UA92503C2 - Соединения 5-(фенилизоксазолилэтокси)-триазол-3-ил-замещенного пиридина для лечения неврологических, психиатрических или болевых расстройств - Google Patents

Соединения 5-(фенилизоксазолилэтокси)-триазол-3-ил-замещенного пиридина для лечения неврологических, психиатрических или болевых расстройств

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Publication number
UA92503C2
UA92503C2 UAA200802884A UAA200802884A UA92503C2 UA 92503 C2 UA92503 C2 UA 92503C2 UA A200802884 A UAA200802884 A UA A200802884A UA A200802884 A UAA200802884 A UA A200802884A UA 92503 C2 UA92503 C2 UA 92503C2
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UA
Ukraine
Prior art keywords
phenylisoxazolylethoxy
psychiatric
triazol
neurological
treatment
Prior art date
Application number
UAA200802884A
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English (en)
Ukrainian (uk)
Inventor
Александер Минидис
Давид Венсбо
Абдельмалик Сласси
Метвин Айзаак
Каролине Эрикссон
Вероника Профир
Пер-Олув Бергстром
Луиз Эдвардз
Джалай Арора
Тао Синь
Original Assignee
Астразенека Аб
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Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA92503C2 publication Critical patent/UA92503C2/ru

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    • C07ORGANIC CHEMISTRY
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    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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Abstract

Заявленное изобретение касается новых соединений формулы II, применение в терапии и фармацевтических композициях, которые содержат указанные новые соединения.(II)
UAA200802884A 2005-09-29 2006-09-20 Соединения 5-(фенилизоксазолилэтокси)-триазол-3-ил-замещенного пиридина для лечения неврологических, психиатрических или болевых расстройств UA92503C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72152705P 2005-09-29 2005-09-29

Publications (1)

Publication Number Publication Date
UA92503C2 true UA92503C2 (ru) 2010-11-10

Family

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Family Applications (1)

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UAA200802884A UA92503C2 (ru) 2005-09-29 2006-09-20 Соединения 5-(фенилизоксазолилэтокси)-триазол-3-ил-замещенного пиридина для лечения неврологических, психиатрических или болевых расстройств

Country Status (18)

Country Link
US (4) US20080227824A1 (ru)
EP (1) EP1934209A1 (ru)
JP (2) JP2009510064A (ru)
KR (1) KR20080050421A (ru)
CN (1) CN101273037A (ru)
AR (1) AR058807A1 (ru)
AU (1) AU2006297462A1 (ru)
BR (1) BRPI0616228A2 (ru)
CA (1) CA2623009A1 (ru)
EC (1) ECSP088283A (ru)
IL (1) IL189990A0 (ru)
NO (1) NO20081434L (ru)
RU (1) RU2008108219A (ru)
TW (1) TW200800976A (ru)
UA (1) UA92503C2 (ru)
UY (1) UY29796A1 (ru)
WO (1) WO2007040982A1 (ru)
ZA (1) ZA200802163B (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014881A2 (en) * 2002-08-09 2004-02-19 Astra Zeneca Ab '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
UY29796A1 (es) * 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor
TW200821305A (en) * 2006-10-05 2008-05-16 Astrazeneca Ab MGluR5 modulators
BRPI0818448A2 (pt) * 2007-10-19 2015-05-12 Astrazeneca Ab Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento ou prevenção de um distúrbio madiano pelo receptor mglur5.
TW200922585A (en) * 2007-10-26 2009-06-01 Astrazeneca Ab Amino 1,2,4-triazole derivatives as modulators of mGluR5
EP2324019A4 (en) * 2008-08-12 2011-10-05 Astrazeneca Ab CRYSTALLINE FORM OF (5- {(IR) -1- [5- (3-CHLOROPHENYL) ISOXAZOL-3-YL] ETHOXY} -4-METHYL-4H-L, 2, 4-TRIAZOL-3-YL) -PYRIDINE
WO2010019100A1 (en) * 2008-08-12 2010-02-18 Astrazeneca Ab A new crystalline form of 4- (5- { (ir) -1- [5- (3- chlorophenyl) isoxazol-3-yl] ethoxy } -4-methyl-4h-l, 2, 4- triazol-3-yl) pyridine
CA2751761A1 (en) 2008-10-22 2010-04-29 House Ear Institute Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
BRPI0923215A2 (pt) * 2008-12-12 2017-06-06 Astrazeneca Ab método para fabricar um composto.
CA2747507A1 (en) * 2008-12-18 2010-06-24 Astrazeneca Ab New process for the preparation of 1- [5-(3-chloro-phenyl)-isooxazol-3-yl]-ethanone and (r)-1-[5-(3-chloro-phenyl)-isooxazol-3-yl]-ethanol
EP2379531A1 (en) * 2008-12-18 2011-10-26 AstraZeneca AB Processes for the manufacture of 3-{4-methyl-5- [ (ir) -1- (2- (3-methylphenyl) -2h-tetrazol-5-yl) -ethoxy]-4h- [1,2, 4]triazol-3-yl} -pyridine, 4-methyl-3-methylthio-5- (3- pyridyl)-l,2,4-triazole, and (ir) -1- [2- (3-methylphenyl) -2h- tetrazol-5-yl]ethanol
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
CA2764339A1 (en) * 2009-06-05 2010-12-09 Oslo University Hospital Hf Azole derivatives as wtn pathway inhibitors
ES2443578T3 (es) 2009-12-29 2014-02-19 Eli Lilly And Company Compuestos de tetrahidrotriazolopiridina como potenciadores de receptores selectivos de mGlu5 útiles para el tratamiento de la esquizofrenia
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
JP2013518085A (ja) 2010-02-01 2013-05-20 ノバルティス アーゲー CRF−1受容体アンタゴニストとしてのピラゾロ[5,1b]オキサゾール誘導体
JP5748777B2 (ja) 2010-02-02 2015-07-15 ノバルティス アーゲー Crf受容体アンタゴニストとしてのシクロヘキシルアミド誘導体
US8080568B1 (en) * 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
UA112418C2 (uk) * 2010-09-07 2016-09-12 Астеллас Фарма Інк. Терапевтичний болезаспокійливий засіб
RU2013128448A (ru) 2010-12-08 2015-01-20 Осло Юниверсити Хоспитал Хф Производные триазола в качестве ингибиторов сигнального пути wnt
AU2012232711B2 (en) 2011-03-18 2016-04-28 Novartis Ag Combinations of alpha 7 nicotinic acetylcholine receptor activators and mGluR5 antagonists for use in dopamine induced dyskinesia in Parkinson's Disease
WO2016163754A1 (en) * 2015-04-07 2016-10-13 Medpacto Inc. Pharmaceutical composition for preventing or treating cancer and method using thereof
KR20160120157A (ko) 2015-04-07 2016-10-17 주식회사 메드팩토 암 예방 또는 치료용 약학적 조성물 및 이를 이용한 방법
KR102027368B1 (ko) * 2018-05-29 2019-10-01 서울대학교산학협력단 통증의 강도를 측정하는 방법
AU2019384074B2 (en) 2018-11-20 2025-04-10 Sparrow Pharmaceuticals, Inc. Methods for administering corticosteroids
CN113811297B (zh) * 2019-05-15 2024-03-26 克拉斯·图林 用于预防和/或治疗动物中的疼痛的4-[5-[(rac)-1-[5-(3-氯苯基)-3-异噁唑基]乙氧基]-4-甲基-4H-1,2,4-三唑-3-基]吡啶
KR20220097405A (ko) 2019-11-05 2022-07-07 클라에스 툴린 포유동물에서의 혹사의 예방 및/또는 치료에 사용하기 위한 4-[5-[(rac)-1-[5-(3-클로로페닐)-3-이속사졸일]에톡시]-4-메틸-4H-1,2,4-트리아졸-3-일]피리딘
EP4525983A4 (en) 2022-05-16 2025-09-03 Sparrow Pharmaceuticals Inc METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS
EP4583872A1 (en) 2022-10-28 2025-07-16 Orphelion Ab Mglur5 receptor antagonists for use in prevention and/or treatment of bone marrow lesions (bml) and/or osteoporosis, cartilage loss, osteosclerosis, osteitis in a mammal

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100875222B1 (ko) 1999-08-19 2008-12-19 아스트라제네카 아베 헤테로폴리사이클릭 화합물 및 간접 글루타메이트 수용체길항제로서의 그들의 용도
MXPA03007513A (es) 2001-02-21 2004-07-30 Nps Pharma Inc Compuestos heteropoliciclicos y su uso como antagonistas del receptor metabotropico de glutamato.
WO2004014881A2 (en) 2002-08-09 2004-02-19 Astra Zeneca Ab '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5
US7074809B2 (en) 2002-08-09 2006-07-11 Astrazeneca Ab Compounds
TW200424183A (en) 2002-08-09 2004-11-16 Nps Pharma Inc New compounds
WO2005060971A1 (en) 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of reflux-related diseases
CA2548039A1 (en) 2003-12-19 2005-07-21 Astrazenca Ab 5-fluoro-, chloro- and cyano-pyridin-2-yl-tetrazoles as ligands of the metabotropic glutamate receptor-5
WO2005077345A1 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease
WO2005077368A2 (en) 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
DE602005008558D1 (de) 2004-02-18 2008-09-11 Astrazeneca Ab Kondensierte heterocyclische verbindungen und deren verwendung als antagonisten des metabotropen reznkungen
TW200531694A (en) 2004-02-18 2005-10-01 Astrazeneca Ab Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists
US20070185100A1 (en) 2004-02-18 2007-08-09 Astrazeneca Ab Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005080356A1 (en) 2004-02-18 2005-09-01 Astrazeneca Ab Tetrazole compounds and their use as metabotropic glutamate receptor antagonits
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
RU2006127575A (ru) 2004-02-18 2008-03-27 Астразенека Аб (Se) Соединение триазола и их применение в качестве антагонистов метаботропного рецептора глутамата
UY29796A1 (es) * 2005-09-29 2007-04-30 Astrazeneca Ab Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor

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US7476684B2 (en) 2009-01-13
AU2006297462A1 (en) 2007-04-12
UY29796A1 (es) 2007-04-30
US20070129408A1 (en) 2007-06-07
JP2010013476A (ja) 2010-01-21
RU2008108219A (ru) 2009-11-10
AR058807A1 (es) 2008-02-27
CA2623009A1 (en) 2007-04-12
ZA200802163B (en) 2009-09-30
CN101273037A (zh) 2008-09-24
NO20081434L (no) 2008-05-19
WO2007040982A1 (en) 2007-04-12
EP1934209A1 (en) 2008-06-25
US20070270468A1 (en) 2007-11-22
US20080227824A1 (en) 2008-09-18
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TW200800976A (en) 2008-01-01
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