MX2016000735A - Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica. - Google Patents

Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica.

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Publication number
MX2016000735A
MX2016000735A MX2016000735A MX2016000735A MX2016000735A MX 2016000735 A MX2016000735 A MX 2016000735A MX 2016000735 A MX2016000735 A MX 2016000735A MX 2016000735 A MX2016000735 A MX 2016000735A MX 2016000735 A MX2016000735 A MX 2016000735A
Authority
MX
Mexico
Prior art keywords
amide
benzyl
heteroaromatic ring
autotaxin inhibitors
cycle core
Prior art date
Application number
MX2016000735A
Other languages
English (en)
Other versions
MX368059B (es
Inventor
Mckenna Jeffrey
Thomson Christopher
Baettig Urs
Andrew Sandham David
Mark Legrand Darren
Beattie David
Stuart Lister Andrew
William Pearce David
Ross Steward Oliver
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2016000735A publication Critical patent/MX2016000735A/es
Publication of MX368059B publication Critical patent/MX368059B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Abstract

La presente invención se refiere a compuestos novedosos que son inhibidores de autotaxina, a procesos para su preparación, a composiciones farmacéuticas y medicamentos que los contienen, y a su uso en las enfermedades y los trastornos mediados por autotaxina. (ver Fórmula).
MX2016000735A 2013-07-18 2014-07-16 Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica. MX368059B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13177061 2013-07-18
PCT/IB2014/063143 WO2015008230A1 (en) 2013-07-18 2014-07-16 Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core

Publications (2)

Publication Number Publication Date
MX2016000735A true MX2016000735A (es) 2016-10-21
MX368059B MX368059B (es) 2019-09-18

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MX2016000735A MX368059B (es) 2013-07-18 2014-07-16 Inhibidores de autotaxina que comprenden un núcleo de anillo heteroaromático de bencil-amida cíclica.

Country Status (25)

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US (2) US9763957B2 (es)
EP (1) EP3022202B1 (es)
JP (1) JP6424219B2 (es)
KR (1) KR20160033726A (es)
CN (1) CN105555783B (es)
AP (1) AP2016009020A0 (es)
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