ES2253526T3 - Derivados de carbonilo sustituidos heterociclicos y su uso como ligandos de receptores d3 de dopamina. - Google Patents

Derivados de carbonilo sustituidos heterociclicos y su uso como ligandos de receptores d3 de dopamina.

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Publication number
ES2253526T3
ES2253526T3 ES02718999T ES02718999T ES2253526T3 ES 2253526 T3 ES2253526 T3 ES 2253526T3 ES 02718999 T ES02718999 T ES 02718999T ES 02718999 T ES02718999 T ES 02718999T ES 2253526 T3 ES2253526 T3 ES 2253526T3
Authority
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Spain
Prior art keywords
disorders
dopamine
compounds
receptors
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02718999T
Other languages
English (en)
Inventor
James A. Hendrix
Horst Hemmerle
Matthias Urmann
Gregory Shutske
Joseph T. Strupczewski
Kenneth J. Bordeau
John G. Jurcak
Thaddeus Nieduzak
Sharon Anne Jackson
Paul Angell
David M. Fink
Jean-Francois Sabuco
Yulin Chiang
Nicola Collar
James P. Carey
George E. Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0117577.7A external-priority patent/GB0117577D0/en
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2253526T3 publication Critical patent/ES2253526T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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Abstract

Un compuesto de la **fórmula** en la que A es CH o N; n es 1 ó 2; cuando n es 1, y es 2; cuando n es 2, y es 0; g es 1 ó 2; cada R3 es independientemente, alquilo C1-C6, o en la que w es 1, 2, ó 3 R se selecciona entre el grupo constituido por (a) - (w): en las que cada R4, R5, R6, R7, R8, R9, R10, R11, R12 y R18 es independientemente alquilo C1-C6, halógeno, trifluorometilo, -CO2alquilo C1-C6, alcoxi C1-C6, halógeno, trifluorometilo, -CO2alquilo C1-C6, o -CH2Oalquilo C1-C6; cada R71, R72, R73, y R80 es independientemente hidrógenoalquilo C1-C6, halógeno, trifluorometilo, -CO2alquilo C1-C6, -CO2alquilo C1 - C6, o -CH2Oalquilo C1-C6.
ES02718999T 2001-02-16 2002-02-15 Derivados de carbonilo sustituidos heterociclicos y su uso como ligandos de receptores d3 de dopamina. Expired - Lifetime ES2253526T3 (es)

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