DE602006018149D1 - Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors - Google Patents

Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors

Info

Publication number
DE602006018149D1
DE602006018149D1 DE602006018149T DE602006018149T DE602006018149D1 DE 602006018149 D1 DE602006018149 D1 DE 602006018149D1 DE 602006018149 T DE602006018149 T DE 602006018149T DE 602006018149 T DE602006018149 T DE 602006018149T DE 602006018149 D1 DE602006018149 D1 DE 602006018149D1
Authority
DE
Germany
Prior art keywords
sup
receptor
neurokinin
antagonists
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006018149T
Other languages
English (en)
Inventor
Luca Claudio Gobbi
Marius Hoener
Claus Riemer
Will Spooren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602006018149D1 publication Critical patent/DE602006018149D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602006018149T 2005-07-25 2006-07-17 Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors Active DE602006018149D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05106802 2005-07-25
PCT/EP2006/064310 WO2007012579A1 (en) 2005-07-25 2006-07-17 Substituted triazole derivatives and their use as neurokinin 3 receptor antagonists

Publications (1)

Publication Number Publication Date
DE602006018149D1 true DE602006018149D1 (de) 2010-12-23

Family

ID=37000130

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006018149T Active DE602006018149D1 (de) 2005-07-25 2006-07-17 Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors

Country Status (14)

Country Link
US (1) US7268154B2 (de)
EP (1) EP1910316B1 (de)
JP (1) JP4860696B2 (de)
KR (1) KR100978961B1 (de)
CN (1) CN101228137B (de)
AT (1) ATE487704T1 (de)
AU (1) AU2006274051B2 (de)
BR (1) BRPI0613881A2 (de)
CA (1) CA2616576A1 (de)
DE (1) DE602006018149D1 (de)
ES (1) ES2353724T3 (de)
IL (1) IL188723A (de)
MX (1) MX2008000781A (de)
WO (1) WO2007012579A1 (de)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2348526A1 (en) * 1998-10-30 2000-05-11 Merck & Co., Inc. Process for the preparation of 2-(r)-(1- (r)-(3,5-bis (trifluoromethyl) phenyl)ethoxy) -4-((5-dimethylaminomethyl) -1,2,3-triazol -4-yl)methyl) -3-(s)-(4- fluorophenyl) morpholine
DE10036818A1 (de) * 2000-07-28 2002-02-07 Solvay Pharm Gmbh Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten
AR039329A1 (es) * 2002-04-26 2005-02-16 Lilly Co Eli Derivados de triazol, antagonistas de receptor de taquicinina
PT1501808E (pt) * 2002-04-26 2008-09-26 Lilly Co Eli Antagonistas de receptores taquiquininas
ES2265596T3 (es) * 2002-11-27 2007-02-16 Boehringer Ingelheim Pharmaceuticals Inc. Derivados de 1,2,3-triazol-amida como inhibidores de citocinas.
US20060160794A1 (en) * 2003-06-12 2006-07-20 Amegadzie Albert K Tachykinin receptor antagonists
GB0318727D0 (en) 2003-08-08 2003-09-10 Smithkline Beecham Corp Novel compounds
WO2005056535A1 (en) * 2003-12-03 2005-06-23 Boehringer Ingelheim Pharmaceuticals, Inc. 1,2,3-triazole amide derivatives as inhibitors of cytokine production

Also Published As

Publication number Publication date
ATE487704T1 (de) 2010-11-15
JP2009502855A (ja) 2009-01-29
CA2616576A1 (en) 2007-02-01
EP1910316A1 (de) 2008-04-16
BRPI0613881A2 (pt) 2011-02-15
US7268154B2 (en) 2007-09-11
AU2006274051A1 (en) 2007-02-01
IL188723A (en) 2012-05-31
AU2006274051B2 (en) 2012-03-22
CN101228137A (zh) 2008-07-23
KR100978961B1 (ko) 2010-08-30
IL188723A0 (en) 2008-08-07
ES2353724T3 (es) 2011-03-04
EP1910316B1 (de) 2010-11-10
US20070021475A1 (en) 2007-01-25
JP4860696B2 (ja) 2012-01-25
KR20080020698A (ko) 2008-03-05
MX2008000781A (es) 2008-03-10
WO2007012579A1 (en) 2007-02-01
CN101228137B (zh) 2010-09-29

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