MX376207B - Inhibidores de demetilasa-1 especifica de lisina. - Google Patents

Inhibidores de demetilasa-1 especifica de lisina.

Info

Publication number
MX376207B
MX376207B MX2017000168A MX2017000168A MX376207B MX 376207 B MX376207 B MX 376207B MX 2017000168 A MX2017000168 A MX 2017000168A MX 2017000168 A MX2017000168 A MX 2017000168A MX 376207 B MX376207 B MX 376207B
Authority
MX
Mexico
Prior art keywords
cancer
compositions
compounds
lysine
specific demethylase
Prior art date
Application number
MX2017000168A
Other languages
English (en)
Other versions
MX2017000168A (es
Inventor
James Marvin Veal
Jeffrey Alan Stafford
Toufike Kanouni
Young K Chen
Zhe Nie
Original Assignee
Celgene Quanticel Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Quanticel Res Inc filed Critical Celgene Quanticel Res Inc
Publication of MX2017000168A publication Critical patent/MX2017000168A/es
Publication of MX376207B publication Critical patent/MX376207B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyamides (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se relaciona generalmente a composiciones y métodos para tratar cáncer y enfermedad neoplásica. Se proporcionan en la presente compuestos derivados heterocíclicos sustituidos y composiciones farmacéuticas que comprenden los compuestos. Los presentes compuestos y composiciones son útiles para la inhibición de demetilasa-1 específica de lisina. Además, los presentes compuestos y composiciones son útiles para el tratamiento de cáncer, tales como cáncer de próstata, cáncer de seno, cáncer de vejiga, cáncer de pulmón y/o melanoma y los similares.
MX2017000168A 2014-07-03 2015-06-29 Inhibidores de demetilasa-1 especifica de lisina. MX376207B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462020886P 2014-07-03 2014-07-03
PCT/US2015/038345 WO2016003917A1 (en) 2014-07-03 2015-06-29 Inhibitors of lysine specific demethylase-1

Publications (2)

Publication Number Publication Date
MX2017000168A MX2017000168A (es) 2017-05-01
MX376207B true MX376207B (es) 2025-03-07

Family

ID=55019883

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020010900A MX395534B (es) 2014-07-03 2015-06-29 Inhibidores de demetilasa-1 especifica de lisina.
MX2017000168A MX376207B (es) 2014-07-03 2015-06-29 Inhibidores de demetilasa-1 especifica de lisina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020010900A MX395534B (es) 2014-07-03 2015-06-29 Inhibidores de demetilasa-1 especifica de lisina.

Country Status (29)

Country Link
US (3) US9902719B2 (es)
EP (2) EP3164380B1 (es)
JP (2) JP6663866B2 (es)
KR (1) KR102475498B1 (es)
CN (2) CN106795103B (es)
AU (1) AU2015284383B2 (es)
BR (1) BR112017000043A2 (es)
CA (1) CA2954049A1 (es)
CL (1) CL2016003422A1 (es)
CO (1) CO2017000549A2 (es)
CY (1) CY1125127T1 (es)
DK (2) DK3164380T3 (es)
EA (2) EA033698B1 (es)
EC (1) ECSP17006821A (es)
ES (2) ES2907676T3 (es)
FI (1) FI3511319T3 (es)
HR (2) HRP20220414T1 (es)
HU (2) HUE058852T2 (es)
IL (2) IL249881B (es)
LT (2) LT3164380T (es)
MX (2) MX395534B (es)
PL (2) PL3164380T3 (es)
PT (2) PT3164380T (es)
RS (2) RS64423B1 (es)
SA (1) SA517380651B1 (es)
SG (2) SG10201802501RA (es)
SI (2) SI3164380T1 (es)
SM (2) SMT202200136T1 (es)
WO (1) WO2016003917A1 (es)

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CN108530424A (zh) 2018-09-14
CA2954049A1 (en) 2016-01-07
FI3511319T3 (fi) 2023-07-20
EP3164380B1 (en) 2022-02-09
CY1125127T1 (el) 2024-02-16
IL249881A0 (en) 2017-03-30
SI3164380T1 (sl) 2022-06-30
RS63074B1 (sr) 2022-04-29
DK3511319T3 (da) 2023-07-31
SA517380651B1 (ar) 2020-09-30
LT3164380T (lt) 2022-06-27
IL249881B (en) 2020-01-30
EA201790085A1 (ru) 2017-08-31
JP6768857B2 (ja) 2020-10-14
SMT202300205T1 (it) 2023-09-06
PL3164380T3 (pl) 2022-04-04
KR102475498B1 (ko) 2022-12-07
PT3164380T (pt) 2022-03-02
JP2017525668A (ja) 2017-09-07
EA033698B1 (ru) 2019-11-18
ES2907676T3 (es) 2022-04-26
IL272130B (en) 2021-03-25
WO2016003917A1 (en) 2016-01-07
CN106795103A (zh) 2017-05-31
LT3511319T (lt) 2023-08-25
US10100046B2 (en) 2018-10-16
MX2017000168A (es) 2017-05-01
US20180127408A1 (en) 2018-05-10
SMT202200136T1 (it) 2022-05-12
EP3511319B1 (en) 2023-05-03
BR112017000043A2 (pt) 2018-07-17
MX395534B (es) 2025-03-25
EP3164380A4 (en) 2018-07-18
RS64423B1 (sr) 2023-09-29
CL2016003422A1 (es) 2017-11-10
PL3511319T3 (pl) 2023-09-11
CN106795103B (zh) 2019-07-12
US20170129882A1 (en) 2017-05-11
AU2015284383B2 (en) 2019-04-18
CO2017000549A2 (es) 2017-04-20
ES2948782T3 (es) 2023-09-19
CN108530424B (zh) 2021-10-01
KR20170018100A (ko) 2017-02-15
EP3511319A1 (en) 2019-07-17
HUE062558T2 (hu) 2023-11-28
ECSP17006821A (es) 2017-03-31
SG11201610975RA (en) 2017-01-27
US9902719B2 (en) 2018-02-27
US20190002456A1 (en) 2019-01-03
PT3511319T (pt) 2023-06-29
EA201891526A3 (ru) 2019-05-31
IL272130A (en) 2020-03-31
SG10201802501RA (en) 2018-05-30
EA201891526A2 (ru) 2018-12-28
MX2020010900A (es) 2022-09-13
EP3164380A1 (en) 2017-05-10
JP2019108346A (ja) 2019-07-04
SI3511319T1 (sl) 2023-10-30
DK3164380T3 (da) 2022-03-28
HUE058852T2 (hu) 2022-09-28
AU2015284383A1 (en) 2017-02-02
JP6663866B2 (ja) 2020-03-13
HRP20230595T1 (hr) 2023-09-15
HRP20220414T1 (hr) 2022-05-27

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