JP7224914B2 - タンパク質のアミノ酸配列の同定及び分析方法 - Google Patents

タンパク質のアミノ酸配列の同定及び分析方法 Download PDF

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JP7224914B2
JP7224914B2 JP2018540821A JP2018540821A JP7224914B2 JP 7224914 B2 JP7224914 B2 JP 7224914B2 JP 2018540821 A JP2018540821 A JP 2018540821A JP 2018540821 A JP2018540821 A JP 2018540821A JP 7224914 B2 JP7224914 B2 JP 7224914B2
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sample
seq
protein
test protein
amino acid
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JP2019507341A5 (enExample
JP2019507341A (ja
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シアオ シアオヤオ
リー リンホイ
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アウトルック セラピューティクス，インコーポレイティド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
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  • Analytical Chemistry (AREA)
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  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2018540821A 2016-02-04 2017-02-03 タンパク質のアミノ酸配列の同定及び分析方法 Active JP7224914B2 (ja)

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US201662291216P 2016-02-04 2016-02-04
US62/291,216 2016-02-04
PCT/US2017/016549 WO2017136753A1 (en) 2016-02-04 2017-02-03 Methods for identifying and analyzing amino acid sequences of proteins

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JP2019507341A JP2019507341A (ja) 2019-03-14
JP2019507341A5 JP2019507341A5 (enExample) 2020-03-12
JP7224914B2 true JP7224914B2 (ja) 2023-02-20

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US (1) US20210255194A1 (enExample)
EP (1) EP3411719A1 (enExample)
JP (1) JP7224914B2 (enExample)
CN (1) CN109073655A (enExample)
AU (1) AU2017214586A1 (enExample)
CA (1) CA3013340A1 (enExample)
MX (1) MX2018009339A (enExample)
WO (1) WO2017136753A1 (enExample)

Families Citing this family (9)

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US10376582B2 (en) 2013-10-16 2019-08-13 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
US10696735B2 (en) 2015-01-21 2020-06-30 Outlook Therapeutics, Inc. Modulation of charge variants in a monoclonal antibody composition
MX2018009341A (es) 2016-02-03 2019-05-15 Oncobiologics Inc Formulaciones tamponadas para una mayor estabilidad de anticuerpos.
WO2019178280A1 (en) 2018-03-13 2019-09-19 Amgen Inc. Sequential digestion of polypeptides for mass spectrometric analysis
CN113227785A (zh) 2019-01-16 2021-08-06 瑞泽恩制药公司 识别和定量抗体片段化的方法和系统
CN111579702A (zh) * 2019-02-18 2020-08-25 上海美吉生物医药科技有限公司 一种蛋白质氨基酸序列覆盖度的检测方法
FR3096459B1 (fr) * 2019-05-20 2024-03-08 Ct Hospitalier Universitaire Montpellier Procédé de préparation d’un échantillon peptidique
US20210087514A1 (en) * 2019-09-23 2021-03-25 Genzyme Corporation Product quality attribute measurement
WO2023118561A1 (en) * 2021-12-23 2023-06-29 F.Hoffmann-La Roche Ag Method of extracting information about protein sequence modifications

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104509A1 (en) 1998-07-15 2003-06-05 Affinium Pharmaceuticals, Inc. Device and method for the determination of protein domain boundaries
US20120277165A1 (en) 2009-06-05 2012-11-01 Collins Brian E Methods of modulating fucosylation of glycoproteins
JP2014052331A (ja) 2012-09-10 2014-03-20 Shimadzu Corp アミノ酸配列解析方法及び装置
JP2014534423A (ja) 2011-10-04 2014-12-18 エクスプレッション、パソロジー、インコーポレイテッドＥｘｐｒｅｓｓｉｏｎ Ｐａｔｈｏｌｏｇｙ， Ｉｎｃ． エフリンａ型受容体２タンパク質に対するｓｒｍ／ｍｒｍアッセイ

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2081025B1 (en) * 2008-01-15 2010-03-10 Universiteit Utrecht Holding B.V. Method for determining the amino acid sequence of peptides
CN102348979A (zh) * 2009-03-09 2012-02-08 乔治亚大学研究基金公司 胃癌诊断用蛋白标记的鉴定
JPWO2012111249A1 (ja) * 2011-02-14 2014-07-03 学校法人麻布獣医学園 質量分析法における質量変化を検出する方法及び安定同位体標識タンパク質の絶対量の定量方法
JP5682986B2 (ja) * 2011-07-22 2015-03-11 国立大学法人東北大学 質量分析における安定同位体標識標的ペプチド断片の作製方法
EP3114476A4 (en) * 2013-10-03 2017-11-01 Bioanalytix, Inc. Mass spectrometry-based method for identifying and maintaining quality control factors during the development and manufacture of a biologic
CN105044222B (zh) * 2014-12-19 2017-09-12 浙江辉肽生命健康科技有限公司 生物活性多肽的分析测试和鉴定方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104509A1 (en) 1998-07-15 2003-06-05 Affinium Pharmaceuticals, Inc. Device and method for the determination of protein domain boundaries
US20120277165A1 (en) 2009-06-05 2012-11-01 Collins Brian E Methods of modulating fucosylation of glycoproteins
JP2014534423A (ja) 2011-10-04 2014-12-18 エクスプレッション、パソロジー、インコーポレイテッドＥｘｐｒｅｓｓｉｏｎ Ｐａｔｈｏｌｏｇｙ， Ｉｎｃ． エフリンａ型受容体２タンパク質に対するｓｒｍ／ｍｒｍアッセイ
JP2014052331A (ja) 2012-09-10 2014-03-20 Shimadzu Corp アミノ酸配列解析方法及び装置

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CA3013340A1 (en) 2017-08-10
CN109073655A (zh) 2018-12-21
US20210255194A1 (en) 2021-08-19
MX2018009339A (es) 2019-01-10
EP3411719A1 (en) 2018-12-12
WO2017136753A1 (en) 2017-08-10
JP2019507341A (ja) 2019-03-14
AU2017214586A1 (en) 2018-08-16

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