IL157413A0 - Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands - Google Patents
Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligandsInfo
- Publication number
- IL157413A0 IL157413A0 IL15741302A IL15741302A IL157413A0 IL 157413 A0 IL157413 A0 IL 157413A0 IL 15741302 A IL15741302 A IL 15741302A IL 15741302 A IL15741302 A IL 15741302A IL 157413 A0 IL157413 A0 IL 157413A0
- Authority
- IL
- Israel
- Prior art keywords
- disorders
- dopamine
- compounds
- substituted carbonyl
- heterocyclic substituted
- Prior art date
Links
- 102000004073 Dopamine D3 Receptors Human genes 0.000 title abstract 4
- 108090000525 Dopamine D3 Receptors Proteins 0.000 title abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000015114 central nervous system disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000017164 Chronobiology disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 230000000142 dyskinetic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 201000009032 substance abuse Diseases 0.000 abstract 1
- 231100000736 substance abuse Toxicity 0.000 abstract 1
- 201000006152 substance dependence Diseases 0.000 abstract 1
Classifications
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26967201P | 2001-02-16 | 2001-02-16 | |
GBGB0117577.7A GB0117577D0 (en) | 2001-02-16 | 2001-07-19 | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
PCT/US2002/004713 WO2002066446A1 (en) | 2001-02-16 | 2002-02-15 | Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
IL157413A0 true IL157413A0 (en) | 2004-03-28 |
Family
ID=26246325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15741302A IL157413A0 (en) | 2001-02-16 | 2002-02-15 | Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands |
Country Status (12)
Country | Link |
---|---|
EP (3) | EP1632483B1 (xx) |
JP (2) | JP2009185054A (xx) |
AT (3) | ATE455108T1 (xx) |
AU (1) | AU2002250107B8 (xx) |
CA (1) | CA2438264A1 (xx) |
DE (2) | DE60208157T2 (xx) |
DK (2) | DK1362039T3 (xx) |
ES (2) | ES2317116T3 (xx) |
IL (1) | IL157413A0 (xx) |
MX (1) | MXPA03006943A (xx) |
PT (1) | PT1632483E (xx) |
WO (1) | WO2002066446A1 (xx) |
Families Citing this family (31)
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US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
CA2503720A1 (en) * | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Gamma-aminoamide modulators of chemokine receptor activity |
DE10358004A1 (de) * | 2003-12-11 | 2005-07-14 | Abbott Gmbh & Co. Kg | Ketolactam-Verbindungen und ihre Verwendung |
RU2403247C2 (ru) * | 2004-07-20 | 2010-11-10 | СЬЕНА БИОТЕК С.п.А. | Модуляторы никотиновых ацетилхолиновых рецепторов альфа 7 и их терапевтические применения |
MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
JP5149009B2 (ja) | 2004-09-20 | 2013-02-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトステアロイル−CoAデサチュラーゼを阻害するためのピリダジン誘導体 |
MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
TW200626154A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
JP5043668B2 (ja) | 2004-09-20 | 2012-10-10 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 複素環誘導体および治療薬としてのそれらの使用 |
EP1804799B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
BRPI0515483A (pt) * | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase |
BRPI0610258A2 (pt) * | 2005-04-26 | 2012-09-25 | Hypnion Inc | composto ou um sal farmaceuticamente eficaz do mesmo, composição farmacêutica, e, uso de um composto |
DE602006012650D1 (de) | 2005-04-26 | 2010-04-15 | Hypnion Inc | Benzisoxazolpiperidinverbindungen und verfahren zu deren anwendung |
BRPI0611370A2 (pt) | 2005-05-23 | 2010-08-31 | Sagami Chem Res | derivados de pirazol-1-carboxilato, processos para a producão destes e processos para a producão de derivados de pirazol |
MX2007015216A (es) | 2005-06-03 | 2008-02-22 | Xenon Pharmaceuticals Inc | Derivados de aminotiazol y sus usos como agentes terapeuticos. |
DK2041088T3 (da) | 2006-06-28 | 2014-04-07 | Amgen Inc | Glycintransporter-1 inhibitorer |
EP2074105A4 (en) * | 2006-10-13 | 2010-10-06 | Neuromed Pharmaceuticals Ltd | CYCLOPROPYL-PIPERAZINE COMPOUNDS AS CALCIUM INHIBITORS |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
EP2183245B1 (en) | 2007-07-26 | 2014-07-09 | F. Hoffmann-La Roche AG | Dual modulators of 5-ht2a and d3 receptors |
AU2009294695B2 (en) | 2008-09-22 | 2012-09-13 | F. Hoffmann-La Roche Ag | Piperazine D3 and 5-HT2a receptor modulators |
AU2009296045B2 (en) * | 2008-09-23 | 2013-07-04 | F. Hoffmann-La Roche Ag | Benzo[d]isoxazol-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors |
WO2010040808A1 (en) * | 2008-10-10 | 2010-04-15 | Neurosearch A/S | Novel quinolinylamide derivatives useful as modulators of dopamine and serotonin receptors |
WO2011000945A2 (en) | 2009-07-03 | 2011-01-06 | Nensius Research A/S | Aminoalkamides for use in the treatment of inflammatory, degenerative or demyelinating diseases of the cns |
WO2011059784A1 (en) | 2009-10-29 | 2011-05-19 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
US8877778B2 (en) | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
SG11201503959VA (en) * | 2012-11-20 | 2015-06-29 | Merial Inc | Anthelmintic compounds and compositions and method of using thereof |
WO2015179414A1 (en) | 2014-05-19 | 2015-11-26 | Merial, Inc. | Anthelmintic compounds |
WO2018021447A1 (ja) | 2016-07-28 | 2018-02-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する含窒素縮環化合物 |
WO2019146740A1 (ja) | 2018-01-26 | 2019-08-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する環式化合物 |
CN111801330B (zh) | 2018-01-26 | 2024-04-05 | 盐野义制药株式会社 | 具有多巴胺d3受体拮抗作用的稠环化合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
US5134139A (en) | 1989-08-31 | 1992-07-28 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and preparation thereof |
US5143923B1 (en) | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
GB9821978D0 (en) * | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
PL348294A1 (en) | 1998-12-18 | 2002-05-20 | Schering Corp | Farnesyl protein transferase inhibitors |
DE19922443A1 (de) | 1999-05-07 | 2000-11-09 | Basf Ag | Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen |
-
2002
- 2002-02-15 EP EP05018120A patent/EP1632483B1/en not_active Expired - Lifetime
- 2002-02-15 CA CA002438264A patent/CA2438264A1/en not_active Abandoned
- 2002-02-15 AT AT08004461T patent/ATE455108T1/de not_active IP Right Cessation
- 2002-02-15 WO PCT/US2002/004713 patent/WO2002066446A1/en active IP Right Grant
- 2002-02-15 DE DE60208157T patent/DE60208157T2/de not_active Expired - Lifetime
- 2002-02-15 DK DK02718999T patent/DK1362039T3/da active
- 2002-02-15 AT AT05018120T patent/ATE412638T1/de active
- 2002-02-15 EP EP02718999A patent/EP1362039B1/en not_active Expired - Lifetime
- 2002-02-15 DK DK05018120T patent/DK1632483T3/da active
- 2002-02-15 DE DE60235130T patent/DE60235130D1/de not_active Expired - Lifetime
- 2002-02-15 MX MXPA03006943A patent/MXPA03006943A/es active IP Right Grant
- 2002-02-15 EP EP08004461A patent/EP1935887B1/en not_active Expired - Lifetime
- 2002-02-15 ES ES05018120T patent/ES2317116T3/es not_active Expired - Lifetime
- 2002-02-15 AU AU2002250107A patent/AU2002250107B8/en not_active Ceased
- 2002-02-15 IL IL15741302A patent/IL157413A0/xx unknown
- 2002-02-15 ES ES02718999T patent/ES2253526T3/es not_active Expired - Lifetime
- 2002-02-15 AT AT02718999T patent/ATE313534T1/de not_active IP Right Cessation
- 2002-02-15 PT PT05018120T patent/PT1632483E/pt unknown
-
2009
- 2009-04-14 JP JP2009097547A patent/JP2009185054A/ja not_active Abandoned
- 2009-04-14 JP JP2009097550A patent/JP2009185055A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2317116T3 (es) | 2009-04-16 |
DE60235130D1 (de) | 2010-03-04 |
AU2002250107B2 (en) | 2008-05-29 |
DE60208157D1 (de) | 2006-01-26 |
EP1362039B1 (en) | 2005-12-21 |
EP1632483B1 (en) | 2008-10-29 |
ATE313534T1 (de) | 2006-01-15 |
CA2438264A1 (en) | 2002-08-29 |
PT1632483E (pt) | 2009-01-12 |
MXPA03006943A (es) | 2005-04-29 |
WO2002066446A1 (en) | 2002-08-29 |
EP1935887A1 (en) | 2008-06-25 |
ATE412638T1 (de) | 2008-11-15 |
EP1362039A1 (en) | 2003-11-19 |
ES2253526T3 (es) | 2006-06-01 |
DK1362039T3 (da) | 2006-05-08 |
DE60208157T2 (de) | 2006-08-10 |
JP2009185055A (ja) | 2009-08-20 |
EP1632483A1 (en) | 2006-03-08 |
ATE455108T1 (de) | 2010-01-15 |
EP1935887B1 (en) | 2010-01-13 |
JP2009185054A (ja) | 2009-08-20 |
DK1632483T3 (da) | 2009-03-02 |
AU2002250107B8 (en) | 2008-06-12 |
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