Claims
1. Use of a compound of formula IH, Ar!-L-Ar2 (IH) where Ar1 is an optionally substituted heterocyclic moiety and Ar2 is an optionally substituted carbocyclic moiety; wherein the L moiety is made up of 1-14 atoms; or a pharmaceutically acceptable salt or an optical isomer thereof, for the manufacture of a medicament for the inhibition of transient lower esophageal sphincter relaxations (TLESRs).
2. Use of a compound of formula in as defined in claim 1, or a pharmaceutically acceptable salt or an optical isomer thereof, for the manufacture of a medicament for the treatment of gastro-esophageal reflux disease (GERD).
3. Use of a compound of formula III as defined in claim 1, or a pharmaceutically acceptable salt or an optical isomer thereof, for the manufacture of a medicament for the prevention of reflux.
4. Use of a compound of formula III as defined in claim 1, or a pharmaceutically acceptable salt or an optical isomer thereof, for the manufacture of a medicament for the treatment of, or prevention of, regurgitation. 5. Use of a compound of formula IH as defined in claim 1, or a pharmaceutically acceptable salt or an optical isomer thereof, for the manufacture of a medicament for the treatment of, or prevention of, asthma.
6. Use according to claim 5, wherein the asthma is reflux-related asthma.
7. Use of a compound of formula HI as defined in claim 1, or a pharmaceutically acceptable salt or an optical isomer thereof, for the manufacture of a medicament for the treatment of, or prevention of, laryngitis.
8. Use of a compound of formula IH as defined in claim 1, or a pharmaceutically acceptable salt or an optical isomer thereof, for the manufacture of a medicament for the treatment of, or prevention of, lung disease.
9. Use of a compound of formula HI as defined in claim 1, or a pharmaceutically acceptable salt or an optical isomer thereof, for the manufacture of a medicament for managing failure to thrive.
10. Use according to any one of claims 1-9, wherein the compound is selected from the group of compounds consisting of 3-(2-pyridyl)-5-(3-methoxyphenyl)- 1,2,4- oxadiazole, 3-(2-pyridyl)-5-(3,5-dichlorophenyl)-l,2,4-oxadiazole, 3-(2-ρyridyl)- 5-(3-chlorophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(2-chlorophenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-[3-(trifluoromethyl)phenyl]- 1 ,2,4-oxadiazole, 3-(2- ρyridyl)-5-(3-methylphenyl)- 1,2,4-oxadiazole, 3-(2-ρyridyl)-5-(l-naphthyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-[3-(trifluoromethoxy)phenyl]-l,2,4- oxadiazole, 3-(2- pyridyl)-5-(2,3-difluorophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl) -5-(2,5- difluorophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3,5-difluorophenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-cyanophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5- (3,5-dimethoxyphenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(2,3-dichlorophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-chloro-5-cyanophenyl)-l,2,4-oxadiazole, 3- (2-ρyridyl)-5-(3-fluoro-5-cyanophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(3- chloro-5-fluorophenyl)- 1,2,4-oxadiazole, 3-(5-chloropyrid-2-yl)-5-(3- cyanophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyanophenyl)-l,2,4- oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-fluorophenyl)-l,2,4-oxadiazole, 3-(3-fluoropyrid-2-yl)-5-(3-cyanophenyl)-l,2,4-oxadiazole, 3-(5-fluoropyrid-2- yl)-5-(3,5-dimethoxyphenyl)-l,2,4-oxadiazole, 3-(5-methoxypyrid-2-yl)-5-(3- cyanophenyl)- 1,2,4-oxadiazole, 3-(2-quinolinyl)-5-(3-cyanophenyl)-l,2,4-
oxadiazole, 3-(3-chloro-5-trifluoromethylpyrid-2-yl)-5-(3-cyanophenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(5-chloro-2-methoxyphenyl)-l,2,4-oxadiazole, 3-(2- pyridyl)-5-(2-chloro-5-methylthiophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(2- bromo-5-methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(2,5,6- trifluorophenyl)-l ,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-nitrophenyl)-l ,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-bromophenyl)-l,2,4-oxadiazole, 2-(3,5- dichlorophenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(3-chlorophenyl)-4-(2-pyridyl)-l,3- oxazole, 2-(3-methoxyphenyl)-4-(2-pyridyl)- 1 ,3-oxazole, 2-(2-chlorophenyl)-4- (2-pyridyl)- 1,3-oxazole, 2-(3-trifluoiOphenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3- methyl phenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(l-naphthyl)-4-(2-pyridyl)-l,3- oxazole, 2-(3-trifluoromethoxyphenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(2,3- difluorophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(2,5-difluorophenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(3,5-difluorophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3- cyanophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3,5-dimethoxyphenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(2,3-dichlorophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3-chloro-5- cyanophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3-fluoro-5-cyanophenyl)-4-(2- pyridyl)- 1,3-oxazole, 2-(3-chloro-5-fluorophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3- cyanophenyl)-4-(5-chloropyrid-2-yl)-l,3-oxazole, 2-(3-cyanophenyl)-4-(5- fluoropyrid- 2-yl)- 1,3-oxazole, 2-(3-cyano-5-fluorophenyl)-4-(5-fluoropyrid-2-yl)- 1,3-oxazole, 2-(3-cyanoρhenyl)-4-(3-fluoropyrid-2-yl)-l,3-oxazole, 2-(3,5- dimethoxyphenyl)-4-(5-fluoropyrid-2-yl)-l,3-oxazole, 2-(3-cyanophenyl)-4-(5- methoxypyrid-2-yl)-l,3-oxazole, 2-(3-cyanophenyl)-4-(2-quinolinyl)-l,3-oxazole, 2-(3-cyanophenyl)-4-(3-chloro-5-trifluoromethylpyrid-2-yl)- 1 ,3-oxazole, 2-(5- chloro-2-methoxyphenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(2-chloro-5- methylthiophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(2-bromo-5-methoxyphenyl)-4-
(2-pyridyl)- 1,3-oxazole, 2-(2,5,6-trifluoroρhenyl)-4-(2-pyridyl)-l,3-oxazole, 2-[3- chlorophenyl]-4-[pyridin-2-yl]-l,3-oxazole, 2-(2,5,6-trifluorophenyl)-4-(2- pyridyl)- 1,3-oxazole, 2-(3-nitrophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3- bromophenyl)-4-(2-pyridyl)-l,3-oxazole and pharmaceutically acceptable salts or optical isomers thereof.
1. Use according to any one of claims 1-9, wherein the compound is selected from the group of compounds consisting of 3-(5-Methyl-pyrid-2-yl)-5-(3- cyanoρhenyl)-l ,2,4-oxadiazole, 3-(5-Cyano-pyrid-2-yl)-5-(3-cyanophenyl)-l ,2,4- oxadiazole, 3-(2-Pyridyl)-5-(5-bromo-2-methoxyphenyl)-l ,2,4-oxadiazole, 3-(2- Pyridyl)-5-(5-bromo-2-fluorophenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano- 2-fluorophenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-bromopyrid-3-yl)-l,2,4- oxadiazole, 3-(2-Pyridyl)-5-(5-chloro-pyrid-3-yl)-l,2,4-oxadiazole, 3-(5- Cyanopyrid-2-yl)-5-(5-bromo-pyrid-3-yl)-l,2,4-oxadiazole, 3-(5-Fluoropyrid-2- yl)-5-(5-bromo-pyrid-3-yl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(2-thiomethoxy- pyrid-3-yl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-methylpyrid-3-yl)-l,2,4- oxadiazole, 3-(2-Pyridyl)-5-(5-methoxypyrid-3-yl)-l ,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-cyano-5-methylphenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-fluoro- 5-bromophenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-iodo-5-bromophenyl)-l,2,4- oxadiazole, 3-(5-Fluoro-2-pyridyl)-5-(3-fluoro-5-bromophenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-iodo-5-(methylphenylester)-l ,2,4-oxadiazole, 3-(2-Pyridyl)-5- (3-methoxy-5-(methoxycarbonyl)phenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3- bromo-5-cyanophenyl)- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano-3-iodophenyl)- 1 ,2,4-oxadiazole, 3-(5-Cyano-2-pyridyl)-5-(3-bromophenyl)-l ,2,4-oxadiazole, 3- (5-Cyano-2-pyridyl)-5-(3-cyano-5-fluorophenyl)-l,2,4-oxadiazole, 3-(5-Cyano-2- pyridyl)-5-(3-bromo-5-fluorophenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano- 2-methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(2-cyano-5-methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano-pyrid-3-yl)-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-cyano-5-(methoxycarbonyl)phenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)- 5-(5-phenyl-pyrid-3-yl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5- methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5-hydroxyphenyl)- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5-propoxyphenyl)-l ,2,4-oxadiazole, 2- (3-Cyanophenyl)-4-(pyridin-2-yl)- 1 ,3-thiazole, 2-((3-Bromo-5-iodophenyl)-4- pyridin-2-yl)- 1,3-oxazole, 2-(2-Pyridyl)-5-(3-iodophenyl)-l,3,4-oxadiazole, 2-(2- Pyridyl)-5-(3-cyanophenyl)-l,3,4-oxadiazole, 2-(2-Pyridyl)-5-(3-cyanophenyl)- 1,3,4-triazole, 3-(5-Chloropyrid-2-yl)-5-(3-cyano-5-fluorophenyl)-l,2,4- oxadiazole, 3-(5-Chloropyrid-2-yl)-5-(3-cyano-5-chlorophenyl)-l,2,4-oxadiazole, 3-(5-Chloropyrid-2-yl)-5-(3-chloro-5-fluoroρhenyl)-l,2,4-oxadiazole, 3-(5-
Chloropyrid-2-yl)-5-(3-cyano-5-methoxyphenyl)-l,2,4-oxadiazole, 3-(5- Fluoropyrid-2-yl)-5-(3-cyano-5-chlorophenyl)-l,2,4-oxadiazole, 3-(5- Fluoropyrid-2-yl)-5-(3-fluoro-5-chlorophenyl)-l,2,4-oxadiazole, 3-(5- Fluoropyrid-2-yl)-5-(3-cyano-5-methoxyphenyl)-l,2,4-oxadiazole, 3-(5- Cyanopyrid-2-yl)-5-(3-cyano-5-chlorophenyl)-l ,2,4-oxadiazole, 3-(5-Cyanopyrid- 2-yl)-5-(3-fluoro-5-chlorophenyl)-l,2,4-oxadiazole, 3-(5-Cyanopyrid-2-yl)-5-(3- cyano-5-methoxyphenyl)- 1,2,4-oxadiazole, 3-(5-Fluoropyrid-2-yl)-5-(3,5-di- cyanophenyl)- 1 ,2,4-oxadiazole, 3-(3-(4-Dimethylaminobutoxy)-pyrid-2-yl)-5-(3- cyano-5-fluorophenyl)-l,2,4-oxadiazole, 3-(3-(5-Dimethylaminopentyloxy)- pyrid-2-yl)-5-(3-Cyano-5-fluorophenyl)-l,2,4-oxadiazole, and [3-(3-(6- Dimethylaminohexyloxy)-pyrid-2-yl)-5-(3-cyano-5-fluorophenyl)-l,2,4- and pharmaceutically acceptable salts or optical isomers thereof.
12. Use according to any one of claims 1-9, wherein the compound is selected from the group of compounds consisting of 3-(2-Pyridyl)-5-(3-allyloxy-5- (methoxycarbonyl)phenyl)-l ,2,4- oxadiazole, 3-(2-Pyridyl)~5-(3-N,N- dimethylaminophenyl)-l,2,4-oxadiazole), 3-(2-Pyridyl)-5-(3-cyano-5-(4- pyridyl)phenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-[2-methoxy-5-(4- pyridyl)phenyl]-l ,2,4- oxadiazole, 3-(2-pyridyl)-5-[2-fluoro-5-(4-pyridyl)phenyl]- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-fluoro-5-(4-pyridyl)ρhenyl)- 1,2,4- oxadiazole, 3- (2-Pyridyl)-5-(3-fluoro-5-(3-pyridyl) phenyl)- 1,2,4-oxadiazole, 3- (2-Pyridyl)-5-[2-fluoro-5-(3-pyridyl)phenyl]-l,2,4-oxediazole, 3-(2-Pyridyl)-5-[2- methoxy-5-(3-pyridyl)phenyl]-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5-(3- pyridyl)phenyl)- 1,2,4-oxadiazole, 3-(5-Fluoro-2-pyridyl)-5-(3-fluoro-5-(3- pyridyl)phenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-[5-(3-pyridyl-pyrid-3-yl)]-]- 1,2,4-oxadiazole, 3-(5-Fluoropyrid-2-yl)]-5-[5-(3-ρyridyl-pyrid-3-yl)]-3-l,2,4- oxadiazole, 3-(5-Cyanopyrid-2-yl)-5-(3-(pyrid-3-yl)phenyl)- 1 ,2,4-oxadiazole, to 3-(5-Cyanopyrid-2-yl)-5-(3-fluoro-5- (pyrid-3-yl)phenyl)-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-cyano-5- (2-ρyridyl)ρhenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-[2- methoxy-5-(2-pyridyl)phenyl]-l,2,4-oxediazole, 3-(2-Pyridyl)-5-[2-fluoro-5- (2- pyridyl)phenyl]- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-[(3-(3-fluorophenyl)-5- fluorophenyl)]- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3- cyano-5-(3-
thiophene)phenyl)- 1,2,4-oxadiazole, 3- (2-Pyridyl)-5-[5-(3-thienyl)-pyrid-3-yl]- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-[5-3-furyl)-pyrid-3-yl]-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-[5-(3-methoxyphenyl)-pyrid-3-yl]-l,2,4-oxadiazole, 3-(2-Pyridyl)-5- (3-cyano-5-(5-pyrimidyl)phenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)- 5-(3-cyano-5- (3-aminophenyl)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl) -5-(3-cyano-5-(3- fluorophenyl)phenyl)-l,2,4-oxediazole, 3-(2-Pyridyl)-5-[5-(5-pyrimidyl)-pyrid-3- yl]-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-aminomethyl-5-cyanophenyl)-l,2,4- oxadiazole, 3-(2-Pyridyl)-5-[5[(2-propenyl)-pyrid-3-yl]-l,2,4-oxediazole, 3-(2- Pyridyl)-5- (3-cyano-5-vinylphenyl)-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-cyano- 5-(2-hydroxyethyl)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5-(2,3- dichloropropoxy)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-allyloxy-5- carboxyphenyl)- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-allyloxy-5-cyanophenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano-3-[3-hydroxypropyn-l-yl]phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(2-N-methylaminophenyl)-l,2,4-oxadiazole, and 3-(2-Pyridyl)-5- [5-(3-N-benzyl-l,2,5,6, tetrahydropyridine)-pyrid-3-yl]- 1,2,4-oxadiazole.
13. Use according to any one of claims 1-9, wherein the compound is selected from the group of compounds consisting of 3-(2-pyridyl)-5-(3-fluorophenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(2,3-dimethoxyphenyl)-l,2,4-oxadiazole, 3-(2- pyridyl)-5-(3-phenoxyphenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(3- benzoylphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(2-chloro-5- (trifluoromethyl)phenyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)-5-(3 ,4,5- trifluorophenyl)- 1 ,2,4-oxadiazole, 3-(3-methoxyphenyl)-5-(2-pyridyl)- 1 ,2,4- oxadiazole, 3-(pyrid-2-yl)-5-(2-hydroxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5- (5-chloro-2-hydroxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(2-aminophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(5-chloro-2-aminophenyl)- 1,2,4-oxadiazole, 5- [3-hydroxyphenyl]-3-[pyridin-2-yl]-l,2-oxazole, 5-[3-cyanophenyl]-3-[pyridin-2- yl]-l,2-oxazole, 3-(2-pyridyl)-5-(3-chlorophenyl)-l,2,4-triazole, 3-(2-pyridyl)-5- (3-iodophenyl)-l,2,4-triazole, 3-(2-pyridyl)-5-(5-hydroxypyrid-3-yl)-l,2,4- oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(5-fluoro-3-(thiomethyl)phenyl)-l,2,4- oxadiazole, 5-(2-pyridyl)-3-[3-(lH-imidazol-l-yl)-5-fluorophenyl)]-l,2,4-
oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-trifluoromethylphenyl)-l,2,4-oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-fluoro-5-trifluoromethylphenyl)-l,2,4-oxadiazole, 3- (5-cyanopyrid-2-yl)-5-(3-alloxy-5-cyanophenyl)-l,2,4-oxadiazole, 3-(5- fluoropyrid-2-yl)-5-(3-alloxy-5-cyanophenyl)-l,2,4-oxadiazole, 3-(5-cyanopyrid- 2-yl)-5-(3-cyano-5-propoxyphenyl)-l ,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3- cyano-5-propoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- nitrophenyl)- 1 ,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-nitrophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-dimethylaminophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-(2-methoxyethoxy)phenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-(lH-imidazol-l- ylmethyl)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- (methoxymethyl)phenyl)- 1,2,4-oxadiazole, 3-(3-cyano-5-methoxyphenyl)-5-(2- pyridyl)- 1 ,2,4-oxadiazole, 3-(3-cyano-5-methoxyphenyl)-5-(5-fluoropyrid-2-yl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-ethoxyphenyl)-l,2,4- oxadiazole, 3-(5-cyanopyrid-2-yl)-5-(3-cyano-5-ethoxyphenyl)- 1,2,4-oxadiazole,
3-(5-chloropyrid-2-yl)-5-(3-allyloxy-5-cyanophenyl)-l,2,4-oxadiazole, 3-(5- chloropyrid-2-yl)-5-(3-cyano-5-propoxyphenyl)-l,2,4-oxadiazole, 3-(5- chloropyrid-2-yl)-5-(3-cyano-5-ethoxyphenyl)-l,2,4-oxadiazole, 3-(5-fluoropyrid- 2-yl)-5-(3-cyano-5-hexyloxyphenyl)-l,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5- (3-cyano-5-(methoxymethyl)phenyl)-l,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-
(5-cyano-2-methoxyphenyl)- 1,2,4-oxadiazole, 5-(5-cyano-2-methoxyphenyl)-3- (5-cyano-pyrid-2-yl)- 1,2,4-oxadiazole, 3-(5-fluoro-pyrid-2-yl)-5-(3- bromophenyl)- 1,2,4-oxadiazole, 5-(3-chloro-5-methyl-pyrid-4-yl)-3-(2-pyridyl)- 1,2,4-oxadiazole, 5-(3-chloro-5-methoxy-pyrid-4-yl)-3-(2-pyridyl)-l,2,4- oxadiazole, 3-(3-cyano-5-methylphenyl)-5-(2-pyridyl)-l,2,4-oxadiazole, 3-(5- bromo-pyrid-3-yl)-5-(2-pyridyl)- 1 ,2,4-oxadiazole, 3-(3-cyano-5-fluorophenyl)-5- (2-pyridyl)- 1,2,4-oxadiazole, 3-(3-iodophenyl)-5-(2-pyridyl)-l,2,4-oxadiazole, 3- (3-cyanophenyl)-5-(2-pyridyl)- 1,2,4-oxadiazole, 3-(3-cyano-5-dimethylamino- phenyl)-5-(2-pyridyl)-l,2,4-oxadiazole, 3-(3-cyano-5-methylphenyl)-5-(5-fluoro- pyrid-2-yl)- 1,2,4-oxadiazole, 3-(3-cyano-5-fluorophenyl)-5-(5-fluoro-pyrid-2-yl)-
1,2,4-oxadiazole, 3-(4-cyanophenyl)-3-(6-cyano-pyrid-2-yl)-l,2,4-oxadiazole, 5- (3-cyano-5-trifluoromethoxyphenyl)-3-(2-pyridyl)-l,2,4-oxadiazole, 5-(3-
methoxycarbonyl-5-trifluoromethoxyphenyl)-3-(2-pyridyl)- 1 ,2,4-oxadiazole, 5- (3-cyano-5-trifluoromethoxyphenyl)-3-(5-fluoro-pyrid-2-yl)-l,2,4-oxadiazole, 3- (5-cyano-pyrid-2-yl)-5-(3-cyano-5-trifluoromethoxyphenyl)-l,2,4-oxadiazole, 3- (3-cyano-5-dimethylaminophenyl)-5-(5-fluoro-pyrid-2-yl)-l,2,4-oxadiazole, 5-(5- chloro-pyrid-2-yl)-3-(3-cyano-5-dimethylaminophenyl)-l,2,4-oxadiazole, 5-(5- chloro-pyrid-2-yl)-3-(3-cyano-5-methoxyphenyl)- 1 ,2,4-oxadiazole, 5-(5-chloro- pyrid-2-yl)-3-(6-cyano-4-methoxy-pyrid-2-yl)-l,2,4-oxadiazole, 5-(5-chloro- pyrid-2-yl)-3-(6-cyano-4-hydroxy-pyrid-2-yl)-l,2,4-oxadiazole, 5-(5-chloro- pyrid-2-yl)-3-(3-cyano-5-trifluoromethoxyphenyl)-l,2,4-oxadiazole, 5-(5-chloro- pyrid-2-yl)-3-(3-cyanophenyl)- 1,2,4-oxadiazole, 5-(5-chloro-pyrid-2-yl)-3-(3- cyano-5-methylphenyl)-l,2,4-oxadiazole, 5-(5-chloro-pyrid-2-yl)-3-(3-cyano-5- fluorophenyl)- 1,2,4-oxadiazole, 3-(3-cyano-5-trifluoromethoxyphenyl)-5-(2- pyridyl)- 1,2,4-oxadiazole, 3-(3-fluoro-5-methoxyphenyl)-5-(2-pyridyl)- 1,2,4- oxadiazole, 3-(3-cyanoρhenyl)-5-(5-fluoro-pyrid-2-yl)-l ,2,4-oxadiazole, 3-(3- cyano-5-trifluoromethoxyphenyl)-5-(5-fluoro-pyrid-2-yl)-l ,2,4-oxadiazole, 3-(3- fluoro-5-methoxyphenyl)-5-(5-fluoropyrid-2-yl)- 1,2,4-oxadiazole, 3-(3,5- dimethoxyphenyl)-5-(5-fluoropyrid-2-yl)- 1,2,4-oxadiazole, 3-[3-fluoro-5-(lH- imidazol-l-yl)phenyl]-5-(2-pyridyl)- 1,2,4-oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3- fluoro-5-(3-pyridyl)phenyl)-l,2,4-oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-bromo- 5-(3-pyridyl)phenyl)- 1,2,4-oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-fluoro-5- methoxyphenyl)-l ,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(3-cyano-5- thiomethylphenyl)- 1,2,4-oxadiazole, 3-(5-fluoro-pyrid-2-yl)-5-(3-cyano-5- thiomethylphenyl)- 1 ,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(3-fluoro-5- thiomethylphenyl)- 1,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(3-fluoro-5- thiomethylsulphoxidephenyl)- 1,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(3-fluoro-5- thioethylphenyl)-l ,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(5-fluoro-3- thiotertbutylphenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5- methylphenyl)- 1 ,2,4-oxadiazole, 3-(5-cyanopyrid-2-yl)-5-(3-cyano-5- thiomethylphenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(4-cyano-2-thienyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-trifluoromethylphenyl)-l ,2,4- oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-cyano-5-trifluoromethylphenyl)-l,2,4- oxadiazole, 3-(5-fluoro-pyrid-2-yl)-5-[3-(3-pyridyl)phenyl]-l,2,4-oxadiazole, 5-
[3-methyl-5-(3-pyridyl)-pyrid-4-yl]-3-(2-pyridyl)-l,2,4-oxadiazole, 5-[3- methoxy-5-(3-pyridyl)-pyrid-4-yl]-3-(2-pyridyl)- 1 ,2,4-oxadiazole, 5-(2-pyridyl)- 3-[5-(3-pyridyl)-pyrid-3-yl]-l,2,4-oxadiazole, 5-(2-pyridyl)-3-[3-(3-pyridyl)- phenyl]-l,2,4-oxadiazole, 5-(5-fluoro-pyrid-2-yl)-3-[3-fluoro-5-(3-pyridyl)- phenyl] -1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-carboxy-5-methoxyphenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-(carboxamido)-5-methoxyphenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(2-N,N-dimethylaminoethoxy)phenyl)- 1,2,4-oxadiazole, 3-(2-ρyridyl)-5-(3-cyano-5-(N,N- dimethylaminopropoxy)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(2- aminoethoxy)phenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(2- hydroxyethoxy)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- isopropoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-ethoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(2,2,2-trifluoroethoxy)phenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-cyclopropylmethoxyphenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-amino-5-cyanophenyl)-l,2,4-oxadiazole, 3-(5- fluoropyrid-2-yl)-5-(3-amino-5-cyanophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5- (3-cyano-5-(trifluoromethylsulfonyloxy)phenyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)- 5-(3-cyano-5-(2-methoxy-2-oxoethoxy)phenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5- (3-cyano-5-(2-tert-butoxy-2-oxoethoxy)phenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5- (3-cyano-5-(methoxymethoxy)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3- cyano-5-(methoxyethoxy)phenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3- cyano-5-cyclopentylaminophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- hexyloxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- (dimethylamino)carbonylphenyl)- 1 ,2,4-oxadiazole, 3-(5-fluoroρyrid-2-yl)-5-(3- cyano-5-ethylaminophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-
5-diethylaminophenyl)- 1 ,2,4-oxadiazole, 3-(5-fluoro-pyrid-2-yl)-5-[3-fluoro-5- (lH-tetraazol-5-yl)-phenyl]-l,2,4-oxadiazole, 5-[3-fluoro-5-(l-methyl-lH- tetraazol-5-yl)-phenyl]-3-(5-fluoro-pyrid-2-yl)-l,2,4-oxadiazole, 3-(5-fluoro-2- pyridyl)-5-(3-(l-benzyl-l,2,5,6-tetrahydropyridin-3-yl)-5-fluorophenyl)-l,2,4- oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-fluoro-5-(lH-imidazol-4-yl)phenyl)-l,2,4- oxadiazole, l-(3-cyanophenyl)-4-(5-fluoro-2-pyridyl)-lΗ-imidazole, 3-(2- pyridyl)-5-(3-(lH-imidazol-l-yl)-5-thiomethoxyphenyl)-l,2,4-oxadiazole, 3-(3-
cyano-5-(lH-imidazol-l-yl)phenyl)-5-(2-pyridyl)-l,2,4-oxadiazole, 3-(2-pyridyl)- 5-(3-cyano-5-(lH-imidazol-l-yl)phenyl)-l,2,4-oxadiazole, 2-(3-iodophenyl)-4- (pyridin-2-yl)-l,3-thiazole, 3-(2-pyridyl)-2-(3-cyanophenyl)-furan, 3-(5-fluoro-2- pyridyl)-2-(3-cyanophenyl)-furan, 3-(5-chloro-2-pyridyl)-2-(3-cyanophenyl)- furan, 2-(2-pyridyl)-5-(5-fluoro-3-(l-imidazolyl)phenyl)-furan, 3-(5-(2-pyridyl)- 2-furyl)-benzonitrile, 3-(5-(5-chloro-2-pyridyl)-2-furyl)-benzonitrile, 3-(5-(5- cyano-2-pyridyl)-2-furyl)-benzonitrile, 3-(5-(5-fluoro-2-pyridyl)-2-furyl)- benzonitrile, 3-fluoro-5-(5-(2-pyridyl)-2-furyl)-benzonitrile, 2-(3-cyanophenyl)-4- (5-fluoropyrid-2-yl)-l,3-oxazole, 2-(3-cyano-5-fluorophenyl)-4-(5-fluoropyrid-2- yl)-l,3-oxazole, 2-(3-cyano-5-fluorophenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(5- allyloxy-3-cyanophenyl)-4-(5-fluoropyrid-2-yl)-l,3-oxazole, 2-(3-cyano-5- methoxyphenyl)-4-(pyrid-2-yl)- 1 ,3-oxazole, 2-(3-cyano-5-methoxyphenyl)-4-(5- fluoropyrid-2-yl)-l,3-oxazole, 2-(3-cyano-5-n-propyloxyphenyl)-4-(5- fluoropyrid-2-yl)- 1,3-oxazole, and 2-(3-cyano-5-methoxyphenyl)-4-(4-pyrid-2- yl)-5-chloro- 1,3-oxazole.
14. A method for the inhibition of transient lower esophageal sphincter relaxations (TLESRs), whereby a pharmaceutically and pharmacologically effective amount of a compound of formula in,
Arx-L-Ar2 (III) where Ar1 is an optionally substituted heterocyclic moiety and Ar2 is an optionally substituted carbocyclic moiety; wherein the L moiety is made up of 1-14 atoms; or a pharmaceutically acceptable salt or an optical isomer thereof; or a pharmaceutically acceptable salt or an optical isomer thereof, is administered to a subject in need of such inhibition.
15. A method for the treatment of gastro-esophageal reflux disease (GERD), whereby a pharmaceutically and pharmacologically effective amount of a compound of
formula HI as defined in claim 14, or a pharmaceutically acceptable salt or an optical isomer thereof, is administered to a subject in need of such treatment.
16. A method for the prevention of reflux, whereby a pharmaceutically and pharmacologically effective amount of a compound of formula IH as defined in claim 14, or a pharmaceutically acceptable salt or an optical isomer thereof, is administered to a subject in need of such prevention.
17. A method for the treatment of, or prevention of, regurgitation, whereby a pharmaceutically and pharmacologically effective amount of a compound of formula III as defined in claim 14, or a pharmaceutically acceptable salt or an optical isomer thereof, is administered to a subject in need of such treatment or prevention.
18. A method for the prevention of, or treatment of, lung disease, whereby a pharmaceutically and pharmacologically effective amount of a compound of formula in as defined in claim 14, or a pharmaceutically acceptable salt or an optical isomer thereof, is administered to a subject in need of such treatment or prevention.
19. A method for managing failure to thrive, whereby a pharmaceutically and pharmacologically effective amount of a compound of formula III as defined in claim 14, or a pharmaceutically acceptable salt or an optical isomer thereof, is administered to a subject in need of such management.
20. A method for treatment or prevention of asthma, whereby a pharmaceutically and pharmacologically effective amount of a compound of formula HI as defined in claim 14, or a pharmaceutically acceptable salt or an optical isomer thereof, is administered to a subject in need of such treatment or prevention.
21. A method according to claim 18, wherein the asthma is reflux-related asthma.
22. A method for treatment or prevention of laryngitis, whereby a pharmaceutically and pharmacologically effective amount of a compound of formula IH as defined in claim 14, or a pharmaceutically acceptable salt or an optical isomer thereof, is administered to a subject in need of such treatment or prevention.
23. A method according to any one of claims 14-22, wherein the compound of formula HI is selected from the group of compounds consisting of 3-(2-pyridyl)-5- (3-methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3,5-dichlorophenyl)- 1,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-chlorophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(2- chlorophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-methylphenyl)-l,2,4-oxadiazole, 3-(2- pyridyl)-5-(l-naphthyl)-l ,2,4-oxadiazole, 3-(2-pyridyl)-5-[3- (trifluoromethoxy)phenyl]- 1,2,4- oxadiazole, 3-(2-pyridyl)-5-(2,3- difluorophenyl)-l ,2,4-oxadiazole, 3-(2-pyridyl) -5-(2,5-difluorophenyl)- 1 ,2,4- oxadiazole, 3-(2-pyridyl)-5-(3,5-difluorophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)~ 5-(3-cyanophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3,5-dimethoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(2,3-dichlorophenyl)-l,2,4-oxadiazole, 3-(2- pyridyl)-5-(3-chloro-5-cyanophenyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-fluoro- 5-cyanophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-chloro-5-fluorophenyl)- 1,2,4-oxadiazole, 3-(5-chloropyrid-2-yl)-5-(3-cyanophenyl)- 1,2,4-oxadiazole, 3- (5-fluoropyrid-2-yl)-5-(3-cyanophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)- 5-(3-cyano-5-fluorophenyl)- 1,2,4-oxadiazole, 3-(3-fluoropyrid-2-yl)-5-(3- cyanophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3,5-dimethoxyphenyl)- 1,2,4-oxadiazole, 3-(5-methoxypyrid-2-yl)-5-(3-cyanophenyl)- 1,2,4-oxadiazole, 3-(2-quinolinyl)-5-(3-cyanophenyl)- 1,2,4-oxadiazole, 3-(3-chloro-5- trifluoromethylpyrid-2-yl)-5-(3-cyanophenyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)-5- (5-chloro-2-methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(2-chloro-5- methylthiophenyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)-5-(2-bromo-5- methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(2,5,6-trifluorophenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-nitrophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(3- bromophenyl)- 1,2,4-oxadiazole, 2-(3,5-dichlorophenyl)-4-(2-pyridyl)-l,3- oxazole, 2-(3-chlorophenyl)-4-(2-pyridyl)- 1 ,3-oxazole, 2-(3-methoxyphenyl)-4-
(2-pyridyl)- 1,3-oxazole, 2-(2-chloroρhenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(3- trifluorophenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(3-methyl phenyl)-4-(2-pyridyl)-l,3- oxazole, 2-(l-naphthyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3-trifluoromethoxyphenyl)- 4-(2-pyridyl)-l,3-oxazole, 2-(2,3-difluorophenyl)-4-(2-pyridyl)-l,3-oxazole, 2- (2,5-difluorophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3,5-difluorophenyl)-4-(2- pyridyl)- 1,3-oxazole, 2-(3-cyanophenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(3,5- dimethoxyphenyl)-4-(2-pyridyl)- 1 ,3-oxazole, 2-(2,3-dichlorophenyl)-4-(2- pyridyl)-l,3-oxazole, 2-(3-chloro-5-cyanophenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(3- fluoro-5-cyanophenyl)-4-(2-pyridyl)- 1 ,3-oxazole, 2-(3-chloro-5-fluorophenyl)-4- (2-pyridyl)-l,3-oxazole, 2-(3-cyanophenyl)-4-(5-chloropyrid-2-yl)-l,3-oxazole, 2- (3-cyanophenyl)-4-(5-fluoropyrid-2-yl)- 1 ,3-oxazole, 2-(3-cyano-5-fluorophenyl)- 4-(5-fluoropyrid-2-yl)- 1 ,3-oxazole, 2-(3-cyanophenyl)-4-(3-fluoropyrid-2-yl)- 1 ,3- oxazole, 2-(3,5-dimethoxyphenyl)-4-(5-fluoropyrid-2-yl)-l,3-oxazole, 2-(3- cyanophenyl)-4-(5-methoxypyrid-2-yl)-l,3-oxazole, 2-(3-cyanophenyl)-4-(2- quinolinyl)-l ,3-oxazole, 2-(3-cyanophenyl)-4-(3-chloro-5-trifluoromethylpyrid-2- yl)-l,3-oxazole, 2-(5-chloro-2-methoxyphenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(2- chloro-5-methylthiophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(2-bromo-5- methoxyphenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(2,5,6-trifluorophenyl)-4-(2- pyridyl)- 1,3-oxazole, 2-[3-chlorophenyl]-4-[pyridin-2-yl]-l,3-oxazole, 2-(2,5,6- trifluorophenyl)-4-(2-pyridyl)-l,3-oxazole, 2-(3-nitrophenyl)-4-(2-pyridyl)- 1,3- oxazole, 2-(3-bromophenyl)-4-(2-pyridyl)- 1,3-oxazole and pharmaceutically acceptable salts or optical isomers thereof.
24. A method according to any one of claims 14-22, wherein the compound of formula HI is selected from the group of compounds consisting of 3-(5-Methyl- pyrid-2-yl)-5-(3-cyanophenyl)- 1,2,4-oxadiazole, 3-(5-Cyano-pyrid-2-yl)-5-(3- cyanophenyl)- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-bromo-2-methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-bromo-2-fluorophenyl)-l,2,4-oxadiazole, 3- (2-Pyridyl)-5-(5-cyano-2-fluorophenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5- bromopyrid-3-yl)-l ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-chloro-pyrid-3-yl)-l ,2,4- oxadiazole, 3-(5-Cyanopyrid-2-yl)-5-(5-bromo-pyrid-3-yl)-l,2,4-oxadiazole, 3-(5- Fluoropyrid-2-yl)-5-(5-bromo-ρyrid-3-yl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(2-
thiomethoxy-pyrid-3-yl)- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-methylpyrid-3-yl)- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-methoxypyrid-3-yl)-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-cyano-5-methylphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-fluoro- 5-bromophenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-iodo-5-bromophenyl)- 1,2,4- oxadiazole, 3-(5-Fluoro-2-pyridyl)-5-(3-fluoro-5-bromophenyl)-l ,2,4-oxadiazole,
3-(2-Pyridyl)-5-(3-iodo-5-(methylρhenylester)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5- (3-methoxy-5-(methoxycarbonyl)phenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3- bromo-5-cyanophenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano-3-iodophenyl)- 1,2,4-oxadiazole, 3-(5-Cyano-2-pyridyl)-5-(3-bromophenyl)-l,2,4-oxadiazole, 3- (5-Cyano-2-pyridyl)-5-(3-cyano-5-fluorophenyl)-l ,2,4-oxadiazole, 3-(5-Cyano-2- pyridyl)-5-(3-bromo-5-fluorophenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano- 2-methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(2-cyano-5-methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano-pyrid-3-yl)-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-cyano-5-(methoxycarbonyl)phenyl)-l,2,4-oxadiazole, 3-(2-Pyridyl)- 5-(5-phenyl-pyrid-3-yl)-l ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5- methoxyphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5-hydroxyphenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5-propoxyphenyl)- 1,2,4-oxadiazole, 2- (3-Cyanophenyl)-4-(pyridin-2-yl)-l,3-thiazole, 2-((3-Bromo-5-iodophenyl)-4- pyridin-2-yl)-l,3-oxazole, 2-(2-Pyridyl)-5-(3-iodophenyl)-l,3,4-oxadiazole, 2-(2- Pyridyl)-5-(3-cyanophenyl)-l ,3,4-oxadiazole, 2-(2-Pyridyl)-5-(3-cyanophenyl)-
1,3,4-triazole, 3-(5-Chloropyrid-2-yl)-5-(3-cyano-5-fluorophenyl)- 1,2,4- oxadiazole, 3-(5-Chloropyrid-2-yl)-5-(3-cyano-5-chlorophenyl)-l,2,4-oxadiazole, 3-(5-Chloropyrid-2-yl)-5-(3-chloro-5-fluorophenyl)-l,2,4-oxadiazole, 3-(5- Chloropyrid-2-yl)-5-(3-cyano-5-methoxyphenyl)- 1 ,2,4-oxadiazole, 3-(5- Fluoropyrid-2-yl)-5-(3-cyano-5-chlorophenyl)-l,2,4-oxadiazole, 3-(5-
Fluoroρyrid-2-yl)-5-(3-fluoro-5-chlorophenyl)-l,2,4-oxadiazole, 3-(5- Fluoropyrid-2-yl)-5-(3-cyano-5-methoxyphenyl)- 1,2,4-oxadiazole, 3-(5- Cyanopyrid-2-yl)-5-(3-cyano-5-chlorophenyl)-l,2,4-oxadiazole, 3-(5-Cyanopyrid- 2-yl)-5-(3-fluoro-5-chlorophenyl)- 1,2,4-oxadiazole, 3-(5-Cyanopyrid-2-yl)-5-(3- cyano-5-methoxyphenyl)- 1,2,4-oxadiazole, 3-(5-Fluoropyrid-2-yl)-5-(3,5-di- cyanophenyl)- 1,2,4-oxadiazole, 3-(3-(4-Dimethylaminobutoxy)-pyrid-2-yl)-5-(3- cyano-5-fluorophenyl)- 1,2,4-oxadiazole, 3-(3-(5-Dimethylaminopentyloxy)-
pyrid-2-yl)-5-(3-Cyano-5-fluorophenyl)-l,2,4-oxadiazole, and [3-(3-(6- Dimethylaminohexyloxy)-pyrid-2-yl)-5-(3-cyano-5-fluorophenyl)-l,2,4- oxadiazole and pharmaceutically acceptable salts or optical isomers thereof.
25. A method according to any one of claims 14-22, wherein the compound of formula in is selected from the group of compounds consisting of 3-(2-Pyridyl)- 5-(3-allyloxy-5-(methoxycarbonyl)phenyl)-l,2,4- oxadiazole, 3-(2-Pyridyl)-5-(3- N,N-dimethylaminophenyl)- 1,2,4-oxadiazole), 3-(2-Pyridyl)-5-(3-cyano-5-(4- pyridyl)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-[2-methoxy-5-(4- pyridyl)phenyl]-l,2,4- oxadiazole, 3-(2-pyridyl)-5-[2-fluoro-5-(4-pyridyl)phenyl]- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-fluoro-5-(4-pyridyl)phenyl)-l,2,4- oxadiazole, 3- (2-Pyridyl)-5-(3-fluoro-5-(3-pyridyl) phenyl)- 1,2,4-oxadiazole, 3- (2-Pyridyl)-5-[2-fluoro-5-(3-pyridyl)phenyl]-l,2,4-oxediazole, 3-(2-Pyridyl)-5-[2- methoxy-5-(3-pyridyl)phenyl]-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5-(3- pyridyl)phenyl)-l ,2,4-oxadiazole, 3-(5-Fluoro-2-pyridyl)-5-(3-fluoro-5-(3- pyridyl)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-[5-(3-pyridyl-pyrid-3-yl)]-]- 1,2,4-oxadiazole, 3-(5-Fluoropyrid-2-yl)]-5-[5-(3-pyridyl-pyrid-3-yl)]-3-l,2,4- oxadiazole, 3-(5-Cyanopyrid-2-yl)-5-(3-(pyrid-3-yl)phenyl)-l ,2,4-oxadiazole, to 3-(5-Cyanopyrid-2-yl)-5-(3-fluoro-5- (pyrid-3-yl)phenyl)-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-cyano-5- (2-pyridyl)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-[2- methoxy-5-(2-pyridyl)phenyl]-l,2,4-oxediazole, 3-(2-Pyridyl)-5-[2-fluoro-5- (2- pyridyl)phenyl]-l,2,4-oxadiazole, 3-(2-Pyridyl)-5-[(3-(3-fluorophenyl)-5- fluorophenyl)]- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3- cyano-5-(3- thiophene)phenyl)- 1 ,2,4-oxadiazole, 3- (2-Pyridyl)-5-[5-(3-thienyl)-pyrid-3-yl]- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-[5-3-furyl)-pyrid-3-yl]-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-[5-(3-methoxyphenyl)-pyrid-3-yl]-l,2,4-oxadiazole, 3-(2-Pyridyl)-5- (3-cyano-5-(5-pyrimidyl)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)- 5-(3-cyano-5- (3-aminophenyl)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl) -5-(3-cyano-5-(3- fluorophenyl)phenyl)-l,2,4-oxediazole, 3-(2-Pyridyl)-5-[5-(5-pyrimidyl)-pyrid-3- yl]- 1,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-aminomethyl-5-cyanophenyl)-l,2,4- oxadiazole, 3-(2-Pyridyl)-5-[5[(2-propenyl)-pyrid-3-yl]-l,2,4-oxediazole, 3-(2- Pyridyl)-5- (3-cyano-5-vinylphenyl)-l,2,4-oxadiazole, 3-(2- Pyridyl)-5-(3-cyano-
5-(2-hydroxyethyl)phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-cyano-5-(2,3- (iichloropropoxy)phenyl)- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-allyloxy-5- carboxyphenyl)- 1 ,2,4-oxadiazole, 3-(2-Pyridyl)-5-(3-allyloxy-5-cyanophenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(5-cyano-3-[3-hydroxypropyn-l-yl]phenyl)- 1,2,4-oxadiazole, 3-(2-Pyridyl)-5-(2-N-methylaminophenyl)- 1,2,4-oxadiazole, and 3-(2-Pyridyl)-5- [5-(3-N-benzyl-l, 2,5,6, tetrahydropyridine)-pyrid-3-yl]- 1,2,4-oxadiazole.
26. A method according to any one of claims 14-22, wherein the compound of formula HI is selected from the group of compounds consisting of 3-(2-pyridyl)-5- (3-fhιorophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(2,3-dimethoxyphenyl)- 1,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-phenoxyphenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5- (3-benzoylphenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(2-chloro-5- (trifluoromethyl)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3,4,5- trifluorophenyl)- 1,2,4-oxadiazole, 3-(3-methoxyphenyl)-5-(2-pyridyl)-l,2,4- oxadiazole, 3-(pyrid-2-yl)-5-(2-hydroxyphenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5- (5-chloro-2-hydroxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(2-aminophenyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)-5-(5-chloro-2-aminophenyl)-l ,2,4-oxadiazole, 5- [3-hydroxyphenyl]-3-[pyridin-2-yl]-l,2-oxazole, 5-[3-cyanophenyl]-3-[pyridin-2- yl]-l,2-oxazole, 3-(2-pyridyl)-5-(3-chlorophenyl)-l,2,4-triazole, 3-(2-pyridyl)-5- (3-iodophenyl)-l,2,4-triazole, 3-(2-pyridyl)-5-(5-hydroxypyrid-3-yl)-l,2,4- oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(5-fluoro-3-(thiomethyl)phenyl)- 1 ,2,4- oxadiazole, 5-(2-pyridyl)-3-[3-(lH-imidazol-l-yl)-5-fluorophenyl)]-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-trifluoromethylphenyl)-l,2,4-oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-fluoro-5-trifluoromethylphenyl)-l ,2,4-oxadiazole, 3- (5-cyanopyrid-2-yl)-5-(3-alloxy-5-cyanophenyl)- 1,2,4-oxadiazole, 3-(5- fluoropyrid-2-yl)-5-(3-alloxy-5-cyanophenyl)- 1,2,4-oxadiazole, 3-(5-cyanopyrid- 2-yl)-5-(3-cyano-5-propoxyphenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3- cyano-5-propoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- nitrophenyl)-l ,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-nitrophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-dimethylaminophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-(2-methoxyethoxy)phenyl)-
1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-(lH-imidazol-l- ylmethyl)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- (methoxymethyl)phenyl)- 1,2,4-oxadiazole, 3-(3-cyano-5-methoxyphenyl)-5-(2- pyridyl)- 1 ,2,4-oxadiazole, 3-(3-cyano-5-methoxyphenyl)-5-(5-fluoropyrid-2-yl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5-ethoxyphenyl)-l,2,4- oxadiazole, 3-(5-cyanopyrid-2-yl)-5-(3-cyano-5-ethoxyphenyl)- 1,2,4-oxadiazole, 3-(5-chloropyrid-2-yl)-5-(3-allyloxy-5-cyanophenyl)-l,2,4-oxadiazole, 3-(5- chloropyrid-2-yl)-5-(3-cyano-5-propoxyphenyl)-l,2,4-oxadiazole, 3-(5- chloropyrid-2-yl)-5-(3-cyano-5-ethoxyphenyl)-l,2,4-oxadiazole, 3-(5-fluoropyrid- 2-yl)-5-(3-cyano-5-hexyloxyphenyl)-l ,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-
(3-cyano-5-(methoxymethyl)phenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5- (5-cyano-2-methoxyphenyl)-l,2,4-oxadiazole, 5-(5-cyano-2-methoxyphenyl)-3- (5-cyano-pyrid-2-yl)-l,2,4-oxadiazole, 3-(5-fluoro-pyrid-2-yl)-5-(3- bromophenyl)- 1,2,4-oxadiazole, 5-(3-chloro-5-methyl-pyrid-4-yl)-3-(2-pyridyl)- 1,2,4-oxadiazole, 5-(3-chloro-5-methoxy-pyrid-4-yl)-3-(2-pyridyl)- 1,2,4- oxadiazole, 3-(3-cyano-5-methylphenyl)-5-(2-pyridyl)- 1,2,4-oxadiazole, 3-(5- bromo-pyrid-3-yl)-5-(2-pyridyl)-l,2,4-oxadiazole, 3-(3-cyano-5-fluorophenyl)-5- (2-pyridyl)- 1,2,4-oxadiazole, 3-(3-iodophenyl)-5-(2-pyridyl)-l,2,4-oxadiazole, 3- (3-cyanophenyl)-5-(2-pyridyl)-l,2,4-oxadiazole, 3-(3-cyano-5-dimethylamino- phenyl)-5-(2-pyridyl)- 1,2,4-oxadiazole, 3-(3-cyano-5-methylphenyl)-5-(5-fluoro- pyrid-2-yl)- 1,2,4-oxadiazole, 3-(3-cyano-5-fluorophenyl)-5-(5-fluoro-pyrid-2-yl)- 1,2,4-oxadiazole, 3-(4-cyanophenyl)-3-(6-cyano-pyrid-2-yl)- 1,2,4-oxadiazole, 5- (3-cyano-5-trifluoromethoxyphenyl)-3-(2-pyridyl)-l,2,4-oxadiazole, 5-(3- methoxycarbonyl-5-trifluoromethoxyphenyl)-3-(2-pyridyl)-l,2,4-oxadiazole, 5- (3-cyano-5-trifluoromethoxyphenyl)-3-(5-fluoro-pyrid-2-yl)-l,2,4-oxadiazole, 3-
(5-cyano-pyrid-2-yl)-5-(3-cyano-5-trifluoromethoxyphenyl)- 1,2,4-oxadiazole, 3- (3-cyano-5-dimethylaminophenyl)-5-(5-fluoro-pyrid-2-yl)- 1 ,2,4-oxadiazole, 5-(5- chloro-pyrid-2-yl)-3-(3-cyano-5-dimethylaminophenyl)-l,2,4-oxadiazole, 5-(5- chloro-pyrid-2-yl)-3-(3-cyano-5-methoxyphenyl)- 1 ,2,4-oxadiazole, 5-(5-chloro- pyrid-2-yl)-3-(6-cyano-4-methoxy-pyrid-2-yl)-l ,2,4-oxadiazole, 5-(5-chloro- pyrid-2-yl)-3-(6-cyano-4-hydroxy-pyrid-2-yl)-l,2,4-oxadiazole, 5-(5-chloro- pyrid-2-yl)-3-(3-cyano-5-trifluoromethoxyphenyl)-l,2,4-oxadiazole, 5-(5-chloro-
pyrid-2-yl)-3-(3-cyanophenyl)- 1,2,4-oxadiazole, 5-(5-chloro-pyrid-2-yl)-3-(3- cyano-5-methylphenyl)- 1,2,4-oxadiazole, 5-(5-chloro-pyrid-2-yl)-3-(3-cyano-5- fluorophenyl)- 1,2,4-oxadiazole, 3-(3-cyano-5-trifluoromethoxyphenyl)-5-(2- pyridyl)- 1,2,4-oxadiazole, 3-(3-fluoro-5-methoxyphenyl)-5-(2-pyridyl)-l,2,4- oxadiazole, 3-(3-cyanophenyl)-5-(5-fluoro-pyrid-2-yl)-l,2,4-oxadiazole, 3-(3- cyano-5-trifluoromethoxyphenyl)-5-(5-fluoro-pyrid-2-yl)-l,2,4-oxadiazole, 3-(3- fluoro-5-methoxyphenyl)-5-(5-fluoropyrid-2-yl)-l,2,4-oxadiazole, 3-(3,5- dimethoxyρhenyl)-5-(5-fluoropyrid-2-yl)-l,2,4-oxadiazole, 3-[3-fluoro-5-(lH- imidazol-l-yl)phenyl]-5-(2-pyridyl)-l,2,4-oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3- fluoro-5-(3-pyridyl)phenyl)-l ,2,4-oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-bromo-
5-(3-pyridyl)phenyl)- 1,2,4-oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-fTuoro-5- methoxyphenyl)-l ,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(3-cyano-5- thiomethylphenyl)- 1,2,4-oxadiazole, 3-(5-fluoro-pyrid-2-yl)-5-(3-cyano-5- thiomethylphenyl)- 1,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(3-fluoro-5- thiomethylphenyl)- 1,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(3-fluoro-5- thiomethylsulphoxidephenyl)- 1 ,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(3-fluoro-5- thioethylphenyl)- 1,2,4-oxadiazole, 3-(pyrid-2-yl)-5-(5-fluoro-3- thiotertbutylphenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano-5- methylphenyl)- 1,2,4-oxadiazole, 3-(5-cyanopyrid-2-yl)-5-(3-cyano-5- thiomethylphenyl)- 1 ,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(4-cyano-2-thienyl)-
1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-trifluoromethylphenyl)-l,2,4- oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-cyano-5-trifluoromethylphenyl)- 1 ,2,4- oxadiazole, 3-(5-fluoro-pyrid-2-yl)-5-[3-(3-pyridyl)phenyl]-l ,2,4-oxadiazole, 5- [3-methyl-5-(3-pyridyl)-pyrid-4-yl]-3-(2-pyridyl)-l,2,4-oxadiazole, 5-[3- methoxy-5-(3-pyridyl)-pyrid-4-yl]-3-(2-pyridyl)- 1 ,2,4-oxadiazole, 5-(2-pyridyl)-
3-[5-(3-pyridyl)-pyrid-3-yl]-l,2,4-oxadiazole, 5-(2-pyridyl)-3-[3-(3-ρyridyl)- phenyl]- 1,2,4-oxadiazole, 5-(5-fluoro-ρyrid-2-yl)-3-[3-fluoro-5-(3-pyridyl)- phenyl]-l,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-carboxy-5-methoxyphenyl)- 1,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-(carboxamido)-5-methoxyphenyl)- 1 ,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(2-N)N-dimethylaminoethoxy)phenyl)-
1 ,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(N,N- dimethylaminopropoxy)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(2-
aminoethoxy)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(2- hydroxyethoxy)phenyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- isopropoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-ethoxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-(2,2,2-trifluoroethoxy)phenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5-cyclopropylmethoxyphenyl)-l,2,4- oxadiazole, 3-(2-pyridyl)-5-(3-amino-5-cyanophenyl)-l,2,4-oxadiazole, 3-(5- fluoropyrid-2-yl)-5-(3-amino-5-cyanophenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5- (3-cyano-5-(trifluoromethylsulfonyloxy)phenyl)- 1 ,2,4-oxadiazole, 3-(2-pyridyl)- 5-(3-cyano-5-(2-methoxy-2-oxoethoxy)phenyl)-l,2,4-oxadiazole, 3-(2-pyridyl)-5- (3-cyano-5-(2-tert-butoxy-2-oxoethoxy)phenyl)-l ,2,4-oxadiazole, 3-(2-pyridyl)-5-
(3-cyano-5-(methoxymethoxy)phenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3- cyano-5-(methoxyethoxy)phenyl)-l,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3- cyano-5-cyclopentylaminophenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- hexyloxyphenyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)-5-(3-cyano-5- (dimethylamino)carbonylphenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3- cyano-5-ethylaminophenyl)- 1,2,4-oxadiazole, 3-(5-fluoropyrid-2-yl)-5-(3-cyano- 5-diethylaminophenyl)-l,2,4-oxadiazole, 3-(5-fluoro-pyrid-2-yl)-5-[3-fluoro-5- (lH-tetraazol-5-yl)-phenyl]-l,2,4-oxadiazole, 5-[3-fluoro-5-(l-methyl-lH- tetraazol-5-yl)-phenyl]-3-(5-fluoro-pyrid-2-yl)-l,2,4-oxadiazole, 3-(5-fluoro-2- pyridyl)-5-(3-(l-benzyl-l,2,5,6-tetrahydropyridin-3-yl)-5-fluorophenyl)-l,2,4- oxadiazole, 3-(5-fluoro-2-pyridyl)-5-(3-fluoro-5-(lH-imidazol-4-yl)phenyl)-l,2,4- oxadiazole, l-(3-cyanophenyl)-4-(5-fluoro-2-pyridyl)-lΗ-imidazole, 3-(2- ρyridyl)-5-(3-(lH-imidazol-l-yl)-5-thiomethoxyphenyl)-l,2,4-oxadiazole, 3-(3- cyano-5-(lH-imidazol-l-yl)phenyl)-5-(2-pyridyl)- 1,2,4-oxadiazole, 3-(2-pyridyl)- 5-(3-cyano-5-(lH-imidazol-l-yl)phenyl)-l,2,4-oxadiazole, 2-(3-iodophenyl)-4-
(pyridin-2-yl)-l,3-thiazole, 3-(2-pyridyl)-2-(3-cyanophenyl)-furan, 3-(5-fluoro-2- ρyridyl)-2-(3-cyanophenyl)-furan, 3-(5-chloro-2-pyridyl)-2-(3-cyanophenyl)- furan, 2-(2-pyridyl)-5-(5-fluoro-3-(l-imidazolyl)phenyl)-furan, 3-(5-(2-pyridyl)~ 2-furyl)-benzonitrile, 3-(5-(5-chloro-2-pyridyl)-2-furyl)-benzonitrile, 3-(5-(5- cyano-2-pyridyl)-2-furyl)-benzonitrile, 3-(5-(5-fluoro-2-pyridyl)-2-furyl)- benzonitrile, 3-fluoro-5-(5-(2-pyridyl)-2-furyl)-benzonitrile, 2-(3-cyanophenyl)-4- (5-fluoropyrid-2-yl)- 1 ,3-oxazole, 2-(3-cyano-5-fluorophenyl)-4-(5-fluoropyrid-2-
yl)-l,3-oxazole, 2-(3-cyano-5-fluorophenyl)-4-(2-pyridyl)- 1,3-oxazole, 2-(5- allyloxy-3-cyanophenyl)-4-(5-fluoropyrid-2-yl)-l,3-oxazole, 2-(3-cyano-5- methoxyphenyl)-4-(pyrid-2-yl)-l,3-oxazole, 2-(3-cyano-5-methoxyphenyl)-4-(5- fluoropyrid-2-yl)-l,3-oxazole, 2-(3-cyano-5-n-propyloxyphenyl)-4-(5- fluoropyrid-2-yl)-l ,3-oxazole, and 2-(3-cyano-5-methoxyphenyl)-4-(4-pyrid-2- yl)-5-chloro- 1,3-oxazole.