CN105849096B - 具有抗疼痛的多重模式活性的哌啶衍生物 - Google Patents

具有抗疼痛的多重模式活性的哌啶衍生物 Download PDF

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Publication number
CN105849096B
CN105849096B CN201480070057.7A CN201480070057A CN105849096B CN 105849096 B CN105849096 B CN 105849096B CN 201480070057 A CN201480070057 A CN 201480070057A CN 105849096 B CN105849096 B CN 105849096B
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CN
China
Prior art keywords
methyl
substituted
unsubstituted
piperidin
triazol
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Expired - Fee Related
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CN201480070057.7A
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English (en)
Chinese (zh)
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CN105849096A (zh
Inventor
科多韦斯 费利克斯·奎瓦斯
卡门·阿尔曼萨-罗萨莱斯
洛佩斯 莫妮卡·加西亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteven Pharmaceutical Co ltd
Esteve Pharmaceuticals SA
Original Assignee
Esteven Pharmaceutical Co ltd
Laboratorios del Dr Esteve SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480070057.7A 2013-12-20 2014-12-19 具有抗疼痛的多重模式活性的哌啶衍生物 Expired - Fee Related CN105849096B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13384004 2013-12-20
EP13384004.1 2013-12-20
PCT/EP2014/078717 WO2015091939A1 (en) 2013-12-20 2014-12-19 Piperidine derivatives having multimodal activity against pain

Publications (2)

Publication Number Publication Date
CN105849096A CN105849096A (zh) 2016-08-10
CN105849096B true CN105849096B (zh) 2019-11-29

Family

ID=49998040

Family Applications (1)

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CN201480070057.7A Expired - Fee Related CN105849096B (zh) 2013-12-20 2014-12-19 具有抗疼痛的多重模式活性的哌啶衍生物

Country Status (7)

Country Link
US (1) US9981942B2 (enExample)
EP (1) EP3083601B1 (enExample)
JP (1) JP2017502010A (enExample)
CN (1) CN105849096B (enExample)
CA (1) CA2931051A1 (enExample)
MX (1) MX2016006604A (enExample)
WO (1) WO2015091939A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201718533A (zh) * 2015-07-29 2017-06-01 艾斯提夫博士實驗股份有限公司 針對疼痛具有多模式活性的經取代的醯胺衍生物
EP3328847B1 (en) * 2015-07-29 2019-09-11 Esteve Pharmaceuticals, S.A. N-(2-(3-(benzyl(methyl)amino)pyrrolidin-1-yl)ethyl)-n-phenyl)propionamide derivatives and related compounds as dual sigma 1 and mu opioid receptor ligands for the treatment of pain
CN109153671A (zh) * 2016-05-20 2019-01-04 埃斯蒂文制药股份有限公司 针对疼痛具有多模式活性的四氢吡喃和噻喃衍生物
EP3472151A4 (en) 2016-06-21 2020-03-04 Orion Ophthalmology LLC CARBOCYCLIC PROLINAMIDE DERIVATIVES
WO2017222915A1 (en) 2016-06-21 2017-12-28 Inception 4, Inc. Heterocyclic prolinamide derivatives
AU2018211057B2 (en) 2017-01-17 2021-12-23 Mebias Discovery, Inc. Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
WO2019168164A1 (ja) * 2018-03-02 2019-09-06 国立大学法人大阪大学 タンパク質及び／又はペプチド修飾用分子
TW202304448A (zh) * 2021-04-07 2023-02-01 西班牙商塔拉森斯調節公司 作為西格瑪配位基的新（高）哌啶基雜環
WO2023156386A2 (en) * 2022-02-16 2023-08-24 Duke Street Bio Limited Pharmaceutical compound
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1072592A2 (en) * 1999-05-28 2001-01-31 Pfizer Inc. 4-arylpiperidine derivatives for the treatment of pruritus
EP1072596A2 (en) * 1999-05-28 2001-01-31 Pfizer Inc. 4-arylpiperidine derivatives for the treatment of pruritus
US6727264B1 (en) * 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists
US20060189623A1 (en) * 2004-10-22 2006-08-24 Illig Carl R Inhibitors of c-fms kinase
CN101426774A (zh) * 2006-04-19 2009-05-06 安斯泰来制药有限公司 唑类甲酰胺衍生物
CN101917994A (zh) * 2007-11-02 2010-12-15 詹森药业有限公司 Cfms抑制剂用于治疗或预防骨癌以及与骨癌相关的骨丢失和骨痛的用途

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NL275537A (enExample) 1961-03-06
DE2109155A1 (en) 1971-02-26 1972-09-14 CH. Boehringer Sohn, 6507 Ingelheim 1-furylmethyl-4-phenyl-4-methoxycarbonylpiperidines - - with analgesic activity anorectic activity salt
JP2004536104A (ja) * 2001-07-05 2004-12-02 シナプティック・ファーマスーティカル・コーポレーション Ｍｃｈ選択的アンタゴニストとしての置換されたアニリン−ピペリジン誘導体
US7381721B2 (en) 2003-03-17 2008-06-03 Adolor Corporation Substituted piperidine compounds
WO2005100341A1 (ja) 2004-04-15 2005-10-27 Astellas Pharma Inc. ２－アミノピリミジン誘導体
BRPI0614692A2 (pt) * 2005-07-29 2009-05-19 Hoffmann La Roche derivados de indol-3-il-carbonil-piperidina e piperazina
JP2009542809A (ja) * 2006-07-12 2009-12-03 メルク エンド カムパニー インコーポレーテッド グレリン受容体アンタゴニストとしての置換ピラゾール
WO2008157844A1 (en) 2007-06-21 2008-12-24 Forest Laboratories Holdings Limited Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase
WO2009029253A1 (en) 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
WO2010046780A2 (en) 2008-10-22 2010-04-29 Institut Pasteur Korea Anti viral compounds
US8809538B2 (en) 2009-01-12 2014-08-19 Array Biopharma Inc. Piperidine-containing compounds and use thereof
GB2474748B (en) * 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
KR20120140658A (ko) 2010-02-12 2012-12-31 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
CN105829297B (zh) 2013-12-20 2019-08-09 埃斯蒂文制药股份有限公司 具有抗疼痛的多重模式活性的哌啶化合物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1072592A2 (en) * 1999-05-28 2001-01-31 Pfizer Inc. 4-arylpiperidine derivatives for the treatment of pruritus
EP1072596A2 (en) * 1999-05-28 2001-01-31 Pfizer Inc. 4-arylpiperidine derivatives for the treatment of pruritus
US6727264B1 (en) * 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists
US20060189623A1 (en) * 2004-10-22 2006-08-24 Illig Carl R Inhibitors of c-fms kinase
CN101426774A (zh) * 2006-04-19 2009-05-06 安斯泰来制药有限公司 唑类甲酰胺衍生物
CN101917994A (zh) * 2007-11-02 2010-12-15 詹森药业有限公司 Cfms抑制剂用于治疗或预防骨癌以及与骨癌相关的骨丢失和骨痛的用途

Also Published As

Publication number Publication date
WO2015091939A1 (en) 2015-06-25
US20170001978A1 (en) 2017-01-05
EP3083601A1 (en) 2016-10-26
JP2017502010A (ja) 2017-01-19
MX2016006604A (es) 2016-09-08
US9981942B2 (en) 2018-05-29
CN105849096A (zh) 2016-08-10
EP3083601B1 (en) 2020-09-09
CA2931051A1 (en) 2015-06-25

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Address after: Spain Barcelona

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Address before: Spain Barcelona

Applicant before: Enrique Manosas-Barrera/Attorney

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Termination date: 20201219