DE60324449D1 - Inhibitoren der phosphodiesterase der zyklischen n, und deren verwendung in therapie - Google Patents
Inhibitoren der phosphodiesterase der zyklischen n, und deren verwendung in therapieInfo
- Publication number
- DE60324449D1 DE60324449D1 DE60324449T DE60324449T DE60324449D1 DE 60324449 D1 DE60324449 D1 DE 60324449D1 DE 60324449 T DE60324449 T DE 60324449T DE 60324449 T DE60324449 T DE 60324449T DE 60324449 D1 DE60324449 D1 DE 60324449D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- cyclic
- phosphodiesterase
- therapy
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/22—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0213607A FR2846653B1 (fr) | 2002-10-30 | 2002-10-30 | Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations |
US45587403P | 2003-03-20 | 2003-03-20 | |
PCT/FR2003/003247 WO2004041258A2 (fr) | 2002-10-30 | 2003-10-30 | Utilisation d’inhibiteurs des phosphodiesterases des nucleotides cycliques, ayant une structure benzodiazepinique en therapie |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60324449D1 true DE60324449D1 (de) | 2008-12-11 |
Family
ID=32313949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60324449T Expired - Fee Related DE60324449D1 (de) | 2002-10-30 | 2003-10-30 | Inhibitoren der phosphodiesterase der zyklischen n, und deren verwendung in therapie |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060128695A1 (de) |
EP (1) | EP1556055B1 (de) |
JP (1) | JP2006509832A (de) |
AT (1) | ATE412415T1 (de) |
AU (1) | AU2003288352A1 (de) |
CA (1) | CA2503716A1 (de) |
DE (1) | DE60324449D1 (de) |
ES (1) | ES2315546T3 (de) |
NZ (1) | NZ540167A (de) |
WO (1) | WO2004041258A2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004064865A1 (ja) * | 2003-01-17 | 2004-08-05 | Takeda Pharmaceutical Company Limited | 骨格筋保護剤 |
EP1749824A1 (de) * | 2005-08-03 | 2007-02-07 | Neuro3D | Benzodiazepinederivate, Herstellung und Verwendung als Arzneimittel |
US7858620B2 (en) | 2007-09-19 | 2010-12-28 | H. Lundbeck A/S | Cyanoisoquinoline |
TW200918519A (en) * | 2007-09-19 | 2009-05-01 | Lundbeck & Co As H | Cyanoisoquinoline |
UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
KR101435729B1 (ko) | 2009-09-28 | 2014-09-01 | 닛뽕소다 가부시키가이샤 | 함질소 헤테로 고리 화합물 및 그의 염, 그리고 농원예용 살균제 |
TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑的2-芳基咪唑衍生物 |
TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
TW201200516A (en) | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
TWI487705B (zh) | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物 |
US8343970B2 (en) | 2010-03-12 | 2013-01-01 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
EP2705039B1 (de) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomainhemmer und ihre verwendung |
EP2721031B1 (de) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomainhemmer und ihre verwendungen |
EP2803662B1 (de) | 2012-01-13 | 2017-03-01 | Nippon Chemiphar Co., Ltd. | P2x4-rezeptor-antagonisten |
CN102690239B (zh) * | 2012-04-01 | 2015-01-28 | 浙江工业大学 | 一种1,5-苯并二氮卓类衍生物的合成方法 |
SG11201406552UA (en) | 2012-04-25 | 2014-11-27 | Takeda Pharmaceutical | Nitrogenated heterocyclic compound |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
RU2657540C2 (ru) * | 2012-06-26 | 2018-06-14 | Янссен Фармацевтика Нв | Комбинации, содержащие ингибиторы pde 2, такие как 1-арил-4-метил-[1,2,4]триазоло[4,3-а]хиноксалиновые соединения, и ингибиторы pde 10, для применения в лечении неврологических или метаболических расстройств |
EP2873669A4 (de) | 2012-07-13 | 2015-11-25 | Takeda Pharmaceutical | Heterocyclische verbindung |
WO2014142255A1 (ja) | 2013-03-14 | 2014-09-18 | 武田薬品工業株式会社 | 複素環化合物 |
WO2015002230A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | アミド化合物 |
WO2015002231A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | 複素環化合物 |
US9873683B2 (en) | 2013-07-12 | 2018-01-23 | Nippon Chemiphar Co., Ltd | P2X4 receptor antagonist |
WO2015106032A1 (en) | 2014-01-08 | 2015-07-16 | Intra-Cellular Therapies, Inc. | Products and pharmaceutical compositions |
NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
NZ716462A (en) | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
US9969747B2 (en) | 2014-06-20 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide |
WO2016090380A1 (en) | 2014-12-06 | 2016-06-09 | Intra-Cellular Therapies, Inc. | Organic compounds |
MX2017007377A (es) | 2014-12-06 | 2017-11-06 | Intra-Cellular Therapies Inc | Compuestos organicos. |
EP3285760A4 (de) | 2015-04-24 | 2018-09-26 | Omeros Corporation | Pde10-hemmer sowie entsprechende zusammensetzungen und verfahren |
JP2018535969A (ja) | 2015-11-04 | 2018-12-06 | オメロス コーポレーション | Pde10阻害剤の固体状態形態 |
CA3083176A1 (en) | 2017-11-23 | 2019-05-31 | Oslo University Hospital Hf | Treatment of tachycardia |
CN110511259B (zh) * | 2019-08-22 | 2022-08-16 | 陕西师范大学 | 环二核苷酸人工金属酶及其制备和催化不对称Friedel-Crafts反应的应用 |
WO2023220395A1 (en) * | 2022-05-13 | 2023-11-16 | University Of Cincinnati | Benzodiazepine analogs and methods of use in treating cancer |
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DE1136709B (de) * | 1959-12-10 | 1962-09-20 | Hoffmann La Roche | Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-1, 4-benzodiazepinen |
DE1145626B (de) * | 1959-12-10 | 1963-03-21 | Hoffmann La Roche | Verfahren zur Herstellung von 3H-1, 4-Benzodiazepin-2(1H)-on-derivaten |
US3515755A (en) * | 1968-06-18 | 1970-06-02 | Hoffmann La Roche | Lower alkanoyl amido benzophenones |
US3609146A (en) * | 1968-11-01 | 1971-09-28 | Sandoz Ag | Substituted benzodiazepinone derivatives |
US3573282A (en) * | 1969-03-27 | 1971-03-30 | Upjohn Co | 4h-(1,3)oxazino(3,2-d)(1,4)benzodiazepine-4,7(6h)-diones |
DE1942744A1 (de) * | 1969-08-22 | 1971-03-04 | Cassella Farbwerke Mainkur Ag | 2-Imino-1,2-dihydro-3H-1,4-benzodiazepine und Verfahren zu ihrer Herstellung |
US3778433A (en) * | 1969-04-18 | 1973-12-11 | Sumitomo Chemical Co | Process for producing benzodiazepine derivatives |
GB1346176A (en) * | 1970-08-25 | 1974-02-06 | American Home Prod | Benzodiazepines |
US3803129A (en) * | 1972-08-10 | 1974-04-09 | American Home Prod | 1,5-dihydro-3-alkoxy-5-phenyl-2h-1,4-benzodiazepin-2-ones |
US4056525A (en) * | 1975-06-02 | 1977-11-01 | American Home Products Corporation | 2,3-dialkoxy-3h-1,4-benzodiazepines |
JPS54157585A (en) * | 1978-05-30 | 1979-12-12 | Yasumitsu Tamura | Manufacture of 1*44benzodiazepin |
IL93401A (en) * | 1989-03-08 | 1994-08-26 | Kali Chemie Pharma Gmbh | H1 - Indole - 2 - Carboxylic acid 1, 7 - Consolidated N -) 1, 4 - Benzodiazepine - 3 - Il (amides, their preparation and drugs containing them |
WO1999058117A1 (fr) * | 1998-05-13 | 1999-11-18 | Sanofi-Synthelabo | Utilisation de composes reduisant l'apoptose |
AU2002317910B2 (en) * | 2001-06-07 | 2008-06-19 | Via Pharmaceuticals, Inc. | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof |
-
2003
- 2003-10-30 JP JP2005502123A patent/JP2006509832A/ja active Pending
- 2003-10-30 US US10/533,157 patent/US20060128695A1/en not_active Abandoned
- 2003-10-30 AU AU2003288352A patent/AU2003288352A1/en not_active Abandoned
- 2003-10-30 CA CA002503716A patent/CA2503716A1/fr not_active Abandoned
- 2003-10-30 AT AT03780257T patent/ATE412415T1/de not_active IP Right Cessation
- 2003-10-30 EP EP03780257A patent/EP1556055B1/de not_active Expired - Lifetime
- 2003-10-30 NZ NZ540167A patent/NZ540167A/en unknown
- 2003-10-30 DE DE60324449T patent/DE60324449D1/de not_active Expired - Fee Related
- 2003-10-30 ES ES03780257T patent/ES2315546T3/es not_active Expired - Lifetime
- 2003-10-30 WO PCT/FR2003/003247 patent/WO2004041258A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1556055B1 (de) | 2008-10-29 |
ATE412415T1 (de) | 2008-11-15 |
WO2004041258A8 (fr) | 2005-06-23 |
WO2004041258A2 (fr) | 2004-05-21 |
NZ540167A (en) | 2007-06-29 |
JP2006509832A (ja) | 2006-03-23 |
WO2004041258A3 (fr) | 2004-09-23 |
CA2503716A1 (fr) | 2004-05-21 |
AU2003288352A1 (en) | 2004-06-07 |
EP1556055A2 (de) | 2005-07-27 |
US20060128695A1 (en) | 2006-06-15 |
ES2315546T3 (es) | 2009-04-01 |
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