CA2931051A1 - Piperidine derivatives having multimodal activity against pain - Google Patents

Piperidine derivatives having multimodal activity against pain Download PDF

Info

Publication number
CA2931051A1
CA2931051A1 CA2931051A CA2931051A CA2931051A1 CA 2931051 A1 CA2931051 A1 CA 2931051A1 CA 2931051 A CA2931051 A CA 2931051A CA 2931051 A CA2931051 A CA 2931051A CA 2931051 A1 CA2931051 A1 CA 2931051A1
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
methyl
piperidin
triazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2931051A
Other languages
English (en)
French (fr)
Inventor
Felix Cuevas Cordobes
Carmen ALMANSA-ROSALES
Monica Garcia Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of CA2931051A1 publication Critical patent/CA2931051A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
CA2931051A 2013-12-20 2014-12-19 Piperidine derivatives having multimodal activity against pain Abandoned CA2931051A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13384004.1 2013-12-20
EP13384004 2013-12-20
PCT/EP2014/078717 WO2015091939A1 (en) 2013-12-20 2014-12-19 Piperidine derivatives having multimodal activity against pain

Publications (1)

Publication Number Publication Date
CA2931051A1 true CA2931051A1 (en) 2015-06-25

Family

ID=49998040

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2931051A Abandoned CA2931051A1 (en) 2013-12-20 2014-12-19 Piperidine derivatives having multimodal activity against pain

Country Status (7)

Country Link
US (1) US9981942B2 (enExample)
EP (1) EP3083601B1 (enExample)
JP (1) JP2017502010A (enExample)
CN (1) CN105849096B (enExample)
CA (1) CA2931051A1 (enExample)
MX (1) MX2016006604A (enExample)
WO (1) WO2015091939A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018000418A (es) * 2015-07-29 2018-08-14 Esteve Labor Dr Derivados de amida que tienen actividad multimodal contra el dolor.
EP3328853B1 (en) * 2015-07-29 2019-09-11 Esteve Pharmaceuticals, S.A. Substituted amide derivatives having multimodal activity against pain
AR108535A1 (es) * 2016-05-20 2018-08-29 Esteve Labor Dr Derivados de tetrahidropirano y tiopirano que tienen actividad multimodal contra el dolor
PT3472149T (pt) 2016-06-21 2023-11-23 Orion Opthalmology Llc Derivados de prolinamida heterocíclicos
US10526315B2 (en) 2016-06-21 2020-01-07 Orion Ophthalmology LLC Carbocyclic prolinamide derivatives
EP3570838B1 (en) 2017-01-17 2024-06-05 Mebias Discovery, Inc. Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
JP7013048B2 (ja) * 2018-03-02 2022-01-31 国立大学法人大阪大学 タンパク質及び／又はペプチド修飾用分子
TW202304448A (zh) * 2021-04-07 2023-02-01 西班牙商塔拉森斯調節公司 作為西格瑪配位基的新（高）哌啶基雜環
EP4674841A2 (en) * 2022-02-16 2026-01-07 Duke Street Bio Limited Pharmaceutical compound
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL275537A (enExample) * 1961-03-06
DE2109155A1 (en) * 1971-02-26 1972-09-14 CH. Boehringer Sohn, 6507 Ingelheim 1-furylmethyl-4-phenyl-4-methoxycarbonylpiperidines - - with analgesic activity anorectic activity salt
GB9912411D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
US6727264B1 (en) * 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists
HUP0401880A2 (hu) * 2001-07-05 2005-01-28 Synaptic Pharmaceutical Corporation Helyettesített anilin-piperidinek mint MCH-szelektív antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US7381721B2 (en) 2003-03-17 2008-06-03 Adolor Corporation Substituted piperidine compounds
WO2005100341A1 (ja) 2004-04-15 2005-10-27 Astellas Pharma Inc. ２－アミノピリミジン誘導体
US7645755B2 (en) * 2004-10-22 2010-01-12 Janssen Pharmaceutical N.V. Inhibitors of c-fms kinase
MX2008001292A (es) * 2005-07-29 2008-03-25 Hoffmann La Roche Nuevos derivados de indol-3-il-carbonil-piperidina y piperazina.
US8163746B2 (en) * 2006-04-19 2012-04-24 Astellas Pharma Inc. Azolecarboxamide derivative
EP2043634A2 (en) * 2006-07-12 2009-04-08 Merck & Co., Inc. Substituted pyrazoles as ghrelin receptor antagonists
WO2008157844A1 (en) 2007-06-21 2008-12-24 Forest Laboratories Holdings Limited Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase
EP2195313B1 (en) * 2007-08-27 2014-04-02 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
EP2222298A1 (en) * 2007-11-02 2010-09-01 Janssen Pharmaceutica N.V. Use of cfms inhibitor for treating or preventing bone cancer and the bone loss and bone pain associated with bone cancer
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds
EP2375899B1 (en) 2009-01-12 2015-02-25 Array Biopharma Inc. Piperidine-containing compounds and use thereof in the treatment of diabetes
GB2474748B (en) * 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
KR20120140658A (ko) 2010-02-12 2012-12-31 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
EP3083595B1 (en) 2013-12-20 2020-05-27 Esteve Pharmaceuticals, S.A. Piperidine compounds having multimodal activity against pain

Also Published As

Publication number Publication date
EP3083601B1 (en) 2020-09-09
CN105849096A (zh) 2016-08-10
MX2016006604A (es) 2016-09-08
CN105849096B (zh) 2019-11-29
WO2015091939A1 (en) 2015-06-25
US20170001978A1 (en) 2017-01-05
JP2017502010A (ja) 2017-01-19
EP3083601A1 (en) 2016-10-26
US9981942B2 (en) 2018-05-29

Similar Documents

Publication Publication Date Title
CA2931051A1 (en) Piperidine derivatives having multimodal activity against pain
US10745361B2 (en) Piperazine derivatives having multimodal activity against pain
CA2949573C (en) Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
EP3149005B1 (en) Amide derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
CA2991937A1 (en) Substituted amide derivatives having multimodal activity against pain
WO2017178515A1 (en) Piperidinylalkylamide derivatives having multimodal activity against pain
JP2017516819A (ja) 疼痛に対する多様な活性を有する１−オキサ−４，９−ジアザスピロウンデカン化合物のアルキルおよびアリール誘導体
WO2016078770A1 (en) Spiro-isoquinoline-1,4'-piperidine compounds having multimodal activity against pain
EP3083595B1 (en) Piperidine compounds having multimodal activity against pain
CA2967857A1 (en) 1,9-diazaspiro undecane compounds having multimodal activity against pain
WO2017198339A1 (en) Tetrahydropyran and thiopyran derivatives having multimodal activity against pain
US10189828B2 (en) 1-methylpyrazole-piperazine compounds having multimodal activity against pain
US10071968B2 (en) Methyl-1H-pyrazole alkylamine compounds having multimodal activity against pain
EP3328847B1 (en) N-(2-(3-(benzyl(methyl)amino)pyrrolidin-1-yl)ethyl)-n-phenyl)propionamide derivatives and related compounds as dual sigma 1 and mu opioid receptor ligands for the treatment of pain
WO2018153545A1 (en) Piperidine methanone derivatives having multimodal activity against pain
WO2018153546A1 (en) Tetrahydropyran and tetrahydrothiopyran methanone derivatives having multimodal activity against pain
WO2018108319A1 (en) Tetrahydropyran and tetrahydrothiopyran amide derivatives having multimodal activity against pain

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210309

FZDE Discontinued

Effective date: 20210309