MX2016004259A - Conjugados de insulina sensibles a glucosa. - Google Patents

Conjugados de insulina sensibles a glucosa.

Info

Publication number
MX2016004259A
MX2016004259A MX2016004259A MX2016004259A MX2016004259A MX 2016004259 A MX2016004259 A MX 2016004259A MX 2016004259 A MX2016004259 A MX 2016004259A MX 2016004259 A MX2016004259 A MX 2016004259A MX 2016004259 A MX2016004259 A MX 2016004259A
Authority
MX
Mexico
Prior art keywords
glucose
saccharide
insulin conjugates
ligand
insulin
Prior art date
Application number
MX2016004259A
Other languages
English (en)
Other versions
MX366852B (es
Inventor
Ravi P Nargund
Zhiqiang Zhao
Dmitri Pissarnitski
Ahmet Kekec
Danqing Feng
Lin Yan
Songnian Lin
Yuping Zhu
David N Hunter
Pei Huo
Christopher R Moyes
Brenda Pipik
Erin N Guidry
Joseph L Duffy
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2016004259A publication Critical patent/MX2016004259A/es
Publication of MX366852B publication Critical patent/MX366852B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen conjugados de insulina comprenden una molécula de insulina unida covalentemente a al menos un enlazador bidentado que tiene dos brazos, cada brazo está unido independientemente a un ligando que comprende un sacárido y en donde el sacárido de al menos un ligando del enlazador es fucosa; los conjugados de insulina presentan un perfil farmacocinético (PK) y/o un perfil farmacodinámico (PD) que es sensible a las concentraciones sistémicas de un sacárido tal como glucosa o alfa-metilmanosa incluso cuando se administran a un sujeto que lo necesita en ausencia de una molécula de unión a sacárido multivalente exógena tal como Con A.
MX2016004259A 2013-10-04 2014-10-02 Conjugados de insulina sensibles a glucosa. MX366852B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361886717P 2013-10-04 2013-10-04
PCT/US2014/058714 WO2015051052A2 (en) 2013-10-04 2014-10-02 Glucose-responsive insulin conjugates

Publications (2)

Publication Number Publication Date
MX2016004259A true MX2016004259A (es) 2016-07-08
MX366852B MX366852B (es) 2019-07-25

Family

ID=51794958

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016004259A MX366852B (es) 2013-10-04 2014-10-02 Conjugados de insulina sensibles a glucosa.

Country Status (13)

Country Link
US (3) US9427475B2 (es)
EP (1) EP3052134B1 (es)
JP (1) JP6491649B2 (es)
KR (1) KR20160065930A (es)
CN (1) CN105792852B (es)
AR (1) AR097893A1 (es)
AU (1) AU2014329567B2 (es)
BR (1) BR112016007176A2 (es)
CA (1) CA2924743A1 (es)
MX (1) MX366852B (es)
RU (1) RU2676307C2 (es)
TW (1) TW201605470A (es)
WO (1) WO2015051052A2 (es)

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WO2016164288A1 (en) * 2015-04-08 2016-10-13 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
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CN108778318B (zh) * 2016-01-14 2022-05-03 北卡罗莱纳州立大学 葡萄糖响应性胰岛素递送组合物和方法
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BR112018074716A2 (pt) * 2016-06-02 2019-03-12 Sanofi conjugados de um agente farmacêutico e porção capaz de ligar-se a uma proteína sensível à glicose
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US20180318426A1 (en) * 2017-05-05 2018-11-08 Merck Sharp & Dohme Corp. Pharmaceutical formulations comprising insulin or insulin analogs conjugated to fucose for providing a basal pharmacodynamic profile
RU2020108281A (ru) 2017-08-17 2021-08-26 Ново Нордиск А/С Новые ацилированные аналоги инсулина и варианты их применения
JP6874266B2 (ja) * 2017-09-22 2021-05-19 国立研究開発法人日本原子力研究開発機構 テトラアルキルニトリロ酢酸ジアセトアミド化合物の合成方法
EP3694539A4 (en) * 2017-10-10 2021-07-14 North Carolina State University GLUCOSE CARRIER INHIBITOR MODIFIED INSULIN FOR THE DELIVERY OF GLUCOSE SENSITIVE INSULIN
WO2019106122A1 (en) 2017-12-01 2019-06-06 Sanofi Novel conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein
WO2019125879A2 (en) * 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Conjugate based systems for controlled insulin delivery
EP3727424A4 (en) * 2017-12-18 2021-10-27 Merck Sharp & Dohme Corp. CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN RELEASE
EP3768291A4 (en) 2018-03-22 2022-01-26 Merck Sharp & Dohme Corp. TYROSIN-SPECIFIC FUNCTIONALIZED INSULIN AND INSULIN ANALOGUES
US20220233647A1 (en) * 2019-06-06 2022-07-28 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
EP4003405A4 (en) * 2019-07-30 2023-08-23 Merck Sharp & Dohme LLC GLUCOSE-RESPONDING INSULIN CONJUGATES
TWI773009B (zh) 2019-12-11 2022-08-01 丹麥商諾佛 儂迪克股份有限公司 新穎之胰島素類似物及其用途
JP2023521920A (ja) * 2020-04-15 2023-05-25 シェンチェン・エンデュアリング・バイオテック・リミテッド 抗体－薬物コンジュゲート
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CN105792852B (zh) 2019-12-10
JP2016533348A (ja) 2016-10-27
AU2014329567A1 (en) 2016-04-07
MX366852B (es) 2019-07-25
RU2016116513A (ru) 2017-11-09
RU2016116513A3 (es) 2018-06-28
EP3052134B1 (en) 2021-05-05
AR097893A1 (es) 2016-04-20
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US20160251407A1 (en) 2016-09-01
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AU2014329567B2 (en) 2019-07-25
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US9427475B2 (en) 2016-08-30
US9889205B2 (en) 2018-02-13
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US20150105317A1 (en) 2015-04-16
RU2676307C2 (ru) 2018-12-27
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CA2924743A1 (en) 2015-04-09
US9884125B2 (en) 2018-02-06

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