MX2020001434A - Analogos de insulina acilados novedosos y usos de estos. - Google Patents
Analogos de insulina acilados novedosos y usos de estos.Info
- Publication number
- MX2020001434A MX2020001434A MX2020001434A MX2020001434A MX2020001434A MX 2020001434 A MX2020001434 A MX 2020001434A MX 2020001434 A MX2020001434 A MX 2020001434A MX 2020001434 A MX2020001434 A MX 2020001434A MX 2020001434 A MX2020001434 A MX 2020001434A
- Authority
- MX
- Mexico
- Prior art keywords
- insulin analogues
- acylated insulin
- novel acylated
- novel
- analogues
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
- G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17186612 | 2017-08-17 | ||
| EP17204872 | 2017-12-01 | ||
| PCT/EP2018/072191 WO2019034726A1 (en) | 2017-08-17 | 2018-08-16 | NOVEL ACYLATED INSULIN ANALOGUES AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020001434A true MX2020001434A (es) | 2020-03-20 |
Family
ID=63165388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020001434A MX2020001434A (es) | 2017-08-17 | 2018-08-16 | Analogos de insulina acilados novedosos y usos de estos. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10919949B2 (enExample) |
| EP (1) | EP3668892A1 (enExample) |
| JP (2) | JP2020531451A (enExample) |
| KR (1) | KR20200038502A (enExample) |
| CN (1) | CN111032685A (enExample) |
| AU (1) | AU2018317810A1 (enExample) |
| BR (1) | BR112020002364A2 (enExample) |
| CA (1) | CA3071686A1 (enExample) |
| CL (1) | CL2020000310A1 (enExample) |
| CO (1) | CO2020002500A2 (enExample) |
| IL (1) | IL272394A (enExample) |
| MA (1) | MA49896A (enExample) |
| MX (1) | MX2020001434A (enExample) |
| PE (1) | PE20211264A1 (enExample) |
| PH (1) | PH12020550050A1 (enExample) |
| RU (1) | RU2020108281A (enExample) |
| SG (1) | SG11202001077UA (enExample) |
| TW (1) | TW201917134A (enExample) |
| WO (1) | WO2019034726A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1969004B1 (en) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| CN114096269B (zh) | 2019-07-12 | 2024-06-11 | 诺和诺德股份有限公司 | 高浓度胰岛素制剂 |
| KR20240118914A (ko) | 2021-01-20 | 2024-08-05 | 바이킹 테라퓨틱스 인코포레이티드 | 대사 및 간 질환 치료를 위한 조성물 및 방법 |
| CA3231953A1 (en) | 2021-09-15 | 2023-03-23 | Brian Lian | Compositions and methods for the treatment of metabolic and liver disorders |
| JPWO2024185897A1 (enExample) * | 2023-03-09 | 2024-09-12 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE50892B1 (en) | 1980-02-11 | 1986-08-06 | Novo Industri As | Process for preparing insulin esters |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| US5616729A (en) | 1986-07-17 | 1997-04-01 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
| DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| DK33591D0 (enExample) | 1991-02-27 | 1991-02-27 | Novo Nordisk As | |
| ZA954983B (en) | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
| ATE317443T1 (de) | 1996-12-20 | 2006-02-15 | Novo Nordisk As | N-terminal verlängerte proteine exprimiert in hefe |
| JP2002535287A (ja) | 1999-01-26 | 2002-10-22 | イーライ・リリー・アンド・カンパニー | 単分散性６量体のアシル化されたインスリンアナログ製剤 |
| CA2372393A1 (en) | 1999-05-19 | 2000-11-23 | Bassil I. Dahiyat | Novel proteins with insulin-like activity useful in the treatment of diabetes |
| RU2283846C2 (ru) | 1999-12-29 | 2006-09-20 | Ново Нордиск А/С | Предшественник инсулина, способ его получения и применение |
| ES2369895T3 (es) | 2003-12-03 | 2011-12-07 | Novo Nordisk A/S | Insulina monocatenaria. |
| WO2006008238A1 (en) * | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
| WO2006082204A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
| JP5202338B2 (ja) | 2006-02-27 | 2013-06-05 | ノボ・ノルデイスク・エー／エス | 新規インシュリン誘導体 |
| CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
| AU2008288413B2 (en) | 2007-08-15 | 2013-09-26 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
| CN101970477B (zh) | 2008-03-14 | 2014-12-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定的胰岛素类似物 |
| HUE032284T2 (en) * | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
| US8697632B2 (en) | 2008-12-19 | 2014-04-15 | Indiana University Research And Technology Corporation | Amide based insulin prodrugs |
| EP2376099A4 (en) | 2008-12-19 | 2012-04-25 | Univ Indiana Res & Tech Corp | INSULIN AGAIN YL-BASED GROWTH FACTORS WITH HIGH ACTIVITY AT THE INSULIN RECEPTOR |
| JP5789515B2 (ja) | 2008-12-19 | 2015-10-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン類似体 |
| WO2011003820A1 (de) | 2009-07-06 | 2011-01-13 | Sanofi-Aventis Deutschland Gmbh | Hitze- und schüttelstabile insulinzubereitungen |
| WO2011159882A2 (en) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Novel stabilized insulin agonists |
| JP5969469B2 (ja) | 2010-06-16 | 2016-08-17 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト |
| EP2585484A1 (en) | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
| WO2011163460A1 (en) | 2010-06-24 | 2011-12-29 | Indiana University Research And Technology Corporation | Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor |
| CA2803164C (en) | 2010-06-24 | 2018-08-21 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| JP2013535467A (ja) | 2010-07-28 | 2013-09-12 | スマートセルズ・インコーポレイテツド | 組換えにより発現されたインスリンポリペプチドおよびその使用 |
| JP2013540771A (ja) | 2010-10-15 | 2013-11-07 | ノヴォ ノルディスク アー／エス | 新規ｎ末端修飾インスリン誘導体 |
| AR087433A1 (es) | 2011-08-08 | 2014-03-26 | Merck Sharp & Dohme | Analogos de insulina n-glicosilados |
| CN104114183A (zh) | 2011-12-20 | 2014-10-22 | 印第安纳大学研究及科技有限公司 | 用于治疗糖尿病的基于ctp的胰岛素类似物 |
| WO2013093009A1 (en) | 2011-12-21 | 2013-06-27 | Novo Nordisk A/S | N -terminally modified insulin derivatives |
| CN108383902A (zh) | 2012-09-26 | 2018-08-10 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物二聚体 |
| EP2925345B1 (en) | 2012-12-03 | 2018-09-05 | Merck Sharp & Dohme Corp. | Method for making o-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues |
| US10421795B2 (en) | 2012-12-17 | 2019-09-24 | Merck Sharp & Dohme Corp. | Process for purifying insulin and analogues thereof |
| JP6538645B2 (ja) | 2013-03-14 | 2019-07-03 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン‐インクレチン複合物 |
| EP3024447A1 (en) | 2013-07-24 | 2016-06-01 | Novo Nordisk A/S | Pharmaceutical composition for oral insulin administration comprising a tablet core and an anionic copolymer coating |
| US9884125B2 (en) | 2013-10-04 | 2018-02-06 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| CN108271356A (zh) | 2014-09-24 | 2018-07-10 | 印第安纳大学研究及科技有限公司 | 肠降血糖素-胰岛素缀合物 |
| EP3197912B1 (en) | 2014-09-24 | 2023-01-04 | Indiana University Research & Technology Corporation | Lipidated amide-based insulin prodrugs |
| AU2015349890B2 (en) | 2014-11-21 | 2018-08-30 | Merck Sharp & Dohme Llc | Insulin receptor partial agonists |
| JP6737793B2 (ja) | 2015-01-29 | 2020-08-12 | ノヴォ ノルディスク アー／エス | 錠剤コアとポリビニルアルコールコーティングとを含む経口インスリン投与のための医薬組成物 |
| EP3268384B1 (en) | 2015-03-10 | 2021-11-03 | Merck Sharp & Dohme Corp. | Process for preparing recombinant insulin using microfiltration |
| EP3280450A4 (en) | 2015-04-08 | 2018-12-12 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| WO2016172269A2 (en) | 2015-04-20 | 2016-10-27 | University Of Utah Research Foundation | Insulin analogs having shortened b chain peptides and associated methods |
| EP3341401A1 (en) * | 2015-08-25 | 2018-07-04 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
| CN108368163A (zh) * | 2015-08-25 | 2018-08-03 | 诺和诺德股份有限公司 | 新型胰岛素衍生物及其医学用途 |
| BR112018002416A2 (pt) | 2015-08-25 | 2018-09-18 | Novo Nordisk As | derivados de insulina e seus usos médicos |
| WO2017040363A1 (en) | 2015-09-02 | 2017-03-09 | Merck Sharp & Dohme Corp. | A process for obtaining insulin with correctly formed disulfide bonds |
-
2018
- 2018-08-16 CA CA3071686A patent/CA3071686A1/en not_active Withdrawn
- 2018-08-16 RU RU2020108281A patent/RU2020108281A/ru unknown
- 2018-08-16 TW TW107128618A patent/TW201917134A/zh unknown
- 2018-08-16 CN CN201880052683.1A patent/CN111032685A/zh not_active Withdrawn
- 2018-08-16 MA MA049896A patent/MA49896A/fr unknown
- 2018-08-16 JP JP2020508562A patent/JP2020531451A/ja not_active Withdrawn
- 2018-08-16 SG SG11202001077UA patent/SG11202001077UA/en unknown
- 2018-08-16 US US15/998,755 patent/US10919949B2/en active Active
- 2018-08-16 MX MX2020001434A patent/MX2020001434A/es unknown
- 2018-08-16 AU AU2018317810A patent/AU2018317810A1/en not_active Withdrawn
- 2018-08-16 EP EP18752779.1A patent/EP3668892A1/en not_active Withdrawn
- 2018-08-16 KR KR1020207006535A patent/KR20200038502A/ko not_active Withdrawn
- 2018-08-16 WO PCT/EP2018/072191 patent/WO2019034726A1/en not_active Ceased
- 2018-08-16 PE PE2020000179A patent/PE20211264A1/es unknown
- 2018-08-16 BR BR112020002364-7A patent/BR112020002364A2/pt not_active Application Discontinuation
-
2020
- 2020-01-31 IL IL272394A patent/IL272394A/en unknown
- 2020-02-05 CL CL2020000310A patent/CL2020000310A1/es unknown
- 2020-02-07 PH PH12020550050A patent/PH12020550050A1/en unknown
- 2020-03-04 CO CONC2020/0002500A patent/CO2020002500A2/es unknown
- 2020-11-05 US US17/089,993 patent/US20210094999A1/en not_active Abandoned
-
2022
- 2022-04-25 JP JP2022071578A patent/JP2022105082A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MA49896A (fr) | 2020-06-24 |
| US20210094999A1 (en) | 2021-04-01 |
| EP3668892A1 (en) | 2020-06-24 |
| US10919949B2 (en) | 2021-02-16 |
| CA3071686A1 (en) | 2019-02-21 |
| JP2022105082A (ja) | 2022-07-12 |
| SG11202001077UA (en) | 2020-03-30 |
| WO2019034726A1 (en) | 2019-02-21 |
| AU2018317810A1 (en) | 2020-03-19 |
| IL272394A (en) | 2020-03-31 |
| US20190194285A1 (en) | 2019-06-27 |
| CO2020002500A2 (es) | 2020-06-09 |
| JP2020531451A (ja) | 2020-11-05 |
| TW201917134A (zh) | 2019-05-01 |
| KR20200038502A (ko) | 2020-04-13 |
| BR112020002364A2 (pt) | 2020-09-01 |
| CN111032685A (zh) | 2020-04-17 |
| RU2020108281A3 (enExample) | 2022-03-09 |
| PH12020550050A1 (en) | 2020-10-19 |
| CL2020000310A1 (es) | 2020-07-10 |
| PE20211264A1 (es) | 2021-07-15 |
| RU2020108281A (ru) | 2021-08-26 |
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