CU20160007A7 - Derivados de 2((( oxadiazol/triazol/tetrazol/isoxazol) metil) fenil)-1-(heterociclil)-ona como inhibidores activos de autotaxina - Google Patents
Derivados de 2((( oxadiazol/triazol/tetrazol/isoxazol) metil) fenil)-1-(heterociclil)-ona como inhibidores activos de autotaxinaInfo
- Publication number
- CU20160007A7 CU20160007A7 CUP2016000007A CU20160007A CU20160007A7 CU 20160007 A7 CU20160007 A7 CU 20160007A7 CU P2016000007 A CUP2016000007 A CU P2016000007A CU 20160007 A CU20160007 A CU 20160007A CU 20160007 A7 CU20160007 A7 CU 20160007A7
- Authority
- CU
- Cuba
- Prior art keywords
- heterociclyl
- isoxazol
- oxadiazol
- tetrazol
- triazol
- Prior art date
Links
- 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 title abstract 3
- 108050004000 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 title 1
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- AXLOCHLTNQDFFS-BESJYZOMSA-N azastene Chemical compound C([C@H]1[C@@H]2CC[C@@]([C@]2(CC[C@@H]1[C@@]1(C)C2)C)(O)C)C=C1C(C)(C)C1=C2C=NO1 AXLOCHLTNQDFFS-BESJYZOMSA-N 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/4245—Oxadiazoles
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- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a nuevos compuestos que son inhibidores de autotaxina, procesos para su preparación, composiciones farmaceúticas y medicamentos que los contienen útiles en enfermedades y trastornos mediados por autotaxina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13177061 | 2013-07-18 | ||
PCT/IB2014/063143 WO2015008230A1 (en) | 2013-07-18 | 2014-07-16 | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
Publications (2)
Publication Number | Publication Date |
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CU20160007A7 true CU20160007A7 (es) | 2016-07-29 |
CU24355B1 CU24355B1 (es) | 2018-08-06 |
Family
ID=48793121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2016000007A CU24355B1 (es) | 2013-07-18 | 2014-07-16 | Derivados de 2((( oxadiazol/triazol/tetrazol/isoxazol) metil) fenil)-1-(heterociclil)-ona como inhibidores activos de autotaxina |
Country Status (25)
Country | Link |
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US (2) | US9763957B2 (es) |
EP (1) | EP3022202B1 (es) |
JP (1) | JP6424219B2 (es) |
KR (1) | KR20160033726A (es) |
CN (1) | CN105555783B (es) |
AP (1) | AP2016009020A0 (es) |
AU (1) | AU2014291711B2 (es) |
BR (1) | BR112016000779A8 (es) |
CA (1) | CA2918284A1 (es) |
CL (1) | CL2016000117A1 (es) |
CR (1) | CR20160033A (es) |
CU (1) | CU24355B1 (es) |
EA (1) | EA035256B1 (es) |
ES (1) | ES2742077T3 (es) |
HK (1) | HK1219483A1 (es) |
IL (1) | IL243595A0 (es) |
MA (1) | MA38837B1 (es) |
MX (1) | MX368059B (es) |
PE (1) | PE20160521A1 (es) |
PH (1) | PH12016500094A1 (es) |
PL (1) | PL3022202T3 (es) |
PT (1) | PT3022202T (es) |
SG (1) | SG11201600241RA (es) |
TN (1) | TN2016000022A1 (es) |
WO (1) | WO2015008230A1 (es) |
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AU2014291711B2 (en) * | 2013-07-18 | 2017-02-02 | Novartis Ag | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
UA118201C2 (uk) | 2013-11-26 | 2018-12-10 | Ф. Хоффманн-Ля Рош Аг | НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ |
EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
EA037928B1 (ru) | 2014-03-26 | 2021-06-08 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
CN107106559A (zh) | 2014-04-04 | 2017-08-29 | X-Rx股份有限公司 | 自分泌运动因子的取代的螺环抑制剂 |
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-
2014
- 2014-07-16 AU AU2014291711A patent/AU2014291711B2/en not_active Ceased
- 2014-07-16 MA MA38837A patent/MA38837B1/fr unknown
- 2014-07-16 SG SG11201600241RA patent/SG11201600241RA/en unknown
- 2014-07-16 EP EP14766806.5A patent/EP3022202B1/en active Active
- 2014-07-16 KR KR1020167003766A patent/KR20160033726A/ko active IP Right Grant
- 2014-07-16 EA EA201690246A patent/EA035256B1/ru not_active IP Right Cessation
- 2014-07-16 PE PE2016000080A patent/PE20160521A1/es unknown
- 2014-07-16 WO PCT/IB2014/063143 patent/WO2015008230A1/en active Application Filing
- 2014-07-16 CU CUP2016000007A patent/CU24355B1/es unknown
- 2014-07-16 PL PL14766806T patent/PL3022202T3/pl unknown
- 2014-07-16 MX MX2016000735A patent/MX368059B/es active IP Right Grant
- 2014-07-16 CA CA2918284A patent/CA2918284A1/en not_active Abandoned
- 2014-07-16 JP JP2016526741A patent/JP6424219B2/ja not_active Expired - Fee Related
- 2014-07-16 PT PT14766806T patent/PT3022202T/pt unknown
- 2014-07-16 TN TN2016000022A patent/TN2016000022A1/en unknown
- 2014-07-16 AP AP2016009020A patent/AP2016009020A0/en unknown
- 2014-07-16 ES ES14766806T patent/ES2742077T3/es active Active
- 2014-07-16 CN CN201480051343.9A patent/CN105555783B/zh not_active Expired - Fee Related
- 2014-07-16 US US14/906,161 patent/US9763957B2/en active Active
- 2014-07-16 BR BR112016000779A patent/BR112016000779A8/pt active Search and Examination
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2016
- 2016-01-13 IL IL243595A patent/IL243595A0/en unknown
- 2016-01-14 PH PH12016500094A patent/PH12016500094A1/en unknown
- 2016-01-15 CL CL2016000117A patent/CL2016000117A1/es unknown
- 2016-01-18 CR CR20160033A patent/CR20160033A/es unknown
- 2016-06-28 HK HK16107547.5A patent/HK1219483A1/zh unknown
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2017
- 2017-08-09 US US15/673,155 patent/US10183025B2/en not_active Expired - Fee Related
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