MX2018005292A - Inhibidores de acc y usos de los mismos. - Google Patents
Inhibidores de acc y usos de los mismos.Info
- Publication number
- MX2018005292A MX2018005292A MX2018005292A MX2018005292A MX2018005292A MX 2018005292 A MX2018005292 A MX 2018005292A MX 2018005292 A MX2018005292 A MX 2018005292A MX 2018005292 A MX2018005292 A MX 2018005292A MX 2018005292 A MX2018005292 A MX 2018005292A
- Authority
- MX
- Mexico
- Prior art keywords
- acc inhibitors
- acc
- inhibitors
- compositions
- useful
- Prior art date
Links
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 title 1
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 abstract 2
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 abstract 2
- 108010018763 Biotin carboxylase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246318P | 2015-10-26 | 2015-10-26 | |
| PCT/US2016/058867 WO2017075056A1 (en) | 2015-10-26 | 2016-10-26 | Acc inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018005292A true MX2018005292A (es) | 2018-08-01 |
Family
ID=57233943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018005292A MX2018005292A (es) | 2015-10-26 | 2016-10-26 | Inhibidores de acc y usos de los mismos. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10179793B2 (enExample) |
| EP (1) | EP3368540A1 (enExample) |
| JP (1) | JP2018538246A (enExample) |
| KR (1) | KR20180067603A (enExample) |
| CN (1) | CN108368125A (enExample) |
| AR (1) | AR106472A1 (enExample) |
| AU (1) | AU2016344392A1 (enExample) |
| BR (1) | BR112018008227A2 (enExample) |
| CA (1) | CA3003275A1 (enExample) |
| EA (1) | EA201890749A1 (enExample) |
| IL (1) | IL258636A (enExample) |
| MX (1) | MX2018005292A (enExample) |
| SG (1) | SG11201802989QA (enExample) |
| WO (1) | WO2017075056A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3628320B1 (en) | 2011-11-11 | 2022-03-16 | Gilead Apollo, LLC | Acc inhibitors and uses thereof |
| US10301292B2 (en) | 2014-11-26 | 2019-05-28 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| MX2018006286A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc pirazolicos y usos de los mismos. |
| EP3380478B1 (en) | 2015-11-25 | 2020-12-23 | Gilead Apollo, LLC | Ester acc inhibitors and uses thereof |
| CA3005900C (en) | 2015-11-25 | 2023-10-31 | Gilead Apollo, Llc | Triazole acc inhibitors and uses thereof |
| JP2019503338A (ja) | 2015-11-25 | 2019-02-07 | ギリアド アポロ， エルエルシー | ２，４−ジオキソ−１，４−ジヒドロチエノ［２，３−ｄ］ピリミジンの誘導体を含む殺真菌組成物 |
| CN108699078A (zh) * | 2016-03-02 | 2018-10-23 | 吉利德阿波罗公司 | 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法 |
| SG11201902588PA (en) | 2016-09-23 | 2019-05-30 | Bayer Ag | N3-Cyclically Substituted Thienouracils And Use Thereof |
| AU2018209006B2 (en) | 2017-01-22 | 2021-04-22 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
| AU2018227575A1 (en) * | 2017-03-03 | 2019-09-19 | Gilead Apollo, Llc | Processes for the preparation of fungicidal compounds |
| EP4424364B1 (en) | 2017-03-28 | 2026-01-21 | Gilead Sciences, Inc. | Combinations for use in the treatment of cirrhosis and liver fibrosis |
| WO2018228369A1 (zh) * | 2017-06-15 | 2018-12-20 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
| CA3070525C (en) * | 2017-07-26 | 2022-03-15 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Compound as acc inhibitor and use thereof |
| CA3094988A1 (en) | 2018-03-30 | 2019-10-03 | Biotheryx, Inc. | Thienopyrimidinone compounds |
| CN112218871B (zh) * | 2018-06-05 | 2022-10-18 | 南京明德新药研发有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类衍生物及其应用 |
| AU2019372059A1 (en) * | 2018-11-02 | 2021-06-03 | Dow Agrosciences Llc | Compositions comprising halauxifen and other herbicides and methods thereof |
| JP2022513101A (ja) * | 2018-11-20 | 2022-02-07 | 中国医▲薬▼研究▲開▼▲発▼中心有限公司 | スピロ環系化合物及びその医薬用途 |
| CN111484504B (zh) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Acc抑制剂的光学异构体及其应用 |
| US20220152164A1 (en) * | 2019-03-22 | 2022-05-19 | Kallyope, Inc. | Gpcr combination therapies |
| JP7374233B2 (ja) | 2019-07-02 | 2023-11-06 | ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 | 立体配置を有するチエノピリミジン誘導体及び薬物におけるその応用 |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
| WO2021110135A1 (zh) * | 2019-12-05 | 2021-06-10 | 漳州片仔癀药业股份有限公司 | 作为acc1和acc2抑制剂的晶型及其制备方法和应用 |
| WO2021110138A1 (zh) * | 2019-12-05 | 2021-06-10 | 漳州片仔癀药业股份有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
| WO2021112213A1 (ja) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤 |
| WO2021207530A1 (en) * | 2020-04-08 | 2021-10-14 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
| WO2022133097A1 (en) * | 2020-12-17 | 2022-06-23 | Biogen Ma Inc. | Synthesis of compounds that modulate use-dependent voltage-gated sodium channels |
| TW202241908A (zh) | 2020-12-24 | 2022-11-01 | 日商模數探索股份有限公司 | 四氫噻吩并嘧啶磺醯胺化合物 |
| WO2022268520A1 (de) * | 2021-06-21 | 2022-12-29 | Bayer Aktiengesellschaft | Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen. |
| CN115677551A (zh) * | 2021-12-28 | 2023-02-03 | 武汉市振邦生物科技有限公司 | 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺 |
| CN119731159A (zh) | 2022-08-05 | 2025-03-28 | 吉利德科学公司 | SARS-CoV2主蛋白酶抑制剂 |
| CN115433756B (zh) * | 2022-08-30 | 2024-04-09 | 山东新华制药股份有限公司 | 一种泼尼松龙的制备方法 |
| US20250276979A1 (en) * | 2024-02-07 | 2025-09-04 | Gilead Sciences, Inc. | Sars-cov2 main protease inhibitors |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670560A (en) | 1986-04-28 | 1987-06-02 | Ortho Pharmaceutical Corporation | Thienopyrimidine-2,4-dione derivatives and intermediates thereof |
| US4835157A (en) * | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
| JPH02225485A (ja) | 1989-02-27 | 1990-09-07 | Taiho Yakuhin Kogyo Kk | チエノピリミジン―３―酢酸誘導体 |
| JP3035745B2 (ja) * | 1990-02-22 | 2000-04-24 | 武田薬品工業株式会社 | 縮合チオフェン誘導体 |
| JP3811196B2 (ja) | 1993-08-26 | 2006-08-16 | 武田薬品工業株式会社 | エンドセリン拮抗剤、チエノピリミジン誘導体およびその製造法 |
| TW276256B (enExample) | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
| EP0846119B1 (en) | 1995-08-17 | 2002-11-13 | Takeda Chemical Industries, Ltd. | Thienopyrimidine derivatives, their production and use as endothelin antagonists |
| JPH09110873A (ja) | 1995-08-17 | 1997-04-28 | Takeda Chem Ind Ltd | チエノピリミジン誘導体、その製造法および用途 |
| CA2250908C (en) | 1996-04-30 | 2012-03-13 | Takeda Chemical Industries, Ltd. | Combined use of gnrh agonist and antagonist |
| JP2007302703A (ja) | 1996-04-30 | 2007-11-22 | Takeda Chem Ind Ltd | 医薬組成物 |
| SE9702001D0 (sv) | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
| US6984644B2 (en) | 1997-05-28 | 2006-01-10 | Astrazeneca Ab | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones |
| DE19754082A1 (de) | 1997-12-05 | 1999-06-10 | Knoll Ag | Methode zur Bekämpfung der Fettleibigkeit |
| US6166019A (en) * | 1998-07-16 | 2000-12-26 | Abbott Laboratories | Piperazinyl pyrimidine dione compounds selective for adrenoceptors |
| MXPA01010143A (es) | 1999-04-09 | 2003-07-14 | Cell Therapeutics Inc | Derivados de xantina y analogos como inhibidores de transmision de senales celulares. |
| BR0207216A (pt) | 2001-02-14 | 2004-03-09 | Warner Lambert Co | Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz |
| US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| JP5072166B2 (ja) * | 2002-01-30 | 2012-11-14 | 武田薬品工業株式会社 | チエノピリミジン化合物、その製造法および用途 |
| EP1478437B1 (en) | 2002-02-27 | 2005-08-31 | Pfizer Products Inc. | Acc inhibitors |
| AU2003253165A1 (en) | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| ES2324472T3 (es) | 2003-01-06 | 2009-08-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Herbicidas que inhiben la accion de acetil-coa carboxilasa en vegetales para su uso como pesticidas. |
| ZA200506611B (en) | 2003-01-29 | 2006-12-27 | Takeda Pharmaceutical | Thienopyrimidine compounds and use thereof |
| US7947691B2 (en) | 2004-07-21 | 2011-05-24 | Athersys, Inc. | Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof |
| US20070208040A1 (en) | 2006-03-02 | 2007-09-06 | Elfatih Elzein | A2a adenosine receptor antagonists |
| JPWO2008143262A1 (ja) | 2007-05-21 | 2010-08-12 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JP5535931B2 (ja) | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| EP2519527B1 (en) | 2009-12-29 | 2013-12-18 | Poxel | Thieno[2,3-b]pyridinedione activators of ampk and therapeutic uses thereof |
| AU2011252874A1 (en) | 2010-05-14 | 2012-11-29 | University Of Rochester | Compositions and methods for targeting A3G:RNA complexes |
| EP3628320B1 (en) * | 2011-11-11 | 2022-03-16 | Gilead Apollo, LLC | Acc inhibitors and uses thereof |
| CN105358152A (zh) | 2013-05-10 | 2016-02-24 | 尼普斯阿波罗有限公司 | Acc抑制剂和其用途 |
| MX2015015422A (es) | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
| EA030958B1 (ru) | 2013-05-10 | 2018-10-31 | Джилид Аполло, Ллс | Ингибиторы акк и их применение |
| HK1221662A1 (zh) | 2013-05-10 | 2017-06-09 | Gilead Apollo, Llc | Acc抑制剂和其用途 |
| TWI652012B (zh) | 2013-05-20 | 2019-03-01 | 杜邦股份有限公司 | 殺真菌吡唑的固態形式 |
| WO2015007453A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| WO2015007451A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| JP2019503338A (ja) | 2015-11-25 | 2019-02-07 | ギリアド アポロ， エルエルシー | ２，４−ジオキソ−１，４−ジヒドロチエノ［２，３−ｄ］ピリミジンの誘導体を含む殺真菌組成物 |
| MX2018006286A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc pirazolicos y usos de los mismos. |
| CA3005900C (en) | 2015-11-25 | 2023-10-31 | Gilead Apollo, Llc | Triazole acc inhibitors and uses thereof |
| EP3380478B1 (en) | 2015-11-25 | 2020-12-23 | Gilead Apollo, LLC | Ester acc inhibitors and uses thereof |
| CN108699078A (zh) | 2016-03-02 | 2018-10-23 | 吉利德阿波罗公司 | 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法 |
-
2016
- 2016-10-25 AR ARP160103255A patent/AR106472A1/es unknown
- 2016-10-26 US US15/334,955 patent/US10179793B2/en not_active Expired - Fee Related
- 2016-10-26 SG SG11201802989QA patent/SG11201802989QA/en unknown
- 2016-10-26 AU AU2016344392A patent/AU2016344392A1/en not_active Abandoned
- 2016-10-26 JP JP2018521087A patent/JP2018538246A/ja active Pending
- 2016-10-26 KR KR1020187013132A patent/KR20180067603A/ko not_active Withdrawn
- 2016-10-26 EP EP16791253.4A patent/EP3368540A1/en not_active Withdrawn
- 2016-10-26 BR BR112018008227A patent/BR112018008227A2/pt not_active Application Discontinuation
- 2016-10-26 CA CA3003275A patent/CA3003275A1/en not_active Abandoned
- 2016-10-26 EA EA201890749A patent/EA201890749A1/ru unknown
- 2016-10-26 WO PCT/US2016/058867 patent/WO2017075056A1/en not_active Ceased
- 2016-10-26 CN CN201680072737.1A patent/CN108368125A/zh active Pending
- 2016-10-26 MX MX2018005292A patent/MX2018005292A/es unknown
-
2018
- 2018-04-11 IL IL258636A patent/IL258636A/en unknown
- 2018-11-27 US US16/201,571 patent/US20190330224A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017075056A1 (en) | 2017-05-04 |
| AR106472A1 (es) | 2018-01-17 |
| US10179793B2 (en) | 2019-01-15 |
| CN108368125A (zh) | 2018-08-03 |
| KR20180067603A (ko) | 2018-06-20 |
| SG11201802989QA (en) | 2018-05-30 |
| JP2018538246A (ja) | 2018-12-27 |
| US20190330224A1 (en) | 2019-10-31 |
| EA201890749A1 (ru) | 2018-11-30 |
| BR112018008227A2 (pt) | 2018-10-23 |
| AU2016344392A1 (en) | 2018-05-10 |
| IL258636A (en) | 2018-06-28 |
| EP3368540A1 (en) | 2018-09-05 |
| CA3003275A1 (en) | 2017-05-04 |
| US20170145028A1 (en) | 2017-05-25 |
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