001-01-15 | セイコーインスツルメンツ株式会社 | タンパク質あるいはペプチドのカルボキシ末端からのアミノ酸配列を決定する方法 |
| US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| DK0971946T3 (da) * | 1997-01-21 | 2006-10-30 | Gen Hospital Corp | Selektion af proteiner ved anvendelse af RNA-protein-fusioner |
| US6306588B1 (en) | 1997-02-07 | 2001-10-23 | Invitrogen Corporation | Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof |
| WO2000034527A2 (en) | 1998-12-11 | 2000-06-15 | The Regents Of The University Of California | Targeted molecular bar codes |
| US6875851B1 (en) | 1999-03-05 | 2005-04-05 | University Of Georgia Research Foundation, Inc. | Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis |
| DE60029572T2 (de) * | 1999-03-23 | 2007-07-26 | Biovation Ltd. | Isolierung und analyse von proteinen |
| WO2000071755A2 (en) | 1999-05-25 | 2000-11-30 | Praelux Incorporated | Method for sequency and characterizing polymeric biomolecules using aptamers and a method for producing aptamers |
| IL147037A0 (en) * | 1999-07-27 | 2002-08-14 | Phylos Inc | Peptide acceptor ligation methods |
| GB9927320D0 (en) | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| US7306904B2 (en) | 2000-02-18 | 2007-12-11 | Olink Ab | Methods and kits for proximity probing |
| US6511809B2 (en) | 2000-06-13 | 2003-01-28 | E. I. Du Pont De Nemours And Company | Method for the detection of an analyte by means of a nucleic acid reporter |
| CA2314398A1 (en) | 2000-08-10 | 2002-02-10 | Edward Shipwash | Microarrays and microsystems for amino acid analysis and protein sequencing |
| ATE538380T1 (de) | 2001-01-23 | 2012-01-15 | Harvard College | Nukleinsäure-programmierbare protein-arrays |
| US20030087232A1 (en) | 2001-01-25 | 2003-05-08 | Fred Christians | Methods for screening polypeptides |
| US20030118585A1 (en) | 2001-10-17 | 2003-06-26 | Agy Therapeutics | Use of protein biomolecular targets in the treatment and visualization of brain tumors |
| EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| AU2002330671B2 (en) * | 2001-07-06 | 2008-04-03 | Centre National De La Recherche Scientifique (Cnrs) | Method for obtaining cells with new properties |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| US7169894B2 (en) | 2001-11-14 | 2007-01-30 | Mirari Biosciences, Inc. | Methods and compositions for reverse translation |
| WO2003044231A1 (en) | 2001-11-23 | 2003-05-30 | Simon Fredriksson | Method and kit for proximity probing with multivalent proximity probes |
| DE10242016A1 (de) | 2002-09-11 | 2004-03-25 | Esplora GmbH c/o TU Darmstadt Institut für Biochemie | Verfahren zur Identifizierung BHS-spezifischer Proteine und Fragmente davon |
| BR0314558A (pt) | 2002-10-10 | 2005-08-09 | Diversa Corp | Proteases, ácidos nucléicos codificando as mesmas e processos para preparar e usar as mesmas |
| US20090246879A1 (en) * | 2002-12-20 | 2009-10-01 | Callida Genomics | Materials and Methods Relating to Nano-Tags and Nano-Brands |
| WO2005015239A2 (en) | 2003-08-07 | 2005-02-17 | Cornell Research Foundation, Inc. | Method for n-terminal labeling of proteins |
| US7198900B2 (en) | 2003-08-29 | 2007-04-03 | Applera Corporation | Multiplex detection compositions, methods, and kits |
| WO2005026387A1 (en) | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
| EP1561755A2 (en) | 2003-10-16 | 2005-08-10 | Shimadzu Corporation | Method for derivatizing protein or peptide to sulfonic acid derivative |
| RU2470077C2 (ru) | 2003-12-17 | 2012-12-20 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Биологически активное соединение, содержащее кодирующий олигонуклеотид (варианты), способ его синтеза, библиотека соединений (варианты), способ ее синтеза и способ поиска соединения, связывающегося с биологической мишенью (варианты) |
| GB0404187D0 (en) | 2004-02-25 | 2004-03-31 | Biotransformations Ltd | Binding agents |
| WO2005090566A2 (en) | 2004-03-22 | 2005-09-29 | Nuevolution A/S | Ligational encoding using building block oligonucleotides |
| US20050260653A1 (en) | 2004-04-14 | 2005-11-24 | Joshua Labaer | Nucleic-acid programmable protein arrays |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| US20060199279A1 (en) * | 2005-03-07 | 2006-09-07 | Viorica Lopez-Avila | Methods for identifying post-translationally modified polypeptides |
| US7229769B2 (en) | 2005-03-25 | 2007-06-12 | Illumina, Inc. | Compositions and methods for detecting protease activity |
| CA2541986A1 (en) | 2005-04-21 | 2006-10-21 | Co2 Solution Inc. | Carbonic anhydrase having increased stability under high temperatue conditions |
| US7883848B2 (en) | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| US7611834B2 (en) | 2005-09-30 | 2009-11-03 | Sandia Corporation | Methods and devices for protein assays |
| LT2336315T (lt) * | 2005-12-01 | 2017-11-10 | Nuevolution A/S | Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei |
| US20070218503A1 (en) | 2006-02-13 | 2007-09-20 | Mitra Robi D | Methods of polypeptide identification, and compositions therefor |
| DE102006015001A1 (de) | 2006-03-31 | 2007-10-11 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Verfahren zum Nachweis und/oder zur Anreicherung von Analytproteinen und/oder Analytpeptiden aus einer komplexen Proteinmischung |
| WO2007127848A1 (en) | 2006-04-26 | 2007-11-08 | University Of Louisville Research Foundation, Inc | Isolation of membrane vesicles from biological fluids and methods of using same |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| WO2008085912A1 (en) | 2007-01-05 | 2008-07-17 | Massachusetts Institute Of Technology | Compositions of and methods of using sulfatases from flavobacterium heparinum |
| US8568994B2 (en) | 2007-08-03 | 2013-10-29 | Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Offentlichen Rechts | Method for prenatal diagnosis |
| EP2210109A1 (en) * | 2007-10-19 | 2010-07-28 | Pronota NV | Preparation of samples for proteome analysis |
| WO2010065531A1 (en) | 2008-12-01 | 2010-06-10 | Robi David Mitra | Single molecule protein screening |
| CA2745197A1 (en) | 2008-12-01 | 2010-06-10 | Research Triangle Institute | Concurrent identification of multitudes of polypeptides |
| WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US9566335B1 (en) | 2009-09-25 | 2017-02-14 | The Governing Council Of The University Of Toronto | Protein sequencing method and reagents |
| US9175340B2 (en) | 2009-11-04 | 2015-11-03 | President And Fellows Of Harvard College | Reactivity-dependent and interaction-dependent PCR |
| US20110245101A1 (en) | 2010-04-05 | 2011-10-06 | Prognosys Biosciences, Inc. | Co-localization affinity assays |
| AU2011237729B2 (en) | 2010-04-05 | 2014-04-03 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| US20130059741A1 (en) | 2010-05-13 | 2013-03-07 | Illumina, Inc. | Binding assays for markers |
| WO2012041633A1 (en) | 2010-09-27 | 2012-04-05 | Vipergen | A method for making an enriched library |
| EP2638057B1 (en) | 2010-11-10 | 2019-03-06 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| GB201101621D0 (en) * | 2011-01-31 | 2011-03-16 | Olink Ab | Method and product |
| EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| EP2694709B1 (en) | 2011-04-08 | 2016-09-14 | Prognosys Biosciences, Inc. | Peptide constructs and assay systems |
| AU2012242847B2 (en) | 2011-04-15 | 2017-01-19 | The Johns Hopkins University | Safe sequencing system |
| ES2744589T3 (es) | 2011-05-11 | 2020-02-25 | Exosome Diagnostics Inc | Extracción de ácido nucleico de materiales biológicos heterogéneos |
| WO2016069124A1 (en) | 2014-09-15 | 2016-05-06 | Board Of Regents, The University Of Texas System | Improved single molecule peptide sequencing |
| DE112012002570B4 (de) | 2011-06-23 | 2023-11-23 | Board Of Regents, The University Of Texas System | Identifizieren von Peptiden auf der Einzelmolekülebene |
| WO2013028788A1 (en) | 2011-08-22 | 2013-02-28 | Exosome Diagnostics, Inc. | Urine biomarkers |
| US20130052665A1 (en) | 2011-08-25 | 2013-02-28 | Bruce Xuefeng Ling | Methods for diagnosis of systemic juvenile idiopathic arthritis |
| US9335292B2 (en) * | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
| US10174361B2 (en) | 2011-11-10 | 2019-01-08 | Exosome Diagnostics, Inc. | Cerebrospinal fluid assay |
| WO2013101896A1 (en) | 2011-12-30 | 2013-07-04 | Quest Diagnostics Investments Incorporated | Nucleic acid analysis using emulsion pcr |
| US20150087526A1 (en) | 2012-01-24 | 2015-03-26 | The Regents Of The University Of Colorado, A Body Corporate | Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation |
| HUE053360T2 (hu) | 2012-02-17 | 2021-06-28 | Hutchinson Fred Cancer Res | Kompozíciók és eljárások mutációk pontos azonosítására |
| EP2825675B1 (en) | 2012-03-13 | 2017-12-27 | Patel, Abhijit Ajit | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| ES2828661T3 (es) | 2012-03-20 | 2021-05-27 | Univ Washington Through Its Center For Commercialization | Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria |
| US9005888B2 (en) | 2012-06-14 | 2015-04-14 | System Biosciences, Llc | Methods for microvesicle isolation and selective removal |
| US9267127B2 (en) | 2012-06-21 | 2016-02-23 | President And Fellows Of Harvard College | Evolution of bond-forming enzymes |
| NL2009191C2 (en) | 2012-07-16 | 2014-01-20 | Univ Delft Tech | Single molecule protein sequencing. |
| US20140378322A1 (en) | 2012-08-14 | 2014-12-25 | 10X Technologies, Inc. | Compositions and methods for sample processing |
| JP6367196B2 (ja) | 2012-08-14 | 2018-08-01 | テンエックス・ジェノミクス・インコーポレイテッド | マイクロカプセル組成物および方法 |
| US9557336B2 (en) | 2012-09-07 | 2017-01-31 | University Of Rochester | Methods and compositions for site-specific labeling of peptides and proteins |
| CN105025878A (zh) | 2012-10-03 | 2015-11-04 | 外来体诊断公司 | 微泡在医学疾病和病况的诊断、预后和治疗中的用途 |
| KR20150090072A (ko) | 2012-10-23 | 2015-08-05 | 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 | 압타머 및 이의 용도 |
| US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| EP2925337B1 (en) | 2012-11-21 | 2019-07-03 | The Trustees of Columbia University in the City of New York | Mutant ngal proteins and uses thereof |
| US9435810B2 (en) | 2013-03-15 | 2016-09-06 | Washington University | Molecules and methods for iterative polypeptide analysis and processing |
| EP2971071B1 (en) | 2013-03-15 | 2018-02-28 | Illumina, Inc. | Enzyme-linked nucleotides |
| EP3611262B1 (en) | 2013-03-15 | 2020-11-11 | Lineage Biosciences, Inc. | Methods of sequencing the immune repertoire |
| WO2014145123A2 (en) | 2013-03-15 | 2014-09-18 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State Unversity | Peptide array quality control |
| US10053725B2 (en) | 2013-04-23 | 2018-08-21 | President And Fellows Of Harvard College | In situ interaction determination |
| WO2014189768A1 (en) | 2013-05-19 | 2014-11-27 | The Board Of Trustees Of The Leland | Devices and methods for display of encoded peptides, polypeptides, and proteins on dna |
| EP3004385B1 (en) | 2013-05-24 | 2018-11-28 | Quantapore Inc. | Nanopore-based nucleic acid analysis with mixed fret detection |
| US10065988B2 (en) | 2013-05-31 | 2018-09-04 | Stefano Menegatti | Peptoid affinity ligands |
| WO2014201273A1 (en) | 2013-06-12 | 2014-12-18 | The Broad Institute, Inc. | High-throughput rna-seq |
| DK3013983T3 (da) | 2013-06-25 | 2023-03-06 | Prognosys Biosciences Inc | Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning |
| US10876177B2 (en) | 2013-07-10 | 2020-12-29 | President And Fellows Of Harvard College | Compositions and methods relating to nucleic acid-protein complexes |
| WO2015031694A2 (en) | 2013-08-28 | 2015-03-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| US10466248B2 (en) | 2013-09-23 | 2019-11-05 | The Trustees Of Columbia University In The City Of New York | High-throughput single molecule protein identification |
| US10288608B2 (en) | 2013-11-08 | 2019-05-14 | Prognosys Biosciences, Inc. | Polynucleotide conjugates and methods for analyte detection |
| WO2015073538A2 (en) | 2013-11-12 | 2015-05-21 | Echogen, Inc. | Interaction with metalloenzymes |
| US9834814B2 (en) | 2013-11-22 | 2017-12-05 | Agilent Technologies, Inc. | Spatial molecular barcoding of in situ nucleic acids |
| WO2015131153A1 (en) | 2014-02-27 | 2015-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions for isolating exosomes |
| US10858698B2 (en) | 2014-03-25 | 2020-12-08 | President And Fellows Of Harvard College | Barcoded protein array for multiplex single-molecule interaction profiling |
| LT3134536T (lt) | 2014-04-21 | 2020-05-11 | President And Fellows Of Harvard College | Sistemos ir būdai, skirti nukleorūgščių brūkšniniam kodavimui |
| CN106459160B (zh) | 2014-04-24 | 2022-03-29 | 南洋理工大学 | Asx特异性蛋白质连接酶 |
| JP6593710B2 (ja) | 2014-05-02 | 2019-10-23 | Ｉｄａｃセラノスティクス株式会社 | 単一細胞由来核酸の解析方法 |
| US20170074855A1 (en) * | 2014-05-15 | 2017-03-16 | Two Pore Guys, Inc. | Scaffold Data Storage and Target Detection in a Sample Using a Nanopore |
| EP4574974A3 (en) | 2014-06-26 | 2025-10-08 | 10x Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| WO2015200869A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| WO2016004068A1 (en) | 2014-06-30 | 2016-01-07 | Jae-Won Shin | Hydrogel compositions comprising encapsulated cells and methods of use thereof |
| US10465183B2 (en) | 2014-07-09 | 2019-11-05 | Exosome Diagnostics, Inc. | Methods for isolating microvesicles and extracting nucleic acids from biological samples |
| US20160060687A1 (en) * | 2014-07-18 | 2016-03-03 | Cdi Laboratories, Inc. | Methods and compositions to identify, quantify, and characterize target analytes and binding moieties |
| EP4219710A3 (en) | 2014-08-01 | 2023-08-16 | Dovetail Genomics, LLC | Tagging nucleic acids for sequence assembly |
| JP6808617B2 (ja) | 2014-10-17 | 2021-01-06 | イルミナ ケンブリッジ リミテッド | 連続性を維持した転位 |
| US9771412B2 (en) | 2014-10-31 | 2017-09-26 | Wisconsin Alumni Research Foundation | Engineered intein for improved production of protein-intein fusions |
| EP3218477A4 (en) * | 2014-11-10 | 2018-07-18 | The Board of Trustees of The Leland Stanford Junior University | Compositions and methods for expressing polypeptides on the surface of cells |
| BR112017017025B1 (pt) | 2015-02-10 | 2024-01-02 | Illumina, Inc | Métodos e composições para analizar componentes celulares |
| CN107208158B (zh) * | 2015-02-27 | 2022-01-28 | 贝克顿迪金森公司 | 空间上可寻址的分子条形编码 |
| WO2016145416A2 (en) | 2015-03-11 | 2016-09-15 | The Broad Institute, Inc. | Proteomic analysis with nucleic acid identifiers |
| WO2016164530A1 (en) | 2015-04-07 | 2016-10-13 | University Of Maryland, College Park | Compositions and methods for high throughput protein sequencing |
| AU2016276750A1 (en) | 2015-06-09 | 2018-01-18 | The Board Of Regents Of The University Of Texas System | Diagnostic test for early stage cancer |
| CN108449941B (zh) | 2015-09-22 | 2022-03-11 | 豪夫迈·罗氏有限公司 | OmpG变体 |
| EP3766987B1 (en) | 2015-09-24 | 2023-08-02 | F. Hoffmann-La Roche AG | Alpha-hemolysin variants |
| EP3397764A4 (en) * | 2015-12-30 | 2019-05-22 | Bio-Rad Laboratories, Inc. | DIGITAL PROTEIN QUANTIFICATION |
| WO2017125565A1 (en) | 2016-01-21 | 2017-07-27 | Genia Technologies, Inc. | Nanopore sequencing complexes |
| EP3417078B1 (en) | 2016-02-17 | 2021-05-05 | President and Fellows of Harvard College | Molecular programming tools |
| EP4299803A3 (en) | 2016-05-02 | 2024-03-27 | Encodia, Inc. | Macromolecule analysis employing nucleic acid encoding |
| WO2017205719A1 (en) | 2016-05-27 | 2017-11-30 | President And Fellows Of Harvard College | Conditional primer extension for single-molecule detection |
| WO2018005720A1 (en) | 2016-06-30 | 2018-01-04 | President And Fellows Of Harvard College | Method of determining the molecular binding between libraries of molecules |
| EP3488018B1 (en) | 2016-07-22 | 2026-02-18 | President and Fellows of Harvard College | Methods for protein identification |
| DK3548652T3 (da) | 2016-12-01 | 2024-07-08 | Nautilus Subsidiary Inc | Fremgangsmåder til proteinanalyse |
| EP4310183B1 (en) | 2017-01-30 | 2025-07-09 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| EP4324931A3 (en) | 2017-02-02 | 2024-05-29 | New York Genome Center, Inc. | Methods and compositions for identifying or quantifying targets in a biological sample |
| AU2018358057B2 (en) | 2017-10-31 | 2023-03-02 | Encodia, Inc. | Kits for analysis using nucleic acid encoding and/or label |
| WO2019089846A1 (en) | 2017-10-31 | 2019-05-09 | Encodia, Inc. | Methods and compositions for polypeptide analysis |
| SG11202003923PA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Methods and kits using nucleic acid encoding and/or label |
| IL326759A (en) | 2017-12-29 | 2026-04-01 | Nautilus Subsidiary Inc | Decoding approaches for protein identification |
| US20190219578A1 (en) | 2018-01-18 | 2019-07-18 | Nanosomix, Inc. | Dectection of exosomes and exosomal biomarkers for the diagnosis and prognosis of diseases and disorders |
| US12270741B2 (en) | 2018-04-03 | 2025-04-08 | Tymora Analytical Operations, Llc | Methods for affinity-based non-antibody capture and purification of extracellular vesicles |
| WO2020006409A1 (en) | 2018-06-28 | 2020-01-02 | Trustees Of Boston University | Systems and methods for control of gene expression |
| TWI863941B (zh) | 2018-11-15 | 2024-12-01 | 美商寬騰矽公司 | 用於蛋白質定序之方法及組合物 |
| CN113474651B (zh) | 2019-01-08 | 2024-05-17 | 麻省理工学院 | 单分子蛋白质和肽测序 |
| US11427814B2 (en) | 2019-03-26 | 2022-08-30 | Encodia, Inc. | Modified cleavases, uses thereof and related kits |
| AU2020247918B2 (en) | 2019-03-26 | 2022-06-30 | Encodia, Inc. | Modified cleavases, uses thereof and related kits |
| CN114072499B (zh) | 2019-04-30 | 2024-08-06 | Encodia公司 | 用于制备分析物的方法和相关试剂盒 |
| US20220227889A1 (en) | 2019-04-30 | 2022-07-21 | Encodia, Inc. | Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide |
| WO2020252404A1 (en) | 2019-06-12 | 2020-12-17 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| US11834664B2 (en) | 2019-09-13 | 2023-12-05 | Google Llc | Methods and compositions for protein and peptide sequencing |
| WO2022072560A1 (en) | 2020-09-30 | 2022-04-07 | Encodia, Inc. | Polypeptide terminal binders and uses thereof |
| WO2022094148A1 (en) | 2020-10-30 | 2022-05-05 | Encodia, Inc. | Conjugation reagents and methods using 1,2-cyclohexanediones |
| EP4271997A4 (en) | 2020-12-31 | 2024-12-04 | Encodia, Inc. | METALLOENZYMES FOR THE BIOMOLECULAR RECOGNITION OF N-TERMINAL MODIFIED PEPTIDES |
| EP4430206A1 (en) | 2021-11-10 | 2024-09-18 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
-
2018
- 2018-10-31 AU AU2018358057A patent/AU2018358057B2/en active Active
- 2018-10-31 CA CA3081441A patent/CA3081441C/en active Active
- 2018-10-31 SG SG11202003924YA patent/SG11202003924YA/en unknown
- 2018-10-31 CN CN202411678798.5A patent/CN119716077A/zh active Pending
- 2018-10-31 EP EP18874783.6A patent/EP3704249B1/en active Active
- 2018-10-31 CN CN201880084553.6A patent/CN112272703B/zh active Active
- 2018-10-31 KR KR1020207015546A patent/KR102556494B1/ko active Active
- 2018-10-31 US US16/760,028 patent/US11513126B2/en active Active
- 2018-10-31 MX MX2020004559A patent/MX2020004559A/es unknown
- 2018-10-31 JP JP2020524114A patent/JP7390027B2/ja active Active
- 2018-10-31 WO PCT/US2018/058565 patent/WO2019089836A1/en not_active Ceased
-
2022
- 2022-08-11 US US17/819,263 patent/US12130291B2/en active Active
-
2023
- 2023-02-08 US US18/166,461 patent/US11782062B2/en active Active
-
2024
- 2024-07-05 US US18/764,943 patent/US12467928B2/en active Active
- 2024-07-29 US US18/787,946 patent/US12292446B2/en active Active
- 2024-10-22 US US18/923,452 patent/US20250060371A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240377408A1 (en) | 2024-11-14 |
| AU2018358057A1 (en) | 2020-05-21 |
| JP7390027B2 (ja) | 2023-12-01 |
| SG11202003924YA (en) | 2020-05-28 |
| US20200348308A1 (en) | 2020-11-05 |
| CN112272703A (zh) | 2021-01-26 |
| WO2019089836A1 (en) | 2019-05-09 |
| CA3081441C (en) | 2023-08-29 |
| US12130291B2 (en) | 2024-10-29 |
| US20240377409A1 (en) | 2024-11-14 |
| CN112272703B (zh) | 2024-12-27 |
| KR20200093557A (ko) | 2020-08-05 |
| AU2018358057B2 (en) | 2023-03-02 |
| EP3704249B1 (en) | 2025-05-21 |
| CN119716077A (zh) | 2025-03-28 |
| US20230168254A1 (en) | 2023-06-01 |
| US20230236198A1 (en) | 2023-07-27 |
| CA3081441A1 (en) | 2019-05-09 |
| KR102556494B1 (ko) | 2023-07-18 |
| JP2021501577A (ja) | 2021-01-21 |
| US12292446B2 (en) | 2025-05-06 |
| EP3704249A1 (en) | 2020-09-09 |
| US11782062B2 (en) | 2023-10-10 |
| EP3704249A4 (en) | 2021-10-27 |
| EP3704249C0 (en) | 2025-05-21 |
| US11513126B2 (en) | 2022-11-29 |
| US12467928B2 (en) | 2025-11-11 |
| US20250060371A1 (en) | 2025-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2019089851A8 (en) | Methods and kits using nucleic acid encoding and/or label | |
| Wilhelm et al. | Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics | |
| Wittmann‐Liebold et al. | Two‐dimensional gel electrophoresis as tool for proteomics studies in combination with protein identification by mass spectrometry | |
| Sprung Jr et al. | Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis | |
| Ritz et al. | High‐sensitivity HLA class I peptidome analysis enables a precise definition of peptide motifs and the identification of peptides from cell lines and patients’ sera | |
| Parker et al. | A plausible simultaneous synthesis of amino acids and simple peptides on the primordial Earth | |
| Götze et al. | StavroX—a software for analyzing crosslinked products in protein interaction studies | |
| WO2003102220A3 (en) | Methods for high throughput and quantitative proteome analysis | |
| EP4372383A3 (en) | Methods and systems for protein identification | |
| Denslow et al. | Application of proteomics technology to the field of neurotrauma | |
| JP2019523635A5 (enExample) | ||
| MX2023000877A (es) | Metodos para la caracterizacion de anticuerpos de tipo del medio hacia abajo. | |
| Susnea et al. | Application of MALDI-TOF-mass spectrometry to proteome analysis using stain-free gel electrophoresis | |
| Gu et al. | Use of deuterium-labeled lysine for efficient protein identification and peptide de novo sequencing | |
| PE20220564A1 (es) | Metodo para la caracterizacion de polipeptidos que se unen a complejos de peptido.mhc | |
| JP2019507341A5 (enExample) | ||
| BR112023002580A2 (pt) | Métodos para identificar a presença e/ou concentração e/ou quantidade de proteínas ou proteomas | |
| BR112021002029A2 (pt) | métodos para sequenciação de proteínas de novo | |
| Gomase et al. | Immunoproteomics: A review of techniques, applications, and advancements | |
| RU2010145112A (ru) | Соединения и способы мечения и отбора по аффинности белковых молекул | |
| Lee et al. | Preparing to read the ubiquitin code: top‐down analysis of unanchored ubiquitin tetramers | |
| Kalia et al. | Proteomics: a paradigm shift | |
| Steckel et al. | Mapping the tandem mass spectrometric characteristics of citrulline‐containing peptides | |
| WO2010140774A3 (ko) | 데이터 비의존성 분석법과 데이터 의존성 분석법을 복합화한 단백질 분석방법 | |
| EA201991019A1 (ru) | Способ скрининга и детекции белка |