MX2020004559A - Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico. - Google Patents

Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.

Info

Publication number
MX2020004559A
MX2020004559A MX2020004559A MX2020004559A MX2020004559A MX 2020004559 A MX2020004559 A MX 2020004559A MX 2020004559 A MX2020004559 A MX 2020004559A MX 2020004559 A MX2020004559 A MX 2020004559A MX 2020004559 A MX2020004559 A MX 2020004559A
Authority
MX
Mexico
Prior art keywords
kits
nucleic acid
acid encoding
analysis
barcoding
Prior art date
Application number
MX2020004559A
Other languages
English (en)
Spanish (es)
Inventor
Lei Shi
Kevin Gunderson
Michael Phillip Weiner
Luca Monfregola
John M Beierle
Mark S Chee
Norihito Muranaka
Robert C James
Original Assignee
Encodia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Encodia Inc filed Critical Encodia Inc
Publication of MX2020004559A publication Critical patent/MX2020004559A/es

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6416Metalloendopeptidases (3.4.24)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60Detection means characterised by use of a special device
    • C12Q2565/619Detection means characterised by use of a special device being a video camera
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
MX2020004559A 2017-10-31 2018-10-31 Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico. MX2020004559A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762579844P 2017-10-31 2017-10-31
US201762582312P 2017-11-06 2017-11-06
US201762583448P 2017-11-08 2017-11-08
PCT/US2018/058565 WO2019089836A1 (en) 2017-10-31 2018-10-31 Kits for analysis using nucleic acid encoding and/or label

Publications (1)

Publication Number Publication Date
MX2020004559A true MX2020004559A (es) 2020-10-05

Family

ID=66333623

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004559A MX2020004559A (es) 2017-10-31 2018-10-31 Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.

Country Status (10)

Country Link
US (6) US11513126B2 (enExample)
EP (1) EP3704249B1 (enExample)
JP (1) JP7390027B2 (enExample)
KR (1) KR102556494B1 (enExample)
CN (2) CN112272703B (enExample)
AU (1) AU2018358057B2 (enExample)
CA (1) CA3081441C (enExample)
MX (1) MX2020004559A (enExample)
SG (1) SG11202003924YA (enExample)
WO (1) WO2019089836A1 (enExample)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112012002570B4 (de) 2011-06-23 2023-11-23 Board Of Regents, The University Of Texas System Identifizieren von Peptiden auf der Einzelmolekülebene
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
EP3543703A1 (en) 2014-09-15 2019-09-25 Board of Regents, The University of Texas System Improved single molecule peptide sequencing
KR102741603B1 (ko) 2016-05-02 2024-12-16 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
EP3548652B1 (en) 2016-12-01 2024-04-03 Nautilus Subsidiary, Inc. Methods of assaying proteins
KR102556494B1 (ko) 2017-10-31 2023-07-18 엔코디아, 인코포레이티드 핵산 암호화 및/또는 표지를 이용한 분석용 키트
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
CA3086915A1 (en) 2017-12-29 2019-07-04 Sujal M. Patel Decoding approaches for protein identification
WO2019195633A1 (en) * 2018-04-04 2019-10-10 Ignite Biosciences, Inc. Methods of generating nanoarrays and microarrays
US11302421B2 (en) * 2018-04-13 2022-04-12 The Hong Kong Polytechnic University Data storage using peptides
WO2020014586A1 (en) 2018-07-12 2020-01-16 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
CN108866046A (zh) * 2018-07-25 2018-11-23 辽宁润基生物科技有限公司 一种分离、纯化样品中外泌体和/或游离核酸的方法
US10836798B2 (en) * 2018-11-08 2020-11-17 Government Of The United States Of America, As Represented By The Secretary Of Commerce Amino acid-specific binder and selectively identifying an amino acid
MX2021005757A (es) 2018-11-15 2021-08-11 Quantum Si Inc Metodos y composiciones para la secuenciacion de proteinas.
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
EP3963070A4 (en) 2019-04-30 2023-02-22 Encodia, Inc. METHODS OF PREPARATION OF ANALYTES AND RELATED KITS
US20220235405A1 (en) * 2019-05-20 2022-07-28 Encodia, Inc. Methods and related kits for spatial analysis
CN115175998A (zh) * 2019-10-18 2022-10-11 Encodia 公司 分析用大分子的自动化处理及相关设备
CN114929897A (zh) * 2019-10-28 2022-08-19 宽腾矽公司 制备用于多肽测序的富集样品的方法
WO2021086918A1 (en) * 2019-10-28 2021-05-06 Quantum-Si Incorporated Methods of single-polypeptide sequencing and reconstruction
CN114929888A (zh) * 2019-10-28 2022-08-19 宽腾矽公司 制备用于多重多肽测序的样品的方法、试剂盒和装置
WO2021141924A1 (en) 2020-01-07 2021-07-15 Encodia, Inc. Methods for stable complex formation and related kits
WO2021141922A1 (en) * 2020-01-07 2021-07-15 Encodia, Inc. Methods for information transfer and related kits
EP4073263A4 (en) 2020-01-07 2023-11-08 Encodia, Inc. METHOD FOR STABLE COMPLEX FORMATION AND CORRESPONDING KITS
KR20220136080A (ko) 2020-02-03 2022-10-07 일루미나, 인코포레이티드 바이오틴-스트렙타비딘 절단 조성물 및 라이브러리 단편 절단
JP7445966B2 (ja) * 2020-03-24 2024-03-08 国立研究開発法人産業技術総合研究所 糖鎖を解析する方法
JP2023527764A (ja) 2020-05-20 2023-06-30 クアンタム-エスアイ インコーポレイテッド タンパク質シーケンスのための方法及び組成物
CA3182266A1 (en) 2020-06-11 2021-12-16 Vadim Lobanov Methods and systems for computational decoding of biological, chemical, and physical entities
JP2023538074A (ja) * 2020-08-19 2023-09-06 エンコディア, インコーポレイテッド 連続エンコーディング方法及び関連キット
US20230220589A1 (en) * 2020-09-30 2023-07-13 Encodia, Inc. Polypeptide terminal binders and uses thereof
WO2022094148A1 (en) 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones
KR20230118570A (ko) 2020-11-11 2023-08-11 노틸러스 서브시디어리, 인크. 강화된 결합 및 검출 특성을 갖는 친화성 시약
EP4271997A4 (en) * 2020-12-31 2024-12-04 Encodia, Inc. METALLOENZYMES FOR THE BIOMOLECULAR RECOGNITION OF N-TERMINAL MODIFIED PEPTIDES
US12092642B2 (en) 2021-01-20 2024-09-17 Nautilus Subsidiary, Inc. Systems and methods for biomolecule quantitation
AU2022209365A1 (en) 2021-01-21 2023-07-20 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
CN112899152B (zh) * 2021-02-02 2023-11-17 中国科学院苏州纳米技术与纳米仿生研究所 核酸快速扩增和检测的微流控芯片、检测方法及系统
WO2022173690A1 (en) * 2021-02-09 2022-08-18 University Of Washington Methods for protein identification through combinatorial barcoding
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
CN113129996B (zh) * 2021-03-22 2022-04-12 复旦大学 一种基于分子动力学模拟的核酸适配体优化设计方法
WO2022200793A1 (en) * 2021-03-25 2022-09-29 The University Of Birmingham Analyte capture
WO2022217112A1 (en) * 2021-04-09 2022-10-13 Ultima Genomics, Inc. Systems and methods for spatial screening of analytes
CN113281507B (zh) * 2021-05-23 2022-08-16 吉林大学 一种金黄色葡萄球菌快速检测方法及试剂盒
US20220412998A1 (en) 2021-06-24 2022-12-29 Nautilus Biotechnology, Inc. Methods and systems for assay refinement
CA3227872A1 (en) 2021-09-09 2023-03-16 James Henry JOLY Characterization and localization of protein modifications
EP4405683A1 (en) * 2021-09-22 2024-07-31 Nautilus Subsidiary, Inc. Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
US12474346B2 (en) 2021-11-05 2025-11-18 Encodia, Inc. Methods and kits for multicycle encoding assay
US11753677B2 (en) * 2021-11-10 2023-09-12 Encodia, Inc. Methods for barcoding macromolecules in individual cells
CN113881753B (zh) * 2021-12-08 2022-02-18 南京邮电大学 一种非诊断目的的基因定位方法
EP4448789A4 (en) * 2021-12-15 2025-12-10 Biolegend Inc COMPOSITIONS AND METHODS FOR IMPROVED SAMPLE MULTIPLEXING
EP4206674B1 (en) 2021-12-28 2025-10-22 Encodia, Inc. High-throughput serotyping and antibody profiling assays
AU2023241893A1 (en) 2022-03-29 2024-09-26 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023201365A1 (en) * 2022-04-15 2023-10-19 Encodia, Inc. High throughput peptide identification using conjugated binders and kinetic encoding
WO2023212490A1 (en) 2022-04-25 2023-11-02 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
WO2023241720A1 (zh) * 2022-06-17 2023-12-21 上海高探生物科技有限公司 样本处理系统及其制备方法
US20250376716A1 (en) 2022-06-21 2025-12-11 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
CN119790193A (zh) 2022-07-12 2025-04-08 阿布鲁斯生物公司 通过将氨基酸聚合物重新编码为dna聚合物来确定蛋白质信息
CN120092180A (zh) 2022-08-02 2025-06-03 格里菲克生物技术公司 通过可聚合分子偶联进行蛋白质测序
WO2024040236A2 (en) 2022-08-19 2024-02-22 Abrus Bio, Inc. Determination of protein information by recoding amino acid polymers into dna polymers
US20240087679A1 (en) 2022-09-13 2024-03-14 Nautilus Subsidiary, Inc. Systems and methods of validating new affinity reagents
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
WO2024177827A1 (en) 2023-02-24 2024-08-29 Nautilus Subsidiary, Inc. Modifying, separating and detecting proteoforms
CN115976655A (zh) * 2023-03-20 2023-04-18 深圳市小分子新药创新中心有限公司 On-DNA酰肼化合物的合成方法、DNA编码化合物库
WO2024206122A1 (en) 2023-03-24 2024-10-03 Nautilus Subsidiary, Inc. Improved transfer of nanoparticles to array surfaces
WO2024243237A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
WO2024263696A1 (en) 2023-06-21 2024-12-26 Nautilus Subsidiary, Inc. Compositions and methods for improving affinity reagent avidity
CN117019248B (zh) * 2023-08-17 2025-05-02 杭州跃真生物科技有限公司 一种微孔芯片与单细胞分析方法
US20250066841A1 (en) * 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
WO2025080862A1 (en) * 2023-10-10 2025-04-17 Fluid Discovery Quantitative partitioned amplification
GB202317028D0 (en) * 2023-11-06 2023-12-20 Oxford Nanopore Tech Ltd Method
US20250189519A1 (en) 2023-12-11 2025-06-12 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
WO2025137166A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
WO2025199236A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation
CN119851760B (zh) * 2025-01-14 2025-09-30 大连理工大学 一种基于三进制dna编码库的核酸检测方法
CN120078882A (zh) * 2025-05-07 2025-06-03 中国人民解放军军事科学院军事医学研究院 一种多糖-蛋白缀合物、其纳米颗粒以及疫苗组合物

Family Cites Families (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863870A (en) 1988-03-10 1989-09-05 Bio-Affinity Systems, Inc. Method of thioacylation peptide sequencing with alcoholysis of thiazolinones
US5484735A (en) 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
US5049507A (en) 1989-12-21 1991-09-17 Applied Biosystems, Inc. Method of C-terminal peptide sequencing
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
GB9421819D0 (en) 1994-10-29 1994-12-14 Cancer Res Campaign Tech Sequence analysis of saccharide material
CA2176414A1 (en) 1995-05-18 1996-11-19 S. David Kimball Acyl guanidine and amidine prodrugs
EP0841945B1 (en) 1995-08-03 2006-03-08 Rijksuniversiteit te Leiden Cell derived antigen presenting vesicles
JP3124507B2 (ja) 1996-05-24 2001-01-15 セイコーインスツルメンツ株式会社 タンパク質あるいはペプチドのカルボキシ末端からのアミノ酸配列を決定する方法
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
PT971946E (pt) * 1997-01-21 2006-11-30 Gen Hospital Corp Selecção de proteínas utilizando fusões arn-proteína
US6306588B1 (en) 1997-02-07 2001-10-23 Invitrogen Corporation Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
US6465193B2 (en) 1998-12-11 2002-10-15 The Regents Of The University Of California Targeted molecular bar codes and methods for using the same
US6875851B1 (en) 1999-03-05 2005-04-05 University Of Georgia Research Foundation, Inc. Prolyl tripeptidyl peptidases nucleic acid of Porphyromonas gingivalis
JP2003536048A (ja) * 1999-03-23 2003-12-02 バイオヴェイション リミテッド タンパク質の単離および分析
WO2000071755A2 (en) 1999-05-25 2000-11-30 Praelux Incorporated Method for sequency and characterizing polymeric biomolecules using aptamers and a method for producing aptamers
ES2284508T3 (es) * 1999-07-27 2007-11-16 Adnexus Therapeutics, Inc. Procedimientos de ligadura de aceptador de peptidos.
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
US6511809B2 (en) 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US6800453B2 (en) 2001-01-23 2004-10-05 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US20030087232A1 (en) 2001-01-25 2003-05-08 Fred Christians Methods for screening polypeptides
US20030118585A1 (en) 2001-10-17 2003-06-26 Agy Therapeutics Use of protein biomolecular targets in the treatment and visualization of brain tumors
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
AU2002330671B2 (en) * 2001-07-06 2008-04-03 Centre National De La Recherche Scientifique (Cnrs) Method for obtaining cells with new properties
WO2003029462A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
US7169894B2 (en) 2001-11-14 2007-01-30 Mirari Biosciences, Inc. Methods and compositions for reverse translation
EP1451356A1 (en) 2001-11-23 2004-09-01 Simon Fredriksson Method and kit for proximity probing with multivalent proximity probes
DE10242016A1 (de) 2002-09-11 2004-03-25 Esplora GmbH c/o TU Darmstadt Institut für Biochemie Verfahren zur Identifizierung BHS-spezifischer Proteine und Fragmente davon
EP1578935A2 (en) 2002-10-10 2005-09-28 Diversa Corporation Proteases, nucleic acids encoding them and methods for making and using them
US20090246879A1 (en) * 2002-12-20 2009-10-01 Callida Genomics Materials and Methods Relating to Nano-Tags and Nano-Brands
WO2005015239A2 (en) 2003-08-07 2005-02-17 Cornell Research Foundation, Inc. Method for n-terminal labeling of proteins
US7198900B2 (en) 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
EP1561755A2 (en) 2003-10-16 2005-08-10 Shimadzu Corporation Method for derivatizing protein or peptide to sulfonic acid derivative
JP5646127B2 (ja) * 2003-12-17 2014-12-24 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC コードされたライブラリーの合成のための方法
GB0404187D0 (en) 2004-02-25 2004-03-31 Biotransformations Ltd Binding agents
DE602005017370D1 (de) 2004-03-22 2009-12-10 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
AU2005241003B2 (en) 2004-04-14 2011-05-19 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
US20060199279A1 (en) 2005-03-07 2006-09-07 Viorica Lopez-Avila Methods for identifying post-translationally modified polypeptides
US7229769B2 (en) 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
CA2541986A1 (en) 2005-04-21 2006-10-21 Co2 Solution Inc. Carbonic anhydrase having increased stability under high temperatue conditions
US7883848B2 (en) 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7611834B2 (en) 2005-09-30 2009-11-03 Sandia Corporation Methods and devices for protein assays
LT3018206T (lt) 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
US20070218503A1 (en) 2006-02-13 2007-09-20 Mitra Robi D Methods of polypeptide identification, and compositions therefor
DE102006015001A1 (de) 2006-03-31 2007-10-11 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Verfahren zum Nachweis und/oder zur Anreicherung von Analytproteinen und/oder Analytpeptiden aus einer komplexen Proteinmischung
US8758991B2 (en) 2006-04-26 2014-06-24 University Of Louisville Research Foundation, Inc. Isolation of membrane vesicles from biological fluids and methods of using same
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
WO2008085912A1 (en) 2007-01-05 2008-07-17 Massachusetts Institute Of Technology Compositions of and methods of using sulfatases from flavobacterium heparinum
WO2009019215A1 (en) 2007-08-03 2009-02-12 Dkfz Deutsches Krebsforschungszentrum Method for prenatal diagnosis using exosomes and cd24 as a marker
WO2009050261A1 (en) * 2007-10-19 2009-04-23 Pronota N.V. Preparation of samples for proteome analysis
WO2010065531A1 (en) 2008-12-01 2010-06-10 Robi David Mitra Single molecule protein screening
WO2010065322A1 (en) 2008-12-01 2010-06-10 Research Triangle Institute Concurrent identification of multitudes of polypeptides
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
US9566335B1 (en) 2009-09-25 2017-02-14 The Governing Council Of The University Of Toronto Protein sequencing method and reagents
WO2011056185A2 (en) 2009-11-04 2011-05-12 President And Fellows Of Harvard College Reactivity-dependent and interaction-dependent pcr
US20110245101A1 (en) 2010-04-05 2011-10-06 Prognosys Biosciences, Inc. Co-localization affinity assays
PT2556171E (pt) 2010-04-05 2015-12-21 Prognosys Biosciences Inc Ensaios biológicos codificados espacialmente
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
WO2011143583A1 (en) 2010-05-13 2011-11-17 Illumina, Inc. Binding assays for markers
EP2622073B1 (en) 2010-09-27 2018-04-18 Vipergen A method for making an enriched library
EP2638057B1 (en) 2010-11-10 2019-03-06 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
EP3150750B1 (en) 2011-04-08 2018-12-26 Prognosys Biosciences, Inc. Peptide constructs and assay systems
DK3246416T3 (da) 2011-04-15 2024-09-02 Univ Johns Hopkins Sikkert sekventeringssystem
EP3569607A1 (en) 2011-05-11 2019-11-20 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
DE112012002570B4 (de) 2011-06-23 2023-11-23 Board Of Regents, The University Of Texas System Identifizieren von Peptiden auf der Einzelmolekülebene
EP2748335B1 (en) 2011-08-22 2018-10-03 Exosome Diagnostics, Inc. Urine biomarkers
US20130052665A1 (en) 2011-08-25 2013-02-28 Bruce Xuefeng Ling Methods for diagnosis of systemic juvenile idiopathic arthritis
US9335292B2 (en) * 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
US10174361B2 (en) 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
WO2013101896A1 (en) 2011-12-30 2013-07-04 Quest Diagnostics Investments Incorporated Nucleic acid analysis using emulsion pcr
US20150087526A1 (en) 2012-01-24 2015-03-26 The Regents Of The University Of Colorado, A Body Corporate Peptide identification and sequencing by single-molecule detection of peptides undergoing degradation
EP2814959B1 (en) 2012-02-17 2018-01-17 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
WO2013138510A1 (en) 2012-03-13 2013-09-19 Patel Abhijit Ajit Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
EP4234713A3 (en) 2012-03-20 2024-02-14 University Of Washington Through Its Center For Commercialization Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
US9005888B2 (en) 2012-06-14 2015-04-14 System Biosciences, Llc Methods for microvesicle isolation and selective removal
US9267127B2 (en) 2012-06-21 2016-02-23 President And Fellows Of Harvard College Evolution of bond-forming enzymes
NL2009191C2 (en) 2012-07-16 2014-01-20 Univ Delft Tech Single molecule protein sequencing.
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US20140378322A1 (en) 2012-08-14 2014-12-25 10X Technologies, Inc. Compositions and methods for sample processing
WO2014039715A1 (en) 2012-09-07 2014-03-13 University Of Rochester Methods and compositions for site-specific labeling of peptides and proteins
CN105025878A (zh) 2012-10-03 2015-11-04 外来体诊断公司 微泡在医学疾病和病况的诊断、预后和治疗中的用途
EP2912182B1 (en) 2012-10-23 2021-12-08 Caris Science, Inc. Aptamers and uses thereof
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
WO2014081980A2 (en) 2012-11-21 2014-05-30 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
US10767221B2 (en) 2013-03-15 2020-09-08 Illumina, Inc. Enzyme-linked nucleotides
DK2970958T3 (en) 2013-03-15 2018-02-19 Lineage Biosciences Inc METHODS FOR SEQUENCING THE IMMUN REPERTOIR
US9435810B2 (en) 2013-03-15 2016-09-06 Washington University Molecules and methods for iterative polypeptide analysis and processing
WO2014145123A2 (en) 2013-03-15 2014-09-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State Unversity Peptide array quality control
WO2014176355A1 (en) 2013-04-23 2014-10-30 President And Fellows Of Harvard College In situ interaction determination
WO2014189768A1 (en) 2013-05-19 2014-11-27 The Board Of Trustees Of The Leland Devices and methods for display of encoded peptides, polypeptides, and proteins on dna
AU2014268322B2 (en) 2013-05-24 2019-01-24 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed FRET detection
US10065988B2 (en) 2013-05-31 2018-09-04 Stefano Menegatti Peptoid affinity ligands
WO2014201273A1 (en) 2013-06-12 2014-12-18 The Broad Institute, Inc. High-throughput rna-seq
EP4234716A3 (en) 2013-06-25 2023-12-06 Prognosys Biosciences, Inc. Methods for determining spatial patterns of biological targets in a sample
CA2917435A1 (en) 2013-07-10 2015-01-15 Children's Medical Center Corporation Compositions and methods relating to nucleic acid-protein complexes
US20160319361A1 (en) 2013-08-28 2016-11-03 Caris Life Sciences Switzerland Holdings Gmbh Oligonucleotide probes and uses thereof
WO2015042506A1 (en) 2013-09-23 2015-03-26 The Trustees Of Columbia University In The City Of New York High-throughput single molecule protein identification
WO2015070037A2 (en) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
WO2015073538A2 (en) 2013-11-12 2015-05-21 Echogen, Inc. Interaction with metalloenzymes
US9834814B2 (en) 2013-11-22 2017-12-05 Agilent Technologies, Inc. Spatial molecular barcoding of in situ nucleic acids
CA2940823C (en) 2014-02-27 2017-03-28 Board Of Regents, The University Of Texas System Methods and compositions for isolating exosomes
WO2015148606A2 (en) * 2014-03-25 2015-10-01 President And Fellows Of Harvard College Barcoded protein array for multiplex single-molecule interaction profiling
LT3456846T (lt) 2014-04-21 2022-09-12 President And Fellows Of Harvard College Nukleorūgšties unikalios sekos įvedimo sistemos ir būdai
US10590407B2 (en) 2014-04-24 2020-03-17 Nanyang Technological University Asx-specific protein ligase
US10738352B2 (en) 2014-05-02 2020-08-11 Idac Theranostics, Inc. Method for analyzing nucleic acid derived from single cell
EP3143165A4 (en) * 2014-05-15 2018-05-16 Two Pore Guys, Inc. Scaffold data storage and target detection in a sample using a nanopore
CN113249435B (zh) 2014-06-26 2024-09-03 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
JP2017522866A (ja) 2014-06-26 2017-08-17 10エックス ジェノミクス, インコーポレイテッド 核酸配列の分析
US11229607B2 (en) 2014-06-30 2022-01-25 President And Fellows Of Harvard College Hydrogel compositions comprising encapsulated cells and methods of use thereof
CA2954576C (en) 2014-07-09 2020-08-11 Daniel ENDERLE Methods for isolating microvesicles and extracting nucleic acids from biological samples
WO2016011364A1 (en) * 2014-07-18 2016-01-21 Cdi Laboratories, Inc. Methods and compositions to identify, quantify, and characterize target analytes and binding moieties
WO2016019360A1 (en) 2014-08-01 2016-02-04 Dovetail Genomics Llc Tagging nucleic acids for sequence assembly
EP3543703A1 (en) 2014-09-15 2019-09-25 Board of Regents, The University of Texas System Improved single molecule peptide sequencing
KR102472027B1 (ko) 2014-10-17 2022-11-30 일루미나 케임브리지 리미티드 근접 보존 전위
US9771412B2 (en) 2014-10-31 2017-09-26 Wisconsin Alumni Research Foundation Engineered intein for improved production of protein-intein fusions
JP7235436B2 (ja) * 2014-11-10 2023-03-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 細胞の表面上にポリペプチドを発現させるための組成物および方法
US11634707B2 (en) 2015-02-10 2023-04-25 Illumina, Inc. Methods and compositions for analyzing cellular components
EP3262192B1 (en) 2015-02-27 2020-09-16 Becton, Dickinson and Company Spatially addressable molecular barcoding
US20180284125A1 (en) * 2015-03-11 2018-10-04 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2016164530A1 (en) 2015-04-07 2016-10-13 University Of Maryland, College Park Compositions and methods for high throughput protein sequencing
US10345310B2 (en) 2015-06-09 2019-07-09 The Board Of Regents Of The University Of Texas System Diagnostic test for early stage cancer
JP6956709B2 (ja) 2015-09-22 2021-11-02 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Ompgバリアント
EP3353317A1 (en) 2015-09-24 2018-08-01 H. Hoffnabb-La Roche Ag Alpha-hemolysin variants
US11965891B2 (en) * 2015-12-30 2024-04-23 Bio-Rad Laboratories, Inc. Digital protein quantification
WO2017125565A1 (en) 2016-01-21 2017-07-27 Genia Technologies, Inc. Nanopore sequencing complexes
CN116949140A (zh) 2016-02-17 2023-10-27 哈佛学院院长及董事 分子编程工具
KR102741603B1 (ko) * 2016-05-02 2024-12-16 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
CN109312337B (zh) 2016-05-27 2022-10-04 哈佛学院院长及董事 用于单分子检测的条件性引物延伸
WO2018005720A1 (en) 2016-06-30 2018-01-04 President And Fellows Of Harvard College Method of determining the molecular binding between libraries of molecules
WO2018017914A1 (en) 2016-07-22 2018-01-25 President And Fellows Of Harvard College Methods and compositions for protein identification
EP3548652B1 (en) 2016-12-01 2024-04-03 Nautilus Subsidiary, Inc. Methods of assaying proteins
EP4029939B1 (en) 2017-01-30 2023-06-28 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US20180251825A1 (en) 2017-02-02 2018-09-06 New York Genome Center Inc. Methods and compositions for identifying or quantifying targets in a biological sample
US20200348307A1 (en) 2017-10-31 2020-11-05 Encodia, Inc. Methods and compositions for polypeptide analysis
SG11202003923PA (en) 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
KR102556494B1 (ko) 2017-10-31 2023-07-18 엔코디아, 인코포레이티드 핵산 암호화 및/또는 표지를 이용한 분석용 키트
CA3086915A1 (en) 2017-12-29 2019-07-04 Sujal M. Patel Decoding approaches for protein identification
JP2021511510A (ja) 2018-01-18 2021-05-06 ナノソミックス・インコーポレイテッドNanoSomiX, Inc. 疾患および障害の診断および予後診断のためのエキソソームおよびエキソソームバイオマーカーの検出
US12270741B2 (en) 2018-04-03 2025-04-08 Tymora Analytical Operations, Llc Methods for affinity-based non-antibody capture and purification of extracellular vesicles
US11781149B2 (en) 2018-06-28 2023-10-10 Trustees Of Boston University Systems and methods for control of gene expression
MX2021005757A (es) 2018-11-15 2021-08-11 Quantum Si Inc Metodos y composiciones para la secuenciacion de proteinas.
CN113474651B (zh) 2019-01-08 2024-05-17 麻省理工学院 单分子蛋白质和肽测序
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
MX2021011726A (es) 2019-03-26 2021-10-22 Encodia Inc Escindasas modificadas, usos de las mismas y kits relacionados.
EP3963070A4 (en) 2019-04-30 2023-02-22 Encodia, Inc. METHODS OF PREPARATION OF ANALYTES AND RELATED KITS
US20220227889A1 (en) 2019-04-30 2022-07-21 Encodia, Inc. Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide
WO2020252404A1 (en) 2019-06-12 2020-12-17 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
US11834664B2 (en) 2019-09-13 2023-12-05 Google Llc Methods and compositions for protein and peptide sequencing
US20230220589A1 (en) 2020-09-30 2023-07-13 Encodia, Inc. Polypeptide terminal binders and uses thereof
WO2022094148A1 (en) 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones
EP4271997A4 (en) 2020-12-31 2024-12-04 Encodia, Inc. METALLOENZYMES FOR THE BIOMOLECULAR RECOGNITION OF N-TERMINAL MODIFIED PEPTIDES
US11753677B2 (en) 2021-11-10 2023-09-12 Encodia, Inc. Methods for barcoding macromolecules in individual cells

Also Published As

Publication number Publication date
KR102556494B1 (ko) 2023-07-18
US20230236198A1 (en) 2023-07-27
US20240377409A1 (en) 2024-11-14
SG11202003924YA (en) 2020-05-28
AU2018358057A1 (en) 2020-05-21
KR20200093557A (ko) 2020-08-05
CN112272703B (zh) 2024-12-27
CN119716077A (zh) 2025-03-28
CA3081441A1 (en) 2019-05-09
US12130291B2 (en) 2024-10-29
US20200348308A1 (en) 2020-11-05
US12467928B2 (en) 2025-11-11
CA3081441C (en) 2023-08-29
WO2019089836A1 (en) 2019-05-09
US20240377408A1 (en) 2024-11-14
EP3704249B1 (en) 2025-05-21
US20230168254A1 (en) 2023-06-01
US20250060371A1 (en) 2025-02-20
EP3704249C0 (en) 2025-05-21
US11782062B2 (en) 2023-10-10
EP3704249A4 (en) 2021-10-27
US11513126B2 (en) 2022-11-29
JP2021501577A (ja) 2021-01-21
US12292446B2 (en) 2025-05-06
JP7390027B2 (ja) 2023-12-01
AU2018358057B2 (en) 2023-03-02
EP3704249A1 (en) 2020-09-09
CN112272703A (zh) 2021-01-26

Similar Documents

Publication Publication Date Title
MX2020004559A (es) Kits para análisis utilizando codificación y/o etiqueta de ácido nucleico.
WO2019089851A8 (en) Methods and kits using nucleic acid encoding and/or label
Wilhelm et al. Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics
Wittmann‐Liebold et al. Two‐dimensional gel electrophoresis as tool for proteomics studies in combination with protein identification by mass spectrometry
Sprung Jr et al. Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis
Huesgen et al. N‐and C‐terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification
WO2003102220A3 (en) Methods for high throughput and quantitative proteome analysis
EP4372383A3 (en) Methods and systems for protein identification
Denslow et al. Application of proteomics technology to the field of neurotrauma
RU2009120683A (ru) Соединения и способы двойного мечения полипептидов, предоставляющие возможность мультиплексирования при масс-спектрометрическом анализе
MX2023000877A (es) Metodos para la caracterizacion de anticuerpos de tipo del medio hacia abajo.
Polasky et al. Pervasive charge solvation permeates native-like protein ions and dramatically influences top-down sequencing data
Susnea et al. Application of MALDI-TOF-mass spectrometry to proteome analysis using stain-free gel electrophoresis
Admon et al. Tumor antigens and proteomics from the point of view of the major histocompatibility complex peptides
BR112021002029A2 (pt) métodos para sequenciação de proteínas de novo
BR112023002580A2 (pt) Métodos para identificar a presença e/ou concentração e/ou quantidade de proteínas ou proteomas
RU2010145112A (ru) Соединения и способы мечения и отбора по аффинности белковых молекул
Chakrabarty et al. High confidence identification of cross-linked peptides by an enrichment-based dual cleavable cross-linking technology and data analysis tool cleave-XL
Lee et al. Preparing to read the ubiquitin code: top‐down analysis of unanchored ubiquitin tetramers
EA202091713A1 (ru) Биологический синтез аминокислотных цепей для получения пептидов и белков
Paulson et al. Proteomics and peptidomics in neuroscience. Experience of capabilities and limitations in a neurochemical laboratory
Steckel et al. Mapping the tandem mass spectrometric characteristics of citrulline‐containing peptides
Gomase et al. Immunoproteomics: A Review of Techniques, Applications, and Advancements
Nguyen-Tien et al. Identification of the interacting partners of a lysosomal membrane protein in living cells by BioID technique
EA201991019A1 (ru) Способ скрининга и детекции белка