MX2018014856A - Llamador de pulso y llamador de base. - Google Patents
Llamador de pulso y llamador de base.Info
- Publication number
- MX2018014856A MX2018014856A MX2018014856A MX2018014856A MX2018014856A MX 2018014856 A MX2018014856 A MX 2018014856A MX 2018014856 A MX2018014856 A MX 2018014856A MX 2018014856 A MX2018014856 A MX 2018014856A MX 2018014856 A MX2018014856 A MX 2018014856A
- Authority
- MX
- Mexico
- Prior art keywords
- points
- nucleotide incorporation
- caller
- characteristic
- light
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 abstract 7
- 125000003729 nucleotide group Chemical group 0.000 abstract 7
- 238000010348 incorporation Methods 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 230000002123 temporal effect Effects 0.000 abstract 3
- 230000005284 excitation Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Data Mining & Analysis (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Burglar Alarm Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662343997P | 2016-06-01 | 2016-06-01 | |
| PCT/US2017/035420 WO2017210413A1 (en) | 2016-06-01 | 2017-06-01 | Pulse caller and base caller |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018014856A true MX2018014856A (es) | 2019-03-07 |
Family
ID=59055317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014856A MX2018014856A (es) | 2016-06-01 | 2017-06-01 | Llamador de pulso y llamador de base. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10711299B2 (enExample) |
| EP (2) | EP4009330A1 (enExample) |
| JP (1) | JP6931665B2 (enExample) |
| KR (1) | KR102425257B1 (enExample) |
| CN (1) | CN109313925B (enExample) |
| AU (1) | AU2017274412B2 (enExample) |
| BR (1) | BR112018074572B1 (enExample) |
| CA (1) | CA3026061A1 (enExample) |
| MX (1) | MX2018014856A (enExample) |
| TW (1) | TWI755400B (enExample) |
| WO (1) | WO2017210413A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111710687B (zh) | 2014-08-08 | 2023-11-14 | 宽腾矽公司 | 基于入射光子到达时间的识别、成像、测序法及存储介质 |
| TW202139919A (zh) | 2016-02-17 | 2021-11-01 | 美商太斯萊特健康股份有限公司 | 用於生命期成像及偵測應用之感測器及裝置 |
| KR102627237B1 (ko) * | 2016-06-01 | 2024-01-23 | 퀀텀-에스아이 인코포레이티드 | 분자들을 검출 및 분석하기 위한 통합 디바이스 |
| MX2019007247A (es) | 2016-12-19 | 2019-08-16 | Quantum Si Inc | Carga de moleculas en pocillos para muestra para su analisis. |
| CN110168732B (zh) | 2016-12-22 | 2024-03-08 | 宽腾矽公司 | 具有直接合并像素的整合式光电侦测器 |
| US11120104B2 (en) | 2017-03-01 | 2021-09-14 | Stmicroelectronics (Research & Development) Limited | Method and apparatus for processing a histogram output from a detector sensor |
| JP7356909B2 (ja) | 2017-05-05 | 2023-10-05 | クアンタム－エスアイ インコーポレイテッド | 生物学的反応における表面反応性と防汚特性が改変された基板 |
| NL2020621B1 (en) | 2018-01-08 | 2019-07-15 | Illumina Inc | Multiplexing of an active sensor detector using structured illumination |
| US11378544B2 (en) | 2018-01-08 | 2022-07-05 | Illumina, Inc. | High-throughput sequencing with semiconductor-based detection |
| KR102370055B1 (ko) | 2018-01-08 | 2022-03-03 | 일루미나, 인코포레이티드 | 반도체-기반 검출을 사용하는 고-처리율 서열분석용 시스템 및 디바이스 |
| BR112020014542A2 (pt) | 2018-01-26 | 2020-12-08 | Quantum-Si Incorporated | Aprendizado de máquina habilitado por aplicação de pulso e de base para dispositivos de sequenciamento |
| MX2020013788A (es) | 2018-06-22 | 2021-03-02 | Quantum Si Inc | Fotodetector integrado con deposito de almacenamiento de carga con tiempo de deteccion variado. |
| EP3844486A1 (en) * | 2018-08-29 | 2021-07-07 | Quantum-Si Incorporated | System and methods for detecting lifetime using photon counting photodetectors |
| US11347965B2 (en) | 2019-03-21 | 2022-05-31 | Illumina, Inc. | Training data generation for artificial intelligence-based sequencing |
| US11210554B2 (en) | 2019-03-21 | 2021-12-28 | Illumina, Inc. | Artificial intelligence-based generation of sequencing metadata |
| US11423306B2 (en) | 2019-05-16 | 2022-08-23 | Illumina, Inc. | Systems and devices for characterization and performance analysis of pixel-based sequencing |
| US11593649B2 (en) | 2019-05-16 | 2023-02-28 | Illumina, Inc. | Base calling using convolutions |
| CN114829669B (zh) | 2019-10-11 | 2024-10-01 | 宽腾矽公司 | 气相表面改性 |
| AU2021208557A1 (en) | 2020-01-14 | 2022-09-01 | Quantum-Si Incorporated | Sensor for lifetime plus spectral characterization |
| CA3168138A1 (en) | 2020-01-14 | 2021-07-22 | Quantum-Si Incorporated | Integrated sensor for lifetime characterization |
| US12354008B2 (en) | 2020-02-20 | 2025-07-08 | Illumina, Inc. | Knowledge distillation and gradient pruning-based compression of artificial intelligence-based base caller |
| US12592298B2 (en) | 2020-02-20 | 2026-03-31 | Illumina, Inc. | Hardware execution and acceleration of artificial intelligence-based base caller |
| JP7747643B2 (ja) | 2020-02-20 | 2025-10-01 | イルミナ インコーポレイテッド | 人工知能ベースの多対多ベースコール |
| US12591780B2 (en) | 2020-02-20 | 2026-03-31 | Illumina, Inc. | Data compression for artificial intelligence-based base calling |
| TW202147591A (zh) * | 2020-03-02 | 2021-12-16 | 美商寬騰矽公司 | 用於多維信號分析之整合感應器 |
| KR20220165754A (ko) | 2020-04-08 | 2022-12-15 | 퀀텀-에스아이 인코포레이티드 | 스큐가 감소된 통합 센서 |
| US20220065785A1 (en) * | 2020-07-23 | 2022-03-03 | Quantum-Si Incorporated | System and method for detecting change points |
| AU2021372456A1 (en) * | 2020-10-27 | 2023-06-08 | Quantum-Si Incorporated | Calibration of single-molecule detection system |
| US20220301657A1 (en) | 2021-03-16 | 2022-09-22 | Illumina, Inc. | Tile location and/or cycle based weight set selection for base calling |
| US12217829B2 (en) | 2021-04-15 | 2025-02-04 | Illumina, Inc. | Artificial intelligence-based analysis of protein three-dimensional (3D) structures |
| US12444482B2 (en) | 2021-04-15 | 2025-10-14 | Illumina, Inc. | Multi-channel protein voxelization to predict variant pathogenicity using deep convolutional neural networks |
| US12530882B2 (en) | 2021-07-01 | 2026-01-20 | Illumina, Inc. | Efficient artificial intelligence-based base calling of index sequences |
| WO2023137051A2 (en) | 2022-01-12 | 2023-07-20 | Quantum-Si Incorporated | Integrated sensor |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2155186A1 (en) * | 1993-02-01 | 1994-08-18 | Kevin M. Ulmer | Methods and apparatus for dna sequencing |
| DE19744490A1 (de) * | 1997-10-08 | 1999-04-15 | Temp Rite International Gmbh | Trinkwasseraufbereitungsanlage |
| JP4566299B2 (ja) * | 1998-04-09 | 2010-10-20 | シスメックス株式会社 | 赤芽球の分類計数方法 |
| AU5479599A (en) * | 1998-08-11 | 2000-03-06 | Caliper Technologies Corporation | Methods and systems for sequencing dna by distinguishing the decay times of fluorescent probes |
| DE19844931C1 (de) * | 1998-09-30 | 2000-06-15 | Stefan Seeger | Verfahren zur DNS- oder RNS-Sequenzierung |
| US7056661B2 (en) * | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| GB2382648B (en) * | 2001-12-11 | 2003-11-12 | Amersham Pharm Biotech Uk Ltd | System and method for time correlated multi-photon counting measurements |
| WO2005120204A2 (en) * | 2004-06-07 | 2005-12-22 | The Regents Of The University Of California | Method for single molecule fluorescence analysis |
| US8182993B2 (en) * | 2007-06-06 | 2012-05-22 | Pacific Biosciences Of California, Inc. | Methods and processes for calling bases in sequence by incorporation methods |
| WO2009085473A2 (en) | 2007-11-21 | 2009-07-09 | Cosmosid Inc. | Genome identification system |
| WO2009091847A2 (en) * | 2008-01-14 | 2009-07-23 | Life Technologies Corporation | Compositions, methods and systems for single molecule sequencing |
| US8592158B2 (en) * | 2009-07-10 | 2013-11-26 | Perkinelmer Health Sciences, Inc. | Detecting multinucleotide repeats |
| US9670243B2 (en) * | 2010-06-02 | 2017-06-06 | Industrial Technology Research Institute | Compositions and methods for sequencing nucleic acids |
| WO2012177792A2 (en) * | 2011-06-24 | 2012-12-27 | Sequenom, Inc. | Methods and processes for non-invasive assessment of a genetic variation |
| US9145623B2 (en) | 2011-07-20 | 2015-09-29 | Thermo Fisher Scientific Oy | Transposon nucleic acids comprising a calibration sequence for DNA sequencing |
| JP5790242B2 (ja) * | 2011-07-25 | 2015-10-07 | 富士ゼロックス株式会社 | 故障予測装置及びプログラム |
| EP2831283A4 (en) * | 2012-03-30 | 2015-11-04 | Pacific Biosciences California | METHODS AND COMPOSITION FOR SEQUENCING MODIFIED NUCLEIC ACIDS |
| CA2877094A1 (en) * | 2012-06-18 | 2013-12-27 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| EP3000088A4 (en) * | 2013-05-23 | 2018-06-27 | Iphenotype LLC | Method and system for maintaining or improving wellness |
| EP3709003A1 (en) | 2013-11-17 | 2020-09-16 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| CN105980578B (zh) | 2013-12-16 | 2020-02-14 | 深圳华大智造科技有限公司 | 用于使用机器学习进行dna测序的碱基判定器 |
| US10216895B2 (en) | 2014-05-12 | 2019-02-26 | Roche Molecular Systems, Inc. | Rare variant calls in ultra-deep sequencing |
| US9885657B2 (en) | 2014-08-08 | 2018-02-06 | Quantum-Si Incorporated | Integrated device with external light source for probing detecting and analyzing molecules |
| CN111710687B (zh) * | 2014-08-08 | 2023-11-14 | 宽腾矽公司 | 基于入射光子到达时间的识别、成像、测序法及存储介质 |
| KR102738114B1 (ko) * | 2014-08-08 | 2024-12-06 | 퀀텀-에스아이 인코포레이티드 | 분자들을 프로빙, 검출 및 분석하기 위한 광학계 및 검정 칩 |
| US10185803B2 (en) | 2015-06-15 | 2019-01-22 | Deep Genomics Incorporated | Systems and methods for classifying, prioritizing and interpreting genetic variants and therapies using a deep neural network |
| US9922285B1 (en) | 2017-07-13 | 2018-03-20 | HumanCode, Inc. | Predictive assignments that relate to genetic information and leverage machine learning models |
-
2017
- 2017-06-01 EP EP21199556.8A patent/EP4009330A1/en not_active Withdrawn
- 2017-06-01 KR KR1020187037813A patent/KR102425257B1/ko not_active Expired - Fee Related
- 2017-06-01 AU AU2017274412A patent/AU2017274412B2/en not_active Ceased
- 2017-06-01 US US15/611,573 patent/US10711299B2/en active Active
- 2017-06-01 WO PCT/US2017/035420 patent/WO2017210413A1/en not_active Ceased
- 2017-06-01 MX MX2018014856A patent/MX2018014856A/es unknown
- 2017-06-01 CN CN201780034484.3A patent/CN109313925B/zh not_active Expired - Fee Related
- 2017-06-01 CA CA3026061A patent/CA3026061A1/en active Pending
- 2017-06-01 TW TW106118155A patent/TWI755400B/zh not_active IP Right Cessation
- 2017-06-01 EP EP17730003.5A patent/EP3465503B1/en active Active
- 2017-06-01 BR BR112018074572-3A patent/BR112018074572B1/pt not_active IP Right Cessation
- 2017-06-01 JP JP2018562554A patent/JP6931665B2/ja not_active Expired - Fee Related
-
2020
- 2020-06-02 US US16/889,917 patent/US20200291467A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3465503A1 (en) | 2019-04-10 |
| KR102425257B1 (ko) | 2022-07-27 |
| CA3026061A1 (en) | 2017-12-07 |
| CN109313925A (zh) | 2019-02-05 |
| KR20190015371A (ko) | 2019-02-13 |
| EP3465503B1 (en) | 2021-09-29 |
| US20170349944A1 (en) | 2017-12-07 |
| AU2017274412B2 (en) | 2022-07-21 |
| US20200291467A1 (en) | 2020-09-17 |
| US10711299B2 (en) | 2020-07-14 |
| CN109313925B (zh) | 2022-09-02 |
| TWI755400B (zh) | 2022-02-21 |
| JP6931665B2 (ja) | 2021-09-08 |
| JP2019529865A (ja) | 2019-10-17 |
| EP4009330A1 (en) | 2022-06-08 |
| BR112018074572B1 (pt) | 2024-02-27 |
| TW201800739A (zh) | 2018-01-01 |
| BR112018074572A2 (pt) | 2019-03-12 |
| AU2017274412A1 (en) | 2018-12-06 |
| WO2017210413A1 (en) | 2017-12-07 |
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