MX2017016331A - Sales de ácido graso de glicopirronio y métodos para elaborar las mismas. - Google Patents
Sales de ácido graso de glicopirronio y métodos para elaborar las mismas.Info
- Publication number
- MX2017016331A MX2017016331A MX2017016331A MX2017016331A MX2017016331A MX 2017016331 A MX2017016331 A MX 2017016331A MX 2017016331 A MX2017016331 A MX 2017016331A MX 2017016331 A MX2017016331 A MX 2017016331A MX 2017016331 A MX2017016331 A MX 2017016331A
- Authority
- MX
- Mexico
- Prior art keywords
- fatty acid
- glycopyrronium
- acid salts
- methods
- reaction mixture
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/126—Acids containing more than four carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
- C07C57/12—Straight chain carboxylic acids containing eighteen carbon atoms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
- G01N2030/8854—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds involving hydrocarbons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8868—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample elemental analysis, e.g. isotope dilution analysis
Abstract
Se han desarrollado nuevas sales de ácido graso de glicopirronio. Las condiciones de reacción bi-fásicas permiten las reacciones de intercambio de contraión deseadas entre bromuro de glicopirronio y sales de ácido graso de metales alcalinos y metales alcalinotérreos en métodos para formar sales de ácido graso de glicopirronio. En modalidades preferidas, un exceso del ácido graso libre en la mezcla de reacción estabiliza la sal de ácido graso de glicopirronio y reduce la formación de la impureza, Ácido A. En algunas modalidades preferidas, entre 0.2 y 1.2 equivalentes molares de ácido graso libre en exceso se adiciona a la mezcla de reacción. En otra modalidad, aproximadamente 1.2 equivalentes molares de ácido graso libre en exceso se adiciona a la mezcla de reacción.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562175737P | 2015-06-15 | 2015-06-15 | |
PCT/US2016/035967 WO2016204998A1 (en) | 2015-06-15 | 2016-06-06 | Glycopyrronium fatty acid salts and methods of making same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017016331A true MX2017016331A (es) | 2018-09-05 |
Family
ID=57546015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017016331A MX2017016331A (es) | 2015-06-15 | 2016-06-06 | Sales de ácido graso de glicopirronio y métodos para elaborar las mismas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US10519109B2 (es) |
EP (1) | EP3307250B1 (es) |
JP (1) | JP6910069B2 (es) |
KR (1) | KR20180037947A (es) |
CN (1) | CN108024967B (es) |
AU (1) | AU2016279798B2 (es) |
CA (1) | CA2989579A1 (es) |
ES (1) | ES2942176T3 (es) |
MA (1) | MA43047A (es) |
MX (1) | MX2017016331A (es) |
WO (1) | WO2016204998A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10954191B2 (en) * | 2017-03-12 | 2021-03-23 | Sol-Gel Technologies Ltd. | Process for the preparation of glycopyrrolate tosylate |
CN109884205A (zh) * | 2019-03-12 | 2019-06-14 | 康诚科瑞医药研发(武汉)有限公司 | 一种血浆中曲司氯铵的定量检测方法 |
KR20200129895A (ko) | 2019-05-10 | 2020-11-18 | 오남주 | 스마트 태양광 파고라 |
TW202245748A (zh) | 2021-02-05 | 2022-12-01 | 日商三和化學研究所股份有限公司 | 包含吡咯醣・水楊酸鹽之藥品 |
CA3206833A1 (en) | 2021-02-05 | 2022-08-11 | Sanwa Kagaku Kenkyusho Co., Ltd. | Medicine comprising glycopyrronium salicylate |
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EP0412798A3 (en) | 1989-08-08 | 1992-07-01 | Merck Sharp & Dohme Ltd. | Substituted pyridines, their preparation, formulations and use in dementia |
US5861431A (en) | 1995-06-07 | 1999-01-19 | Iotek, Inc. | Incontinence treatment |
US6063808A (en) | 1996-07-01 | 2000-05-16 | Sepracor Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (S,S)-glycopyrrolate |
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KR20000022239A (ko) | 1996-07-11 | 2000-04-25 | 토마스 헤인 | 인돌 선택성 세로토닌 작용약을 함유한 내포 복합체 |
CN1183124C (zh) * | 1999-10-15 | 2005-01-05 | 丹尼斯科卡尔特美国公司 | 山梨醇与脂肪酸的直接酯化法 |
GB0008660D0 (en) * | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
EP2283818B1 (en) * | 2000-11-30 | 2017-08-02 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
AU2003298514A1 (en) | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
JP2004083456A (ja) * | 2002-08-26 | 2004-03-18 | Fuji Photo Film Co Ltd | ジアゾニウム塩の製造方法 |
US7635709B2 (en) | 2002-09-26 | 2009-12-22 | The United States Of America As Represented By The Department Of Veterans Affairs | Compositions and methods for bowel care in individuals with chronic intestinal pseudo-obstruction |
WO2005003108A1 (ja) * | 2003-07-01 | 2005-01-13 | Otsuka Chemical Co., Ltd. | 第4級アンモニウム塩および電解質並びに電気化学デバイス |
US7091236B1 (en) | 2003-08-20 | 2006-08-15 | Sciele Pharma, Inc. | Method for increasing the bioavailability of glycopyrrolate |
EP1616567A1 (en) * | 2004-07-16 | 2006-01-18 | Boehringer Ingelheim Pharma GmbH & Co.KG | Medicaments for inhalation comprising PDE IV inhibitors and glycopyrrolate salts |
AU2005302452B2 (en) | 2004-11-01 | 2010-12-09 | Seo Hong Yoo | Methods and compositions for reducing neurodegeneration in Amyotrophic Lateral Sclerosis |
ATE520390T1 (de) * | 2004-12-27 | 2011-09-15 | Beiersdorf Ag | Glycopyrrolat in kosmetischen zubereitungen |
US7915303B2 (en) * | 2005-03-24 | 2011-03-29 | Sosei R&D Ltd. | Glycopyrronium salts and their therapeutic use |
JP2007090557A (ja) * | 2005-09-27 | 2007-04-12 | Fujifilm Corp | 光学フィルムの製造方法、光学フィルム並びに画像表示装置 |
KR20090054434A (ko) * | 2006-07-28 | 2009-05-29 | 바이오그레이드 (홍콩) 피티와이 리미티드 | 마스터배치 및 폴리머 조성물 |
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-
2016
- 2016-06-06 WO PCT/US2016/035967 patent/WO2016204998A1/en active Application Filing
- 2016-06-06 MA MA043047A patent/MA43047A/fr unknown
- 2016-06-06 CN CN201680048007.8A patent/CN108024967B/zh active Active
- 2016-06-06 US US15/736,662 patent/US10519109B2/en active Active
- 2016-06-06 EP EP16812146.5A patent/EP3307250B1/en active Active
- 2016-06-06 MX MX2017016331A patent/MX2017016331A/es unknown
- 2016-06-06 AU AU2016279798A patent/AU2016279798B2/en active Active
- 2016-06-06 JP JP2017566008A patent/JP6910069B2/ja active Active
- 2016-06-06 ES ES16812146T patent/ES2942176T3/es active Active
- 2016-06-06 KR KR1020187001379A patent/KR20180037947A/ko not_active Application Discontinuation
- 2016-06-06 CA CA2989579A patent/CA2989579A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MA43047A (fr) | 2018-08-08 |
EP3307250A4 (en) | 2018-08-08 |
CN108024967B (zh) | 2021-12-21 |
US10519109B2 (en) | 2019-12-31 |
EP3307250B1 (en) | 2022-11-23 |
ES2942176T3 (es) | 2023-05-30 |
US20180179156A1 (en) | 2018-06-28 |
EP3307250A1 (en) | 2018-04-18 |
AU2016279798A1 (en) | 2018-01-18 |
WO2016204998A1 (en) | 2016-12-22 |
CA2989579A1 (en) | 2016-12-22 |
JP6910069B2 (ja) | 2021-07-28 |
KR20180037947A (ko) | 2018-04-13 |
AU2016279798B2 (en) | 2021-07-08 |
JP2018519289A (ja) | 2018-07-19 |
CN108024967A (zh) | 2018-05-11 |
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