AU2011293584B2 - Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes - Google Patents
Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes Download PDFInfo
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- AU2011293584B2 AU2011293584B2 AU2011293584A AU2011293584A AU2011293584B2 AU 2011293584 B2 AU2011293584 B2 AU 2011293584B2 AU 2011293584 A AU2011293584 A AU 2011293584A AU 2011293584 A AU2011293584 A AU 2011293584A AU 2011293584 B2 AU2011293584 B2 AU 2011293584B2
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- piperazinyl
- phenyl
- methyl
- trifluoro
- propanol
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37614110P | 2010-08-23 | 2010-08-23 | |
| US61/376,141 | 2010-08-23 | ||
| US201161492634P | 2011-06-02 | 2011-06-02 | |
| US61/492,634 | 2011-06-02 | ||
| PCT/US2011/048596 WO2012027261A1 (en) | 2010-08-23 | 2011-08-22 | Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2011293584A1 AU2011293584A1 (en) | 2013-03-07 |
| AU2011293584B2 true AU2011293584B2 (en) | 2014-07-31 |
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| AU2011293584A Expired - Fee Related AU2011293584B2 (en) | 2010-08-23 | 2011-08-22 | Sulfonylpiperazine derivatives that interact with glucokinase regulatory protein for the treatment of diabetes |
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| EP (1) | EP2609081A1 (enExample) |
| JP (1) | JP2013536233A (enExample) |
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| WO2013123444A1 (en) * | 2012-02-17 | 2013-08-22 | Amgen Inc. | Sulfonyl compounds that interact with glucokinase regulatory protein |
| WO2013173382A1 (en) * | 2012-05-15 | 2013-11-21 | Amgen Inc. | Benzothiophene sulfonamides and other compounds that interact with glucokinase regulatory protein |
| WO2014035872A1 (en) * | 2012-08-27 | 2014-03-06 | Amgen Inc. | Tricyclic alkynes that interact with glucokinase regulatory protein |
| JP6102637B2 (ja) * | 2013-08-22 | 2017-03-29 | Jsr株式会社 | 芳香族ジハライド化合物、重合体、重合体組成物及び成形体 |
| CN108912020B (zh) * | 2018-06-05 | 2021-05-28 | 上海博志研新药物技术有限公司 | 奥当卡替及其中间体的制备方法 |
| US20240124400A1 (en) * | 2019-10-11 | 2024-04-18 | Duke University | Lpxh targeting compounds, compositions thereof, and methods of making and using the same |
| CN114349711B (zh) * | 2022-02-28 | 2023-08-15 | 四川依维欣医药科技有限公司 | 一种(R)-1-Boc-3-羟甲基哌嗪的合成方法 |
Citations (1)
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| WO2007111921A1 (en) * | 2006-03-23 | 2007-10-04 | Amgen Inc. | 1-phenylsulfonyl-diaza heterocyclic amide compounds and their uses as modulators of hydroxsteroid dehydrogenases |
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| GB9821199D0 (en) | 1998-09-30 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| CN104178491B (zh) | 2002-09-06 | 2018-07-03 | 安姆根有限公司 | 治疗性人抗-il-1r1单克隆抗体 |
| US7705052B2 (en) * | 2003-09-12 | 2010-04-27 | Merck Serono Sa | Sulfonamide derivatives for the treatment of diabetes |
| FR2874011B1 (fr) | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| GB0505084D0 (en) | 2005-03-11 | 2005-04-20 | Glaxo Group Ltd | Compounds |
| EP1916985A4 (en) | 2005-08-19 | 2010-06-09 | Elan Pharm Inc | BRIDGED N-CYCLIC SULPHONAMIDE INHIBITORS OF THE GAMMED CRYSTETRY |
| WO2007070506A2 (en) * | 2005-12-14 | 2007-06-21 | Amgen Inc. | Diaza heterocyclic sulfonamide derivatives and their uses |
| WO2008116107A2 (en) * | 2007-03-21 | 2008-09-25 | Takeda San Diego, Inc. | Piperazine derivatives as glucokinase activators |
| UA101166C2 (ru) | 2007-09-21 | 2013-03-11 | Аррей Биофарма Инк. | Производные пиридин-2-иламино-1,2,4-тиадиазола как активаторы глюкокиназы для лечения сахарного диабета |
| WO2009096198A1 (ja) * | 2008-02-01 | 2009-08-06 | Pharma Ip Limited Liability Intermediary Corporations | 新規ビアリール誘導体 |
| MX2010013333A (es) | 2008-06-04 | 2011-04-05 | Amgen Inc | Mutantes fgf21 y usos de los mismos. |
| FR2935380B1 (fr) | 2008-08-29 | 2010-09-10 | Galderma Res & Dev | Nouveaux composes hexafluoro-2-biphenyl-isopropanol, modulateurs des recepteurs de type lxrs, leur procede de preparation et leur application comme medicaments en medecine humaine ou veterinaire ainsi qu'en cosmetique. |
| CA2736130C (en) | 2008-09-11 | 2014-01-14 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use |
| EA032727B1 (ru) | 2008-10-10 | 2019-07-31 | Амген Инк. | Мутантный резистентный к протеолизу полипептид fgf21 и его применение |
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2011
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- 2011-08-22 JP JP2013526063A patent/JP2013536233A/ja active Pending
- 2011-08-22 EP EP11752398.5A patent/EP2609081A1/en not_active Withdrawn
- 2011-08-22 MX MX2013002208A patent/MX2013002208A/es not_active Application Discontinuation
- 2011-08-22 CA CA2808590A patent/CA2808590A1/en not_active Abandoned
- 2011-08-22 AU AU2011293584A patent/AU2011293584B2/en not_active Expired - Fee Related
- 2011-08-23 TW TW100130164A patent/TW201238941A/zh unknown
- 2011-08-23 UY UY0001033568A patent/UY33568A/es not_active Application Discontinuation
- 2011-08-23 US US13/215,914 patent/US8431563B2/en not_active Expired - Fee Related
- 2011-08-23 AR ARP110103068A patent/AR082534A1/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007111921A1 (en) * | 2006-03-23 | 2007-10-04 | Amgen Inc. | 1-phenylsulfonyl-diaza heterocyclic amide compounds and their uses as modulators of hydroxsteroid dehydrogenases |
Also Published As
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|---|---|
| WO2012027261A1 (en) | 2012-03-01 |
| AU2011293584A1 (en) | 2013-03-07 |
| CA2808590A1 (en) | 2012-03-01 |
| AR082534A1 (es) | 2012-12-12 |
| MX2013002208A (es) | 2013-05-30 |
| US8431563B2 (en) | 2013-04-30 |
| JP2013536233A (ja) | 2013-09-19 |
| TW201238941A (en) | 2012-10-01 |
| US20120225854A1 (en) | 2012-09-06 |
| EP2609081A1 (en) | 2013-07-03 |
| UY33568A (es) | 2012-03-30 |
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