MX2016006604A - Derivados de piperidina con actividad multimodal contra el dolor. - Google Patents
Derivados de piperidina con actividad multimodal contra el dolor.Info
- Publication number
- MX2016006604A MX2016006604A MX2016006604A MX2016006604A MX2016006604A MX 2016006604 A MX2016006604 A MX 2016006604A MX 2016006604 A MX2016006604 A MX 2016006604A MX 2016006604 A MX2016006604 A MX 2016006604A MX 2016006604 A MX2016006604 A MX 2016006604A
- Authority
- MX
- Mexico
- Prior art keywords
- activity against
- piperidine derivatives
- against pain
- multimodal activity
- compounds
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000051367 mu Opioid Receptors Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108010085082 sigma receptors Proteins 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 108020001612 μ-opioid receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13384004 | 2013-12-20 | ||
| PCT/EP2014/078717 WO2015091939A1 (en) | 2013-12-20 | 2014-12-19 | Piperidine derivatives having multimodal activity against pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016006604A true MX2016006604A (es) | 2016-09-08 |
Family
ID=49998040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006604A MX2016006604A (es) | 2013-12-20 | 2014-12-19 | Derivados de piperidina con actividad multimodal contra el dolor. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9981942B2 (enExample) |
| EP (1) | EP3083601B1 (enExample) |
| JP (1) | JP2017502010A (enExample) |
| CN (1) | CN105849096B (enExample) |
| CA (1) | CA2931051A1 (enExample) |
| MX (1) | MX2016006604A (enExample) |
| WO (1) | WO2015091939A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018000419A (es) * | 2015-07-29 | 2018-05-07 | Esteve Labor Dr | Derivados de amida sustituida que tienen actividad multimodal contra el dolor. |
| MX2018000418A (es) | 2015-07-29 | 2018-08-14 | Esteve Labor Dr | Derivados de amida que tienen actividad multimodal contra el dolor. |
| TW201808937A (zh) * | 2016-05-20 | 2018-03-16 | 艾斯提夫博士實驗股份有限公司 | 針對疼痛具有多模態活性的四氫哌喃和噻喃衍生物 |
| MX392422B (es) | 2016-06-21 | 2025-03-24 | Orion Ophthalmology LLC | Derivados de prolinamida heterociclica |
| JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
| CN110392571B (zh) | 2017-01-17 | 2023-07-04 | 梅比斯发现公司 | 取代的3-二烷基氨基甲基-哌啶-4-基-苯甲酰胺及其制备和使用方法 |
| WO2019168164A1 (ja) * | 2018-03-02 | 2019-09-06 | 国立大学法人大阪大学 | タンパク質及び／又はペプチド修飾用分子 |
| TW202304448A (zh) * | 2021-04-07 | 2023-02-01 | 西班牙商塔拉森斯調節公司 | 作為西格瑪配位基的新（高）哌啶基雜環 |
| EP4444305A2 (en) * | 2022-02-16 | 2024-10-16 | Duke Street Bio Limited | Pharmaceutical compound |
| WO2024105225A1 (en) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL275537A (enExample) | 1961-03-06 | |||
| DE2109155A1 (en) | 1971-02-26 | 1972-09-14 | CH. Boehringer Sohn, 6507 Ingelheim | 1-furylmethyl-4-phenyl-4-methoxycarbonylpiperidines - - with analgesic activity anorectic activity salt |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US6727264B1 (en) * | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| EA005934B1 (ru) * | 2001-07-05 | 2005-08-25 | Х. Лундбекк А/С | Замещённые анилиновые пиперидины в качестве селективных антагонистов мсн |
| US7381721B2 (en) * | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| MXPA06011827A (es) | 2004-04-15 | 2007-01-16 | Astellas Pharma Inc | Derivado de 2-aminopirimidina. |
| US7645755B2 (en) * | 2004-10-22 | 2010-01-12 | Janssen Pharmaceutical N.V. | Inhibitors of c-fms kinase |
| CA2616937A1 (en) * | 2005-07-29 | 2007-02-08 | F. Hoffman-La Roche Ag | Indol-3-yl-carbonyl-piperidin and piperazin derivatives |
| CN101426774B (zh) * | 2006-04-19 | 2012-04-25 | 安斯泰来制药有限公司 | 唑类甲酰胺衍生物 |
| EP2043634A2 (en) * | 2006-07-12 | 2009-04-08 | Merck & Co., Inc. | Substituted pyrazoles as ghrelin receptor antagonists |
| WO2008157844A1 (en) | 2007-06-21 | 2008-12-24 | Forest Laboratories Holdings Limited | Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase |
| WO2009029253A1 (en) | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| CA2704517A1 (en) * | 2007-11-02 | 2009-05-07 | Janssen Pharmaceutica, N.V. | Use of cfms inhibitor for treating or preventing bone cancer and the bone loss and bone pain associated with bone cancer |
| WO2010046780A2 (en) | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Anti viral compounds |
| WO2010080864A1 (en) | 2009-01-12 | 2010-07-15 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof |
| GB2474748B (en) * | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| NZ602368A (en) | 2010-02-12 | 2014-10-31 | Pharmascience Inc | Iap bir domain binding compounds |
| CA2931219A1 (en) | 2013-12-20 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Piperidine compounds having multimodal activity against pain |
-
2014
- 2014-12-19 JP JP2016539899A patent/JP2017502010A/ja not_active Ceased
- 2014-12-19 CA CA2931051A patent/CA2931051A1/en not_active Abandoned
- 2014-12-19 EP EP14824836.2A patent/EP3083601B1/en active Active
- 2014-12-19 US US15/106,363 patent/US9981942B2/en not_active Expired - Fee Related
- 2014-12-19 MX MX2016006604A patent/MX2016006604A/es unknown
- 2014-12-19 WO PCT/EP2014/078717 patent/WO2015091939A1/en not_active Ceased
- 2014-12-19 CN CN201480070057.7A patent/CN105849096B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN105849096B (zh) | 2019-11-29 |
| EP3083601B1 (en) | 2020-09-09 |
| WO2015091939A1 (en) | 2015-06-25 |
| JP2017502010A (ja) | 2017-01-19 |
| CN105849096A (zh) | 2016-08-10 |
| US9981942B2 (en) | 2018-05-29 |
| CA2931051A1 (en) | 2015-06-25 |
| US20170001978A1 (en) | 2017-01-05 |
| EP3083601A1 (en) | 2016-10-26 |
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