ES2834959T3 - Inhibidores de histona desmetilasa - Google Patents
Inhibidores de histona desmetilasa Download PDFInfo
- Publication number
- ES2834959T3 ES2834959T3 ES13861234T ES13861234T ES2834959T3 ES 2834959 T3 ES2834959 T3 ES 2834959T3 ES 13861234 T ES13861234 T ES 13861234T ES 13861234 T ES13861234 T ES 13861234T ES 2834959 T3 ES2834959 T3 ES 2834959T3
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- Prior art keywords
- pyrazol
- pyridine
- alkyl
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003118 aryl group Chemical group 0.000 claims abstract description 128
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- 125000004446 heteroarylalkyl group Chemical group 0.000 claims abstract description 88
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 35
- 125000003709 fluoroalkyl group Chemical group 0.000 claims abstract description 20
- 125000001424 substituent group Chemical group 0.000 claims abstract description 12
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- NEPPSDXLISKMNU-UHFFFAOYSA-N 5-chloro-2-(hydroxymethyl)phenol Chemical compound OCC1=CC=C(Cl)C=C1O NEPPSDXLISKMNU-UHFFFAOYSA-N 0.000 description 12
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- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 125000005455 trithianyl group Chemical group 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201261734330P | 2012-12-06 | 2012-12-06 | |
| US201361784414P | 2013-03-14 | 2013-03-14 | |
| PCT/US2013/073424 WO2014089364A1 (en) | 2012-12-06 | 2013-12-05 | Histone demethylase inhibitors |
Publications (1)
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| ES2834959T3 true ES2834959T3 (es) | 2021-06-21 |
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| ES13861234T Active ES2834959T3 (es) | 2012-12-06 | 2013-12-05 | Inhibidores de histona desmetilasa |
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| EP (2) | EP3763367A1 (enExample) |
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-
2013
- 2013-12-05 EP EP20194603.5A patent/EP3763367A1/en not_active Withdrawn
- 2013-12-05 MX MX2015007205A patent/MX2015007205A/es unknown
- 2013-12-05 JP JP2015545854A patent/JP6256771B2/ja not_active Expired - Fee Related
- 2013-12-05 ES ES13861234T patent/ES2834959T3/es active Active
- 2013-12-05 EP EP13861234.6A patent/EP2928471B1/en active Active
- 2013-12-05 US US14/650,241 patent/US9604961B2/en active Active
- 2013-12-05 CA CA2894399A patent/CA2894399A1/en not_active Abandoned
- 2013-12-05 US US14/098,415 patent/US8987461B2/en active Active
- 2013-12-05 WO PCT/US2013/073424 patent/WO2014089364A1/en not_active Ceased
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2015
- 2015-02-24 US US14/630,091 patent/US9107916B2/en active Active
- 2015-06-30 US US14/755,791 patent/US9458129B2/en active Active
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2016
- 2016-08-08 US US15/230,966 patent/US9714230B2/en active Active
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2017
- 2017-02-16 US US15/434,472 patent/US10173996B2/en active Active
- 2017-06-09 US US15/619,363 patent/US9908865B2/en active Active
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| US9107916B2 (en) | 2015-08-18 |
| US9908865B2 (en) | 2018-03-06 |
| WO2014089364A1 (en) | 2014-06-12 |
| US20140194469A1 (en) | 2014-07-10 |
| US10173996B2 (en) | 2019-01-08 |
| US20170275266A1 (en) | 2017-09-28 |
| US20160068507A1 (en) | 2016-03-10 |
| US9714230B2 (en) | 2017-07-25 |
| US9604961B2 (en) | 2017-03-28 |
| US20170158664A1 (en) | 2017-06-08 |
| MX2015007205A (es) | 2016-03-31 |
| JP6256771B2 (ja) | 2018-01-10 |
| EP2928471B1 (en) | 2020-10-14 |
| EP3763367A1 (en) | 2021-01-13 |
| US8987461B2 (en) | 2015-03-24 |
| EP2928471A1 (en) | 2015-10-14 |
| CA2894399A1 (en) | 2014-06-12 |
| US20160347733A1 (en) | 2016-12-01 |
| US9458129B2 (en) | 2016-10-04 |
| US20150164872A1 (en) | 2015-06-18 |
| EP2928471A4 (en) | 2016-06-15 |
| JP2016501882A (ja) | 2016-01-21 |
| US20160002201A1 (en) | 2016-01-07 |
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