DE60208157D1 - Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden - Google Patents

Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden

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Publication number
DE60208157D1
DE60208157D1 DE60208157T DE60208157T DE60208157D1 DE 60208157 D1 DE60208157 D1 DE 60208157D1 DE 60208157 T DE60208157 T DE 60208157T DE 60208157 T DE60208157 T DE 60208157T DE 60208157 D1 DE60208157 D1 DE 60208157D1
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Germany
Prior art keywords
disorders
dopamine
compounds
substituted carbonyl
heterocyclic substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60208157T
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English (en)
Other versions
DE60208157T2 (de
Inventor
James A Hendrix
Horst Hemmerle
Matthias Urmann
Gregory Shutske
Joseph T Strupczewski
Kenneth J Bordeau
John G Jurcak
Thaddeus Nieduzak
Sharon Anne Jackson
Paul Angell
David M Fink
Jean-Francois Sabuco
Yulin Chiang
Nicola Collar
James P Carey
George E Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
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Aventis Pharmaceuticals Inc
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Priority claimed from GBGB0117577.7A external-priority patent/GB0117577D0/en
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of DE60208157D1 publication Critical patent/DE60208157D1/de
Application granted granted Critical
Publication of DE60208157T2 publication Critical patent/DE60208157T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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DE60208157T 2001-02-16 2002-02-15 Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden Expired - Lifetime DE60208157T2 (de)

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GBGB0117577.7A GB0117577D0 (en) 2001-02-16 2001-07-19 Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
PCT/US2002/004713 WO2002066446A1 (en) 2001-02-16 2002-02-15 Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands

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AU2002250107B2 (en) 2008-05-29
EP1632483B1 (de) 2008-10-29
IL157413A0 (en) 2004-03-28
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ATE412638T1 (de) 2008-11-15
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AU2002250107B8 (en) 2008-06-12
CA2438264A1 (en) 2002-08-29
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EP1935887B1 (de) 2010-01-13
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EP1935887A1 (de) 2008-06-25
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