MX2011010658A - Inhibidor de la recaptacion de serotonina y norepinefrina. - Google Patents
Inhibidor de la recaptacion de serotonina y norepinefrina.Info
- Publication number
- MX2011010658A MX2011010658A MX2011010658A MX2011010658A MX2011010658A MX 2011010658 A MX2011010658 A MX 2011010658A MX 2011010658 A MX2011010658 A MX 2011010658A MX 2011010658 A MX2011010658 A MX 2011010658A MX 2011010658 A MX2011010658 A MX 2011010658A
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- pyrrolidine
- mmol
- butyl
- pharmaceutically acceptable
- Prior art date
Links
- 229940121991 Serotonin and norepinephrine reuptake inhibitor Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 30
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- -1 chloro, bromo, methyl Chemical group 0.000 claims description 45
- 208000002193 Pain Diseases 0.000 claims description 37
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 23
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 20
- 208000000094 Chronic Pain Diseases 0.000 claims description 13
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 12
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- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims description 7
- SNNRWIBSGBMYRF-ZFWWWQNUSA-N 6-methoxy-2-methyl-3-[(1s)-3-methyl-1-[(3s)-pyrrolidin-3-yl]butoxy]pyridine Chemical group CC1=NC(OC)=CC=C1O[C@@H](CC(C)C)[C@@H]1CNCC1 SNNRWIBSGBMYRF-ZFWWWQNUSA-N 0.000 claims description 6
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- LBURVPKSZFFLHP-UHFFFAOYSA-N tert-butyl 3-[1-(6-chloropyridin-3-yl)oxy-3-methylbutyl]pyrrolidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CC1C(CC(C)C)OC1=CC=C(Cl)N=C1 LBURVPKSZFFLHP-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US16807909P | 2009-04-09 | 2009-04-09 | |
| PCT/US2010/030038 WO2010117979A2 (en) | 2009-04-09 | 2010-04-06 | Serotonin and norepinephrine reuptake inhibitor |
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| MX2011010658A true MX2011010658A (es) | 2011-10-21 |
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| MX2011010658A MX2011010658A (es) | 2009-04-09 | 2010-04-06 | Inhibidor de la recaptacion de serotonina y norepinefrina. |
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| EP (1) | EP2417124B1 (enExample) |
| JP (1) | JP2012523416A (enExample) |
| KR (1) | KR101378260B1 (enExample) |
| CN (1) | CN102388036A (enExample) |
| AR (1) | AR075988A1 (enExample) |
| AU (1) | AU2010234610B2 (enExample) |
| BR (1) | BRPI1014382A2 (enExample) |
| CA (1) | CA2758251C (enExample) |
| EA (1) | EA201171230A1 (enExample) |
| ES (1) | ES2446644T3 (enExample) |
| MX (1) | MX2011010658A (enExample) |
| TW (1) | TW201103908A (enExample) |
| WO (1) | WO2010117979A2 (enExample) |
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| ES2434250T3 (es) | 2008-07-24 | 2013-12-16 | Theravance, Inc. | Compuestos de 3-(fenoxifenilmetil)pirrolidina |
| EP2419405A1 (en) * | 2009-04-15 | 2012-02-22 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| AU2010273645B2 (en) * | 2009-07-13 | 2014-12-04 | Theravance Biopharma R&D Ip, Llc | 3-phenoxymethylpyrrolidine compounds |
| US8273786B2 (en) * | 2009-07-21 | 2012-09-25 | Theravance, Inc. | 3-phenoxymethylpyrrolidine compounds |
| WO2012051103A1 (en) | 2010-10-11 | 2012-04-19 | Theravance, Inc. | Serotonin reuptake inhibitors |
| US8501964B2 (en) | 2010-12-03 | 2013-08-06 | Theravance, Inc. | Serotonin reuptake inhibitors |
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| NL1004346C2 (nl) | 1996-10-23 | 1998-04-24 | Dsm Nv | Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel. |
| CN1125064C (zh) | 1996-12-10 | 2003-10-22 | 艾博特公司 | 3－吡啶基对映体及其作为镇痛剂的用途 |
| PT1047690E (pt) | 1997-12-19 | 2004-07-30 | Abbott Lab | Compostos eter e tioeter heterociclicos uteis no controlo da transmissao quimica sinaptica |
| US20020151712A1 (en) | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| EP1212319A2 (en) | 1999-09-14 | 2002-06-12 | Abbott Laboratories | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| AP2006003771A0 (en) | 2004-04-30 | 2006-10-31 | Warner Lambert Co | Substituted morpholine compounds for the treatmentof central nervous system disorders |
| CN101506164A (zh) * | 2006-08-23 | 2009-08-12 | 辉瑞产品公司 | 哌啶衍生物 |
| JP5330260B2 (ja) | 2006-12-06 | 2013-10-30 | スミスクライン ビーチャム コーポレーション | 二環式化合物ならびに抗糖尿病薬としての使用 |
| ES2434250T3 (es) | 2008-07-24 | 2013-12-16 | Theravance, Inc. | Compuestos de 3-(fenoxifenilmetil)pirrolidina |
-
2010
- 2010-03-29 AR ARP100101017A patent/AR075988A1/es unknown
- 2010-04-02 TW TW099110421A patent/TW201103908A/zh unknown
- 2010-04-06 MX MX2011010658A patent/MX2011010658A/es active IP Right Grant
- 2010-04-06 JP JP2012504759A patent/JP2012523416A/ja active Pending
- 2010-04-06 EA EA201171230A patent/EA201171230A1/ru unknown
- 2010-04-06 ES ES10713753.1T patent/ES2446644T3/es active Active
- 2010-04-06 CA CA2758251A patent/CA2758251C/en not_active Expired - Fee Related
- 2010-04-06 KR KR1020117023570A patent/KR101378260B1/ko not_active Expired - Fee Related
- 2010-04-06 BR BRPI1014382A patent/BRPI1014382A2/pt not_active IP Right Cessation
- 2010-04-06 CN CN2010800160763A patent/CN102388036A/zh active Pending
- 2010-04-06 EP EP10713753.1A patent/EP2417124B1/en not_active Not-in-force
- 2010-04-06 US US12/754,800 patent/US8173821B2/en not_active Expired - Fee Related
- 2010-04-06 AU AU2010234610A patent/AU2010234610B2/en not_active Ceased
- 2010-04-06 WO PCT/US2010/030038 patent/WO2010117979A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EA201171230A1 (ru) | 2012-03-30 |
| EP2417124B1 (en) | 2013-12-18 |
| ES2446644T3 (es) | 2014-03-10 |
| AR075988A1 (es) | 2011-05-11 |
| AU2010234610B2 (en) | 2013-04-18 |
| JP2012523416A (ja) | 2012-10-04 |
| EP2417124A2 (en) | 2012-02-15 |
| BRPI1014382A2 (pt) | 2016-04-05 |
| US8173821B2 (en) | 2012-05-08 |
| CA2758251C (en) | 2013-08-06 |
| AU2010234610A1 (en) | 2011-10-06 |
| US20100261762A1 (en) | 2010-10-14 |
| WO2010117979A3 (en) | 2011-02-17 |
| KR101378260B1 (ko) | 2014-03-27 |
| KR20110123287A (ko) | 2011-11-14 |
| TW201103908A (en) | 2011-02-01 |
| CA2758251A1 (en) | 2010-10-14 |
| CN102388036A (zh) | 2012-03-21 |
| WO2010117979A2 (en) | 2010-10-14 |
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