MX2012010400A - Inhibidores de fosfodiesterasa 10 (pde10) y composiciones y metodos relacionados. - Google Patents
Inhibidores de fosfodiesterasa 10 (pde10) y composiciones y metodos relacionados.Info
- Publication number
- MX2012010400A MX2012010400A MX2012010400A MX2012010400A MX2012010400A MX 2012010400 A MX2012010400 A MX 2012010400A MX 2012010400 A MX2012010400 A MX 2012010400A MX 2012010400 A MX2012010400 A MX 2012010400A MX 2012010400 A MX2012010400 A MX 2012010400A
- Authority
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- Mexico
- Prior art keywords
- disorders
- disease
- compounds
- pharmaceutically acceptable
- disclosed
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006373 Bell palsy Diseases 0.000 abstract 1
- 208000024254 Delusional disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000011963 Substance-induced psychotic disease Diseases 0.000 abstract 1
- 231100000393 Substance-induced psychotic disorder Toxicity 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 208000036826 VIIth nerve paralysis Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 201000007201 aphasia Diseases 0.000 abstract 1
- 206010008129 cerebral palsy Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 201000002545 drug psychosis Diseases 0.000 abstract 1
- 206010014599 encephalitis Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 208000002851 paranoid schizophrenia Diseases 0.000 abstract 1
- 208000019899 phobic disease Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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Abstract
Se describen compuestos que inhiben PDE1O que tienen utilidad en el tratamiento de una variedad de condiciones, que incluyen (pero no se limitan a) trastornos psicóticos, de ansiedad y de movimiento y/o trastornos neurológicos tal como enfermedad de Parkinson, enfermedad de Huntington, enfermedad de Alzheimer, encefalitis, fobias, epilepsia, afasia, parálisis de Bell, parálisis cerebral, trastornos de sueño, dolor, síndrome de Tourette, esquizofrenia, trastornos delirantes, psicosis inducida por drogas y trastornos de pánico y obsesivo-compulsivos. También se proporcionan sales, estereoisómeros, solvatos y profármacos farmacéuticamente aceptables de los compuestos. También se describen composiciones que contienen un compuesto en combinación con un portador farmacéuticamente aceptable, así como métodos que se refieren al uso de los mismos para inhibir PDE1O en un animal de sangre caliente en necesidad del mismo.
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