JP6584953B2 - 長時間作用型単鎖インスリン類似体 - Google Patents

長時間作用型単鎖インスリン類似体 Download PDF

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Publication number
JP6584953B2
JP6584953B2 JP2015541857A JP2015541857A JP6584953B2 JP 6584953 B2 JP6584953 B2 JP 6584953B2 JP 2015541857 A JP2015541857 A JP 2015541857A JP 2015541857 A JP2015541857 A JP 2015541857A JP 6584953 B2 JP6584953 B2 JP 6584953B2
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insulin
arg
xaa
gly
leu
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Japanese (ja)
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JP2016506366A (ja
JP2016506366A5 (cg-RX-API-DMAC7.html
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ワイス、マイケル
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Case Western Reserve University
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Case Western Reserve University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
JP2015541857A 2012-11-05 2013-11-05 長時間作用型単鎖インスリン類似体 Expired - Fee Related JP6584953B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722350P 2012-11-05 2012-11-05
US61/722,350 2012-11-05
PCT/US2013/068585 WO2014071405A2 (en) 2012-11-05 2013-11-05 Long-acting single-chain insulin analogues

Publications (3)

Publication Number Publication Date
JP2016506366A JP2016506366A (ja) 2016-03-03
JP2016506366A5 JP2016506366A5 (cg-RX-API-DMAC7.html) 2016-12-15
JP6584953B2 true JP6584953B2 (ja) 2019-10-02

Family

ID=50628271

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015541857A Expired - Fee Related JP6584953B2 (ja) 2012-11-05 2013-11-05 長時間作用型単鎖インスリン類似体

Country Status (15)

Country Link
US (2) US9499600B2 (cg-RX-API-DMAC7.html)
EP (1) EP2914620B1 (cg-RX-API-DMAC7.html)
JP (1) JP6584953B2 (cg-RX-API-DMAC7.html)
KR (1) KR102163936B1 (cg-RX-API-DMAC7.html)
CN (2) CN105008395B (cg-RX-API-DMAC7.html)
AU (1) AU2013337250B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015010194B1 (cg-RX-API-DMAC7.html)
CA (1) CA2890719C (cg-RX-API-DMAC7.html)
EA (1) EA201590882A1 (cg-RX-API-DMAC7.html)
ES (1) ES2694418T3 (cg-RX-API-DMAC7.html)
IL (1) IL238651B (cg-RX-API-DMAC7.html)
MX (1) MX2015005662A (cg-RX-API-DMAC7.html)
PH (1) PH12015500989A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201503522RA (cg-RX-API-DMAC7.html)
WO (1) WO2014071405A2 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2877200B1 (en) * 2012-07-17 2019-05-08 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
CN106102763A (zh) 2014-01-13 2016-11-09 塞尔玛琳糖尿病有限责任公司 速效胰岛素制剂和药物递送系统
CZ308383B6 (cs) * 2014-06-30 2020-07-15 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Derivát inzulinu s cyklickou strukturou v C-konci B-řetězce
KR102569743B1 (ko) * 2014-10-06 2023-08-23 케이스 웨스턴 리저브 유니버시티 이상 단일 사슬 인슐린 유사체
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
WO2020106748A1 (en) * 2018-11-19 2020-05-28 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
EP3893934B1 (en) 2018-12-11 2025-09-10 Sanofi Insulin conjugates
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
KR20220112817A (ko) * 2019-12-10 2022-08-11 사노피 설폰아미드 및 폴리펩티드의 콘주게이트를 형성하는 방법
EP4405384A1 (en) 2021-09-20 2024-07-31 Kyon Biotech AG Arginase-insulin fusion protein

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60104069T2 (de) * 2000-10-02 2005-08-25 Yonsei University Einkettige Insulinanaloge
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
BRPI0409600A (pt) * 2003-04-29 2006-04-18 Lilly Co Eli análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina
KR100508616B1 (ko) * 2003-06-20 2005-08-17 신항철 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그
AU2004295023A1 (en) * 2003-12-03 2005-06-16 Novo Nordisk A/S Single-chain insulin
ES2554773T3 (es) * 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
CA2722168A1 (en) * 2008-04-22 2009-10-29 Case Western Reserve University Isoform-specific insulin analogues
TWI520745B (zh) * 2009-07-06 2016-02-11 賽諾菲阿凡提斯德意志有限公司 含甲硫胺酸之胰島素製劑
TW201105346A (en) 2009-07-06 2011-02-16 Sanofi Aventis Deutschland Heat-stable and vibration-stable insulin preparations
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
AU2012328407A1 (en) * 2011-10-27 2014-05-22 Case Western Reserve University Ultra-concentrated rapid-acting insulin analogue formulations
CA2898730A1 (en) * 2012-01-20 2013-07-25 Case Western Reserve University Glutamic acid-stabilized insulin analogues
CA2886228A1 (en) * 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Insulin analog dimers

Also Published As

Publication number Publication date
CN105008395A (zh) 2015-10-28
WO2014071405A2 (en) 2014-05-08
AU2013337250B2 (en) 2017-06-22
KR102163936B1 (ko) 2020-10-13
CN112266414A (zh) 2021-01-26
US20170137488A1 (en) 2017-05-18
US9499600B2 (en) 2016-11-22
US9975940B2 (en) 2018-05-22
MX2015005662A (es) 2015-08-20
US20150274803A1 (en) 2015-10-01
WO2014071405A3 (en) 2014-08-21
EP2914620A2 (en) 2015-09-09
CA2890719A1 (en) 2014-05-08
JP2016506366A (ja) 2016-03-03
CN105008395B (zh) 2020-12-29
SG11201503522RA (en) 2015-06-29
CA2890719C (en) 2023-02-14
EA201590882A1 (ru) 2015-09-30
IL238651A0 (en) 2015-06-30
KR20150096387A (ko) 2015-08-24
PH12015500989A1 (en) 2015-07-13
BR112015010194B1 (pt) 2022-03-22
BR112015010194A2 (pt) 2017-12-12
IL238651B (en) 2020-03-31
EP2914620A4 (en) 2016-05-25
ES2694418T3 (es) 2018-12-20
EP2914620B1 (en) 2018-08-08

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