ATE428401T1 - Suspensionsformulierungen mit einem aktiven wirkstoff, einem poloxamer- oder meroxapol-tensid und einem glycol und ihre verwendung zur herstellung eines medikaments zur behandlung von augenkrankheiten - Google Patents
Suspensionsformulierungen mit einem aktiven wirkstoff, einem poloxamer- oder meroxapol-tensid und einem glycol und ihre verwendung zur herstellung eines medikaments zur behandlung von augenkrankheitenInfo
- Publication number
- ATE428401T1 ATE428401T1 AT06759258T AT06759258T ATE428401T1 AT E428401 T1 ATE428401 T1 AT E428401T1 AT 06759258 T AT06759258 T AT 06759258T AT 06759258 T AT06759258 T AT 06759258T AT E428401 T1 ATE428401 T1 AT E428401T1
- Authority
- AT
- Austria
- Prior art keywords
- glycol
- poloxamer
- medication
- treatment
- production
- Prior art date
Links
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 title abstract 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000502 poloxamer Drugs 0.000 title abstract 2
- 229920001983 poloxamer Polymers 0.000 title abstract 2
- 239000004094 surface-active agent Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 208000030533 eye disease Diseases 0.000 title 1
- 239000000725 suspension Substances 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940023490 ophthalmic product Drugs 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67933205P | 2005-05-10 | 2005-05-10 | |
| PCT/US2006/017606 WO2006121963A2 (en) | 2005-05-10 | 2006-05-08 | Suspension formulations comprising an active principle, a poloxamer or meroxapol surfactant and a glycol, its use for the manufacture of a medicament for treating ophthalmic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE428401T1 true ATE428401T1 (de) | 2009-05-15 |
Family
ID=37081695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06759258T ATE428401T1 (de) | 2005-05-10 | 2006-05-08 | Suspensionsformulierungen mit einem aktiven wirkstoff, einem poloxamer- oder meroxapol-tensid und einem glycol und ihre verwendung zur herstellung eines medikaments zur behandlung von augenkrankheiten |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20060257487A1 (de) |
| EP (1) | EP1885336B1 (de) |
| JP (1) | JP4968954B2 (de) |
| KR (1) | KR20080011310A (de) |
| CN (1) | CN101175475B (de) |
| AT (1) | ATE428401T1 (de) |
| AU (1) | AU2006244244B2 (de) |
| BR (1) | BRPI0609227A2 (de) |
| CA (1) | CA2607608A1 (de) |
| CY (1) | CY1109117T1 (de) |
| DE (1) | DE602006006308D1 (de) |
| DK (1) | DK1885336T3 (de) |
| ES (1) | ES2322200T3 (de) |
| MX (1) | MX2007014083A (de) |
| PL (1) | PL1885336T3 (de) |
| PT (1) | PT1885336E (de) |
| SI (1) | SI1885336T1 (de) |
| WO (1) | WO2006121963A2 (de) |
| ZA (1) | ZA200709251B (de) |
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| PL1906916T3 (pl) * | 2005-05-10 | 2009-02-27 | Alcon Inc | Zawiesina do oczu obejmująca lek okulistyczny, poloksaminę i glikolowy środek regulujący toniczność, zastosowanie wymienionej kompozycji do wytwarzania leku do leczenia zaburzeń wzroku |
| WO2007087609A2 (en) * | 2006-01-25 | 2007-08-02 | Aciex, Inc. | Formulations and methods for treating dry eye |
| US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
| TW200812575A (en) * | 2006-04-28 | 2008-03-16 | Alcon Inc | Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye |
| US20090105245A1 (en) * | 2006-12-21 | 2009-04-23 | Bingaman David P | Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor |
| CA2687717A1 (en) * | 2007-05-24 | 2008-12-18 | Aciex Therapeutics, Inc. | Formulations and methods for treating dry eye |
| TW201023912A (en) | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
| MX2011008680A (es) * | 2009-03-03 | 2011-09-08 | Alcon Res Ltd | Composicion farmaceutica para el suministro de compuestos inhibidores de la tirosina cinasa receptora (rtki) para los ojos. |
| US8912236B2 (en) * | 2009-03-03 | 2014-12-16 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye |
| EP2389355A1 (de) * | 2009-03-12 | 2011-11-30 | Medichem, S.A. | Neue kristalle aus einem benzoylbenzenacetamid-derivat |
| HUE038821T2 (hu) | 2009-12-03 | 2018-11-28 | Novartis Ag | Karboxivinil polimert tartalmazó nanorészecske szuszpenziók |
| CN103764118A (zh) | 2011-06-28 | 2014-04-30 | 拜尔健康护理有限责任公司 | 含有索拉非尼的局部眼用药用组合物 |
| WO2013000917A1 (en) | 2011-06-28 | 2013-01-03 | Bayer Intellectual Property Gmbh | Topical ophthalmological pharmaceutical composition containing regorafenib |
| US20130065888A1 (en) | 2011-08-15 | 2013-03-14 | Biserka Cetina-Cizmek | Ophthalmic formulations and processes for their preparation |
| GR1007906B (el) * | 2012-03-22 | 2013-05-30 | Φαρματεν Αβεε, | Οφθαλμικο φαρμακευτικο σκευασμα περιεχον ενα αναστολεα καρβονικης ανυδρασης και μεθοδος για την παρασκευη αυτου |
| EP3808339B1 (de) | 2012-05-03 | 2025-11-12 | Alcon Inc. | Pharmazeutische nanopartikel mit verbessertem mukosalem transport |
| WO2013166385A1 (en) | 2012-05-03 | 2013-11-07 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| US20150174096A1 (en) | 2012-06-12 | 2015-06-25 | Bayer Healthcare Llc | Topical ophthalmological pharmaceutical composition containing sunitinib |
| UY35183A (es) | 2012-12-21 | 2014-07-31 | Bayer Healthcare Llc | Composición farmacéutica oftalmológica tópica que contiene regorafenib |
| EP2956138B1 (de) | 2013-02-15 | 2022-06-22 | Kala Pharmaceuticals, Inc. | Therapeutische verbindungen und verwendungen davon |
| EP3763710A1 (de) | 2013-02-20 | 2021-01-13 | Kala Pharmaceuticals, Inc. | Therapeutische verbindungen und verwendungen davon |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| WO2014160579A1 (en) * | 2013-03-25 | 2014-10-02 | Insite Vision Incorporated | Combination anti-inflammatory ophthalmic compositions |
| EP3013790A1 (de) | 2013-06-27 | 2016-05-04 | Mylan Laboratories Ltd. | Verfahren zur herstellung von nepafenac |
| US20160279055A1 (en) | 2013-07-22 | 2016-09-29 | Imprimis Pharmaceuticals, Inc. | Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof |
| MX383077B (es) * | 2013-07-22 | 2025-03-13 | Novel Drug Solutions Llc | Composiciones farmaceuticas para la administracion intraocular que comprenden un agente antibacteriano y un agente antiinflamatorio. |
| US20150164882A1 (en) | 2013-07-22 | 2015-06-18 | Imprimis Pharmaceuticals, Inc. | Pharmaceutical compositions for intraocular administration and methods for fabricating thereof |
| CN106061261B (zh) | 2013-11-01 | 2018-04-24 | 卡拉制药公司 | 治疗化合物的结晶形式及其用途 |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CN104706579A (zh) * | 2015-03-12 | 2015-06-17 | 广州仁恒医药科技有限公司 | 一种夫西地酸滴眼液及其制备方法 |
| JP6884755B2 (ja) | 2015-05-01 | 2021-06-09 | オーエヌエル セラピューティクス，インコーポレーテッド | ペプチド組成物および使用方法 |
| EP3509422A4 (de) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | Kristalline formen von therapeutischen verbindungen und verwendungen davon |
| CA3036340A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3036065A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3206106A1 (en) | 2021-02-10 | 2022-08-18 | Bhaskar Chaudhuri | Methods for ophthalmic delivery of roflumilast |
| CA3231766A1 (en) | 2021-09-22 | 2023-03-30 | Elizabeth W. JEFFORDS | Methods of treating ocular inflammatory diseases |
| CN114272207B (zh) * | 2022-01-21 | 2023-04-11 | 山东诺明康药物研究院有限公司 | 一种纳米晶混悬滴眼液及其制备方法 |
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| US4313949A (en) * | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
| CA1325382C (en) * | 1988-01-27 | 1993-12-21 | Takahiro Ogawa | Locally administrable therapeutic composition for inflammatory disease |
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| US5461081A (en) * | 1989-09-28 | 1995-10-24 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
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| IT1252692B (it) * | 1991-11-27 | 1995-06-23 | Zambon Spa | Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi |
| EP0551626A1 (de) * | 1991-12-19 | 1993-07-21 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | Thermoreversible Gel als pharmazeutische Grundmasse für eine galenische Form |
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| WO2003053405A1 (en) * | 2001-11-01 | 2003-07-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method and composition for dry eye treatment |
| JP2003176228A (ja) * | 2001-12-11 | 2003-06-24 | Rohto Pharmaceut Co Ltd | 液 剤 |
| US20030133905A1 (en) * | 2001-12-20 | 2003-07-17 | Zhenze Hu | Composition for treating contact lenses in the eye |
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| TWI358290B (en) * | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| PL1906916T3 (pl) * | 2005-05-10 | 2009-02-27 | Alcon Inc | Zawiesina do oczu obejmująca lek okulistyczny, poloksaminę i glikolowy środek regulujący toniczność, zastosowanie wymienionej kompozycji do wytwarzania leku do leczenia zaburzeń wzroku |
-
2006
- 2006-05-08 US US11/430,239 patent/US20060257487A1/en not_active Abandoned
- 2006-05-08 WO PCT/US2006/017606 patent/WO2006121963A2/en not_active Ceased
- 2006-05-08 CN CN2006800161308A patent/CN101175475B/zh not_active Expired - Fee Related
- 2006-05-08 BR BRPI0609227-6A patent/BRPI0609227A2/pt not_active IP Right Cessation
- 2006-05-08 ES ES06759258T patent/ES2322200T3/es active Active
- 2006-05-08 SI SI200630323T patent/SI1885336T1/sl unknown
- 2006-05-08 AU AU2006244244A patent/AU2006244244B2/en not_active Ceased
- 2006-05-08 PL PL06759258T patent/PL1885336T3/pl unknown
- 2006-05-08 ZA ZA200709251A patent/ZA200709251B/xx unknown
- 2006-05-08 PT PT06759258T patent/PT1885336E/pt unknown
- 2006-05-08 MX MX2007014083A patent/MX2007014083A/es active IP Right Grant
- 2006-05-08 DE DE602006006308T patent/DE602006006308D1/de active Active
- 2006-05-08 DK DK06759258T patent/DK1885336T3/da active
- 2006-05-08 JP JP2008511214A patent/JP4968954B2/ja not_active Expired - Fee Related
- 2006-05-08 AT AT06759258T patent/ATE428401T1/de active
- 2006-05-08 CA CA002607608A patent/CA2607608A1/en not_active Abandoned
- 2006-05-08 EP EP06759258A patent/EP1885336B1/de not_active Not-in-force
- 2006-05-08 KR KR1020077027974A patent/KR20080011310A/ko not_active Ceased
-
2009
- 2009-05-29 CY CY20091100579T patent/CY1109117T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008540532A (ja) | 2008-11-20 |
| DK1885336T3 (da) | 2009-05-25 |
| WO2006121963A2 (en) | 2006-11-16 |
| EP1885336A2 (de) | 2008-02-13 |
| JP4968954B2 (ja) | 2012-07-04 |
| DE602006006308D1 (de) | 2009-05-28 |
| PT1885336E (pt) | 2009-05-07 |
| EP1885336B1 (de) | 2009-04-15 |
| CA2607608A1 (en) | 2006-11-16 |
| KR20080011310A (ko) | 2008-02-01 |
| CY1109117T1 (el) | 2014-07-02 |
| AU2006244244A1 (en) | 2006-11-16 |
| PL1885336T3 (pl) | 2009-08-31 |
| MX2007014083A (es) | 2008-02-07 |
| BRPI0609227A2 (pt) | 2010-03-09 |
| ES2322200T3 (es) | 2009-06-17 |
| WO2006121963A3 (en) | 2007-03-22 |
| SI1885336T1 (sl) | 2009-08-31 |
| ZA200709251B (en) | 2009-08-26 |
| AU2006244244B2 (en) | 2010-11-04 |
| US20060257487A1 (en) | 2006-11-16 |
| CN101175475B (zh) | 2010-04-14 |
| CN101175475A (zh) | 2008-05-07 |
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