MX2016007207A - Metodos mejorados para la produccion de polipeptidos recombinantes. - Google Patents
Metodos mejorados para la produccion de polipeptidos recombinantes.Info
- Publication number
- MX2016007207A MX2016007207A MX2016007207A MX2016007207A MX2016007207A MX 2016007207 A MX2016007207 A MX 2016007207A MX 2016007207 A MX2016007207 A MX 2016007207A MX 2016007207 A MX2016007207 A MX 2016007207A MX 2016007207 A MX2016007207 A MX 2016007207A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptide
- fusion
- pro
- production methods
- recombinant polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 10
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En este documento se reporta un método para producir un polipéptido de fusión que comprende los pasos que consiste en a) cultivar una célula de mamífero que comprende un ácido nucleico que codifica un polipéptido de fusión variante en donde la secuencia de aminoácidos del polipéptido de fusión ha sido modificada por medio del reemplazo en un pro-polipéptido de fusión del sitio de escisión de proteasa endógeno entre el pro-péptido y el polipéptido de fusión con un sitio de escisión de proteasa exógeno (con respecto a los orígenes de las partes del polipéptido de fusión) o artificial y b) recuperar el polipéptido de fusión o pro-polipéptido de fusión de la célula o el medio de cultivo y producir de ese modo el polipéptido de fusión (recombinante).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13198738 | 2013-12-20 | ||
PCT/EP2014/077196 WO2015091144A1 (en) | 2013-12-20 | 2014-12-10 | Improved recombinant polypeptide production methods |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016007207A true MX2016007207A (es) | 2016-07-21 |
MX368656B MX368656B (es) | 2019-10-10 |
Family
ID=49886715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016007207A MX368656B (es) | 2013-12-20 | 2014-12-10 | Métodos mejorados para la producción de polipéptidos recombinantes. |
Country Status (11)
Country | Link |
---|---|
US (2) | US10370692B2 (es) |
EP (1) | EP3083977B1 (es) |
JP (1) | JP6618912B2 (es) |
KR (1) | KR20160098277A (es) |
CN (1) | CN105829542A (es) |
BR (1) | BR112016012229A2 (es) |
CA (1) | CA2929149A1 (es) |
HK (1) | HK1223980A1 (es) |
MX (1) | MX368656B (es) |
RU (2) | RU2019134445A (es) |
WO (1) | WO2015091144A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20221008A1 (es) | 2015-06-24 | 2022-06-15 | Hoffmann La Roche | Anticuerpos anti-receptor de transferrina con afinidad disenada |
PE20181004A1 (es) | 2015-10-02 | 2018-06-26 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
EP4299732A3 (en) | 2017-11-30 | 2024-03-27 | Regeneron Pharmaceuticals, Inc. | Rats comprising a humanized trkb locus |
US20210213102A1 (en) * | 2018-09-21 | 2021-07-15 | Innovent Biologics (Suzhou) Co., Ltd. | Novel interleukin-2 and use thereof |
KR102027955B1 (ko) | 2019-01-24 | 2019-10-02 | 이현종 | 로스터 후드용 내부커버 및 이의 제조방법 |
BR112022016948A2 (pt) * | 2020-02-25 | 2022-11-22 | Momenta Pharmaceuticals Inc | Enzimas para sialilação de glicanos |
IT202000032423A1 (it) * | 2020-12-24 | 2022-06-24 | Univ Degli Studi Di Trieste | Metodo per la produzione di forme processate proteoliticamente di fattori trofici o fattori di crescita |
WO2023086913A2 (en) * | 2021-11-11 | 2023-05-19 | Tectonic Therapeutic, Inc. | Relaxin-2 fusion protein analogs and methods of using same |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ236819A (en) * | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
JPH07509444A (ja) | 1991-11-26 | 1995-10-19 | アルカーメス・インコーポレーテツド | トランスフェリンセレプター特異的抗体−神経薬又は診断薬複合体の製造法 |
US5586553A (en) | 1995-02-16 | 1996-12-24 | Minimed Inc. | Transcutaneous sensor insertion set |
CZ300762B6 (cs) | 1998-10-16 | 2009-08-05 | Biogen Idec Ma Inc. | Fúzní proteiny interferonu-beta-1a a jejich použití |
IL129427A0 (en) | 1999-04-13 | 2000-02-17 | Yeda Res & Dev | Preparation of biologically active molecules |
SE9901428D0 (sv) * | 1999-04-21 | 1999-04-21 | Karolinska Innovations Ab | Amphibodies |
US20020127652A1 (en) * | 2000-02-11 | 2002-09-12 | Schambye Hans Thalsgard | Follicle stimulating hormones |
WO2002002597A2 (en) | 2000-06-30 | 2002-01-10 | Maxygen Aps | Peptide extended glycosylated polypeptides |
AR040778A1 (es) | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
GB0412186D0 (en) | 2004-05-28 | 2004-06-30 | Univ Cambridge Tech | Production of recombinant protein |
US7697967B2 (en) | 2005-12-28 | 2010-04-13 | Abbott Diabetes Care Inc. | Method and apparatus for providing analyte sensor insertion |
BRPI0611765B1 (pt) | 2005-06-07 | 2022-09-27 | Esbatech Ag | Anticorpo ou fragmento de anticorpo estável e solúvel que se liga especificamente ao tnf-alfa seus usos e composição diagnóstica ou terapêutica |
US8142781B2 (en) * | 2005-10-07 | 2012-03-27 | Armagen Technologies, Inc. | Fusion proteins for blood-brain barrier delivery |
WO2008005847A2 (en) | 2006-06-30 | 2008-01-10 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
US8759297B2 (en) | 2006-08-18 | 2014-06-24 | Armagen Technologies, Inc. | Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns |
MX2009001691A (es) * | 2006-08-31 | 2009-02-25 | Hoffmann La Roche | Metodo para produccion del factor de crecimiento i tipo insulina. |
CA2716738A1 (en) * | 2008-04-07 | 2009-10-15 | Zymogenetics, Inc. | Thrombin activator compositions and methods of making and using the same |
CA2731435A1 (en) | 2008-07-21 | 2010-01-28 | Arstasis, Inc. | Devices, methods, and kits for forming tracts in tissue |
KR20110126748A (ko) | 2009-04-07 | 2011-11-23 | 로슈 글리카트 아게 | 이중특이적 항-erbb-1/항-c-met 항체 |
TWI689314B (zh) | 2010-11-30 | 2020-04-01 | 建南德克公司 | 低親和力血腦障壁受體抗體及其用途 |
WO2012087835A2 (en) | 2010-12-22 | 2012-06-28 | Boston Biomedical Research Institute | Compositions and methods for enhancing protein folding |
SG193554A1 (en) | 2011-03-29 | 2013-11-29 | Roche Glycart Ag | Antibody fc variants |
CA2828662A1 (en) | 2011-04-20 | 2012-10-26 | Roche Glycart Ag | Method and constructs for the ph dependent passage of the blood-brain-barrier |
KR20140135959A (ko) * | 2012-02-29 | 2014-11-27 | 에프. 호프만-라 로슈 아게 | 온-컬럼 효소적 절단 |
EP2668901A1 (en) | 2012-05-31 | 2013-12-04 | Roche Diagniostics GmbH | Sensor insertion assembly, sensor cartridge, and inserter |
LT2890712T (lt) | 2012-08-29 | 2019-07-25 | F. Hoffmann-La Roche Ag | Šaudyklinis nešiklis per kraujo ir smegenų barjerą |
-
2014
- 2014-12-10 US US15/106,205 patent/US10370692B2/en active Active
- 2014-12-10 BR BR112016012229A patent/BR112016012229A2/pt not_active Application Discontinuation
- 2014-12-10 MX MX2016007207A patent/MX368656B/es active IP Right Grant
- 2014-12-10 KR KR1020167016420A patent/KR20160098277A/ko not_active Application Discontinuation
- 2014-12-10 RU RU2019134445A patent/RU2019134445A/ru unknown
- 2014-12-10 CN CN201480069054.1A patent/CN105829542A/zh active Pending
- 2014-12-10 EP EP14827183.6A patent/EP3083977B1/en active Active
- 2014-12-10 RU RU2016128367A patent/RU2711322C1/ru not_active IP Right Cessation
- 2014-12-10 CA CA2929149A patent/CA2929149A1/en not_active Abandoned
- 2014-12-10 WO PCT/EP2014/077196 patent/WO2015091144A1/en active Application Filing
- 2014-12-10 JP JP2016541174A patent/JP6618912B2/ja active Active
-
2016
- 2016-10-25 HK HK16112252.0A patent/HK1223980A1/zh unknown
-
2019
- 2019-05-15 US US16/413,063 patent/US11098338B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2929149A1 (en) | 2015-06-25 |
EP3083977A1 (en) | 2016-10-26 |
MX368656B (es) | 2019-10-10 |
RU2019134445A (ru) | 2019-12-20 |
HK1223980A1 (zh) | 2017-08-11 |
CN105829542A (zh) | 2016-08-03 |
WO2015091144A1 (en) | 2015-06-25 |
KR20160098277A (ko) | 2016-08-18 |
JP6618912B2 (ja) | 2019-12-11 |
RU2711322C1 (ru) | 2020-01-16 |
RU2016128367A (ru) | 2018-01-25 |
BR112016012229A2 (pt) | 2017-09-26 |
US11098338B2 (en) | 2021-08-24 |
EP3083977B1 (en) | 2018-02-28 |
US10370692B2 (en) | 2019-08-06 |
US20190271021A1 (en) | 2019-09-05 |
JP2017500040A (ja) | 2017-01-05 |
US20160326562A1 (en) | 2016-11-10 |
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