CN105849096B - 具有抗疼痛的多重模式活性的哌啶衍生物 - Google Patents
具有抗疼痛的多重模式活性的哌啶衍生物 Download PDFInfo
- Publication number
- CN105849096B CN105849096B CN201480070057.7A CN201480070057A CN105849096B CN 105849096 B CN105849096 B CN 105849096B CN 201480070057 A CN201480070057 A CN 201480070057A CN 105849096 B CN105849096 B CN 105849096B
- Authority
- CN
- China
- Prior art keywords
- methyl
- substituted
- unsubstituted
- piperidin
- triazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13384004.1 | 2013-12-20 | ||
| EP13384004 | 2013-12-20 | ||
| PCT/EP2014/078717 WO2015091939A1 (en) | 2013-12-20 | 2014-12-19 | Piperidine derivatives having multimodal activity against pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105849096A CN105849096A (zh) | 2016-08-10 |
| CN105849096B true CN105849096B (zh) | 2019-11-29 |
Family
ID=49998040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480070057.7A Expired - Fee Related CN105849096B (zh) | 2013-12-20 | 2014-12-19 | 具有抗疼痛的多重模式活性的哌啶衍生物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9981942B2 (enExample) |
| EP (1) | EP3083601B1 (enExample) |
| JP (1) | JP2017502010A (enExample) |
| CN (1) | CN105849096B (enExample) |
| CA (1) | CA2931051A1 (enExample) |
| MX (1) | MX2016006604A (enExample) |
| WO (1) | WO2015091939A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018000419A (es) * | 2015-07-29 | 2018-05-07 | Esteve Labor Dr | Derivados de amida sustituida que tienen actividad multimodal contra el dolor. |
| MX2018000418A (es) | 2015-07-29 | 2018-08-14 | Esteve Labor Dr | Derivados de amida que tienen actividad multimodal contra el dolor. |
| TW201808937A (zh) * | 2016-05-20 | 2018-03-16 | 艾斯提夫博士實驗股份有限公司 | 針對疼痛具有多模態活性的四氫哌喃和噻喃衍生物 |
| MX392422B (es) | 2016-06-21 | 2025-03-24 | Orion Ophthalmology LLC | Derivados de prolinamida heterociclica |
| JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
| CN110392571B (zh) | 2017-01-17 | 2023-07-04 | 梅比斯发现公司 | 取代的3-二烷基氨基甲基-哌啶-4-基-苯甲酰胺及其制备和使用方法 |
| WO2019168164A1 (ja) * | 2018-03-02 | 2019-09-06 | 国立大学法人大阪大学 | タンパク質及び／又はペプチド修飾用分子 |
| TW202304448A (zh) * | 2021-04-07 | 2023-02-01 | 西班牙商塔拉森斯調節公司 | 作為西格瑪配位基的新（高）哌啶基雜環 |
| EP4444305A2 (en) * | 2022-02-16 | 2024-10-16 | Duke Street Bio Limited | Pharmaceutical compound |
| WO2024105225A1 (en) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1072592A2 (en) * | 1999-05-28 | 2001-01-31 | Pfizer Inc. | 4-arylpiperidine derivatives for the treatment of pruritus |
| EP1072596A2 (en) * | 1999-05-28 | 2001-01-31 | Pfizer Inc. | 4-arylpiperidine derivatives for the treatment of pruritus |
| US6727264B1 (en) * | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| US20060189623A1 (en) * | 2004-10-22 | 2006-08-24 | Illig Carl R | Inhibitors of c-fms kinase |
| CN101426774A (zh) * | 2006-04-19 | 2009-05-06 | 安斯泰来制药有限公司 | 唑类甲酰胺衍生物 |
| CN101917994A (zh) * | 2007-11-02 | 2010-12-15 | 詹森药业有限公司 | Cfms抑制剂用于治疗或预防骨癌以及与骨癌相关的骨丢失和骨痛的用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL275537A (enExample) | 1961-03-06 | |||
| DE2109155A1 (en) | 1971-02-26 | 1972-09-14 | CH. Boehringer Sohn, 6507 Ingelheim | 1-furylmethyl-4-phenyl-4-methoxycarbonylpiperidines - - with analgesic activity anorectic activity salt |
| EA005934B1 (ru) * | 2001-07-05 | 2005-08-25 | Х. Лундбекк А/С | Замещённые анилиновые пиперидины в качестве селективных антагонистов мсн |
| US7381721B2 (en) * | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| MXPA06011827A (es) | 2004-04-15 | 2007-01-16 | Astellas Pharma Inc | Derivado de 2-aminopirimidina. |
| CA2616937A1 (en) * | 2005-07-29 | 2007-02-08 | F. Hoffman-La Roche Ag | Indol-3-yl-carbonyl-piperidin and piperazin derivatives |
| EP2043634A2 (en) * | 2006-07-12 | 2009-04-08 | Merck & Co., Inc. | Substituted pyrazoles as ghrelin receptor antagonists |
| WO2008157844A1 (en) | 2007-06-21 | 2008-12-24 | Forest Laboratories Holdings Limited | Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase |
| WO2009029253A1 (en) | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2010046780A2 (en) | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Anti viral compounds |
| WO2010080864A1 (en) | 2009-01-12 | 2010-07-15 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof |
| GB2474748B (en) * | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| NZ602368A (en) | 2010-02-12 | 2014-10-31 | Pharmascience Inc | Iap bir domain binding compounds |
| CA2931219A1 (en) | 2013-12-20 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Piperidine compounds having multimodal activity against pain |
-
2014
- 2014-12-19 JP JP2016539899A patent/JP2017502010A/ja not_active Ceased
- 2014-12-19 CA CA2931051A patent/CA2931051A1/en not_active Abandoned
- 2014-12-19 EP EP14824836.2A patent/EP3083601B1/en active Active
- 2014-12-19 US US15/106,363 patent/US9981942B2/en not_active Expired - Fee Related
- 2014-12-19 MX MX2016006604A patent/MX2016006604A/es unknown
- 2014-12-19 WO PCT/EP2014/078717 patent/WO2015091939A1/en not_active Ceased
- 2014-12-19 CN CN201480070057.7A patent/CN105849096B/zh not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1072592A2 (en) * | 1999-05-28 | 2001-01-31 | Pfizer Inc. | 4-arylpiperidine derivatives for the treatment of pruritus |
| EP1072596A2 (en) * | 1999-05-28 | 2001-01-31 | Pfizer Inc. | 4-arylpiperidine derivatives for the treatment of pruritus |
| US6727264B1 (en) * | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| US20060189623A1 (en) * | 2004-10-22 | 2006-08-24 | Illig Carl R | Inhibitors of c-fms kinase |
| CN101426774A (zh) * | 2006-04-19 | 2009-05-06 | 安斯泰来制药有限公司 | 唑类甲酰胺衍生物 |
| CN101917994A (zh) * | 2007-11-02 | 2010-12-15 | 詹森药业有限公司 | Cfms抑制剂用于治疗或预防骨癌以及与骨癌相关的骨丢失和骨痛的用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3083601B1 (en) | 2020-09-09 |
| WO2015091939A1 (en) | 2015-06-25 |
| JP2017502010A (ja) | 2017-01-19 |
| CN105849096A (zh) | 2016-08-10 |
| US9981942B2 (en) | 2018-05-29 |
| CA2931051A1 (en) | 2015-06-25 |
| US20170001978A1 (en) | 2017-01-05 |
| MX2016006604A (es) | 2016-09-08 |
| EP3083601A1 (en) | 2016-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: Spain Barcelona Applicant after: Steven pharmaceutical Limited by Share Ltd Address before: Spain Barcelona Applicant before: Enrique Manosas-Barrera/Attorney |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20191129 Termination date: 20201219 |