MX2015007205A - Inhibidores de la desmetilasa de histona. - Google Patents
Inhibidores de la desmetilasa de histona.Info
- Publication number
- MX2015007205A MX2015007205A MX2015007205A MX2015007205A MX2015007205A MX 2015007205 A MX2015007205 A MX 2015007205A MX 2015007205 A MX2015007205 A MX 2015007205A MX 2015007205 A MX2015007205 A MX 2015007205A MX 2015007205 A MX2015007205 A MX 2015007205A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- histone demethylase
- compounds
- compositions
- demethylase inhibitors
- Prior art date
Links
- 102000008157 Histone Demethylases Human genes 0.000 title abstract 2
- 108010074870 Histone Demethylases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- XEODJMCAUUKTEC-UHFFFAOYSA-N 3-(1h-pyrazol-5-yl)pyridazine Chemical class N1C=CC(C=2N=NC=CC=2)=N1 XEODJMCAUUKTEC-UHFFFAOYSA-N 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
- 150000005292 pyrazolylpyridines Chemical class 0.000 abstract 1
- -1 pyrazolylpyrimidine derivative compounds Chemical class 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734330P | 2012-12-06 | 2012-12-06 | |
| US201361784414P | 2013-03-14 | 2013-03-14 | |
| PCT/US2013/073424 WO2014089364A1 (en) | 2012-12-06 | 2013-12-05 | Histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015007205A true MX2015007205A (es) | 2016-03-31 |
Family
ID=50884011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015007205A MX2015007205A (es) | 2012-12-06 | 2013-12-05 | Inhibidores de la desmetilasa de histona. |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US8987461B2 (enExample) |
| EP (2) | EP3763367A1 (enExample) |
| JP (1) | JP6256771B2 (enExample) |
| CA (1) | CA2894399A1 (enExample) |
| ES (1) | ES2834959T3 (enExample) |
| MX (1) | MX2015007205A (enExample) |
| WO (1) | WO2014089364A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104981458B (zh) | 2012-10-02 | 2017-07-21 | 吉利德科学公司 | 组蛋白去甲基化酶抑制剂 |
| US8987461B2 (en) | 2012-12-06 | 2015-03-24 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| SG10201707027SA (en) | 2013-02-27 | 2017-09-28 | Epitherapeutics Aps | Inhibitors of histone demethylases |
| JP2017066030A (ja) * | 2014-02-04 | 2017-04-06 | アグロカネショウ株式会社 | 新規なピラゾール誘導体およびこれを有効成分とする農園芸用薬剤 |
| CA2946538A1 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| NZ728120A (en) | 2014-06-25 | 2023-06-30 | Celgene Quanticel Res Inc | Histone demethylase inhibitors |
| CN106573893B (zh) * | 2014-07-31 | 2020-06-09 | 巴斯夫欧洲公司 | 制备吡唑的方法 |
| CN107074846B (zh) | 2014-08-12 | 2020-05-19 | 先正达参股股份有限公司 | 具有含硫取代基的杀有害生物活性杂环衍生物 |
| KR20170040805A (ko) | 2014-08-27 | 2017-04-13 | 길리애드 사이언시즈, 인코포레이티드 | 히스톤 데메틸라제를 억제하기 위한 화합물 및 방법 |
| EA201790502A1 (ru) * | 2014-09-16 | 2017-10-31 | Селджен Квонтисел Рисёрч, Инк. | Ингибиторы гистоновых диметилаз |
| US9896436B2 (en) | 2014-09-16 | 2018-02-20 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| EP3294725B1 (en) | 2015-05-11 | 2021-05-05 | Basf Se | Process for preparing 4-amino-pyridazines |
| PE20181539A1 (es) | 2016-02-02 | 2018-09-26 | Basf Se | Proceso de hidrogenacion catalitico para preparar pirazoles |
| US20190055212A1 (en) * | 2016-02-16 | 2019-02-21 | Stephen Gwaltney | Histone demethylase inhibitors |
| EP3436445B1 (en) * | 2016-03-15 | 2023-09-06 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2017198785A1 (en) * | 2016-05-18 | 2017-11-23 | Ieo - Istituto Europeo Di Oncologia S.R.L. | Oxime derivatives useful as inhibitors of histone demethylase kdm4c |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| ES2969239T3 (es) | 2016-05-27 | 2024-05-17 | Gilead Sciences Inc | Combinación de ledipasvir y sofosbuvir para su uso en el tratamiento de infecciones por el virus de la hepatitis B en humanos |
| WO2017207813A1 (en) | 2016-06-03 | 2017-12-07 | Oryzon Genomics, S.A. | Heteroaryl-carboxylic acids as histone demethylase inhibitors |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| KR102268448B1 (ko) | 2016-09-02 | 2021-06-22 | 길리애드 사이언시즈, 인코포레이티드 | 톨 유사 수용체 조정제 화합물 |
| ES2826748T3 (es) | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll |
| MA46535A (fr) | 2016-10-14 | 2019-08-21 | Prec Biosciences Inc | Méganucléases modifiées spécifiques de séquences de reconnaissance dans le génome du virus de l'hépatite b |
| TWI868958B (zh) | 2017-01-31 | 2025-01-01 | 美商基利科學股份有限公司 | 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型 |
| JOP20180008A1 (ar) | 2017-02-02 | 2019-01-30 | Gilead Sciences Inc | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b |
| JP7442439B2 (ja) | 2017-03-30 | 2024-03-04 | アルベルト－ルートヴィヒ－ユニバーシティー フライブルク | Ｋｄｍ４阻害剤 |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| WO2018219478A1 (en) | 2017-06-02 | 2018-12-06 | Oryzon Genomics, S.A. | Heteroaryl-carboxamides as histone demethylase inhibitors |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TW201945388A (zh) | 2018-04-12 | 2019-12-01 | 美商精密生物科學公司 | 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶 |
| WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| US20190359645A1 (en) | 2018-05-03 | 2019-11-28 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides comprising carbocyclic nucleotide |
| BR112020026746A2 (pt) | 2018-07-13 | 2021-03-30 | Gilead Sciences, Inc. | Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1 e para tratar câncer, e, kit para tratar ou prevenir câncer ou uma doença ou condição. |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| CN112955435B (zh) | 2018-10-24 | 2024-09-06 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| FI3873903T3 (fi) | 2018-10-31 | 2024-03-26 | Gilead Sciences Inc | Substituoituja 6-azabentsiimidatsoliyhdisteitä HPK1-inhibiittoreina |
| KR102658602B1 (ko) | 2018-10-31 | 2024-04-19 | 길리애드 사이언시즈, 인코포레이티드 | Hpk1 억제 활성을 갖는 치환된 6-아자벤즈이미다졸 화합물 |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| EP3935065A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| CA3129011C (en) | 2019-03-07 | 2023-12-19 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
| JP7237311B2 (ja) * | 2019-06-06 | 2023-03-13 | 京都府公立大学法人 | 化合物、医薬組成物、ｋｄｍ５ｃ阻害剤及び抗うつ剤 |
| CN110128347A (zh) * | 2019-06-17 | 2019-08-16 | 韶远科技（上海)有限公司 | 一种1-甲基-1h-吲唑-6-甲酸的合成方法 |
| MX2021015452A (es) | 2019-06-25 | 2022-02-11 | Gilead Sciences Inc | Proteinas de fusion flt3l-fc y metodos de uso. |
| WO2021011891A1 (en) | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| KR20220074917A (ko) | 2019-09-30 | 2022-06-03 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 백신 및 hbv를 치료하는 방법 |
| DK4069729T3 (da) | 2019-12-06 | 2025-04-07 | Prec Biosciences Inc | Optimerede, modificerede meganukleaser med specificitet for en genkendelsessekvens i hepatitis b-virusgenomet |
| USD1000624S1 (en) | 2019-12-27 | 2023-10-03 | Thomas Nichols | Personal care device with camera |
| US20230227426A1 (en) * | 2020-03-20 | 2023-07-20 | Akebia Therapeutics, Inc. | Phd inhibitor compounds, compositions, and use |
| JP2023518543A (ja) * | 2020-03-20 | 2023-05-02 | アケビア セラピューティクス インコーポレイテッド | Ｐｈｄ阻害剤化合物、組成物、及びそれらの使用 |
| AU2021240044A1 (en) * | 2020-03-20 | 2022-11-17 | Akebia Therapeutics, Inc. | PHD inhibitor compounds, compositions, and use |
| AR121620A1 (es) | 2020-03-20 | 2022-06-22 | Gilead Sciences Inc | Profármacos de nucleósidos 4-c-sustituidos-2-halo-2-deoxiadenosina y métodos de preparación y uso de los mismos |
| JP7712352B2 (ja) | 2020-08-07 | 2025-07-23 | ギリアード サイエンシーズ， インコーポレイテッド | ホスホンアミドヌクレオチド類似体のプロドラッグ及びその薬学的使用 |
| CN116249692B (zh) * | 2020-09-28 | 2024-08-23 | 四川科伦博泰生物医药股份有限公司 | 吡唑类化合物及其制备方法和用途 |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| EP4337223A1 (en) | 2021-05-13 | 2024-03-20 | Gilead Sciences, Inc. | Combination of a tlr8 modulating compound and anti-hbv sirna therapeutics |
| AU2022298639C1 (en) | 2021-06-23 | 2025-07-17 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240025616A (ko) | 2021-06-23 | 2024-02-27 | 길리애드 사이언시즈, 인코포레이티드 | 다이아실글리세롤 키나제 조절 화합물 |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| CN120282952A (zh) * | 2022-11-09 | 2025-07-08 | 三菱瓦斯化学尼克斯株式会社 | 1-烷基-5-羟基吡唑的制造方法 |
| WO2025240244A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| US20250345389A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
Family Cites Families (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI68369C (fi) | 1983-03-01 | 1985-09-10 | Waertsilae Oy Ab | Bestrykningsanordning |
| US4824859A (en) | 1983-05-21 | 1989-04-25 | Fisons Plc. | Pyrazoline compounds compositions and use |
| FI855180A7 (fi) | 1985-01-18 | 1986-07-19 | Nissan Chemical Ind Ltd | Pyratsolisulfonamidijohdannainen, menetelmä sen valmistamiseksi ja sitä sisältävä rikkaruohomyrkky. |
| US4699647A (en) | 1985-05-30 | 1987-10-13 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
| DE3528477A1 (de) | 1985-08-08 | 1987-02-19 | Bayer Ag | 1-aryl-pyrazole |
| DE3538731A1 (de) | 1985-10-31 | 1987-05-07 | Bayer Ag | 1-aryl-4-nitro-pyrazole |
| DE3539844A1 (de) | 1985-11-09 | 1987-05-14 | Bayer Ag | Substituierte 5-amino-1-aryl-pyrazole |
| DE3543035A1 (de) | 1985-12-05 | 1987-06-11 | Bayer Ag | 5-fluoracylamino-4-nitro-1-aryl-pyrazole |
| DE3543034A1 (de) | 1985-12-05 | 1987-06-11 | Bayer Ag | 5-perfluoracylamino-4-nitro-1-aryl-pyrazol-salze |
| DE3600950A1 (de) | 1986-01-15 | 1987-07-16 | Bayer Ag | 5-acylamido-1-aryl-pyrazole |
| DE3609542A1 (de) | 1986-03-21 | 1987-10-01 | Bayer Ag | 5-acylamino-pyrazol-derivate |
| DE3625686A1 (de) | 1986-07-30 | 1988-02-04 | Bayer Ag | 4-cyano(nitro)-5-oxy(thio)-pyrazol-derivate |
| DE3628892A1 (de) | 1986-08-26 | 1988-03-10 | Bayer Ag | Substituierte 1-aryl-3-tert.-butyl-pyrazole |
| DE3631003A1 (de) | 1986-09-12 | 1988-03-24 | Bayer Ag | Verfahren zur herstellung von 4-substituierten 1-aryl-5-amino-pyrazolen |
| DE3637710A1 (de) | 1986-11-05 | 1988-05-11 | Bayer Ag | 5-acylamino-pyrazol-derivate |
| DE3707551A1 (de) | 1987-03-10 | 1988-09-22 | Bayer Ag | Substituierte 1-arylpyrazole |
| DE3721868A1 (de) | 1987-07-02 | 1989-01-12 | Bayer Ag | 1-arylpyrazole |
| DE3911556A1 (de) | 1989-04-08 | 1990-10-11 | Bayer Ag | Substituierte 1-arylpyrazole |
| DE4023488A1 (de) * | 1990-07-24 | 1992-01-30 | Bayer Ag | 1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide |
| US5298368A (en) | 1991-04-23 | 1994-03-29 | Eastman Kodak Company | Photographic coupler compositions and methods for reducing continued coupling |
| US5292844A (en) | 1991-05-22 | 1994-03-08 | Minnesota Mining And Manufacturing Company | Vinyl acetate modified suspension polymer beads, adhesives made therefrom and a method of making |
| US5262284A (en) | 1991-07-15 | 1993-11-16 | Eastman Kodak Company | Arylidene pyrazolone coupler |
| DE4126244A1 (de) | 1991-08-08 | 1993-02-11 | Bayer Ag | Massefaerben von kunststoffen |
| US5200309A (en) | 1991-08-29 | 1993-04-06 | Eastman Kodak Company | Color photographic materials including magenta coupler, carbonamide compound and aniline or amine compound, and methods |
| US5250405A (en) | 1991-08-29 | 1993-10-05 | Eastman Kodak Company | Color photographic materials including magenta coupler, inhibitor-releasing coupler and carbonamide compound, and methods |
| US5376519A (en) | 1992-04-23 | 1994-12-27 | Eastman Kodak Company | Photographic material containing a coupler composition comprising magenta coupler, phenolic solvent, and at least one aniline or amine |
| US5340707A (en) | 1992-09-16 | 1994-08-23 | Konica Corporation | Silver halide photographic light-sensitive material |
| WO1994022853A1 (en) | 1993-03-26 | 1994-10-13 | Shell Internationale Research Maatschappij B.V. | Herbicidal 1-heteroaryl pyrazolidin-3,5-diones |
| US5389504A (en) | 1993-06-24 | 1995-02-14 | Eastman Kodak Company | Color photographic elements containing a combination of pyrazolone and pyrazoloazole couplers |
| EP0690345B1 (en) | 1994-06-23 | 2001-09-05 | Eastman Kodak Company | Two-equivalent magenta photographic couplers with activity-modifying ballasting groups |
| EP0795548B1 (en) | 1995-09-28 | 2002-07-03 | Suntory Limited | Quinazoline derivatives and use thereof |
| WO1998024785A1 (en) | 1996-12-02 | 1998-06-11 | Fujisawa Pharmaceutical Co., Ltd. | Indole-urea derivatives with 5-ht antagonist properties |
| US5821043A (en) | 1996-12-30 | 1998-10-13 | Eastman Kodak Company | 1,2,4-triazole-releasing pyrazolone DIR couplers |
| ZA981934B (en) | 1997-03-10 | 1999-09-06 | Rhone Poulenc Agrochimie | Pesticidal 1-aryl-3-iminopyrazoles. |
| US5958662A (en) | 1997-03-25 | 1999-09-28 | Eastman Kodak Company | Photographic element containing a DIR coupler |
| US5942381A (en) | 1997-06-12 | 1999-08-24 | Eastman Kodak Company | Photographic element and process employing active, stable benzotriazole-releasing DIR couplers |
| US5998424A (en) | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
| CA2302937C (en) | 1997-09-05 | 2008-12-16 | Basf Aktiengesellschaft | Method for producing (hetero)aromatic hydroxylamines |
| DE19804486A1 (de) | 1998-02-05 | 1999-08-12 | Basf Ag | 2-(Pyrazolyloxy)-pyridin-3-ylessigsäure- Derivate, sie enthaltende Mittel und ihr |
| US6121271A (en) | 1998-05-12 | 2000-09-19 | American Home Products Corporation | Naphtho[2,3-B]heteroar-4-yl derivatives |
| US6010839A (en) | 1998-06-26 | 2000-01-04 | Eastman Kodak Company | Color photographic elements containing yellow-colored magenta dye-forming masking couplers |
| US20030191279A1 (en) | 1999-08-27 | 2003-10-09 | Goldstein Steven Wayne | Urea derivatives useful as anticancer agents |
| US6132943A (en) | 1999-10-14 | 2000-10-17 | Eastman Kodak Company | Color photographic elements containing yellow-colored magenta dye-forming masking couplers |
| JP2001335714A (ja) | 2000-03-22 | 2001-12-04 | Fuji Photo Film Co Ltd | アゾ色素、その製造方法、インクジェット用インク、インクジェット記録方法 |
| JP2003531202A (ja) | 2000-04-25 | 2003-10-21 | ファルマシア・コーポレーション | ３，４−ジ（カルボシクリルまたはヘテロシクリル）チオフェンの位置選択的合成 |
| JP4113323B2 (ja) | 2000-08-07 | 2008-07-09 | 富士フイルム株式会社 | アゾ色素及びそれを含むインクジェット記録用インク、並びにインクジェット記録方法 |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| JP2002167531A (ja) | 2000-11-29 | 2002-06-11 | Fuji Photo Film Co Ltd | インクジェット記録用インク組成物及び画像形成方法 |
| US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| US6603000B2 (en) | 2001-07-11 | 2003-08-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis for heteroarylamine compounds |
| TWI325302B (en) | 2001-08-13 | 2010-06-01 | Du Pont | Benzoxazinone compounds |
| CA2454298A1 (en) | 2001-08-13 | 2003-02-27 | Gary David Annis | Substituted 1h-dihydropyrazoles, their preparation and use |
| TWI327566B (en) | 2001-08-13 | 2010-07-21 | Du Pont | Novel substituted ihydro 3-halo-1h-pyrazole-5-carboxylates,their preparation and use |
| EP1417176B1 (en) | 2001-08-16 | 2008-12-17 | E.I. Du Pont De Nemours And Company | Substituted anthranilamides for controlling invertebrate pests |
| SE0103644D0 (sv) | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
| WO2003068749A1 (en) | 2002-02-15 | 2003-08-21 | Glaxo Group Limited | Vanilloid receptor modulators |
| WO2004009551A1 (ja) | 2002-07-23 | 2004-01-29 | Kuraray Co., Ltd. | ２位置換ピリジン誘導体の製造方法 |
| TWI326283B (en) | 2002-07-31 | 2010-06-21 | Du Pont | Method for preparing fused oxazinones |
| TWI343376B (en) | 2002-07-31 | 2011-06-11 | Du Pont | Method for preparing 3-halo-4, 5-dihydro-1h-pyrazoles |
| PA8578101A1 (es) | 2002-08-13 | 2004-05-07 | Warner Lambert Co | Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz |
| RU2005115493A (ru) | 2002-10-23 | 2005-11-10 | Баниу Фармасьютикал Ко., Лтд. (Jp) | Способ получения пиразольных соединений |
| ATE469143T1 (de) | 2002-11-15 | 2010-06-15 | Du Pont | Neue insektizide vom anthranilamid-typ |
| DE602004005960T2 (de) | 2003-01-16 | 2008-01-17 | Sb Pharmco Puerto Rico Inc. | Heteroaryl-substituierte pyrrolä2, 3- büpyridin-derivate als crf-rezeptor-antagonisten |
| WO2004071426A2 (en) | 2003-02-11 | 2004-08-26 | Kemia Inc. | Compounds for the treatment of viral infection |
| TWI367882B (en) | 2003-03-26 | 2012-07-11 | Du Pont | Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates |
| ZA200508771B (en) | 2003-06-12 | 2008-04-30 | Du Pont | Method for preparing fused oxazinones |
| WO2005023773A1 (en) | 2003-09-04 | 2005-03-17 | Pfizer Limited | Process for the preparation of substituted aryl pyrazoles |
| GB0323585D0 (en) | 2003-10-08 | 2003-11-12 | Glaxo Group Ltd | Compounds |
| DE102004021564A1 (de) | 2003-11-14 | 2005-07-07 | Bayer Cropscience Ag | Wirkstoffkombinationen mit insektiziden Eigenschaften |
| DE10353281A1 (de) | 2003-11-14 | 2005-06-16 | Bayer Cropscience Ag | Wirkstoffkombination mit insektiziden und akariziden Eigenschaften |
| DE102004006075A1 (de) | 2003-11-14 | 2005-06-16 | Bayer Cropscience Ag | Wirkstoffkombinationen mit insektiziden Eigenschaften |
| WO2005053405A1 (de) | 2003-12-04 | 2005-06-16 | Bayer Cropscience Aktiengesellschaft | Wirkstoffkombinationen mit insektiziden und akariziden eigenschaften |
| WO2005053406A1 (de) | 2003-12-04 | 2005-06-16 | Bayer Cropscience Aktiengesellschaft | Wirkstoffkombinationen mit insektiziden eigenschaften |
| DE10356550A1 (de) | 2003-12-04 | 2005-07-07 | Bayer Cropscience Ag | Wirkstoffkombinationen mit insektiziden Eigenschaften |
| DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| NZ552187A (en) | 2004-06-18 | 2010-08-27 | Millennium Pharm Inc | Thiophene-2-carboxamide derivatives |
| DE102004031100A1 (de) | 2004-06-28 | 2006-01-12 | Bayer Cropscience Ag | Anthranilamide |
| DE102004035134A1 (de) | 2004-07-20 | 2006-02-16 | Bayer Cropscience Ag | Selektive Insektizide auf Basis von Halogenalkylnicotinsäurederivaten, Anthranilsäureamiden oder Phthalsäurediamiden und Safenern |
| JP2008510766A (ja) | 2004-08-27 | 2008-04-10 | ゲーペーツェー ビオテック アーゲー | ピリミジン誘導体 |
| WO2006044456A1 (en) | 2004-10-13 | 2006-04-27 | Ptc Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
| JP2008528556A (ja) | 2005-02-01 | 2008-07-31 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の６−ピリジルフェナントリジン |
| WO2006092417A1 (en) | 2005-03-02 | 2006-09-08 | Nycomed Gmbh | 6 -heteroaryl-1, 2, 3,4,4a, 1ob-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders |
| EP1728790A1 (en) | 2005-06-01 | 2006-12-06 | Max-Delbrück-Centrum Für Molekulare Medizin | Shp-2 inhibitors, pharmaceutical compositions comprising them and their use for treating phosphatase-mediated diseases |
| EP1890694A4 (en) | 2005-06-02 | 2010-10-27 | Bayer Cropscience Ag | SUBSTITUTED PHENYLALKYL HETEROARYL DERIVATIVES |
| DE602006011752D1 (de) | 2005-06-24 | 2010-03-04 | Bristol Myers Squibb Co | Als antikoagulationsmittel geeignete phenylglycinamid- und pyridylglycinamidderivate |
| US8143292B2 (en) | 2005-07-07 | 2012-03-27 | Basf Se | N-Thio-anthranilamid compounds and their use as pesticides |
| WO2007131538A1 (en) | 2005-07-15 | 2007-11-22 | Laboratorios Del Dr. Esteve, S.A. | Azepane- or azocane-substituted pyrazoline compounds, their preparation and use as medicaments |
| US7531482B2 (en) | 2005-10-21 | 2009-05-12 | Dow Agrosciences Llc | Thieno-pyrimidine compounds having fungicidal activity |
| JP5243960B2 (ja) | 2005-10-21 | 2013-07-24 | ダウ アグロサイエンシィズ エルエルシー | 殺菌活性を有するチエノ−ピリミジン化合物 |
| US20090088452A1 (en) | 2005-11-22 | 2009-04-02 | Coleman Paul J | Indole Orexin Receptor Antagonists |
| JPWO2007063868A1 (ja) | 2005-11-29 | 2009-05-07 | 東レ株式会社 | アリールメチレンウレア誘導体及びその用途 |
| EP1959959B1 (en) | 2005-12-06 | 2013-04-10 | Merck Sharp & Dohme Corp. | Morpholine carboxamide prokineticin receptor antagonists |
| DE102005059470A1 (de) | 2005-12-13 | 2007-06-14 | Bayer Cropscience Ag | Insektizide Zusammensetzungen mit verbesserter Wirkung |
| RU2462246C2 (ru) | 2006-03-30 | 2012-09-27 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней |
| KR101325062B1 (ko) | 2006-05-19 | 2013-11-05 | 삼성디스플레이 주식회사 | 발광 이종 핵 구리-이리듐 착체 및 이를 이용한 유기 전계발광 소자 |
| KR20090029274A (ko) | 2006-07-21 | 2009-03-20 | 아이알엠 엘엘씨 | Ｉｔｐｋｂ 억제제로서의 화합물 및 조성물 |
| WO2008023235A1 (en) | 2006-08-25 | 2008-02-28 | Pfizer Products Inc. | Pyrazole derivatives as anti-platelet and anti-thrombotic agents |
| EP2527345B1 (en) | 2006-10-16 | 2015-12-16 | Thesan Pharmaceuticals, Inc. | Therapeutic pyrazolyl thienopyridines |
| CN101679297B (zh) * | 2006-12-08 | 2012-01-11 | 埃克塞利希斯股份有限公司 | Lxr和fxr调节剂 |
| CN101611007A (zh) | 2006-12-20 | 2009-12-23 | 先灵公司 | 新颖的jnk抑制剂 |
| EP1958934A1 (en) | 2007-02-16 | 2008-08-20 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalenylamides, a process for their production and their use as anti-inflammatory agents |
| WO2008106202A1 (en) | 2007-02-27 | 2008-09-04 | Housey Gerard M | Theramutein modulators |
| EP2133331A4 (en) | 2007-04-11 | 2011-06-22 | Kissei Pharmaceutical | FIVE-GLASS HETEROCYCLIC DERIVATIVE AND ITS USE IN MEDICAL PURPOSES |
| US8071035B2 (en) | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
| WO2008128335A1 (en) | 2007-04-20 | 2008-10-30 | Merck Frosst Canada Ltd. | Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| US20100137312A1 (en) | 2007-05-15 | 2010-06-03 | Neurosearch A/S | Novel aromatic heterocyclic carboxylic acid amide derivatives useful as potassium channel modulators |
| US7776877B2 (en) | 2007-06-22 | 2010-08-17 | Chemocentryx, Inc. | N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides |
| WO2009022171A1 (en) | 2007-08-13 | 2009-02-19 | Astrazeneca Ab | Pyridinyiioxy pyridines as alk5 inhibitors |
| WO2009067603A1 (en) | 2007-11-21 | 2009-05-28 | Bio-Rad Laboratories, Inc. | Photoluminescent metal complexes for protein staining |
| WO2009073973A1 (en) | 2007-12-11 | 2009-06-18 | Merck Frosst Canada Ltd. | Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| CN101932562B (zh) | 2007-12-20 | 2013-06-12 | 阿斯利康(瑞典)有限公司 | 作为dgat1抑制剂190的氨基甲酰基化合物 |
| AU2009206733A1 (en) | 2008-01-25 | 2009-07-30 | Arena Pharmaceuticals, Inc. | Dihydro- 1H- pyrrolo [1,2-a] indol-1-yl carboxylic derivatives which act as S1P1 agonists |
| CN102046179B (zh) | 2008-04-09 | 2015-01-14 | 英菲尼提制药公司 | 脂肪酸酰胺水解酶抑制剂 |
| JP2011523633A (ja) | 2008-05-08 | 2011-08-18 | ブリストル−マイヤーズ スクイブ カンパニー | ２−アリールグリシンアミド誘導体 |
| EP2321262A1 (de) | 2008-08-14 | 2011-05-18 | Bayer CropScience AG | Insektizide 4-phenyl-1h-pyrazole |
| GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
| JP2012506386A (ja) | 2008-10-21 | 2012-03-15 | メタボレックス， インコーポレイテッド | アリールｇｐｒ１２０受容体アゴニストおよびその使用 |
| SG171954A1 (en) | 2008-12-04 | 2011-07-28 | Hoffmann La Roche | Pyridazinone derivatives |
| CN102388059B (zh) | 2009-02-11 | 2015-03-04 | 陶氏益农公司 | 杀虫组合物 |
| US20110059962A1 (en) | 2009-04-22 | 2011-03-10 | Alekshun Michael N | Transcription factor modulating compounds and methods of use thereof |
| US8927551B2 (en) | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US9149465B2 (en) | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US8637674B2 (en) * | 2009-09-02 | 2014-01-28 | Ewha University-Industry Collaboration Foundation | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same |
| KR101280160B1 (ko) | 2009-09-02 | 2013-06-28 | 이화여자대학교 산학협력단 | 피라졸 유도체, 이의 제조방법 및 이를 포함하는 골다공증 예방 및 치료용 조성물 |
| US8394858B2 (en) | 2009-12-03 | 2013-03-12 | Novartis Ag | Cyclohexane derivatives and uses thereof |
| JP2013515000A (ja) | 2009-12-18 | 2013-05-02 | アクティベサイト ファーマシューティカルズ インコーポレイティッド | 血漿カリクレインの阻害薬のプロドラッグ |
| US9051304B2 (en) | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| US8598211B2 (en) | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
| US20130023534A1 (en) | 2010-03-26 | 2013-01-24 | Casillas Linda N | Pyrazolyl-pyrimidines as kinase inhibitors |
| US9024041B2 (en) | 2010-04-08 | 2015-05-05 | Respivert Ltd. | P38 MAP kinase inhibitors |
| SG185515A1 (en) | 2010-05-13 | 2012-12-28 | Amgen Inc | Nitrogen heterocyclic compounds useful as pde10 inhibitors |
| WO2012004293A2 (de) | 2010-07-08 | 2012-01-12 | Bayer Cropscience Ag | Insektizide und fungizide wirkstoffkombinationen |
| US8772304B2 (en) | 2010-11-01 | 2014-07-08 | Boehringer Ingelheim International Gmbh | Benzimidazole inhibitors of leukotriene production |
| CA2815179A1 (en) | 2010-11-10 | 2012-05-18 | Actelion Pharmaceuticals Ltd | Lactam derivatives useful as orexin receptor antagonists |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| CN103261188A (zh) | 2010-12-17 | 2013-08-21 | 先正达参股股份有限公司 | 杀虫化合物 |
| EP2592154A1 (en) | 2011-11-09 | 2013-05-15 | Cellzome Ag | Immobilization products and methods for the identification of histone demethylase interacting molecules and for the purification of histone demethylase proteins |
| US8987461B2 (en) | 2012-12-06 | 2015-03-24 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
-
2013
- 2013-12-05 US US14/098,415 patent/US8987461B2/en active Active
- 2013-12-05 MX MX2015007205A patent/MX2015007205A/es unknown
- 2013-12-05 WO PCT/US2013/073424 patent/WO2014089364A1/en not_active Ceased
- 2013-12-05 JP JP2015545854A patent/JP6256771B2/ja not_active Expired - Fee Related
- 2013-12-05 ES ES13861234T patent/ES2834959T3/es active Active
- 2013-12-05 EP EP20194603.5A patent/EP3763367A1/en not_active Withdrawn
- 2013-12-05 CA CA2894399A patent/CA2894399A1/en not_active Abandoned
- 2013-12-05 EP EP13861234.6A patent/EP2928471B1/en active Active
- 2013-12-05 US US14/650,241 patent/US9604961B2/en active Active
-
2015
- 2015-02-24 US US14/630,091 patent/US9107916B2/en active Active
- 2015-06-30 US US14/755,791 patent/US9458129B2/en active Active
-
2016
- 2016-08-08 US US15/230,966 patent/US9714230B2/en active Active
-
2017
- 2017-02-16 US US15/434,472 patent/US10173996B2/en active Active
- 2017-06-09 US US15/619,363 patent/US9908865B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2928471A1 (en) | 2015-10-14 |
| US9714230B2 (en) | 2017-07-25 |
| EP3763367A1 (en) | 2021-01-13 |
| US20160002201A1 (en) | 2016-01-07 |
| ES2834959T3 (es) | 2021-06-21 |
| US20160347733A1 (en) | 2016-12-01 |
| US20170158664A1 (en) | 2017-06-08 |
| US9908865B2 (en) | 2018-03-06 |
| US9604961B2 (en) | 2017-03-28 |
| WO2014089364A1 (en) | 2014-06-12 |
| EP2928471B1 (en) | 2020-10-14 |
| US9107916B2 (en) | 2015-08-18 |
| US20160068507A1 (en) | 2016-03-10 |
| US20170275266A1 (en) | 2017-09-28 |
| EP2928471A4 (en) | 2016-06-15 |
| JP2016501882A (ja) | 2016-01-21 |
| US9458129B2 (en) | 2016-10-04 |
| JP6256771B2 (ja) | 2018-01-10 |
| US8987461B2 (en) | 2015-03-24 |
| US20150164872A1 (en) | 2015-06-18 |
| US20140194469A1 (en) | 2014-07-10 |
| CA2894399A1 (en) | 2014-06-12 |
| US10173996B2 (en) | 2019-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2015007205A (es) | Inhibidores de la desmetilasa de histona. | |
| SA515360657B1 (ar) | مثبطات ديميثيلاز هيستون | |
| MX2020010496A (es) | Inhibidores de desmetilasa-1 especifica de lisina. | |
| TW201613882A (en) | Histone demethylase inhibitors | |
| PH12017502141A1 (en) | Compounds and their methods of use | |
| MX381597B (es) | Inhibidores demetilasa-1 específica de lisina. | |
| MX376632B (es) | Inhibidores de demetilasa-1 especifica de lisina. | |
| MX376207B (es) | Inhibidores de demetilasa-1 especifica de lisina. | |
| MX391865B (es) | Inhibidores de demetilasa-1 especifica de lisina. | |
| MX2017003464A (es) | Inhibidores de histona desmetilasa. | |
| MX2017003466A (es) | Inhibidores de histona desmetilasa. | |
| MX359656B (es) | Derivados de oxoquinazolinil-butanamida. | |
| MX2017003463A (es) | Inhibidores de histona desmetilasa. | |
| MY159995A (en) | Pyrimidinyl indole compounds | |
| UA110793C2 (uk) | Піразолілхіноксалінові інгібітори кінази |