MX2012012846A - Composicion oftalmica. - Google Patents
Composicion oftalmica.Info
- Publication number
- MX2012012846A MX2012012846A MX2012012846A MX2012012846A MX2012012846A MX 2012012846 A MX2012012846 A MX 2012012846A MX 2012012846 A MX2012012846 A MX 2012012846A MX 2012012846 A MX2012012846 A MX 2012012846A MX 2012012846 A MX2012012846 A MX 2012012846A
- Authority
- MX
- Mexico
- Prior art keywords
- hyperbranched polyester
- ophthalmic
- carbonic anhydrase
- increases
- ophthalmic composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención proporciona una composición oftálmica que comprende un poliéster hiperramificado. Las composiciones oftálmicas también pueden comprender inhibidores de anhidrasa carbónica, en donde el poliéster hiperramificado aumenta la solubilidad acuosa del inhibidor de anhidrasa carbónica, y aumenta la penetración córnea del agente activo. Las composiciones oftálmicas también pueden comprender agentes tensoactivos no iónicos, tales como PEG, polisorbato, HPMC o HEC, y beta-bloqueadores, tales como Carteolol, Levobunolol, Betaxolol, Metipranolol, Timolol o Propranolol. La concentración del poliéster hiperramificado en la formulación oftálmica no debe ser menor que o igual a 4% (p/v) con el fin de evitar cualquier efecto citotóxico en células córneas humanas y de esta forma la irritación del ojo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/774,419 US8211450B2 (en) | 2010-05-05 | 2010-05-05 | Ophthalmic composition |
PCT/US2011/035147 WO2011140194A1 (en) | 2010-05-05 | 2011-05-04 | Ophthalmic composition |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012012846A true MX2012012846A (es) | 2013-05-22 |
Family
ID=44902332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012012846A MX2012012846A (es) | 2010-05-05 | 2011-05-04 | Composicion oftalmica. |
Country Status (8)
Country | Link |
---|---|
US (2) | US8211450B2 (es) |
EP (1) | EP2566487A4 (es) |
JP (1) | JP2013528589A (es) |
KR (1) | KR20130121685A (es) |
CN (1) | CN103096901A (es) |
CA (1) | CA2797123A1 (es) |
MX (1) | MX2012012846A (es) |
WO (1) | WO2011140194A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103189097B (zh) * | 2010-07-29 | 2016-01-06 | 参天制药株式会社 | 带药剂的支承体及其制造方法 |
WO2013114397A2 (en) * | 2012-01-16 | 2013-08-08 | Biocon Limited | Pharmaceutically acceptable salt of brinzolamide and composition thereof |
US9820991B2 (en) * | 2013-11-08 | 2017-11-21 | Sentiss Pharma Private Limited | Pharmaceutical composition comprising brinzolamide |
CN103740831B (zh) * | 2014-01-13 | 2015-01-28 | 宁波海尔施基因科技有限公司 | 一种指导β-受体阻断药用药的引物组合物、多重基因检测试剂盒及其使用方法 |
JP6487452B2 (ja) * | 2014-01-24 | 2019-03-20 | センティス ファーマ プライベート リミテッド | ブリンゾラミドを含む医薬組成物 |
MX2020008507A (es) | 2014-05-16 | 2022-05-13 | Occidental Chem Co | Metodo para producir 1,1,3,3-tetracloropropeno. |
WO2016006702A1 (ja) * | 2014-07-11 | 2016-01-14 | 富士フイルム株式会社 | 眼科用水性組成物 |
KR101773669B1 (ko) | 2015-07-30 | 2017-08-31 | 포항공과대학교 산학협력단 | 생체적합성 각막세포 전구체 분화방법 및 각막세포 전구체 조성물 |
JP6050454B1 (ja) * | 2015-09-28 | 2016-12-21 | 参天製薬株式会社 | 水性医薬組成物 |
JP6178028B1 (ja) * | 2016-03-14 | 2017-08-09 | 参天製薬株式会社 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
IL275339B2 (en) | 2017-12-15 | 2024-03-01 | Tarsus Pharmaceuticals Inc | Parasitic formulations containing isoxazoline and methods for treating blepharitis |
CA3143071A1 (en) | 2019-07-26 | 2021-02-04 | Proqr Therapeutics Ii B.V. | Ophthalmic compositions comprising viscosifying polymers and nucleic acids |
WO2023140357A1 (ja) * | 2022-01-21 | 2023-07-27 | センジュ ユーエスエー、インコーポレイテッド | 水性液剤 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5136014A (en) * | 1990-06-22 | 1992-08-04 | E. I. Du Pont De Nemours And Company | Hyperbranched polyesters |
IL101537A (en) * | 1991-04-17 | 1997-11-20 | Merck & Co Inc | OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF A CARBONIC ANHYDRASE INHIBITOR AND A b-ADRENERGIC ANTAGONIST |
US6316443B1 (en) * | 1994-08-04 | 2001-11-13 | Merck & Co., Inc. | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist |
DE19726186A1 (de) * | 1997-06-20 | 1998-12-24 | Boehringer Ingelheim Int | Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen |
FR2772771B1 (fr) * | 1997-12-19 | 2000-01-28 | Oreal | Utilisation de polymeres hyperbranches et de dendrimeres comportant un groupement particulier, en tant qu'agent filmogene, les compositions filmogenes les comprenant et leur utilisation notamment en cosmetique ou en pharmacie |
WO2000063409A1 (en) | 1999-04-21 | 2000-10-26 | Massachusetts Institute Of Technology | Endosomolytic agents and cell delivery systems |
US7030097B1 (en) | 1999-07-14 | 2006-04-18 | Cornell Research Foundation, Inc. | Controlled nucleic acid delivery systems |
SK282717B6 (sk) | 2000-03-10 | 2002-11-06 | �Stav Experiment�Lnej Farmakol�Gie Sav | Spôsob prípravy ultravysokomolekulových hyalurónanov |
US7097856B2 (en) | 2000-09-29 | 2006-08-29 | The Regents Of The University Of California | Dendrimeric support or carrier macromolecule |
WO2002067908A1 (en) | 2001-02-26 | 2002-09-06 | Duke University | Novel dendritic polymers and their biomedical uses |
ES2295347T3 (es) | 2001-03-08 | 2008-04-16 | Nymox Pharmaceutical Corporation | Uso de proteinas de la cadena neural para tratar tumores. |
FR2830450B1 (fr) | 2001-10-09 | 2004-02-06 | Univ Pasteur | Utilisation de dendrimeres dans une composition ophtalmique |
AR038269A1 (es) | 2002-01-09 | 2005-01-12 | Novartis Ag | Articulos polimericos que tienen un recubrimiento lubrico, y metodo para fabricarlos |
GB0209022D0 (en) | 2002-04-19 | 2002-05-29 | Imp College Innovations Ltd | Compounds |
WO2004060283A2 (en) | 2002-12-16 | 2004-07-22 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
KR20050111586A (ko) * | 2003-02-13 | 2005-11-25 | 내셔널 센터 포 사이언티픽 리서치 데모크리토스 | 드러그 및 유전자 전달 시스템으로서의 다기능의 덴드리머및 다중결합된 폴리머 |
JP2005008614A (ja) | 2003-03-28 | 2005-01-13 | Nano Career Kk | 高分子ミセルを用いた眼科用ドラッグデリバリーシステム |
US7109247B2 (en) | 2003-05-30 | 2006-09-19 | 3M Innovative Properties Company | Stabilized particle dispersions containing nanoparticles |
US7189456B2 (en) | 2004-03-04 | 2007-03-13 | Transitions Optical, Inc. | Photochromic optical article |
WO2006031358A2 (en) | 2004-08-13 | 2006-03-23 | Hyperbranch Medical Technology, Inc. | Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses |
US20060057215A1 (en) * | 2004-09-15 | 2006-03-16 | Raiche Adrian T | Method for the production of nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility |
US7837986B2 (en) | 2004-12-01 | 2010-11-23 | E. I. Du Pont De Nemours And Company | Protein-based polymer tissue adhesives for medical use |
BRPI0606988A2 (pt) * | 2005-02-21 | 2010-03-23 | Basf Ag | composiÇço, uso de pelo menos um polÍmetro hiper-ramificado contendo Átomos de nitrogÊnio, processo para a preparaÇço de uma composiÇço de substÂncia ativa ou eficaz aquosa, e, agentes cosmÉtico, farmacÊutico, e de proteÇço de planta |
US20060257359A1 (en) | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
US8679536B2 (en) | 2005-08-24 | 2014-03-25 | Actamax Surgical Materials, Llc | Aldol-crosslinked polymeric hydrogel adhesives |
US7666331B2 (en) | 2005-08-31 | 2010-02-23 | Transitions Optical, Inc. | Photochromic article |
CA2636599C (en) | 2006-01-20 | 2014-07-15 | Starpharma Pty Limited | Modified macromolecule |
EP1991277A4 (en) | 2006-03-03 | 2010-12-22 | Dendritic Nanotechnologies Inc | DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS WITH CORE-SHELL TECTO (DENDRITEN POLYMERS) |
US20080031916A1 (en) * | 2006-04-24 | 2008-02-07 | Heather Sheardown | Dendrimer cross-linked collagen |
WO2008027340A2 (en) * | 2006-08-30 | 2008-03-06 | Merck & Co., Inc. | Topical ophthalmic formulations |
WO2008030591A2 (en) | 2006-09-08 | 2008-03-13 | Dendritic Nanotechnologies, Inc. | Peham dendrimers as excipients |
ES2421206T3 (es) * | 2006-11-09 | 2013-08-29 | Alcon Research, Ltd. | Matriz de polímero insoluble en agua para el suministro de fármaco |
US7906214B2 (en) | 2007-01-26 | 2011-03-15 | Transitions Optical, Inc. | Optical elements comprising compatiblizing coatings and methods of making the same |
HUE055815T2 (hu) * | 2007-10-05 | 2021-12-28 | Univ Wayne State | Vegyületek nyújtott felszabadítására alkalmas dendrimerek |
WO2009064963A2 (en) | 2007-11-14 | 2009-05-22 | E. I. Du Pont De Nemours And Company | Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use |
US20100008993A1 (en) | 2008-07-14 | 2010-01-14 | Proksch Joel W | Compositions and Methods for Increasing Bioavailability of Topical Ophthalmic Drugs |
WO2010017184A2 (en) * | 2008-08-08 | 2010-02-11 | Virginia Commonwealth University | Dendrimer hydrogels |
-
2010
- 2010-05-05 US US12/774,419 patent/US8211450B2/en not_active Expired - Fee Related
-
2011
- 2011-05-04 JP JP2013509213A patent/JP2013528589A/ja active Pending
- 2011-05-04 CN CN2011800332340A patent/CN103096901A/zh active Pending
- 2011-05-04 CA CA2797123A patent/CA2797123A1/en not_active Abandoned
- 2011-05-04 MX MX2012012846A patent/MX2012012846A/es not_active Application Discontinuation
- 2011-05-04 US US13/695,930 patent/US20130053374A1/en not_active Abandoned
- 2011-05-04 WO PCT/US2011/035147 patent/WO2011140194A1/en active Application Filing
- 2011-05-04 EP EP20110778244 patent/EP2566487A4/en not_active Withdrawn
- 2011-05-04 KR KR1020127031915A patent/KR20130121685A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2566487A1 (en) | 2013-03-13 |
CA2797123A1 (en) | 2011-11-10 |
US8211450B2 (en) | 2012-07-03 |
EP2566487A4 (en) | 2014-06-18 |
WO2011140194A1 (en) | 2011-11-10 |
CN103096901A (zh) | 2013-05-08 |
US20130053374A1 (en) | 2013-02-28 |
US20110275617A1 (en) | 2011-11-10 |
KR20130121685A (ko) | 2013-11-06 |
JP2013528589A (ja) | 2013-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |