MX2019009867A - Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. - Google Patents
Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae.Info
- Publication number
- MX2019009867A MX2019009867A MX2019009867A MX2019009867A MX2019009867A MX 2019009867 A MX2019009867 A MX 2019009867A MX 2019009867 A MX2019009867 A MX 2019009867A MX 2019009867 A MX2019009867 A MX 2019009867A MX 2019009867 A MX2019009867 A MX 2019009867A
- Authority
- MX
- Mexico
- Prior art keywords
- protein conjugates
- polysaccharide
- streptococcus pneumoniae
- protein
- pneumoniae polysaccharide
- Prior art date
Links
- 241000193998 Streptococcus pneumoniae Species 0.000 title abstract 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 title abstract 2
- 230000002708 enhancing effect Effects 0.000 title 1
- 230000005847 immunogenicity Effects 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 6
- 150000004676 glycans Chemical class 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 108010060123 Conjugate Vaccines Proteins 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463216P | 2017-02-24 | 2017-02-24 | |
| US201762555444P | 2017-09-07 | 2017-09-07 | |
| PCT/US2018/018729 WO2018156491A1 (en) | 2017-02-24 | 2018-02-20 | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019009867A true MX2019009867A (es) | 2019-10-02 |
Family
ID=63254065
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019009867A MX2019009867A (es) | 2017-02-24 | 2018-02-20 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
| MX2023001948A MX2023001948A (es) | 2017-02-24 | 2019-08-19 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
| MX2023001947A MX2023001947A (es) | 2017-02-24 | 2019-08-19 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023001948A MX2023001948A (es) | 2017-02-24 | 2019-08-19 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
| MX2023001947A MX2023001947A (es) | 2017-02-24 | 2019-08-19 | Inmunogenicidad mejorada de conjugados de polisacarido-proteina de streptococcus pneumoniae. |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US11090374B2 (https=) |
| EP (1) | EP3589314A4 (https=) |
| JP (3) | JP7680185B2 (https=) |
| KR (2) | KR20240011879A (https=) |
| CN (1) | CN110337307A (https=) |
| AU (1) | AU2018225099B2 (https=) |
| BR (1) | BR112019017560A2 (https=) |
| CA (1) | CA3050120A1 (https=) |
| MX (3) | MX2019009867A (https=) |
| WO (1) | WO2018156491A1 (https=) |
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| CA2604363C (en) * | 2005-04-08 | 2015-06-16 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN120718167A (zh) | 2014-01-21 | 2025-09-30 | 辉瑞大药厂 | 肺炎链球菌荚膜多糖及其缀合物 |
| CN108367063A (zh) * | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| ES3024474T3 (en) | 2016-12-30 | 2025-06-04 | Vaxcyte Inc | Polypeptide-antigen conjugates with non-natural amino acids |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| ES3048958T3 (en) | 2017-01-31 | 2025-12-12 | Merck Sharp & Dohme Llc | Methods for production of capsular polysaccharide protein conjugates from streptococcus pneumoniae serotype 19f |
| US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| WO2019050813A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| AU2018328040B2 (en) | 2017-09-07 | 2025-01-16 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| EP3678655A4 (en) * | 2017-09-07 | 2021-05-05 | Merck Sharp & Dohme Corp. | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE CARRIER PROTEIN CONJUGATES |
| CN111065387B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| TWI725359B (zh) | 2017-12-06 | 2021-04-21 | 美商默沙東藥廠 | 包含肺炎鏈球菌多醣-蛋白結合物之組合物及其使用方法 |
| JP7397000B2 (ja) | 2018-04-30 | 2023-12-12 | メルク・シャープ・アンド・ドーム・エルエルシー | 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法 |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| KR102879391B1 (ko) * | 2018-09-23 | 2025-10-30 | 바이오로지칼 이 리미티드 | 스트렙토코쿠스 뉴모니아에의 정제된 협막 다당류 |
| GEAP202415690A (en) * | 2018-12-19 | 2024-01-10 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| CA3136278A1 (en) * | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| MX2021014710A (es) * | 2019-06-05 | 2022-01-18 | Merck Sharp & Dohme Llc | Un conjugado inmunogenico de polisacarido de neumococo del serotipo 35b- proteina y proceso de conjugacion para preparar el mismo. |
| CN110804097B (zh) * | 2019-10-30 | 2021-02-26 | 云南沃森生物技术股份有限公司 | 一种同时制备两种单克隆抗体的方法 |
| KR20220146451A (ko) * | 2020-01-17 | 2022-11-01 | 인벤트프라이즈 엘엘씨 | 다가 스트렙토코커스 백신 |
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| WO2021219530A1 (en) * | 2020-04-28 | 2021-11-04 | Janssen Pharmaceuticals, Inc. | Method for identification and quantification of polysaccharides in complex glycoconjugate compositions |
| JP7804673B2 (ja) | 2020-11-10 | 2026-01-22 | ファイザー・インク | コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用 |
| EP4346893A2 (en) * | 2021-05-28 | 2024-04-10 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| CN114965784B (zh) * | 2022-06-01 | 2023-10-27 | 艾美探索者生命科学研发有限公司 | 多糖活化度的测定方法 |
| WO2024059161A1 (en) * | 2022-09-16 | 2024-03-21 | Merck Sharp & Dohme Llc | Method for quantification of polysaccharide content in conjugate vaccines |
| JP2025537898A (ja) | 2022-11-22 | 2025-11-20 | ファイザー・インク | コンジュゲートさせた莢膜糖類抗原を含む免疫原性組成物およびその使用 |
| KR20250163977A (ko) | 2023-03-30 | 2025-11-21 | 화이자 인코포레이티드 | 접합된 피막 사카라이드 항원을 포함하는 면역원성 조성물 및 그의 용도 |
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| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
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| PT3678654T (pt) | 2017-09-07 | 2024-08-05 | Merck Sharp & Dohme Llc | Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora |
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| TWI725359B (zh) | 2017-12-06 | 2021-04-21 | 美商默沙東藥廠 | 包含肺炎鏈球菌多醣-蛋白結合物之組合物及其使用方法 |
| JP7397000B2 (ja) | 2018-04-30 | 2023-12-12 | メルク・シャープ・アンド・ドーム・エルエルシー | 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法 |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| US20210223262A1 (en) | 2018-06-07 | 2021-07-22 | Merck Sharp & Dohme Corp. | Lyosphere critical reagent kit |
| CA3120922A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| GEAP202415690A (en) | 2018-12-19 | 2024-01-10 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| CA3136278A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| MX2021014710A (es) | 2019-06-05 | 2022-01-18 | Merck Sharp & Dohme Llc | Un conjugado inmunogenico de polisacarido de neumococo del serotipo 35b- proteina y proceso de conjugacion para preparar el mismo. |
| MX2021014948A (es) | 2019-06-05 | 2022-01-24 | Merck Sharp & Dohme Llc | Metodos de tratamiento de pacientes con una composicion inmunogenica que protege contra el seroripo 29 de s. pneumoniae. |
-
2018
- 2018-02-20 CA CA3050120A patent/CA3050120A1/en active Pending
- 2018-02-20 EP EP18757315.9A patent/EP3589314A4/en active Pending
- 2018-02-20 BR BR112019017560A patent/BR112019017560A2/pt unknown
- 2018-02-20 AU AU2018225099A patent/AU2018225099B2/en active Active
- 2018-02-20 MX MX2019009867A patent/MX2019009867A/es unknown
- 2018-02-20 CN CN201880013793.7A patent/CN110337307A/zh active Pending
- 2018-02-20 KR KR1020247001331A patent/KR20240011879A/ko active Pending
- 2018-02-20 WO PCT/US2018/018729 patent/WO2018156491A1/en not_active Ceased
- 2018-02-20 JP JP2019546002A patent/JP7680185B2/ja active Active
- 2018-02-20 US US16/487,550 patent/US11090374B2/en active Active
- 2018-02-20 KR KR1020197027396A patent/KR20190121330A/ko not_active Ceased
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2019
- 2019-08-19 MX MX2023001948A patent/MX2023001948A/es unknown
- 2019-08-19 MX MX2023001947A patent/MX2023001947A/es unknown
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2021
- 2021-07-07 US US17/369,230 patent/US20210330778A1/en not_active Abandoned
- 2021-07-07 US US17/369,177 patent/US20210330777A1/en not_active Abandoned
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2023
- 2023-01-05 JP JP2023000606A patent/JP2023036953A/ja active Pending
- 2023-06-22 US US18/339,723 patent/US12295998B2/en active Active
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2024
- 2024-05-24 JP JP2024084665A patent/JP7796163B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20240139303A1 (en) | 2024-05-02 |
| KR20240011879A (ko) | 2024-01-26 |
| RU2019129503A (ru) | 2021-03-24 |
| WO2018156491A1 (en) | 2018-08-30 |
| US20200054733A1 (en) | 2020-02-20 |
| JP2023036953A (ja) | 2023-03-14 |
| JP7680185B2 (ja) | 2025-05-20 |
| CN110337307A (zh) | 2019-10-15 |
| EP3589314A4 (en) | 2021-04-21 |
| US11090374B2 (en) | 2021-08-17 |
| MX2023001947A (es) | 2023-03-14 |
| JP2024112952A (ja) | 2024-08-21 |
| US20210330777A1 (en) | 2021-10-28 |
| MX2023001948A (es) | 2023-03-14 |
| EP3589314A1 (en) | 2020-01-08 |
| JP2020514326A (ja) | 2020-05-21 |
| AU2018225099A1 (en) | 2019-07-25 |
| RU2019129503A3 (https=) | 2021-06-25 |
| AU2018225099B2 (en) | 2024-08-22 |
| US12295998B2 (en) | 2025-05-13 |
| CA3050120A1 (en) | 2018-08-30 |
| KR20190121330A (ko) | 2019-10-25 |
| JP7796163B2 (ja) | 2026-01-08 |
| BR112019017560A2 (pt) | 2020-04-07 |
| US20210330778A1 (en) | 2021-10-28 |
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