MX2013002208A - Derivados de sulfonilpiperazina que interactuan con la proteina reguladora de glucocinasa para el tratamiento de diabetes. - Google Patents
Derivados de sulfonilpiperazina que interactuan con la proteina reguladora de glucocinasa para el tratamiento de diabetes.Info
- Publication number
- MX2013002208A MX2013002208A MX2013002208A MX2013002208A MX2013002208A MX 2013002208 A MX2013002208 A MX 2013002208A MX 2013002208 A MX2013002208 A MX 2013002208A MX 2013002208 A MX2013002208 A MX 2013002208A MX 2013002208 A MX2013002208 A MX 2013002208A
- Authority
- MX
- Mexico
- Prior art keywords
- regulatory protein
- diabetes
- interact
- sulfonylpiperazine
- derivatives
- Prior art date
Links
- 102100040880 Glucokinase regulatory protein Human genes 0.000 title abstract 3
- 101710148430 Glucokinase regulatory protein Proteins 0.000 title abstract 3
- ZECNLXUZYQZMAL-UHFFFAOYSA-N 2-sulfonylpiperazine Chemical class O=S(=O)=C1CNCCN1 ZECNLXUZYQZMAL-UHFFFAOYSA-N 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37614110P | 2010-08-23 | 2010-08-23 | |
| US201161492634P | 2011-06-02 | 2011-06-02 | |
| PCT/US2011/048596 WO2012027261A1 (en) | 2010-08-23 | 2011-08-22 | Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes |
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| WO2013123444A1 (en) * | 2012-02-17 | 2013-08-22 | Amgen Inc. | Sulfonyl compounds that interact with glucokinase regulatory protein |
| WO2013173382A1 (en) * | 2012-05-15 | 2013-11-21 | Amgen Inc. | Benzothiophene sulfonamides and other compounds that interact with glucokinase regulatory protein |
| WO2014035872A1 (en) * | 2012-08-27 | 2014-03-06 | Amgen Inc. | Tricyclic alkynes that interact with glucokinase regulatory protein |
| JP6102637B2 (ja) * | 2013-08-22 | 2017-03-29 | Jsr株式会社 | 芳香族ジハライド化合物、重合体、重合体組成物及び成形体 |
| CN108912020B (zh) * | 2018-06-05 | 2021-05-28 | 上海博志研新药物技术有限公司 | 奥当卡替及其中间体的制备方法 |
| US20240124400A1 (en) * | 2019-10-11 | 2024-04-18 | Duke University | Lpxh targeting compounds, compositions thereof, and methods of making and using the same |
| CN114349711B (zh) * | 2022-02-28 | 2023-08-15 | 四川依维欣医药科技有限公司 | 一种(R)-1-Boc-3-羟甲基哌嗪的合成方法 |
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| GB9821199D0 (en) | 1998-09-30 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| PL377091A1 (pl) | 2002-09-06 | 2006-01-23 | Amgen, Inc. | Ludzkie monoklonalne przeciwciało przeciw-IL-1R1, o właściwościach terapeutycznych |
| EP1663193B1 (en) * | 2003-09-12 | 2012-04-04 | Merck Serono SA | Sulfonamide derivatives for the treatment of diabetes |
| FR2874011B1 (fr) | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| GB0505084D0 (en) | 2005-03-11 | 2005-04-20 | Glaxo Group Ltd | Compounds |
| JP2009506988A (ja) | 2005-08-19 | 2009-02-19 | エラン ファーマシューティカルズ,インコーポレイテッド | ガンマセクレターゼの架橋n−環状スルホンアミド阻害剤 |
| CA2632027A1 (en) * | 2005-12-14 | 2007-06-21 | Amgen Inc. | Diaza heterocyclic sulfonamide derivatives and their uses |
| AU2007231594A1 (en) * | 2006-03-23 | 2007-10-04 | Amgen Inc. | 1-phenylsulfonyl-diaza heterocyclic amide compounds and their uses as modulators of hydroxsteroid dehydrogenases |
| US8173645B2 (en) * | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
| BRPI0816881A2 (pt) | 2007-09-21 | 2015-03-17 | Array Biopharma Inc | Composto, composição farmacêutica, uso de um composto, e, métodos para tratar doenças ou distúrbios e para preparar um composto. |
| JPWO2009096198A1 (ja) * | 2008-02-01 | 2011-05-26 | 一般社団法人ファルマIp | 新規ビアリール誘導体 |
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| FR2935380B1 (fr) | 2008-08-29 | 2010-09-10 | Galderma Res & Dev | Nouveaux composes hexafluoro-2-biphenyl-isopropanol, modulateurs des recepteurs de type lxrs, leur procede de preparation et leur application comme medicaments en medecine humaine ou veterinaire ainsi qu'en cosmetique. |
| MX2011002705A (es) | 2008-09-11 | 2011-09-09 | Amgen Inc | Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso. |
| EP2358749B1 (en) | 2008-10-10 | 2018-07-18 | Amgen, Inc | Fgf21 mutants and uses thereof |
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- 2011-08-22 MX MX2013002208A patent/MX2013002208A/es not_active Application Discontinuation
- 2011-08-22 CA CA2808590A patent/CA2808590A1/en not_active Abandoned
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| UY33568A (es) | 2012-03-30 |
| TW201238941A (en) | 2012-10-01 |
| US8431563B2 (en) | 2013-04-30 |
| EP2609081A1 (en) | 2013-07-03 |
| AU2011293584A1 (en) | 2013-03-07 |
| CA2808590A1 (en) | 2012-03-01 |
| AU2011293584B2 (en) | 2014-07-31 |
| US20120225854A1 (en) | 2012-09-06 |
| WO2012027261A1 (en) | 2012-03-01 |
| JP2013536233A (ja) | 2013-09-19 |
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