JP2019507341A5 - - Google Patents
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- Publication number
- JP2019507341A5 JP2019507341A5 JP2018540821A JP2018540821A JP2019507341A5 JP 2019507341 A5 JP2019507341 A5 JP 2019507341A5 JP 2018540821 A JP2018540821 A JP 2018540821A JP 2018540821 A JP2018540821 A JP 2018540821A JP 2019507341 A5 JP2019507341 A5 JP 2019507341A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- hours
- test protein
- digestion period
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 230000029087 digestion Effects 0.000 claims 6
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000004365 Protease Substances 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 238000011534 incubation Methods 0.000 claims 4
- 229960000106 biosimilars Drugs 0.000 claims 2
- 238000004440 column chromatography Methods 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000004885 tandem mass spectrometry Methods 0.000 claims 2
- 108090000317 Chymotrypsin Proteins 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 229960002376 chymotrypsin Drugs 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291216P | 2016-02-04 | 2016-02-04 | |
| US62/291,216 | 2016-02-04 | ||
| PCT/US2017/016549 WO2017136753A1 (en) | 2016-02-04 | 2017-02-03 | Methods for identifying and analyzing amino acid sequences of proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507341A JP2019507341A (ja) | 2019-03-14 |
| JP2019507341A5 true JP2019507341A5 (enExample) | 2020-03-12 |
| JP7224914B2 JP7224914B2 (ja) | 2023-02-20 |
Family
ID=58046784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540821A Active JP7224914B2 (ja) | 2016-02-04 | 2017-02-03 | タンパク質のアミノ酸配列の同定及び分析方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210255194A1 (enExample) |
| EP (1) | EP3411719A1 (enExample) |
| JP (1) | JP7224914B2 (enExample) |
| CN (1) | CN109073655A (enExample) |
| AU (1) | AU2017214586A1 (enExample) |
| CA (1) | CA3013340A1 (enExample) |
| MX (1) | MX2018009339A (enExample) |
| WO (1) | WO2017136753A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2926588C (en) | 2013-10-16 | 2020-07-21 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| WO2016118707A1 (en) | 2015-01-21 | 2016-07-28 | Oncobiologics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| CA3013336A1 (en) | 2016-02-03 | 2017-08-10 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| WO2019178280A1 (en) * | 2018-03-13 | 2019-09-19 | Amgen Inc. | Sequential digestion of polypeptides for mass spectrometric analysis |
| EP3911947B1 (en) | 2019-01-16 | 2025-04-09 | Regeneron Pharmaceuticals, Inc. | Method and system of identifying and quantifying antibody fragmentation |
| CN111579702A (zh) * | 2019-02-18 | 2020-08-25 | 上海美吉生物医药科技有限公司 | 一种蛋白质氨基酸序列覆盖度的检测方法 |
| FR3096459B1 (fr) * | 2019-05-20 | 2024-03-08 | Ct Hospitalier Universitaire Montpellier | Procédé de préparation d’un échantillon peptidique |
| AU2020352519A1 (en) * | 2019-09-23 | 2022-05-19 | Genzyme Corporation | Product quality attribute measurement |
| WO2023118561A1 (en) * | 2021-12-23 | 2023-06-29 | F.Hoffmann-La Roche Ag | Method of extracting information about protein sequence modifications |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2243230A1 (en) | 1998-07-15 | 2000-01-15 | Aled Edwards | A device and method for the determination of protein domain boundaries |
| DE602008000796D1 (de) * | 2008-01-15 | 2010-04-22 | Univ Utrecht Holding Bv | Verfahren zur Bestimmung der Aminosäurensequenz von Peptiden |
| CN102348979A (zh) * | 2009-03-09 | 2012-02-08 | 乔治亚大学研究基金公司 | 胃癌诊断用蛋白标记的鉴定 |
| AU2010256455A1 (en) | 2009-06-05 | 2012-01-19 | Momenta Pharmaceuticals, Inc. | Methods of modulating fucosylation of glycoproteins |
| WO2012111249A1 (ja) * | 2011-02-14 | 2012-08-23 | 学校法人麻布獣医学園 | 質量分析法における質量変化を検出する方法及び安定同位体標識タンパク質の絶対量の定量方法 |
| JP5682986B2 (ja) * | 2011-07-22 | 2015-03-11 | 国立大学法人東北大学 | 質量分析における安定同位体標識標的ペプチド断片の作製方法 |
| CA2850668A1 (en) | 2011-10-04 | 2013-04-11 | Expression Pathology, Inc. | Srm/mrm assay for the ephrin type-a receptor 2 protein |
| JP5874587B2 (ja) | 2012-09-10 | 2016-03-02 | 株式会社島津製作所 | アミノ酸配列解析方法及び装置 |
| US20160266141A1 (en) * | 2013-10-03 | 2016-09-15 | Bioanalytix, Inc. | Mass spectrometry-based method for identifying and maintaining quality control factors during the development and manufacture of a biologic |
| CN105044222B (zh) * | 2014-12-19 | 2017-09-12 | 浙江辉肽生命健康科技有限公司 | 生物活性多肽的分析测试和鉴定方法 |
-
2017
- 2017-02-03 EP EP17705543.1A patent/EP3411719A1/en not_active Ceased
- 2017-02-03 CN CN201780019687.5A patent/CN109073655A/zh active Pending
- 2017-02-03 AU AU2017214586A patent/AU2017214586A1/en not_active Abandoned
- 2017-02-03 JP JP2018540821A patent/JP7224914B2/ja active Active
- 2017-02-03 CA CA3013340A patent/CA3013340A1/en not_active Abandoned
- 2017-02-03 MX MX2018009339A patent/MX2018009339A/es unknown
- 2017-02-03 WO PCT/US2017/016549 patent/WO2017136753A1/en not_active Ceased
- 2017-02-03 US US16/072,989 patent/US20210255194A1/en not_active Abandoned
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