AU2010234610B2 - Serotonin and norepinephrine reuptake inhibitor - Google Patents

Serotonin and norepinephrine reuptake inhibitor Download PDF

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Publication number
AU2010234610B2
AU2010234610B2 AU2010234610A AU2010234610A AU2010234610B2 AU 2010234610 B2 AU2010234610 B2 AU 2010234610B2 AU 2010234610 A AU2010234610 A AU 2010234610A AU 2010234610 A AU2010234610 A AU 2010234610A AU 2010234610 B2 AU2010234610 B2 AU 2010234610B2
Authority
AU
Australia
Prior art keywords
methyl
pyrrolidine
pyridyloxy
mmol
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010234610A
Other languages
English (en)
Other versions
AU2010234610A1 (en
Inventor
Nicolas Jacques Francois Dreyfus
Sandra Ann Filla
Anette Margareta Johansson
Thierry J. Masquelin
Jikesh Arvind Shah
Eric George Tromiczak
Magnus Wilhelm Walter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2010234610A1 publication Critical patent/AU2010234610A1/en
Application granted granted Critical
Publication of AU2010234610B2 publication Critical patent/AU2010234610B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2010234610A 2009-04-09 2010-04-06 Serotonin and norepinephrine reuptake inhibitor Ceased AU2010234610B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16807909P 2009-04-09 2009-04-09
US61/168,079 2009-04-09
PCT/US2010/030038 WO2010117979A2 (en) 2009-04-09 2010-04-06 Serotonin and norepinephrine reuptake inhibitor

Publications (2)

Publication Number Publication Date
AU2010234610A1 AU2010234610A1 (en) 2011-10-06
AU2010234610B2 true AU2010234610B2 (en) 2013-04-18

Family

ID=42698378

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010234610A Ceased AU2010234610B2 (en) 2009-04-09 2010-04-06 Serotonin and norepinephrine reuptake inhibitor

Country Status (14)

Country Link
US (1) US8173821B2 (enExample)
EP (1) EP2417124B1 (enExample)
JP (1) JP2012523416A (enExample)
KR (1) KR101378260B1 (enExample)
CN (1) CN102388036A (enExample)
AR (1) AR075988A1 (enExample)
AU (1) AU2010234610B2 (enExample)
BR (1) BRPI1014382A2 (enExample)
CA (1) CA2758251C (enExample)
EA (1) EA201171230A1 (enExample)
ES (1) ES2446644T3 (enExample)
MX (1) MX2011010658A (enExample)
TW (1) TW201103908A (enExample)
WO (1) WO2010117979A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2434250T3 (es) 2008-07-24 2013-12-16 Theravance, Inc. Compuestos de 3-(fenoxifenilmetil)pirrolidina
EP2419405A1 (en) * 2009-04-15 2012-02-22 Theravance, Inc. 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds
AU2010273645B2 (en) * 2009-07-13 2014-12-04 Theravance Biopharma R&D Ip, Llc 3-phenoxymethylpyrrolidine compounds
US8273786B2 (en) * 2009-07-21 2012-09-25 Theravance, Inc. 3-phenoxymethylpyrrolidine compounds
WO2012051103A1 (en) 2010-10-11 2012-04-19 Theravance, Inc. Serotonin reuptake inhibitors
US8501964B2 (en) 2010-12-03 2013-08-06 Theravance, Inc. Serotonin reuptake inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151712A1 (en) * 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1004346C2 (nl) 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
CN1125064C (zh) 1996-12-10 2003-10-22 艾博特公司 3－吡啶基对映体及其作为镇痛剂的用途
PT1047690E (pt) 1997-12-19 2004-07-30 Abbott Lab Compostos eter e tioeter heterociclicos uteis no controlo da transmissao quimica sinaptica
EP1212319A2 (en) 1999-09-14 2002-06-12 Abbott Laboratories 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
AP2006003771A0 (en) 2004-04-30 2006-10-31 Warner Lambert Co Substituted morpholine compounds for the treatmentof central nervous system disorders
CN101506164A (zh) * 2006-08-23 2009-08-12 辉瑞产品公司 哌啶衍生物
JP5330260B2 (ja) 2006-12-06 2013-10-30 スミスクライン ビーチャム コーポレーション 二環式化合物ならびに抗糖尿病薬としての使用
ES2434250T3 (es) 2008-07-24 2013-12-16 Theravance, Inc. Compuestos de 3-(fenoxifenilmetil)pirrolidina

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151712A1 (en) * 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission

Also Published As

Publication number Publication date
EA201171230A1 (ru) 2012-03-30
EP2417124B1 (en) 2013-12-18
ES2446644T3 (es) 2014-03-10
AR075988A1 (es) 2011-05-11
JP2012523416A (ja) 2012-10-04
EP2417124A2 (en) 2012-02-15
BRPI1014382A2 (pt) 2016-04-05
US8173821B2 (en) 2012-05-08
CA2758251C (en) 2013-08-06
AU2010234610A1 (en) 2011-10-06
US20100261762A1 (en) 2010-10-14
WO2010117979A3 (en) 2011-02-17
KR101378260B1 (ko) 2014-03-27
KR20110123287A (ko) 2011-11-14
TW201103908A (en) 2011-02-01
CA2758251A1 (en) 2010-10-14
MX2011010658A (es) 2011-10-21
CN102388036A (zh) 2012-03-21
WO2010117979A2 (en) 2010-10-14

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired