MX2015005662A - Analogos de insulina de una sola cadena de larga accion. - Google Patents

Analogos de insulina de una sola cadena de larga accion.

Info

Publication number
MX2015005662A
MX2015005662A MX2015005662A MX2015005662A MX2015005662A MX 2015005662 A MX2015005662 A MX 2015005662A MX 2015005662 A MX2015005662 A MX 2015005662A MX 2015005662 A MX2015005662 A MX 2015005662A MX 2015005662 A MX2015005662 A MX 2015005662A
Authority
MX
Mexico
Prior art keywords
insulin
gly
arg
leu
chain
Prior art date
Application number
MX2015005662A
Other languages
English (en)
Spanish (es)
Inventor
Michael Weiss
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Publication of MX2015005662A publication Critical patent/MX2015005662A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
MX2015005662A 2012-11-05 2013-11-05 Analogos de insulina de una sola cadena de larga accion. MX2015005662A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261722350P 2012-11-05 2012-11-05
PCT/US2013/068585 WO2014071405A2 (en) 2012-11-05 2013-11-05 Long-acting single-chain insulin analogues

Publications (1)

Publication Number Publication Date
MX2015005662A true MX2015005662A (es) 2015-08-20

Family

ID=50628271

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005662A MX2015005662A (es) 2012-11-05 2013-11-05 Analogos de insulina de una sola cadena de larga accion.

Country Status (15)

Country Link
US (2) US9499600B2 (cg-RX-API-DMAC7.html)
EP (1) EP2914620B1 (cg-RX-API-DMAC7.html)
JP (1) JP6584953B2 (cg-RX-API-DMAC7.html)
KR (1) KR102163936B1 (cg-RX-API-DMAC7.html)
CN (2) CN105008395B (cg-RX-API-DMAC7.html)
AU (1) AU2013337250B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015010194B1 (cg-RX-API-DMAC7.html)
CA (1) CA2890719C (cg-RX-API-DMAC7.html)
EA (1) EA201590882A1 (cg-RX-API-DMAC7.html)
ES (1) ES2694418T3 (cg-RX-API-DMAC7.html)
IL (1) IL238651B (cg-RX-API-DMAC7.html)
MX (1) MX2015005662A (cg-RX-API-DMAC7.html)
PH (1) PH12015500989A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201503522RA (cg-RX-API-DMAC7.html)
WO (1) WO2014071405A2 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
EP2877200B1 (en) * 2012-07-17 2019-05-08 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
KR102351111B1 (ko) 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
CZ308383B6 (cs) * 2014-06-30 2020-07-15 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Derivát inzulinu s cyklickou strukturou v C-konci B-řetězce
BR112017004544A2 (pt) * 2014-10-06 2018-01-23 Univ Case Western Reserve insulina de cadeia simples, composição farmacêutica e método para tratar diabetes mellitus
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
EP3393498A4 (en) 2015-12-23 2019-08-07 Case Western Reserve University SECULATION OF ULTRASTABILEN INSULIN ANALOGUE WITH POLYMER MELTS
CN113330025A (zh) * 2018-11-19 2021-08-31 卡斯西部储备大学 具有聚丙氨酸c结构域子区段的单链胰岛素类似物
KR20210102347A (ko) 2018-12-11 2021-08-19 사노피 인슐린 수용체 결합 친화성이 감소된 인슐린 유사체
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
KR20220112817A (ko) * 2019-12-10 2022-08-11 사노피 설폰아미드 및 폴리펩티드의 콘주게이트를 형성하는 방법
CN118201954A (zh) 2021-09-20 2024-06-14 克云生物科技股份公司 精氨酸酶-胰岛素融合蛋白

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
EP1193272B1 (en) * 2000-10-02 2004-06-30 Yonsei University Single-chain insulin analogs
EP1620465A2 (en) * 2003-04-29 2006-02-01 Eli Lilly And Company Insulin analogs having protracted time action
KR100508616B1 (ko) * 2003-06-20 2005-08-17 신항철 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그
EP1692168B1 (en) * 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
WO2008043033A2 (en) * 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
EP2296692A4 (en) * 2008-04-22 2012-06-06 Univ Case Western Reserve ISOFORM-SPECIFIC INSULIN ANALOG
CN102596175A (zh) * 2009-07-06 2012-07-18 赛诺菲-安万特德国有限公司 含有甲硫氨酸的水性胰岛素制备物
US20120241356A1 (en) 2009-07-06 2012-09-27 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
KR20150021011A (ko) * 2011-10-27 2015-02-27 케이스 웨스턴 리저브 유니버시티 초고도 농축된, 속효성 인슐린 유사체 제형
EP2804621A4 (en) * 2012-01-20 2015-11-18 Univ Case Western Reserve GLUTAMINE-SAFE STABILIZED INSULIN ANALOG
EP3395358B1 (en) * 2012-09-26 2019-11-06 Indiana University Research and Technology Corporation Insulin analog dimers

Also Published As

Publication number Publication date
EP2914620A2 (en) 2015-09-09
JP2016506366A (ja) 2016-03-03
CN105008395B (zh) 2020-12-29
EA201590882A1 (ru) 2015-09-30
WO2014071405A3 (en) 2014-08-21
US20150274803A1 (en) 2015-10-01
AU2013337250B2 (en) 2017-06-22
BR112015010194A2 (pt) 2017-12-12
KR20150096387A (ko) 2015-08-24
WO2014071405A2 (en) 2014-05-08
US9499600B2 (en) 2016-11-22
EP2914620B1 (en) 2018-08-08
PH12015500989A1 (en) 2015-07-13
EP2914620A4 (en) 2016-05-25
CN105008395A (zh) 2015-10-28
US9975940B2 (en) 2018-05-22
ES2694418T3 (es) 2018-12-20
JP6584953B2 (ja) 2019-10-02
IL238651B (en) 2020-03-31
CA2890719C (en) 2023-02-14
IL238651A0 (en) 2015-06-30
CA2890719A1 (en) 2014-05-08
CN112266414A (zh) 2021-01-26
US20170137488A1 (en) 2017-05-18
BR112015010194B1 (pt) 2022-03-22
KR102163936B1 (ko) 2020-10-13
SG11201503522RA (en) 2015-06-29

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