MX2019013671A - Microorganismos para la produccion de feromonas de insectos y compuestos relacionados. - Google Patents

Microorganismos para la produccion de feromonas de insectos y compuestos relacionados.

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Publication number
MX2019013671A
MX2019013671A MX2019013671A MX2019013671A MX2019013671A MX 2019013671 A MX2019013671 A MX 2019013671A MX 2019013671 A MX2019013671 A MX 2019013671A MX 2019013671 A MX2019013671 A MX 2019013671A MX 2019013671 A MX2019013671 A MX 2019013671A
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Mexico
Prior art keywords
aldehydes
acetates
fatty alcohols
recombinant microorganisms
production
Prior art date
Application number
MX2019013671A
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English (en)
Inventor
Meinhold Peter
Coelho Pedro
Wampler Keith
Sheppard Micah
Leonard Effendi
Heel Thomas
Original Assignee
Provivi Inc
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Publication date
Application filed by Provivi Inc filed Critical Provivi Inc
Publication of MX2019013671A publication Critical patent/MX2019013671A/es

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    • C12N15/09—Recombinant DNA-technology
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
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    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
    • C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase

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  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente solicitud se relaciona con microorganismos recombinantes útiles en la biosíntesis de alcoholes grasos, aldehídos y acetatos C6-C24 insaturados que pueden ser útiles como feromonas de insectos, fragancias, saborizantes e intermediarios poliméricos. Los microorganismos recombinantes pueden expresar enzimas o variantes de enzimas útiles para la producción de alcoholes grasos, aldehídos y acetatos C6-C24 insaturados y/o pueden ser modificados para regular en descenso las vías a fin de desviar la producción hacia dichos alcoholes grasos, aldehídos y acetatos insaturados C6-C24. Los alcoholes grasos, aldehídos y acetatos C6-C24 descritos en la presente se pueden usar como sustratos para reacciones de metátesis para expandir el repertorio de compuestos y feromonas destinados. La solicitud además se relaciona con microorganismos recombinantes que co-expresan una vía de feromonas y una vía para la producción de una proteína, péptido, oligonucleótido o pequeña molécula tóxicos, adecuados para uso en un enfoque de control de plagas del tipo atracción y exterminio. La solicitud además se relaciona con microorganismos modificados para expresar o regular en descenso enzimas útiles para la producción de alcoholes grasos, aldehídos y acetatos de cadena corta insaturados que pueden ser útiles como feromonas de insectos, fragancias, saborizantes e intermediarios poliméricos. También se proveen métodos para producir alcoholes grasos, aldehídos y acetatos C6-C24 insaturados usando los microorganismos recombinantes, así como también composiciones que comprenden los microorganismos recombinantes y/u opcionalmente, uno o más de los alcoholes grasos, aldehídos o acetatos.
MX2019013671A 2017-05-17 2018-05-17 Microorganismos para la produccion de feromonas de insectos y compuestos relacionados. MX2019013671A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762507654P 2017-05-17 2017-05-17
PCT/US2018/033151 WO2018213554A1 (en) 2017-05-17 2018-05-17 Microorganisms for the production of insect pheromones and related compounds

Publications (1)

Publication Number Publication Date
MX2019013671A true MX2019013671A (es) 2020-01-15

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MX2019013671A MX2019013671A (es) 2017-05-17 2018-05-17 Microorganismos para la produccion de feromonas de insectos y compuestos relacionados.

Country Status (8)

Country Link
US (2) US11104921B2 (es)
EP (1) EP3635124A4 (es)
JP (1) JP7216018B2 (es)
CN (1) CN110914442A (es)
AR (1) AR112543A1 (es)
BR (1) BR112019024258A2 (es)
MX (1) MX2019013671A (es)
WO (1) WO2018213554A1 (es)

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