CO5370677A1 - Nuevos derivados heterociclicos de carbonil sustituido y su uso como ligantes receptores d3 de dopamina - Google Patents

Nuevos derivados heterociclicos de carbonil sustituido y su uso como ligantes receptores d3 de dopamina

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Publication number
CO5370677A1
CO5370677A1 CO02013028A CO02013028A CO5370677A1 CO 5370677 A1 CO5370677 A1 CO 5370677A1 CO 02013028 A CO02013028 A CO 02013028A CO 02013028 A CO02013028 A CO 02013028A CO 5370677 A1 CO5370677 A1 CO 5370677A1
Authority
CO
Colombia
Prior art keywords
disorders
dopamine
compounds
receptors
disease
Prior art date
Application number
CO02013028A
Other languages
English (en)
Inventor
James A Hendrix
Original Assignee
Aventis Pharma Inc
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Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of CO5370677A1 publication Critical patent/CO5370677A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/20—Hypnotics; Sedatives
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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Abstract

La invención se refiere a derivados de carbonilo substituidos heterociclicamente que muestran enlace selectivo a los receptores D3 de dopamina. En otro aspecto la invención se refiere a un método para tratar trastornos del sistema nervioso central asociados con la actividad de los receptores D3 de dopamina en un paciente que requiere dicho tratamiento que comprende administrar a un sujeto una cantidad terapéuticamente eficaz de dichos compuestos para aliviar tal trastorno. Los trastornos del sistema nervioso central que se pueden tratar con estos compuestos incluyen trastornos piscóticos, dependencia de substancias, abuso de substancias, trastornos disquinéticos (por ejemplo enfermedad de Parkinson, parkisonismo, disquinesia tardía inducida neuorolépticamente, síndrome de Gilles de la Tourette y enfermedad de Huntington), demencia, trastornos de ansiedad, trastornos del sueño, trastornos del ritmo circadiano y trastornos del estado de ánimo. La presente invención también se dirige a procedimientos para la preparación de los compuestos descritos aquí y también a métodos para hacer y usar los compuestos como agentes reproductores de la imagen de los receptores D3 de dopamina.
CO02013028A 2001-02-16 2002-02-15 Nuevos derivados heterociclicos de carbonil sustituido y su uso como ligantes receptores d3 de dopamina CO5370677A1 (es)

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PA8540001A1 (es) 2002-12-30
US20090247509A1 (en) 2009-10-01
US20040220173A1 (en) 2004-11-04
JP4685331B2 (ja) 2011-05-18
UY27179A1 (es) 2002-07-31
US7186724B2 (en) 2007-03-06
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US20070161641A1 (en) 2007-07-12
US7521445B2 (en) 2009-04-21

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