BR112018008227A2 - ?composto, composição, e, métodos para inibir acc, para tratar um distúrbio metabólico, um câncer ou outro distúrbio proliferativo, uma infecção fúngica, parasítica ou bacteriana e para controlar patógenos fúngicos agrícolas? - Google Patents
?composto, composição, e, métodos para inibir acc, para tratar um distúrbio metabólico, um câncer ou outro distúrbio proliferativo, uma infecção fúngica, parasítica ou bacteriana e para controlar patógenos fúngicos agrícolas?Info
- Publication number
- BR112018008227A2 BR112018008227A2 BR112018008227A BR112018008227A BR112018008227A2 BR 112018008227 A2 BR112018008227 A2 BR 112018008227A2 BR 112018008227 A BR112018008227 A BR 112018008227A BR 112018008227 A BR112018008227 A BR 112018008227A BR 112018008227 A2 BR112018008227 A2 BR 112018008227A2
- Authority
- BR
- Brazil
- Prior art keywords
- fungal
- methods
- parasitic
- cancer
- treating
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 206010017533 Fungal infection Diseases 0.000 title 1
- 208000031888 Mycoses Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 208000030852 Parasitic disease Diseases 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002538 fungal effect Effects 0.000 title 1
- 244000053095 fungal pathogen Species 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 208000030159 metabolic disease Diseases 0.000 title 1
- 230000003071 parasitic effect Effects 0.000 title 1
- 230000002062 proliferating effect Effects 0.000 title 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562246318P | 2015-10-26 | 2015-10-26 | |
| PCT/US2016/058867 WO2017075056A1 (en) | 2015-10-26 | 2016-10-26 | Acc inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018008227A2 true BR112018008227A2 (pt) | 2018-10-23 |
Family
ID=57233943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018008227A BR112018008227A2 (pt) | 2015-10-26 | 2016-10-26 | ?composto, composição, e, métodos para inibir acc, para tratar um distúrbio metabólico, um câncer ou outro distúrbio proliferativo, uma infecção fúngica, parasítica ou bacteriana e para controlar patógenos fúngicos agrícolas? |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10179793B2 (enExample) |
| EP (1) | EP3368540A1 (enExample) |
| JP (1) | JP2018538246A (enExample) |
| KR (1) | KR20180067603A (enExample) |
| CN (1) | CN108368125A (enExample) |
| AR (1) | AR106472A1 (enExample) |
| AU (1) | AU2016344392A1 (enExample) |
| BR (1) | BR112018008227A2 (enExample) |
| CA (1) | CA3003275A1 (enExample) |
| EA (1) | EA201890749A1 (enExample) |
| IL (1) | IL258636A (enExample) |
| MX (1) | MX2018005292A (enExample) |
| SG (1) | SG11201802989QA (enExample) |
| WO (1) | WO2017075056A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3329919T (lt) | 2011-11-11 | 2020-02-10 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
| EP3225618B1 (en) | 2014-11-26 | 2020-05-06 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| EA201890910A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | ФУНГИЦИДНЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 2,4-ДИОКСО-1,4-ДИГИДРОТИЕНО[2,3-d]ПИРИМИДИНА |
| EA201890949A1 (ru) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
| BR112018010453B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Compostos triazólicos inibindores de acetil coa carboxilase (acc) |
| JP2019502660A (ja) | 2015-11-25 | 2019-01-31 | ギリアド アポロ， エルエルシー | ピラゾールａｃｃ阻害剤およびその使用 |
| TWI844474B (zh) * | 2016-03-02 | 2024-06-01 | 美商基利阿波羅有限責任公司 | 噻吩并嘧啶二酮acc抑制劑之固體型式及其製造方法 |
| AU2017329677A1 (en) | 2016-09-23 | 2019-04-18 | Bayer Aktiengesellschaft | N 3 -cyclically substituted thienouraciles and use thereof |
| US10759812B2 (en) | 2017-01-22 | 2020-09-01 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
| WO2018161008A1 (en) * | 2017-03-03 | 2018-09-07 | Gilead Apollo, Llc | Processes for the preparation of fungicidal compounds |
| EP4424364A3 (en) | 2017-03-28 | 2024-11-27 | Gilead Sciences, Inc. | Methods of treating liver disease |
| WO2018228369A1 (zh) * | 2017-06-15 | 2018-12-20 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途 |
| US11186587B2 (en) | 2017-07-26 | 2021-11-30 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Compound as ACC inhibitor and use thereof |
| WO2019191451A1 (en) | 2018-03-30 | 2019-10-03 | Biotheryx, Inc. | Thienopyrimidinone compounds |
| CN112218871B (zh) * | 2018-06-05 | 2022-10-18 | 南京明德新药研发有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类衍生物及其应用 |
| EP3873210A4 (en) * | 2018-11-02 | 2022-08-10 | Dow AgroSciences, LLC | Compositions comprising halauxifen and other herbicides and methods thereof |
| AU2019385438A1 (en) * | 2018-11-20 | 2021-05-27 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Spiro compound and medical uses thereof |
| CN111484504B (zh) * | 2019-01-25 | 2024-05-10 | 南京圣和药业股份有限公司 | Acc抑制剂的光学异构体及其应用 |
| US20220152164A1 (en) * | 2019-03-22 | 2022-05-19 | Kallyope, Inc. | Gpcr combination therapies |
| EP3995498A4 (en) | 2019-07-02 | 2023-03-01 | Sunshine Lake Pharma Co., Ltd. | THIENOPYRIMIDINE DERIVATIVES HAVING STEREO CONFIGURATION AND THEIR USE IN MEDICINE |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| CN110746439B (zh) * | 2019-10-18 | 2020-10-30 | 南京瑞捷医药科技有限公司 | 一种噻吩并嘧啶二酮化合物的制备方法 |
| WO2021112213A1 (ja) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤 |
| CN114787166B (zh) * | 2019-12-05 | 2023-09-19 | 漳州片仔癀药业股份有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
| CN114746426B (zh) * | 2019-12-05 | 2023-12-01 | 漳州片仔癀药业股份有限公司 | 作为acc1和acc2抑制剂的晶型及其制备方法和应用 |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| CN113968871A (zh) * | 2020-07-25 | 2022-01-25 | 南京圣和药业股份有限公司 | 苯基取代类acc抑制剂的晶型 |
| WO2022133097A1 (en) * | 2020-12-17 | 2022-06-23 | Biogen Ma Inc. | Synthesis of compounds that modulate use-dependent voltage-gated sodium channels |
| EP4269415A1 (en) | 2020-12-24 | 2023-11-01 | Modulus Discovery, Inc. | Tetrahydro thienopyridine sulfonamide compound |
| WO2022268520A1 (de) * | 2021-06-21 | 2022-12-29 | Bayer Aktiengesellschaft | Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen. |
| CN115677551A (zh) * | 2021-12-28 | 2023-02-03 | 武汉市振邦生物科技有限公司 | 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺 |
| CR20250040A (es) | 2022-08-05 | 2025-03-18 | Gilead Sciences Inc | Inhibidores de la proteasa principal de sars-cov2 |
| CN115433756B (zh) * | 2022-08-30 | 2024-04-09 | 山东新华制药股份有限公司 | 一种泼尼松龙的制备方法 |
| US20250276979A1 (en) * | 2024-02-07 | 2025-09-04 | Gilead Sciences, Inc. | Sars-cov2 main protease inhibitors |
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| US4835157A (en) * | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
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| LT3329919T (lt) | 2011-11-11 | 2020-02-10 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
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| US10208044B2 (en) | 2013-05-10 | 2019-02-19 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
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| WO2015007453A1 (en) * | 2013-07-15 | 2015-01-22 | Syngenta Participations Ag | Microbiocidal heterobicyclic derivatives |
| JP2019502660A (ja) | 2015-11-25 | 2019-01-31 | ギリアド アポロ， エルエルシー | ピラゾールａｃｃ阻害剤およびその使用 |
| EA201890910A1 (ru) | 2015-11-25 | 2018-11-30 | Джилид Аполло, Ллс | ФУНГИЦИДНЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 2,4-ДИОКСО-1,4-ДИГИДРОТИЕНО[2,3-d]ПИРИМИДИНА |
| BR112018010453B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Compostos triazólicos inibindores de acetil coa carboxilase (acc) |
| EA201890949A1 (ru) | 2015-11-25 | 2018-12-28 | Джилид Аполло, Ллс | СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ |
| TWI844474B (zh) | 2016-03-02 | 2024-06-01 | 美商基利阿波羅有限責任公司 | 噻吩并嘧啶二酮acc抑制劑之固體型式及其製造方法 |
-
2016
- 2016-10-25 AR ARP160103255A patent/AR106472A1/es unknown
- 2016-10-26 MX MX2018005292A patent/MX2018005292A/es unknown
- 2016-10-26 KR KR1020187013132A patent/KR20180067603A/ko not_active Withdrawn
- 2016-10-26 EP EP16791253.4A patent/EP3368540A1/en not_active Withdrawn
- 2016-10-26 EA EA201890749A patent/EA201890749A1/ru unknown
- 2016-10-26 CA CA3003275A patent/CA3003275A1/en not_active Abandoned
- 2016-10-26 US US15/334,955 patent/US10179793B2/en not_active Expired - Fee Related
- 2016-10-26 CN CN201680072737.1A patent/CN108368125A/zh active Pending
- 2016-10-26 AU AU2016344392A patent/AU2016344392A1/en not_active Abandoned
- 2016-10-26 BR BR112018008227A patent/BR112018008227A2/pt not_active Application Discontinuation
- 2016-10-26 WO PCT/US2016/058867 patent/WO2017075056A1/en not_active Ceased
- 2016-10-26 JP JP2018521087A patent/JP2018538246A/ja active Pending
- 2016-10-26 SG SG11201802989QA patent/SG11201802989QA/en unknown
-
2018
- 2018-04-11 IL IL258636A patent/IL258636A/en unknown
- 2018-11-27 US US16/201,571 patent/US20190330224A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN108368125A (zh) | 2018-08-03 |
| KR20180067603A (ko) | 2018-06-20 |
| WO2017075056A1 (en) | 2017-05-04 |
| JP2018538246A (ja) | 2018-12-27 |
| US20190330224A1 (en) | 2019-10-31 |
| AU2016344392A1 (en) | 2018-05-10 |
| CA3003275A1 (en) | 2017-05-04 |
| EP3368540A1 (en) | 2018-09-05 |
| IL258636A (en) | 2018-06-28 |
| US10179793B2 (en) | 2019-01-15 |
| AR106472A1 (es) | 2018-01-17 |
| EA201890749A1 (ru) | 2018-11-30 |
| SG11201802989QA (en) | 2018-05-30 |
| MX2018005292A (es) | 2018-08-01 |
| US20170145028A1 (en) | 2017-05-25 |
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