MX2016006604A - Derivados de piperidina con actividad multimodal contra el dolor. - Google Patents
Derivados de piperidina con actividad multimodal contra el dolor.Info
- Publication number
- MX2016006604A MX2016006604A MX2016006604A MX2016006604A MX2016006604A MX 2016006604 A MX2016006604 A MX 2016006604A MX 2016006604 A MX2016006604 A MX 2016006604A MX 2016006604 A MX2016006604 A MX 2016006604A MX 2016006604 A MX2016006604 A MX 2016006604A
- Authority
- MX
- Mexico
- Prior art keywords
- activity against
- piperidine derivatives
- against pain
- multimodal activity
- compounds
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000051367 mu Opioid Receptors Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108010085082 sigma receptors Proteins 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 108020001612 μ-opioid receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13384004 | 2013-12-20 | ||
| PCT/EP2014/078717 WO2015091939A1 (en) | 2013-12-20 | 2014-12-19 | Piperidine derivatives having multimodal activity against pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016006604A true MX2016006604A (es) | 2016-09-08 |
Family
ID=49998040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006604A MX2016006604A (es) | 2013-12-20 | 2014-12-19 | Derivados de piperidina con actividad multimodal contra el dolor. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9981942B2 (enExample) |
| EP (1) | EP3083601B1 (enExample) |
| JP (1) | JP2017502010A (enExample) |
| CN (1) | CN105849096B (enExample) |
| CA (1) | CA2931051A1 (enExample) |
| MX (1) | MX2016006604A (enExample) |
| WO (1) | WO2015091939A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018525363A (ja) * | 2015-07-29 | 2018-09-06 | ラボラトリオス・デル・デエレ・エステベ・エセ・ア | 疼痛に対する多様な活性を有する置換アミド誘導体 |
| CA2992054A1 (en) * | 2015-07-29 | 2017-02-02 | Laboratorios Del Dr. Esteve, S.A. | Amide derivatives having multimodal activity against pain |
| CN109153671A (zh) * | 2016-05-20 | 2019-01-04 | 埃斯蒂文制药股份有限公司 | 针对疼痛具有多模式活性的四氢吡喃和噻喃衍生物 |
| WO2017222914A1 (en) | 2016-06-21 | 2017-12-28 | Inception 4, Inc. | Carbocyclic prolinamide derivatives |
| CN109476637B (zh) | 2016-06-21 | 2022-02-01 | 奥瑞恩眼科有限责任公司 | 杂环脯氨酰胺衍生物 |
| US10836728B2 (en) * | 2017-01-17 | 2020-11-17 | Mebias Discovery, Inc. | Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same |
| WO2019168164A1 (ja) * | 2018-03-02 | 2019-09-06 | 国立大学法人大阪大学 | タンパク質及び／又はペプチド修飾用分子 |
| TW202304448A (zh) * | 2021-04-07 | 2023-02-01 | 西班牙商塔拉森斯調節公司 | 作為西格瑪配位基的新（高）哌啶基雜環 |
| WO2023156386A2 (en) * | 2022-02-16 | 2023-08-24 | Duke Street Bio Limited | Pharmaceutical compound |
| WO2024105225A1 (en) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL275537A (enExample) | 1961-03-06 | |||
| DE2109155A1 (en) | 1971-02-26 | 1972-09-14 | CH. Boehringer Sohn, 6507 Ingelheim | 1-furylmethyl-4-phenyl-4-methoxycarbonylpiperidines - - with analgesic activity anorectic activity salt |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US6727264B1 (en) * | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| JP2004536104A (ja) * | 2001-07-05 | 2004-12-02 | シナプティック・ファーマスーティカル・コーポレーション | Ｍｃｈ選択的アンタゴニストとしての置換されたアニリン−ピペリジン誘導体 |
| US7381721B2 (en) * | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| EP1736472A4 (en) | 2004-04-15 | 2007-10-31 | Astellas Pharma Inc | 2-aminopyridine derivative |
| US7645755B2 (en) * | 2004-10-22 | 2010-01-12 | Janssen Pharmaceutical N.V. | Inhibitors of c-fms kinase |
| CN102295636A (zh) * | 2005-07-29 | 2011-12-28 | 弗·哈夫曼-拉罗切有限公司 | 吲哚-3-基-羰基-哌啶和哌嗪衍生物 |
| TW200808788A (en) * | 2006-04-19 | 2008-02-16 | Astellas Pharma Inc | Azolecarboxamide derivative |
| CA2657660A1 (en) * | 2006-07-12 | 2008-01-17 | Merck & Co., Inc. | Substituted pyrazoles as ghrelin receptor antagonists |
| US7842696B2 (en) | 2007-06-21 | 2010-11-30 | Forest Laboratories Holdings Limited | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase |
| WO2009029253A1 (en) | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| JP2011502991A (ja) * | 2007-11-02 | 2011-01-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 骨癌並びに骨癌に伴う骨喪失及び骨痛の処置又は予防のためのｃｆｍｓ阻害物質の使用 |
| WO2010046780A2 (en) | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Anti viral compounds |
| WO2010080864A1 (en) | 2009-01-12 | 2010-07-15 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof |
| GB2474748B (en) * | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| SG182724A1 (en) | 2010-02-12 | 2012-08-30 | Pharmascience Inc | Iap bir domain binding compounds |
| CA2931219A1 (en) | 2013-12-20 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Piperidine compounds having multimodal activity against pain |
-
2014
- 2014-12-19 US US15/106,363 patent/US9981942B2/en not_active Expired - Fee Related
- 2014-12-19 CN CN201480070057.7A patent/CN105849096B/zh not_active Expired - Fee Related
- 2014-12-19 WO PCT/EP2014/078717 patent/WO2015091939A1/en not_active Ceased
- 2014-12-19 EP EP14824836.2A patent/EP3083601B1/en active Active
- 2014-12-19 CA CA2931051A patent/CA2931051A1/en not_active Abandoned
- 2014-12-19 JP JP2016539899A patent/JP2017502010A/ja not_active Ceased
- 2014-12-19 MX MX2016006604A patent/MX2016006604A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9981942B2 (en) | 2018-05-29 |
| CA2931051A1 (en) | 2015-06-25 |
| CN105849096B (zh) | 2019-11-29 |
| US20170001978A1 (en) | 2017-01-05 |
| CN105849096A (zh) | 2016-08-10 |
| JP2017502010A (ja) | 2017-01-19 |
| WO2015091939A1 (en) | 2015-06-25 |
| EP3083601B1 (en) | 2020-09-09 |
| EP3083601A1 (en) | 2016-10-26 |
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