ATE487704T1 - Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors - Google Patents
Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptorsInfo
- Publication number
- ATE487704T1 ATE487704T1 AT06777806T AT06777806T ATE487704T1 AT E487704 T1 ATE487704 T1 AT E487704T1 AT 06777806 T AT06777806 T AT 06777806T AT 06777806 T AT06777806 T AT 06777806T AT E487704 T1 ATE487704 T1 AT E487704T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- neurokinin
- receptor antagonists
- triazole derivatives
- substituted triazole
- Prior art date
Links
- 239000002740 neurokinin 3 receptor antagonist Substances 0.000 title 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 101001125071 Homo sapiens Neuromedin-K receptor Proteins 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003281 allosteric effect Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05106802 | 2005-07-25 | ||
| PCT/EP2006/064310 WO2007012579A1 (en) | 2005-07-25 | 2006-07-17 | Substituted triazole derivatives and their use as neurokinin 3 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE487704T1 true ATE487704T1 (de) | 2010-11-15 |
Family
ID=37000130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06777806T ATE487704T1 (de) | 2005-07-25 | 2006-07-17 | Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7268154B2 (de) |
| EP (1) | EP1910316B1 (de) |
| JP (1) | JP4860696B2 (de) |
| KR (1) | KR100978961B1 (de) |
| CN (1) | CN101228137B (de) |
| AT (1) | ATE487704T1 (de) |
| AU (1) | AU2006274051B2 (de) |
| BR (1) | BRPI0613881A2 (de) |
| CA (1) | CA2616576A1 (de) |
| DE (1) | DE602006018149D1 (de) |
| ES (1) | ES2353724T3 (de) |
| IL (1) | IL188723A (de) |
| MX (1) | MX2008000781A (de) |
| WO (1) | WO2007012579A1 (de) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2348526A1 (en) * | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Process for the preparation of 2-(r)-(1- (r)-(3,5-bis (trifluoromethyl) phenyl)ethoxy) -4-((5-dimethylaminomethyl) -1,2,3-triazol -4-yl)methyl) -3-(s)-(4- fluorophenyl) morpholine |
| DE10036818A1 (de) * | 2000-07-28 | 2002-02-07 | Solvay Pharm Gmbh | Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten |
| BR0309486A (pt) * | 2002-04-26 | 2005-02-09 | Lilly Co Eli | Composto ou um seu sal farmaceuticamente aceitável, composição farmacêutica, e, método para o tratamento de uma condição associada com um excesso de taquicininas |
| KR100755577B1 (ko) * | 2002-04-26 | 2007-09-12 | 일라이 릴리 앤드 캄파니 | 타키키닌 수용체 길항제로서의 트리아졸 유도체 |
| ATE329909T1 (de) * | 2002-11-27 | 2006-07-15 | Boehringer Ingelheim Pharma | 1,2,3-triazolamid-derivate als cytokininhibitoren |
| EP1638944A1 (de) * | 2003-06-12 | 2006-03-29 | Eli Lilly And Company | Tachykininrezeptor-antagonisten |
| GB0318727D0 (en) | 2003-08-08 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| DE602004031759D1 (de) * | 2003-12-03 | 2011-04-21 | Boehringer Ingelheim Pharma | 1,2,3-triazolamidderivate als inhibitoren der cytokinproduktion |
-
2006
- 2006-07-17 ES ES06777806T patent/ES2353724T3/es active Active
- 2006-07-17 EP EP06777806A patent/EP1910316B1/de not_active Not-in-force
- 2006-07-17 DE DE602006018149T patent/DE602006018149D1/de active Active
- 2006-07-17 CN CN2006800271793A patent/CN101228137B/zh not_active Expired - Fee Related
- 2006-07-17 AT AT06777806T patent/ATE487704T1/de active
- 2006-07-17 JP JP2008523311A patent/JP4860696B2/ja not_active Expired - Fee Related
- 2006-07-17 MX MX2008000781A patent/MX2008000781A/es active IP Right Grant
- 2006-07-17 CA CA002616576A patent/CA2616576A1/en not_active Abandoned
- 2006-07-17 WO PCT/EP2006/064310 patent/WO2007012579A1/en not_active Ceased
- 2006-07-17 AU AU2006274051A patent/AU2006274051B2/en not_active Ceased
- 2006-07-17 KR KR1020087001974A patent/KR100978961B1/ko not_active Expired - Fee Related
- 2006-07-17 BR BRPI0613881-0A patent/BRPI0613881A2/pt not_active IP Right Cessation
- 2006-07-18 US US11/488,837 patent/US7268154B2/en not_active Expired - Fee Related
-
2008
- 2008-01-10 IL IL188723A patent/IL188723A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2616576A1 (en) | 2007-02-01 |
| IL188723A0 (en) | 2008-08-07 |
| WO2007012579A1 (en) | 2007-02-01 |
| DE602006018149D1 (de) | 2010-12-23 |
| JP2009502855A (ja) | 2009-01-29 |
| US7268154B2 (en) | 2007-09-11 |
| BRPI0613881A2 (pt) | 2011-02-15 |
| AU2006274051A1 (en) | 2007-02-01 |
| JP4860696B2 (ja) | 2012-01-25 |
| CN101228137B (zh) | 2010-09-29 |
| EP1910316A1 (de) | 2008-04-16 |
| IL188723A (en) | 2012-05-31 |
| KR20080020698A (ko) | 2008-03-05 |
| MX2008000781A (es) | 2008-03-10 |
| US20070021475A1 (en) | 2007-01-25 |
| ES2353724T3 (es) | 2011-03-04 |
| CN101228137A (zh) | 2008-07-23 |
| AU2006274051B2 (en) | 2012-03-22 |
| KR100978961B1 (ko) | 2010-08-30 |
| EP1910316B1 (de) | 2010-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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