MX2012012846A - Composicion oftalmica. - Google Patents

Composicion oftalmica.

Info

Publication number
MX2012012846A
MX2012012846A MX2012012846A MX2012012846A MX2012012846A MX 2012012846 A MX2012012846 A MX 2012012846A MX 2012012846 A MX2012012846 A MX 2012012846A MX 2012012846 A MX2012012846 A MX 2012012846A MX 2012012846 A MX2012012846 A MX 2012012846A
Authority
MX
Mexico
Prior art keywords
hyperbranched polyester
ophthalmic
carbonic anhydrase
increases
ophthalmic composition
Prior art date
Application number
MX2012012846A
Other languages
English (en)
Inventor
Inouejun
Tapan Shah
Original Assignee
Senju Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Usa Inc filed Critical Senju Usa Inc
Publication of MX2012012846A publication Critical patent/MX2012012846A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

La presente invención proporciona una composición oftálmica que comprende un poliéster hiperramificado. Las composiciones oftálmicas también pueden comprender inhibidores de anhidrasa carbónica, en donde el poliéster hiperramificado aumenta la solubilidad acuosa del inhibidor de anhidrasa carbónica, y aumenta la penetración córnea del agente activo. Las composiciones oftálmicas también pueden comprender agentes tensoactivos no iónicos, tales como PEG, polisorbato, HPMC o HEC, y beta-bloqueadores, tales como Carteolol, Levobunolol, Betaxolol, Metipranolol, Timolol o Propranolol. La concentración del poliéster hiperramificado en la formulación oftálmica no debe ser menor que o igual a 4% (p/v) con el fin de evitar cualquier efecto citotóxico en células córneas humanas y de esta forma la irritación del ojo.
MX2012012846A 2010-05-05 2011-05-04 Composicion oftalmica. MX2012012846A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/774,419 US8211450B2 (en) 2010-05-05 2010-05-05 Ophthalmic composition
PCT/US2011/035147 WO2011140194A1 (en) 2010-05-05 2011-05-04 Ophthalmic composition

Publications (1)

Publication Number Publication Date
MX2012012846A true MX2012012846A (es) 2013-05-22

Family

ID=44902332

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012012846A MX2012012846A (es) 2010-05-05 2011-05-04 Composicion oftalmica.

Country Status (8)

Country Link
US (2) US8211450B2 (es)
EP (1) EP2566487A4 (es)
JP (1) JP2013528589A (es)
KR (1) KR20130121685A (es)
CN (1) CN103096901A (es)
CA (1) CA2797123A1 (es)
MX (1) MX2012012846A (es)
WO (1) WO2011140194A1 (es)

Families Citing this family (13)

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CN103189097B (zh) * 2010-07-29 2016-01-06 参天制药株式会社 带药剂的支承体及其制造方法
WO2013114397A2 (en) * 2012-01-16 2013-08-08 Biocon Limited Pharmaceutically acceptable salt of brinzolamide and composition thereof
US9820991B2 (en) * 2013-11-08 2017-11-21 Sentiss Pharma Private Limited Pharmaceutical composition comprising brinzolamide
CN103740831B (zh) * 2014-01-13 2015-01-28 宁波海尔施基因科技有限公司 一种指导β-受体阻断药用药的引物组合物、多重基因检测试剂盒及其使用方法
US10632198B2 (en) * 2014-01-24 2020-04-28 Sentiss Pharma Private Limited Pharmaceutical composition comprising brinzolamide
EP3412648B1 (en) 2014-05-16 2020-04-15 Occidental Chemical Corporation Method for making 1,1,3,3-tetrachloropropene
NZ728131A (en) * 2014-07-11 2017-09-29 Fujifilm Corp Aqueous ophthalmic composition
KR101773669B1 (ko) 2015-07-30 2017-08-31 포항공과대학교 산학협력단 생체적합성 각막세포 전구체 분화방법 및 각막세포 전구체 조성물
JP6050454B1 (ja) * 2015-09-28 2016-12-21 参天製薬株式会社 水性医薬組成物
TW201733577A (zh) * 2016-03-14 2017-10-01 Santen Pharmaceutical Co Ltd 含有多佐胺、噻嗎洛爾和界面活性劑之醫藥組成物
EP3723739B1 (en) 2017-12-15 2024-03-27 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and their use for treating blepharitis
EP4003291A1 (en) 2019-07-26 2022-06-01 ProQR Therapeutics II B.V. Ophthalmic compositions comprising viscosifying polymers and nucleic acids
JPWO2023140357A1 (es) * 2022-01-21 2023-07-27

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Also Published As

Publication number Publication date
US20130053374A1 (en) 2013-02-28
JP2013528589A (ja) 2013-07-11
CA2797123A1 (en) 2011-11-10
EP2566487A4 (en) 2014-06-18
US8211450B2 (en) 2012-07-03
KR20130121685A (ko) 2013-11-06
WO2011140194A1 (en) 2011-11-10
EP2566487A1 (en) 2013-03-13
US20110275617A1 (en) 2011-11-10
CN103096901A (zh) 2013-05-08

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FA Abandonment or withdrawal