AU2013337250B2 - Long-acting single-chain insulin analogues - Google Patents

Long-acting single-chain insulin analogues Download PDF

Info

Publication number
AU2013337250B2
AU2013337250B2 AU2013337250A AU2013337250A AU2013337250B2 AU 2013337250 B2 AU2013337250 B2 AU 2013337250B2 AU 2013337250 A AU2013337250 A AU 2013337250A AU 2013337250 A AU2013337250 A AU 2013337250A AU 2013337250 B2 AU2013337250 B2 AU 2013337250B2
Authority
AU
Australia
Prior art keywords
insulin
gly
chain
arg
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013337250A
Other languages
English (en)
Other versions
AU2013337250A1 (en
Inventor
Michael Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of AU2013337250A1 publication Critical patent/AU2013337250A1/en
Application granted granted Critical
Publication of AU2013337250B2 publication Critical patent/AU2013337250B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
AU2013337250A 2012-11-05 2013-11-05 Long-acting single-chain insulin analogues Ceased AU2013337250B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722350P 2012-11-05 2012-11-05
US61/722,350 2012-11-05
PCT/US2013/068585 WO2014071405A2 (en) 2012-11-05 2013-11-05 Long-acting single-chain insulin analogues

Publications (2)

Publication Number Publication Date
AU2013337250A1 AU2013337250A1 (en) 2015-06-25
AU2013337250B2 true AU2013337250B2 (en) 2017-06-22

Family

ID=50628271

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013337250A Ceased AU2013337250B2 (en) 2012-11-05 2013-11-05 Long-acting single-chain insulin analogues

Country Status (15)

Country Link
US (2) US9499600B2 (cg-RX-API-DMAC7.html)
EP (1) EP2914620B1 (cg-RX-API-DMAC7.html)
JP (1) JP6584953B2 (cg-RX-API-DMAC7.html)
KR (1) KR102163936B1 (cg-RX-API-DMAC7.html)
CN (2) CN105008395B (cg-RX-API-DMAC7.html)
AU (1) AU2013337250B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015010194B1 (cg-RX-API-DMAC7.html)
CA (1) CA2890719C (cg-RX-API-DMAC7.html)
EA (1) EA201590882A1 (cg-RX-API-DMAC7.html)
ES (1) ES2694418T3 (cg-RX-API-DMAC7.html)
IL (1) IL238651B (cg-RX-API-DMAC7.html)
MX (1) MX2015005662A (cg-RX-API-DMAC7.html)
PH (1) PH12015500989A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201503522RA (cg-RX-API-DMAC7.html)
WO (1) WO2014071405A2 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2877200B1 (en) * 2012-07-17 2019-05-08 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
CN106102763A (zh) 2014-01-13 2016-11-09 塞尔玛琳糖尿病有限责任公司 速效胰岛素制剂和药物递送系统
CZ308383B6 (cs) * 2014-06-30 2020-07-15 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Derivát inzulinu s cyklickou strukturou v C-konci B-řetězce
KR102569743B1 (ko) * 2014-10-06 2023-08-23 케이스 웨스턴 리저브 유니버시티 이상 단일 사슬 인슐린 유사체
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
WO2020106748A1 (en) * 2018-11-19 2020-05-28 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
EP3893934B1 (en) 2018-12-11 2025-09-10 Sanofi Insulin conjugates
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
KR20220112817A (ko) * 2019-12-10 2022-08-11 사노피 설폰아미드 및 폴리펩티드의 콘주게이트를 형성하는 방법
EP4405384A1 (en) 2021-09-20 2024-07-31 Kyon Biotech AG Arginase-insulin fusion protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8192957B2 (en) * 2006-10-04 2012-06-05 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60104069T2 (de) * 2000-10-02 2005-08-25 Yonsei University Einkettige Insulinanaloge
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
BRPI0409600A (pt) * 2003-04-29 2006-04-18 Lilly Co Eli análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina
KR100508616B1 (ko) * 2003-06-20 2005-08-17 신항철 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그
AU2004295023A1 (en) * 2003-12-03 2005-06-16 Novo Nordisk A/S Single-chain insulin
CA2722168A1 (en) * 2008-04-22 2009-10-29 Case Western Reserve University Isoform-specific insulin analogues
TWI520745B (zh) * 2009-07-06 2016-02-11 賽諾菲阿凡提斯德意志有限公司 含甲硫胺酸之胰島素製劑
TW201105346A (en) 2009-07-06 2011-02-16 Sanofi Aventis Deutschland Heat-stable and vibration-stable insulin preparations
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
AU2012328407A1 (en) * 2011-10-27 2014-05-22 Case Western Reserve University Ultra-concentrated rapid-acting insulin analogue formulations
CA2898730A1 (en) * 2012-01-20 2013-07-25 Case Western Reserve University Glutamic acid-stabilized insulin analogues
CA2886228A1 (en) * 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Insulin analog dimers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8192957B2 (en) * 2006-10-04 2012-06-05 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues

Also Published As

Publication number Publication date
CN105008395A (zh) 2015-10-28
WO2014071405A2 (en) 2014-05-08
KR102163936B1 (ko) 2020-10-13
CN112266414A (zh) 2021-01-26
JP6584953B2 (ja) 2019-10-02
US20170137488A1 (en) 2017-05-18
US9499600B2 (en) 2016-11-22
US9975940B2 (en) 2018-05-22
MX2015005662A (es) 2015-08-20
US20150274803A1 (en) 2015-10-01
WO2014071405A3 (en) 2014-08-21
EP2914620A2 (en) 2015-09-09
CA2890719A1 (en) 2014-05-08
JP2016506366A (ja) 2016-03-03
CN105008395B (zh) 2020-12-29
SG11201503522RA (en) 2015-06-29
CA2890719C (en) 2023-02-14
EA201590882A1 (ru) 2015-09-30
IL238651A0 (en) 2015-06-30
KR20150096387A (ko) 2015-08-24
PH12015500989A1 (en) 2015-07-13
BR112015010194B1 (pt) 2022-03-22
BR112015010194A2 (pt) 2017-12-12
IL238651B (en) 2020-03-31
EP2914620A4 (en) 2016-05-25
ES2694418T3 (es) 2018-12-20
EP2914620B1 (en) 2018-08-08

Similar Documents

Publication Publication Date Title
AU2013337250B2 (en) Long-acting single-chain insulin analogues
US11142560B2 (en) Biphasic single-chain insulin analogues
US11174303B2 (en) Single-chain insulin analogues stabilized by a fourth disulfide bridge
AU2013337250A1 (en) Long-acting single-chain insulin analogues
US20220002373A1 (en) Single-chain insulin analogues with poly-alanine c-domain sub-segments
US20160083448A1 (en) Site 2 insulin analogues
EP2948166B1 (en) N-terminal truncated insulin analogues
HK40045373A (en) Long-acting single-chain insulin analogues
US20240043493A1 (en) Acylated single-chain insulin analogues
HK1238651A1 (en) Biphasic single-chain insulin analogues

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired