CA2808590A1 - Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes - Google Patents

Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes Download PDF

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Publication number
CA2808590A1
CA2808590A1 CA2808590A CA2808590A CA2808590A1 CA 2808590 A1 CA2808590 A1 CA 2808590A1 CA 2808590 A CA2808590 A CA 2808590A CA 2808590 A CA2808590 A CA 2808590A CA 2808590 A1 CA2808590 A1 CA 2808590A1
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Canada
Prior art keywords
piperazinyl
phenyl
trifluoro
methyl
propanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2808590A
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English (en)
French (fr)
Inventor
Kate Ashton
Michael David Bartberger
Yunxin Bo
Marian C. Bryan
Michael Croghan
Christopher Harold Fotsch
Clarence Henderson Hale
Roxanne Kay Kunz
Longbin Liu
Nobuko Nishimura
Mark H. Norman
Lewis Dale Pennington
Steve Fong Poon
Markian Myroslaw Stec
David Joseph St. Jean, Jr.
Nuria A. Tamayo
Christopher Michael Tegley
Kevin Chao Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
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Amgen Inc
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Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA2808590A1 publication Critical patent/CA2808590A1/en
Abandoned legal-status Critical Current

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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2808590A 2010-08-23 2011-08-22 Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes Abandoned CA2808590A1 (en)

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PCT/US2011/048596 WO2012027261A1 (en) 2010-08-23 2011-08-22 Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes

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JP6102637B2 (ja) * 2013-08-22 2017-03-29 Jsr株式会社 芳香族ジハライド化合物、重合体、重合体組成物及び成形体
CN108912020B (zh) * 2018-06-05 2021-05-28 上海博志研新药物技术有限公司 奥当卡替及其中间体的制备方法
CN114349711B (zh) * 2022-02-28 2023-08-15 四川依维欣医药科技有限公司 一种（R）-1-Boc-3-羟甲基哌嗪的合成方法

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EP2609081A1 (en) 2013-07-03
AU2011293584A1 (en) 2013-03-07
MX2013002208A (es) 2013-05-30
AU2011293584B2 (en) 2014-07-31
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JP2013536233A (ja) 2013-09-19

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