CA3013340A1 - Methods for identifying and analyzing amino acid sequences of proteins - Google Patents

Methods for identifying and analyzing amino acid sequences of proteins Download PDF

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Publication number
CA3013340A1
CA3013340A1 CA3013340A CA3013340A CA3013340A1 CA 3013340 A1 CA3013340 A1 CA 3013340A1 CA 3013340 A CA3013340 A CA 3013340A CA 3013340 A CA3013340 A CA 3013340A CA 3013340 A1 CA3013340 A1 CA 3013340A1
Authority
CA
Canada
Prior art keywords
sample
protein
test protein
amino acid
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3013340A
Other languages
English (en)
French (fr)
Inventor
Xiaoyao XIAO
Linghui LI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Outlook Therapeutics Inc
Original Assignee
Oncobiologics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncobiologics Inc filed Critical Oncobiologics Inc
Publication of CA3013340A1 publication Critical patent/CA3013340A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA3013340A 2016-02-04 2017-02-03 Methods for identifying and analyzing amino acid sequences of proteins Abandoned CA3013340A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662291216P 2016-02-04 2016-02-04
US62/291,216 2016-02-04
PCT/US2017/016549 WO2017136753A1 (en) 2016-02-04 2017-02-03 Methods for identifying and analyzing amino acid sequences of proteins

Publications (1)

Publication Number Publication Date
CA3013340A1 true CA3013340A1 (en) 2017-08-10

Family

ID=58046784

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3013340A Abandoned CA3013340A1 (en) 2016-02-04 2017-02-03 Methods for identifying and analyzing amino acid sequences of proteins

Country Status (8)

Country Link
US (1) US20210255194A1 (enExample)
EP (1) EP3411719A1 (enExample)
JP (1) JP7224914B2 (enExample)
CN (1) CN109073655A (enExample)
AU (1) AU2017214586A1 (enExample)
CA (1) CA3013340A1 (enExample)
MX (1) MX2018009339A (enExample)
WO (1) WO2017136753A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10376582B2 (en) 2013-10-16 2019-08-13 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
US10696735B2 (en) 2015-01-21 2020-06-30 Outlook Therapeutics, Inc. Modulation of charge variants in a monoclonal antibody composition
MX2018009341A (es) 2016-02-03 2019-05-15 Oncobiologics Inc Formulaciones tamponadas para una mayor estabilidad de anticuerpos.
WO2019178280A1 (en) 2018-03-13 2019-09-19 Amgen Inc. Sequential digestion of polypeptides for mass spectrometric analysis
CN113227785A (zh) 2019-01-16 2021-08-06 瑞泽恩制药公司 识别和定量抗体片段化的方法和系统
CN111579702A (zh) * 2019-02-18 2020-08-25 上海美吉生物医药科技有限公司 一种蛋白质氨基酸序列覆盖度的检测方法
FR3096459B1 (fr) * 2019-05-20 2024-03-08 Ct Hospitalier Universitaire Montpellier Procédé de préparation d’un échantillon peptidique
US20210087514A1 (en) * 2019-09-23 2021-03-25 Genzyme Corporation Product quality attribute measurement
WO2023118561A1 (en) * 2021-12-23 2023-06-29 F.Hoffmann-La Roche Ag Method of extracting information about protein sequence modifications

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2243230A1 (en) * 1998-07-15 2000-01-15 Aled Edwards A device and method for the determination of protein domain boundaries
EP2081025B1 (en) * 2008-01-15 2010-03-10 Universiteit Utrecht Holding B.V. Method for determining the amino acid sequence of peptides
CN102348979A (zh) * 2009-03-09 2012-02-08 乔治亚大学研究基金公司 胃癌诊断用蛋白标记的鉴定
WO2010141855A1 (en) * 2009-06-05 2010-12-09 Momenta Pharmaceuticals, Inc. Methods of modulating fucosylation of glycoproteins
JPWO2012111249A1 (ja) * 2011-02-14 2014-07-03 学校法人麻布獣医学園 質量分析法における質量変化を検出する方法及び安定同位体標識タンパク質の絶対量の定量方法
JP5682986B2 (ja) * 2011-07-22 2015-03-11 国立大学法人東北大学 質量分析における安定同位体標識標的ペプチド断片の作製方法
AU2012318590B2 (en) * 2011-10-04 2017-05-18 Expression Pathology, Inc. SRM/MRM assay for the ephrin type-A receptor 2 protein
JP5874587B2 (ja) * 2012-09-10 2016-03-02 株式会社島津製作所 アミノ酸配列解析方法及び装置
EP3114476A4 (en) * 2013-10-03 2017-11-01 Bioanalytix, Inc. Mass spectrometry-based method for identifying and maintaining quality control factors during the development and manufacture of a biologic
CN105044222B (zh) * 2014-12-19 2017-09-12 浙江辉肽生命健康科技有限公司 生物活性多肽的分析测试和鉴定方法

Also Published As

Publication number Publication date
JP7224914B2 (ja) 2023-02-20
CN109073655A (zh) 2018-12-21
US20210255194A1 (en) 2021-08-19
MX2018009339A (es) 2019-01-10
EP3411719A1 (en) 2018-12-12
WO2017136753A1 (en) 2017-08-10
JP2019507341A (ja) 2019-03-14
AU2017214586A1 (en) 2018-08-16

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Effective date: 20220106

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FZDE Discontinued

Effective date: 20240417