MX2019013671A - Microorganismos para la produccion de feromonas de insectos y compuestos relacionados. - Google Patents
Microorganismos para la produccion de feromonas de insectos y compuestos relacionados.Info
- Publication number
- MX2019013671A MX2019013671A MX2019013671A MX2019013671A MX2019013671A MX 2019013671 A MX2019013671 A MX 2019013671A MX 2019013671 A MX2019013671 A MX 2019013671A MX 2019013671 A MX2019013671 A MX 2019013671A MX 2019013671 A MX2019013671 A MX 2019013671A
- Authority
- MX
- Mexico
- Prior art keywords
- aldehydes
- acetates
- fatty alcohols
- recombinant microorganisms
- production
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 5
- 239000003016 pheromone Substances 0.000 title abstract 3
- 241000238631 Hexapoda Species 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000001242 acetic acid derivatives Chemical class 0.000 abstract 5
- 150000001299 aldehydes Chemical class 0.000 abstract 5
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 239000003205 fragrance Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000005649 metathesis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente solicitud se relaciona con microorganismos recombinantes útiles en la biosíntesis de alcoholes grasos, aldehídos y acetatos C6-C24 insaturados que pueden ser útiles como feromonas de insectos, fragancias, saborizantes e intermediarios poliméricos. Los microorganismos recombinantes pueden expresar enzimas o variantes de enzimas útiles para la producción de alcoholes grasos, aldehídos y acetatos C6-C24 insaturados y/o pueden ser modificados para regular en descenso las vías a fin de desviar la producción hacia dichos alcoholes grasos, aldehídos y acetatos insaturados C6-C24. Los alcoholes grasos, aldehídos y acetatos C6-C24 descritos en la presente se pueden usar como sustratos para reacciones de metátesis para expandir el repertorio de compuestos y feromonas destinados. La solicitud además se relaciona con microorganismos recombinantes que co-expresan una vía de feromonas y una vía para la producción de una proteína, péptido, oligonucleótido o pequeña molécula tóxicos, adecuados para uso en un enfoque de control de plagas del tipo atracción y exterminio. La solicitud además se relaciona con microorganismos modificados para expresar o regular en descenso enzimas útiles para la producción de alcoholes grasos, aldehídos y acetatos de cadena corta insaturados que pueden ser útiles como feromonas de insectos, fragancias, saborizantes e intermediarios poliméricos. También se proveen métodos para producir alcoholes grasos, aldehídos y acetatos C6-C24 insaturados usando los microorganismos recombinantes, así como también composiciones que comprenden los microorganismos recombinantes y/u opcionalmente, uno o más de los alcoholes grasos, aldehídos o acetatos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762507654P | 2017-05-17 | 2017-05-17 | |
PCT/US2018/033151 WO2018213554A1 (en) | 2017-05-17 | 2018-05-17 | Microorganisms for the production of insect pheromones and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019013671A true MX2019013671A (es) | 2020-01-15 |
Family
ID=64274732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019013671A MX2019013671A (es) | 2017-05-17 | 2018-05-17 | Microorganismos para la produccion de feromonas de insectos y compuestos relacionados. |
Country Status (8)
Country | Link |
---|---|
US (2) | US11104921B2 (es) |
EP (1) | EP3635124A4 (es) |
JP (1) | JP7216018B2 (es) |
CN (1) | CN110914442A (es) |
AR (1) | AR112543A1 (es) |
BR (1) | BR112019024258A2 (es) |
MX (1) | MX2019013671A (es) |
WO (1) | WO2018213554A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3868890A1 (en) | 2015-11-18 | 2021-08-25 | Provivi, Inc. | Microorganisms for the production of insect pheromones and related compounds |
MX2018015111A (es) | 2016-06-06 | 2019-09-02 | Provivi Inc | Produccion semi-biosintetica de alcoholes grasos y aldehidos grasos. |
JP7216018B2 (ja) | 2017-05-17 | 2023-01-31 | プロヴィヴィ インコーポレイテッド | 昆虫フェロモンの生成のための微生物及び関連する化合物 |
WO2020169389A1 (en) * | 2019-02-19 | 2020-08-27 | Biophero Aps | Methods and cell factories for producing insect pheromones |
WO2020185627A1 (en) * | 2019-03-08 | 2020-09-17 | Massachusetts Institute Of Technology | Human gut microbiome-derived biosynthetic enzymes for production of fatty acid amides |
WO2021119548A1 (en) * | 2019-12-11 | 2021-06-17 | Provivi, Inc. | Biosynthesis of insect pheromones and precursors thereof |
CN110938579A (zh) * | 2019-12-13 | 2020-03-31 | 杭州唯铂莱生物科技有限公司 | 酪氨酸解氨酶重组菌、酪氨酸解氨酶及其制备方法和应用 |
IL293960A (en) * | 2019-12-20 | 2022-08-01 | Biophero Aps | Yeast cells and methods for the production of e10,e8-dodecadienyl coenzyme a, codelmon and its derivatives |
BR112022015690A2 (pt) * | 2020-02-07 | 2022-10-18 | Isca Tech | Métodos de produção de feromônios de insetos |
WO2021262906A1 (en) * | 2020-06-23 | 2021-12-30 | Provivi, Inc. | Synthesis of complex insect pheromone blends and reaction apparatuses for the same |
CN111909915A (zh) * | 2020-07-28 | 2020-11-10 | 深圳润康生态环境股份有限公司 | 脂肪酶基因、脂肪酶及其应用 |
CN112299991B (zh) * | 2020-09-08 | 2022-10-11 | 宁波纽康生物技术有限公司 | (e,e,z)-10,12,14-十六碳三烯乙酸酯的制备方法及组合物和诱芯 |
CN112680365B (zh) * | 2021-02-02 | 2023-01-31 | 吉林农业大学 | 一种白僵菌用液体培养基及白僵菌菌剂制备方法 |
US20230159978A1 (en) * | 2021-11-22 | 2023-05-25 | ExxonMobil Technology and Engineering Company | Screening of Engineered Biocatalysts for Oxyfunctionalization of Olefins |
CN115452991B (zh) * | 2022-09-15 | 2024-07-12 | 江苏科技大学 | 十四碳烯酸和十六碳烯醛在检测检疫性害虫中的应用 |
WO2024161427A1 (en) * | 2023-02-02 | 2024-08-08 | Atgc Biotech Pvt Ltd | A process for producing pheromones and applications thereof |
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2018
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JP2020520644A (ja) | 2020-07-16 |
US20200140902A1 (en) | 2020-05-07 |
US11104921B2 (en) | 2021-08-31 |
EP3635124A1 (en) | 2020-04-15 |
JP7216018B2 (ja) | 2023-01-31 |
US11866760B2 (en) | 2024-01-09 |
US20230034938A1 (en) | 2023-02-02 |
CN110914442A (zh) | 2020-03-24 |
BR112019024258A2 (pt) | 2020-08-18 |
EP3635124A4 (en) | 2021-03-31 |
AR112543A1 (es) | 2019-11-13 |
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